Xingshu Li

发表

Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.

Jinhui Hu, Tingting Pan, B. An, 2019, European journal of medicinal chemistry.

Palladium-catalyzed oxidative C-H bond coupling of steered acetanilides and aldehydes: a facile access to ortho-acylacetanilides.

Xingshu Li, F. Kwong, Yinuo Wu, 2011, Organic letters.

Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.

Xingshu Li, Ling Huang, Jiaxing Xie, 2014, Bioorganic & medicinal chemistry letters.

Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dual β₂-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.

Xingshu Li, Ling Huang, Jiaxing Xie, 2013, Bioorganic & medicinal chemistry letters.

Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry letters.

4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: novel C7 moieties of fluoroquinolones as antibacterial agents.

Xingshu Li, Zhenhua Jia, Xiaoguang Huang, 2010, Bioorganic & medicinal chemistry letters.

The discovery of a potent and selective third-generation EGFR kinase inhibitor as a therapy for EGFR L858R/T790M double mutant non-small cell lung cancer.

A. Chan, Jinhui Hu, Tingting Pan, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel benzodiazepine derivatives as anticancer agents through inhibition of tubulin polymerization in vitro and in vivo.

B. An, Xingshu Li, Yingying Cao, 2019, European journal of medicinal chemistry.

Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors.

W. Zeng, Honghao Yang, B. An, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of new 2-chloro-4-aminopyrimidine and 2,6-dimethyl-4-aminopyrimidine derivatives as tubulin polymerization inhibitors.

Yuxin Li, B. An, Xingshu Li, 2018, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

Synthesis, biological evaluation and mechanism study of chalcone analogues as novel anti-cancer agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents

Xingshu Li, Ling Huang, F. Mao, 2014 .

Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders

R. Pi, H. Ge, Xingshu Li, 2014 .

Efficient and promising asymmetric preparation of enantiopure tolvaptan via transfer hydrogenation with robust catalysts

A. Chan, Xingshu Li, Lu Yin, 2010 .

Natural products as sources of new lead compounds for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, Tao Su, 2013, Current topics in medicinal chemistry.

A Simple, One-Pot Synthesis of Trans-Substituted Spiro [5,5] undecane-1,5,9-triones with Aromatic Aldehydes and Meldrum's Acid as the Starting Materials

Yu Zhao, Xingshu Li, Lingxin Meng, 2015 .

Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.

Jinhui Hu, Xingshu Li, Anqiu Liu, 2017, Bioorganic & medicinal chemistry.

Synthesis and evaluation of new pirfenidone derivatives as anti-fibrosis agents

B. An, Xingshu Li, Wei Li, 2022, RSC advances.

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo.

Jinhui Hu, Xingshu Li, Ling Huang, 2016, Journal of medicinal chemistry.

A convenient synthesis of quinazoline derivatives via cascade imino-Diels-Alder and oxidation reaction

Xingshu Li, X. Chen, Lu Yin, 2010 .

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease.

Yadan Huang, Hai-bin Luo, Jinhui Hu, 2018, ACS chemical neuroscience.

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.

Xingshu Li, Ling Huang, F. Mao, 2012, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.

Xingshu Li, Ling Huang, Bo-Chi Wang, 2015, Journal of medicinal chemistry.

Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.

Hai-bin Luo, Zhe Li, Xingshu Li, 2015, Molecular bioSystems.

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.

Xingshu Li, Ling Huang, Jianwen Chen, 2013, Bioorganic & medicinal chemistry.

A Convenient Synthesis of Imidazolidin‐4‐ones via Domino Reactions

Xingshu Li, Yunyun Chen, Hui Wei, 2009 .

Silver-catalyzed hydrogenation of aldehydes in water.

A. Chan, Chao‐Jun Li, F. Zhou, 2013, Angewandte Chemie.

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

Xingshu Li, Ling Huang, Zonghua Luo, 2010, Bioorganic & medicinal chemistry.

A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, Z. Du, 2013, European journal of medicinal chemistry.

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry.

