L. Felkin

发表

Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy

E. Ashley, S. Colan, S. Cook, 2018, Genome Medicine.

Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease

Tan Ru San, S. Gabriel, F. Cunningham, 2015, Science Translational Medicine.

Heterogeneic nature of adult cardiac side population cells.

M. Yacoub, S. Fukushima, P. Barton, 2008, Biochemical and biophysical research communications.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

Michael D. Schneider, Kristina M. Ilieva, D. O’Regan, 2015, Circulation. Cardiovascular genetics.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

E. Petretto, F. Cambien, Y. Pinto, 2017, Genome Biology.

Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart

W. Linke, L. Maier, M. Wilmanns, 2011, Circulation research.

A quantitative gene expression profile of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) in the myocardium of patients with deteriorating heart failure requiring left ventricular assist device support.

Magdi H Yacoub, A. Khaghani, M. Yacoub, 2006, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Expression of extracellular matrix genes during myocardial recovery from heart failure after left ventricular assist device support.

M. Yacoub, E. Lara-Pezzi, P. Barton, 2009, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure

M. Yacoub, P. Barton, L. Felkin, 2008, Cardiovascular research.

Choice of Cell-Delivery Route for Skeletal Myoblast Transplantation for Treating Post-Infarction Chronic Heart Failure in Rat

M. Yacoub, S. Fukushima, P. Barton, 2008, PloS one.

Quantitative Myocardial Cytokine Expression and Activation of the Apoptotic Pathway in Patients Who Require Left Ventricular Assist Devices

J. Pepper, A. Khaghani, M. Yacoub, 2001, Circulation.

Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure.

M. Yacoub, P. Barton, E. Birks, 2003, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

The Translational Landscape of the Human Heart

Catherine L. Worth, S. V. Heesch, J. Seidman, 2019, Cell.

Recovery of Cardiac Function in Cardiomyopathy Caused by Titin Truncation.

M. Yacoub, S. Cook, J. Ware, 2016, JAMA cardiology.

Titin truncating mutations: A rare cause of dilated cardiomyopathy in the young

Craig C. Benson, W. Chung, J. Seidman, 2016 .

ZBTB 17 ( MIZ 1 ) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure

Michael D. Schneider, Kristina M. Ilieva, Angharad M Roberts, 2015 .

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo

Daniel N. Meijles, O. Rackham, A. Clerk, 2021, bioRxiv.

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

G. Angelini, L. Bottolo, E. Petretto, 2019, Nature Communications.

Translational control of cardiac fibrosis

Eleni G. Christodoulou, Sarah R. Langley, S. Cook, 2018, bioRxiv.

The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.

Gene W. Yeo, B. Sundararaman, E. Lara-Pezzi, 2016, Cell chemical biology.

Direct Intramyocardial But Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model

M. Yacoub, S. Fukushima, P. Barton, 2007, Circulation.

Myocardial Expression of the Arginine:Glycine Amidinotransferase Gene Is Elevated in Heart Failure and Normalized After Recovery: Potential Implications for Local Creatine Synthesis

M. Yacoub, L. Miller, P. Barton, 2006, Circulation.

Real-time quantitative polymerase chain reaction in cardiac transplant research.

P. Barton, A. Taegtmeyer, L. Felkin, 2006, Methods in molecular biology.

Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy.

M. Yacoub, L. Miller, J. E. Rider, 2006, European heart journal.

Reverse Remodelling and Recovery from Heart Failure Are Associated with Complex Patterns of Gene Expression

E. Lara-Pezzi, P. Barton, E. Birks, 2011, Journal of cardiovascular translational research.

A Gene Expression Profile of the Myocardial Response to Clenbuterol

M. Yacoub, E. Lara-Pezzi, P. Barton, 2009, Journal of cardiovascular translational research.

Elevated toll like receptor 4 in the myocardium of patients requiring left ventricular assist devices (LVADS)

M. Yacoub, N. Banner, P. Barton, 2002 .

Myocardial Insulin-Like Growth Factor-I Gene Expression During Recovery From Heart Failure After Combined Left Ventricular Assist Device and Clenbuterol Therapy

M. Yacoub, L. Miller, N. Banner, 2005, Circulation.

Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model Direct Intramyocardial But Not Intracoronary Injection of Bone Marrow Cells Induces

M. Yacoub, S. Fukushima, P. Barton, 2007 .

Expression of follistatin-related genes is altered in heart failure.

