Alexander Amberg

发表

Phototoxicity – from molecular descriptors to classification models

Andreas Evers, Gerhard Hessler, Karl-Heinz Baringhaus, 2011, J. Cheminformatics.

In silico toxicology protocols.

Tudor I. Oprea, Naomi L Kruhlak, Lidiya Stavitskaya, 2018, Regulatory toxicology and pharmacology : RTP.

Proposed minimum reporting standards for chemical analysis

Nigel W. Hardy, Nigel Hardy, John C. Lindon, 2007, Metabolomics.

Establishing best practise in the application of expert review of mutagenicity under ICH M7.

Lidiya Stavitskaya, Alexander Amberg, Steve Gutsell, 2015, Regulatory toxicology and pharmacology : RTP.

Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses

Lidiya Stavitskaya, Raymond Kemper, Glenn J. Myatt, 2018, Regulatory toxicology and pharmacology : RTP.

Genetic toxicology in silico protocol.

Raymond R Tice, Naomi L Kruhlak, Lidiya Stavitskaya, 2019, Regulatory toxicology and pharmacology : RTP.

Generating Modeling Data From Repeat-Dose Toxicity Reports

Ferran Sanz, Alexander Amberg, Philippe Marc, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Introducing the concept of virtual control groups into preclinical toxicology testing.

Thomas Steger-Hartmann, Alexander Amberg, Wolfgang Muster, 2020, ALTEX.

Development and Validation of an In Silico Rabbit Purkinje Cell Action Potential Model: A Step Towards a Drug Safety Testing Tool

Manuel Pastor, Javier Saiz, Ferran Sanz, 2018, 2018 Computing in Cardiology Conference (CinC).

A pharma-wide approach to address the genotoxicity prediction of primary aromatic amines

Mick D. Fellows, Robert A. Jolly, Alexander Amberg, 2018, Computational Toxicology.

Evaluation of a statistics-based Ames mutagenicity QSAR model and interpretation of the results obtained.

Nigel Greene, Alex Harding, Alexander Amberg, 2016, Regulatory toxicology and pharmacology : RTP.

Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses.

Lidiya Stavitskaya, Raymond Kemper, Alexander Amberg, 2016, Regulatory toxicology and pharmacology : RTP.

Use of in silico systems and expert knowledge for structure-based assessment of potentially mutagenic impurities.

Scott Boyer, Nigel Greene, Lutz Müller, 2013, Regulatory toxicology and pharmacology : RTP.

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity?*

Naomi L Kruhlak, Lidiya Stavitskaya, Alexander Amberg, 2018, Mutagenesis.

In Silico Approaches In Carcinogenicity Hazard Assessment: Current Status and Future Needs.

Manuela Pavan, Jordi Mestres, Naomi L. Kruhlak, 2021, Computational toxicology.

EU framework 6 project: predictive toxicology (PredTox)--overview and outcome.

Alexander Amberg, Hans Gmuender, Heidrun Ellinger-Ziegelbauer, 2011, Toxicology and applied pharmacology.

The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury.

Alexander Amberg, Philip Hewitt, Hans Gmuender, 2011, Toxicology and applied pharmacology.

Hepatotoxicity prediction by systems biology modeling of disturbed metabolic pathways using gene expression data.

Pablo Carbonell, Ferran Sanz, Alexander Amberg, 2016, ALTEX.

A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.

Alexander Amberg, Hans Gmuender, Valérie Barbié, 2011, Toxicology and applied pharmacology.

Do Carboxylic/Sulfonic Acid Halides Really Present a Mutagenic and Carcinogenic Risk as Impurities in Final Drug Products?

Alexander Amberg, Angela White, Andreas Czich, 2015 .

Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers.

Alexander Amberg, Philip Hewitt, Hans Gmuender, 2011, Toxicology and applied pharmacology.

Legacy data sharing to improve drug safety assessment: the eTOX project

Anne Hersey, Søren Brunak, Anthony J. Brookes, 2017, Nature Reviews Drug Discovery.

It's difficult, but important, to make negative predictions.

Nigel Greene, Alexander Amberg, Susanne Glowienke, 2016, Regulatory toxicology and pharmacology : RTP.

Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity.

Alexander Amberg, Joseph V Bonventre, Wolfgang Dekant, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope.

Alexander Amberg, Andreas Czich, Denis Mulliner, 2016, Chemical research in toxicology.

Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling.

Alexander Amberg, Robert S Plumb, Elaine Holmes, 2012, Analytical chemistry.

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity.

Lidiya Stavitskaya, Alexander Amberg, Masamitsu Honma, 2016, Regulatory toxicology and pharmacology : RTP.