Discovery of a potent EGFR and ALK dual mutation inhibitor containing N-(3-((4-((2-(cyclopropylsulfinyl)phenyl)amino)pyrimidin-2-yl)amino) phenyl)acrylamide scaffold.

A. Chan, B. An, Xingshu Li, 2022, Bioorganic chemistry.

Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral amino alcohol-based ligands

A. Chan, Zhongyuan Zhou, W. Chan, 2001 .

Vanadium‐Catalyzed Asymmetric Oxidation of Sulfides Using Schiff Base Ligands Derived from β‐Amino Alcohols with Two Stereogenic Centers

A. Chan, Xingshu Li, Yinuo Wu, 2009 .

Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma

A. Chan, J. Tang, Yuanyuan Zhou, 2018, Cells.

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents.

B. An, Xingshu Li, Ling Huang, 2017, Journal of medicinal chemistry.

Simply air：Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

A. Chan, Xingshu Li, Lu Yin, 2010 .

Enantioselective Vanadium‐Catalyzed Oxidation of 1,3‐Dithianes from Aldehydes and Ketones using β‐Amino Alcohol Derived Schiff Base Ligands

Xingshu Li, Yinuo Wu, F. Mao, 2011 .

An efficient synthesis of chiral homophenylalanine derivatives via enantioselective hydrogenation

A. Chan, Xingshu Li, C. Yeung, 1999 .

Pd-catalyzed [3+2] cycloaddition of ketoimines with alkynes via directed sp³ C-H bond activation.

Yuanfu Deng, W. Zeng, Huanfeng Jiang, 2014, Chemical communications.

Highly Air‐ and Water‐Stable Fluorinated Ferrocenylphosphine‐Aminophosphine Ligands and their Applications in Asymmetric Hydrogenations

A. Chan, Lijin Xu, Xingshu Li, 2005 .

Highly enantioselective hydrogenation of enamides catalyzed by rhodium-monodentate phosphoramidite complex derived from H8-BINOL

A. Chan, Xingshu Li, Thomas W. H. Lo, 2003 .

Highly efficient rhodium/monodentate phosphoramidite catalyst and its application in the enantioselective hydrogenation of enamides and alpha-dehydroamino acid derivatives.

A. Chan, Lijin Xu, Xingshu Li, 2003, The Journal of organic chemistry.

Highly enantioselective hydrogenation of enamides catalyzed by rhodium–monodentate phosphoramidite complex

A. Chan, Xingshu Li, Xinsheng Yao, 2002 .

Asymmetric conjugate addition of diethylzinc to chalcone catalyzed by nickel complexes containing derivatives of (1R,2S,3R)-3-mercaptocamphan-2-ol

Xingshu Li, Yingwu Yin, Dong‐Sheng Lee, 2000 .

New 1,3-amino alcohols derived from ketopinic acid and their application in catalytic enantioselective reduction of prochiral ketones

A. Chan, Xingshu Li, C. Yeung, 1999 .

Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl2 catalyst

A. Chan, Xingshu Li, X. Chen, 2009 .

A domino reaction of a β-ketoester, phenylethylamine and ethyl glyoxylate: leading to chiral tricarboxylate containing multiple stereocenters

Xingshu Li, Yunyun Chen, Xiaoguang Huang, 2008 .

Asymmetric hydrogenation of dehydroamino acid derivatives catalyzed by a new aminophosphine phosphinite ligand derived from ketopinic acid

A. Chan, Xingshu Li, C. Yeung, 2000 .

Crystal structure of 4-(((2-(3-(1-(3-(3-cyanophenyl)-6-oxopyridazin-1(6H)-yl)ethyl)phenyl) pyrimidin-5-yl)oxy)methyl)-1-methylpiperidin-1-ium chloride monohydrate, C30H33N6O2Cl

Jinhui Hu, Xingshu Li, Ming-Jie Yan, 2022, Zeitschrift für Kristallographie - New Crystal Structures.