N. Rosenthal, M. Yacoub, E. Lara-Pezzi, 2008, Endocrinology.

Follistatin-Like 3 Mediates Paracrine Fibroblast Activation by Cardiomyocytes

N. Rosenthal, Kazuto Nakamura, E. Lara-Pezzi, 2012, Journal of Cardiovascular Translational Research.

Heat Shock Protein-27 Delays Acute Rejection After Cardiac Transplantation: An Experimental Model

R. Germack, L. Felkin, M. Rose, 2014, Transplantation.

Calcineurin Splicing Variant Calcineurin A&bgr;1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy

N. Rosenthal, E. Lara-Pezzi, R. Germack, 2011, Circulation.

Expression of human membrane skeleton protein genes for protein 4.1 and betaIISigma2-spectrin assayed by real-time RT-PCR.

M. Yacoub, P. Barton, A. Baines, 2005, Cellular & molecular biology letters.

The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart

P. Barton, L. Felkin, G. Dhoot, 2004, Molecular and Cellular Biochemistry.

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies

Catherine L. Worth, S. Teichmann, J. Seidman, 2022, Science.

Myocardial expression of the arginine : glycine aminotransferase (AGAT) gene is elevated in heart failure and normalised following post-LVAD recovery: Potential implications for local creatine synthesis

M. Yacoub, P. Barton, S. Grindle, 2006 .

Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.

M. Yacoub, A. Zorzano, P. Barton, 2005, Journal of molecular and cellular cardiology.

Morphological and molecular effects of clenbuterol on cardiac myocytes - role of IGF-I

M. Yacoub, P. Sugden, P. Barton, 2004 .

Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure

D. Dries, P. Barton, J. Rame, 2014, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease.

Regulated inositol-requiring protein 1-dependent decay as a mechanism of corin RNA and protein deficiency in advanced human systolic heart failure.

D. Dries, P. Barton, J. Rame, 2014, Journal of the American Heart Association.

442: Extracellular Matrix Gene Expression during Myocardial Recovery from Heart Failure Following LVAD Combination Therapy

M. Yacoub, E. Lara-Pezzi, P. Barton, 2008 .

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

S. Cook, J. Dear, S. Chothani, 2019, bioRxiv.

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

J. Dear, S. Chothani, B. Singh, 2021, Science Translational Medicine.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

E. Petretto, Y. Pinto, E. Creemers, 2017, Genome Biology.

Sequential Expression of Three Known Protective Genes in Cardiac Biopsies After Transplantation

N. Banner, P. Barton, L. Felkin, 2005, Transplantation.

Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices.

A. Khaghani, M. Yacoub, N. Banner, 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Reevaluating the Genetic Contribution of Monogenic Dilated Cardiomyopathy

Angharad M Roberts, D. O’Regan, A. Marvao, 2020, Circulation.

Quantitative approaches to variant classification increase the yield and precision of genetic testing in Mendelian diseases: the case of hypertrophic cardiomyopathy

E. Ashley, S. Colan, A. Marvao, 2018, bioRxiv.

A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy

Jacob T. Munro, Angharad M Roberts, J. Seidman, 2018, Genetics in Medicine.

Defining the genetic architecture of hypertrophic cardiomyopathy: re-evaluating the role of non-sarcomeric genes

S. Cook, J. Ware, H. Watkins, 2017, European heart journal.

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

Eleni G. Christodoulou, Stuart A. Cook, Sivakumar Viswanathan, 2019, Circulation.

Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice.

E. Ehler, P. Barton, A. Magee, 2009, Journal of molecular and cellular cardiology.