Titanium-Catalyzed Tandem Sulfoxidation-Kinetic Resolution Process: A Convenient Method for Higher Enantioselectivities and Yields of Chiral Sulfoxide

A. Chan, Lijin Xu, Xingshu Li, 2004 .

Enantioselective alkynylation of aromatic ketones catalyzed by chiral camphorsulfonamide ligands.

A. Chan, W. Chan, Xingshu Li, 2003, Angewandte Chemie.

Highly Enantioselective Catalytic Alkynylation of Ketones – A Convenient Approach to Optically Active Propargylic Alcohols

A. Chan, Xingshu Li, Yue‐Ming Li, 2006 .

Synthesis and application of new chiral catalysts for asymmetric alkynylation reactions

A. Chan, Xingshu Li, Yue‐Ming Li, 2005 .

Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation.

A. Chan, Zhongyuan Zhou, Q. Fan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Bipyridyl-based diphosphine as an efficient ligand in the rhodium-catalyzed asymmetric conjugate addition of arylboronic acids to α,β-unsaturated ketones

A. Chan, Lijin Xu, R. Cao, 2003 .

Asymmetric addition of alkynes to imines in water catalyzed with a recyclable Cu(I)–bis(oxazoline) and stearic acid system

A. Chan, Xingshu Li, Juntao Liu, 2007 .

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.

Xingshu Li, Ling Huang, Hui Miao, 2014, European journal of medicinal chemistry.

Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.

Yang Sun, Hai-Bin Luo, Xingshu Li, 2013, Journal of medicinal chemistry.

Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.

Xingshu Li, Ling Huang, Zonghua Luo, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.

Hai-bin Luo, Xingshu Li, Ling Huang, 2013, Journal of medicinal chemistry.

Organotin perfluorooctanesulfonates as air-stable Lewis acid catalysts: synthesis, characterization, and catalysis.

K. Ohkubo, S. Fukuzumi, A. Orita, 2006, Chemistry.

A cationic distannoxane catalyst. Synthesis and applications to carbon-carbon bond forming reactions

Xingshu Li, A. Kurita, J. Otera, 2005 .

Enantioselective addition of phenylacetylene to N-aryl arylimines catalyzed by Cu(II)-pyridine containing N-tosylatedaminoimine ligand complex.

Xingshu Li, Bao Liu, Yao Zhong, 2009, Chirality.

Asymmetric transfer hydrogenation of ketones with a polyethylene glycol bound Ru catalyst in water

A. Chan, Xingshu Li, Yinuo Wu, 2008 .

Highly Efficient Synthesis of β‐Amino Esters via Mannich‐Type Reaction under Solvent‐Free Conditions Using ZnCl2 Catalyst.

A. Chan, Xingshu Li, X. Chen, 2009 .

The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolones as antibacterial agents.

N. Wu, Xingshu Li, Zhenhua Jia, 2009, Bioorganic & medicinal chemistry letters.

Chiral Cu(II) complex catalyzed enantioselective addition of phenylacetylene to N-aryl arylimines

A. Chan, Xingshu Li, Ling Huang, 2007 .

The synthesis of chiral N-tosylatedaminoimine ligands and their application in enantioselective addition of phenylacetylene to imines

A. Chan, Xingshu Li, Ling Huang, 2007 .

Hydroformylation of olefins catalyzed by chiral phosphite-Rh(I) complexes

A. Chan, Xingshu Li, M. Yan, 2003 .

Copper-catalyzed enantioselective conjugate addition of triethylaluminum to 2-cyclopentenone

A. Chan, W. Chan, Xingshu Li, 2003 .

The applications of Schiff bases in Ti-catalyzed asymmetric alkynylation of aldehydes

Xingshu Li, Xuan-Hui Zhao, Lu Yin, 2007 .

Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease

Xingshu Li, Ling Huang, F. Mao, 2015, Journal of enzyme inhibition and medicinal chemistry.

Enantioselective hydrolysis of long chain α-amino acid esters by chiral sulfur-containing macrocyclic metallomicelles

Xiao‐Qi Yu, Xingshu Li, J. You, 1998 .

Iodide‐Ion‐Catalyzed Carbon–Carbon Bond‐Forming Cross‐Dehydrogenative Coupling for the Synthesis of Indole Derivatives

A. Chan, Xingshu Li, Zhenhua Jia, 2013 .

Enantioselective reduction of prochiral ketones catalyzed by new (R)-4-(phenylmercapto)methyl-5,5-diphenyl-1,3,2-oxazaborolidine and bis-[(R,R)-5,5-diphenyl-1,3,2-oxazaborolidine methyl]disulfide from l-cystine

Xingshu Li, R. Xie, 1997 .

Asymmetric Hydrogenation of Dehydroamino Acid Derivatives Catalyzed by a New Aminophosphine Phosphinite Ligand Derived from Ketopinic Acid.

A. Chan, Xingshu Li, C. Yeung, 2000 .

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry.

Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.

Xingshu Li, Xingshu Li, Ling Huang, 2010, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of New Mesenchymal–Epithelial Transition Factor (c-Met) Kinase Inhibitors with Dual Chiral Centers

Ming Yan, Jinhui Hu, Xingshu Li, 2022, Molecules.

Synthesis, Evaluation, and Mechanism Study of New Tepotinib Derivatives as Antiproliferative Agents

B. An, Xingshu Li, M. Yan, 2019, Molecules.

The Molecular Basis for the Selectivity of Tadalafil toward Phosphodiesterase 5 and 6: A Modeling Study

Zhe Li, Hai-Bin Luo, Yi-You Huang, 2013, J. Chem. Inf. Model..

The synthesis of new chiral phosphine-phosphinites, phosphine-phosphoramidite, and phosphine-phosphite ligands and their applications in asymmetric hydrogenation

A. Chan, Lijin Xu, Xingshu Li, 2004 .

New Types of Homochiral Helical Coordination Polymers Constructed by exo‐Bidentate Binaphthol Derivatives

A. Chan, Lijin Xu, Zhongyuan Zhou, 2004 .

Formation of a palladium(II) complex of 2-(2-pyridinylmethyleneamino)-2′-hydroxy-1,1′-binaphthyl with novel Cσ-coordination and its theoretical investigation

A. Chan, Lijin Xu, Zhongyuan Zhou, 2003 .

Asymmetric Hydroformylation of Olefins Catalyzed by a Chiral Diphosphite‐Rhodium Complex

Xingshu Li, M. Yan, Albert Sun Chan-Chi, 2010 .

A highly effective phosphinite ligand derived from D-mannitol for Rh-catalyzed asymmetric hydrogenation

A. Chan, Xingshu Li, Michael C. K. Choi, 1999 .

Titanium-catalyzed enantioselective alkynylation of aldehydes.

A. Chan, W. Chan, Xingshu Li, 2002, Chemical communications.

Iridium-catalyzed aerobic oxidation of alkylarenes with excellent turnover numbers

W. Zeng, Xingshu Li, M. Yan, 2013 .

A rapid and green approach to chiral α-hydroxy esters: asymmetric transfer hydrogenation (ATH) of α-keto esters in water by use of surfactants

A. Chan, Xingshu Li, Lu Yin, 2009 .

Highly enantioselective alkynylation of aldehydes using a new BINOL/Ti(OiPr)4/chiral sulfonamide catalyst system.

A. Chan, Xingshu Li, G. Lu, 2007, Chirality.

Effective activation of chiral BINOL/Ti(OiPr)4 catalyst with phenolic additives for the enantioselective alkynylation of aldehydes

A. Chan, W. Chan, Xingshu Li, 2003 .

Highly enantioselective alkynylzinc addition to aromatic aldehydes catalyzed by self-assembled titanium catalysts.

A. Chan, Xingshu Li, G. Lu, 2002, Journal of the American Chemical Society.

Structure effect of TsDPEN derivatives on enantioselectivity of asymmetric transfer hydrogenation

A. Chan, Xingshu Li, Yinuo Wu, 2008 .

(R)-2,2′-Dimethoxy-3,3′-bis{[(1S)-1-phenylethyl]iminomethyl}-1,1′-binaphthalene, a new chiral Schiff base

Zhongyuan Zhou, Xingshu Li, X. Jia, 2004 .

Rhodium-catalyzed asymmetric hydrogenation with aminophosphine ligands derived from 1,1'-binaphthyl-2,2'-diamine

A. Chan, Xingshu Li, Michael C. K. Choi, 2002 .

Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel

A. Chan, Xingshu Li, Wenjun Shan, 2009 .

A practical process to chiral ferrocenyl alcohols via asymmetric transfer hydrogenation catalyzed with a PEG-bound Ru catalyst in water and its application in preparing Ugi’s amine

Xingshu Li, Yinuo Wu, Wenjun Shan, 2009 .

An efficient and promising method to prepare Ladostigil (TV3326) via asymmetric transfer hydrogenation catalyzed by Ru–Cs-DPEN in an HCOONa–H2O–surfactant system

Xingshu Li, Zonghua Luo, Fangfei Qin, 2012 .

The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol

Xingshu Li, Ling Huang, Zonghua Luo, 2011 .

The synthesis of a new nitrogen joined N-PEG-TsDPEN ligand and its application in asymmetric transfer hydrogenation of ketones in neat water

Xingshu Li, Yinuo Wu, F. Mao, 2011 .

A convenient synthesis of (R)-salmeterol via Rh-catalyzed asymmetric transfer hydrogenation

A. Chan, Xingshu Li, Ling Huang, 2008 .

The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water.

Xingshu Li, Ling Huang, Wenjun Shan, 2009, Chirality.

Design, synthesis, and evaluation of resveratrol derivatives as Aß(₁-₄₂) aggregation inhibitors, antioxidants, and neuroprotective agents.

Meicun Yao, Q. Liao, Xingshu Li, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of 8-hydroxyquinolin derivatives substituted with (benzo[d][1,2]selenazol-3(2H)-one) as effective inhibitor of metal-induced Aβ aggregation and antioxidant.

Hong Chen, Xingshu Li, Zhiren Wang, 2016, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.

Xingshu Li, Ling Huang, F. Mao, 2015, European journal of medicinal chemistry.

Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.

Ruibo Wu, Zhihong Liu, Xingshu Li, 2015, Dalton transactions.

Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease.

Jinhui Hu, Tingting Pan, Xingshu Li, 2018, MedChemComm.

H8-MonoPhos and its application in catalytic enantioselective hydrogenation of α-dehydroamino acids

A. Chan, Xingshu Li, H. Liu, 2002 .

Highly enantioselective hydrogenation of α-dehydroamino acids by rhodium complex with H8-MonoPhos

A. Chan, X. Cui, Xingshu Li, 2002 .

Redox Catalysis of Halide Ion for Formal Cross-dehydrogenative Coupling: Bromide Ion-catalyzed Direct Oxidative α-Acetoxylation of Ketones

A. Chan, Xingshu Li, M. Yan, 2010 .

Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives

Xingshu Li, Ling Huang, Zechen Wang, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents.

A. Chan, Jinhui Hu, B. An, 2018, Journal of medicinal chemistry.

Targeting DNA Binding for NF-κB as an Anticancer Approach in Hepatocellular Carcinoma

A. Chan, R. Gambari, A. Finotti, 2018, Cells.

Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization.

Li Huang, Jinhui Hu, B. An, 2017, European journal of medicinal chemistry.

Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.

Xingshu Li, Ling Huang, Wenjun Shan, 2011, European journal of medicinal chemistry.

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

Jian-Dong Huang, Sookja K. Chung, Xingshu Li, 2012, Neurobiology of Aging.

Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR.

Baoxia Liang, Xianzhang Huang, Xingshu Li, 2021, European journal of medicinal chemistry.

The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

B. An, Xingshu Li, Ling Huang, 2016 .

The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors.

B. An, Xingshu Li, Ling Huang, 2017, Bioorganic & medicinal chemistry.

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.

Xingshu Li, Ling Huang, Zhiren Wang, 2015, Bioorganic & medicinal chemistry.

Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents.

A. Chan, Jinhui Hu, B. An, 2017, Organic & biomolecular chemistry.

Development of a Novel Quinoline Derivative as a P-Glycoprotein Inhibitor to Reverse Multidrug Resistance in Cancer Cells

A. Chan, K. Chan, J. Tang, 2019, Biology.

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.

Xingshu Li, Ling Huang, Zonghua Luo, 2014, Bioorganic & medicinal chemistry.

A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.

Jinhui Hu, Xingshu Li, Ling Huang, 2015, Biochemical pharmacology.

The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism.

A. Chan, J. Tang, Jinhui Hu, 2018, Organic & biomolecular chemistry.

Identification of Novel Phosphodiesterase-4D Inhibitors Prescreened by Molecular Dynamics-Augmented Modeling and Validated by Bioassay

Xiao Lu, Zhe Li, Ming Liu, 2013, J. Chem. Inf. Model..

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

Hai-Bin Luo, Yinuo Wu, Hai-bin Luo, 2016, Scientific Reports.

Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease

Zhiren Wang, Xingshu Li, Ling Huang, 2016 .

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

Xingshu Li, Ling Huang, Feng He, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, F. Mao, 2014, ACS chemical neuroscience.

Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.

Jinhui Hu, Tingting Pan, B. An, 2018, Bioorganic & medicinal chemistry.

Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.

Haibin Luo, Jinhui Hu, Tingting Pan, 2019, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors.

Shuxian Wei, B. An, Xingshu Li, 2020, European journal of medicinal chemistry.

Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.

Xingshu Li, Xu Wang, Xingshu Li, 2011, Bioorganic & medicinal chemistry.

Novel third-generation pyrimidines-based EGFR tyrosine kinase inhibitors targeting EGFR T790M mutation in advanced non-small cell lung cancer.

Wenyan Nie, Chunhua Yang, Geng Tian, 2022, Bioorganic chemistry.

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol.

Xingshu Li, Ling Huang, F. Mao, 2014, Organic & biomolecular chemistry.

Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.

Xingshu Li, Xingshu Li, Ling Huang, 2011, Bioorganic & medicinal chemistry.

Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.

A. Chan, Xiaoping Yang, Jinhui Hu, 2018, Journal of medicinal chemistry.

Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Journal of medicinal chemistry.

Structural influence of chiral tertiary aminonaphthol ligands on the asymmetric phenyl transfer to aromatic aldehydes.

A. Chan, Haibin Luo, Xingshu Li, 2011, Chirality.

Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis.

Jingwei Zhou, Xingshu Li, Weiwei Zhang, 2022, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors.

B. An, Xingshu Li, Ling Huang, 2017, Organic & biomolecular chemistry.

Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing a sulfoxide moiety as anaplastic lymphoma kinase (ALK) inhibition agents.

A. Chan, B. An, Xingshu Li, 2021, Bioorganic & Medicinal Chemistry Letters.

Remarkably diastereoselective synthesis of a chiral biphenyl diphosphine ligand and its application in asymmetric hydrogenation.

A. Chan, Zhongyuan Zhou, Q. Fan, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity.

Xingshu Li, Ling Huang, Jun Yan, 2013, Bioorganic & medicinal chemistry.

Synthesis and evaluation of sulfonamide derivatives targeting EGFR790M/L858R mutations and ALK rearrangement as anticancer agents.

Xingshu Li, Yu-Jia Ren, X. Jia, 2023, Bioorganic & medicinal chemistry.

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.

Xingshu Li, Ling Huang, Jianwen Chen, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.

Xingshu Li, Ling Huang, Wenjun Shan, 2014, Bioorganic & medicinal chemistry letters.

Highly enantioselective 1,4-conjugate addition of dialkylzinc to α,β-unsaturated lactone catalyzed by diphosphite–copper complexes

A. Chan, Xingshu Li, L. Liang, 2003 .

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.

Xingshu Li, Ling Huang, Hui Miao, 2014, European journal of medicinal chemistry.