Ling Huang

发表

Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.

Jinhui Hu, Tingting Pan, B. An, 2019, European journal of medicinal chemistry.

Transcriptional regulation of the apolipoprotein F (ApoF) gene by ETS and C/EBPα in hepatoma cells.

Wan-nan Chen, Xu Lin, Ling Huang, 2015, Biochimie.

Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study

M. Huang, W. Duan, Shufeng Zhou, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.

Xingshu Li, Ling Huang, Jiaxing Xie, 2014, Bioorganic & medicinal chemistry letters.

Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dual β₂-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.

Xingshu Li, Ling Huang, Jiaxing Xie, 2013, Bioorganic & medicinal chemistry letters.

Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry letters.

A novel targeting drug carrier to deliver chemical bonded and physical entrapped anti-tumor drugs.

Ling Huang, Jinchun Song, Bangyin Chen, 2014, International journal of pharmaceutics.

The discovery of a potent and selective third-generation EGFR kinase inhibitor as a therapy for EGFR L858R/T790M double mutant non-small cell lung cancer.

A. Chan, Jinhui Hu, Tingting Pan, 2019, European journal of medicinal chemistry.

Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B.

M. Huang, Ling Huang, H. Bi, 2014, Chemico-biological interactions.

Genomic and Functional Uniqueness of the TNF Receptor-Associated Factor Gene Family in Amphioxus, the Basal Chordate1

A. Xu, Shengfeng Huang, Xin Tao, 2009, The Journal of Immunology.

Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

Synthesis, biological evaluation and mechanism study of chalcone analogues as novel anti-cancer agents

Jinhui Hu, Xingshu Li, Ling Huang, 2015 .

The convenient aqueous synthesis and biological evaluation of ortho-(3,4,5-trimethoxybenzoyl)-acetanilides as novel anti-cancer agents

Xingshu Li, Ling Huang, F. Mao, 2014 .

Mulberroside A suppresses PXR‐mediated transactivation and gene expression of P‐gp in LS174T cells

M. Huang, Ling Huang, H. Bi, 2017, Journal of biochemical and molecular toxicology.

CAR-mediated up-regulation of CYP3A4 expression in LS174T cells by Chinese herbal compounds.

M. Huang, Yi-Tao Wang, Ling Huang, 2011, Drug metabolism and pharmacokinetics.

Erratum to “PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn”

Yi-Tao Wang, Ling Huang, H. Bi, 2014, Evidence-based complementary and alternative medicine : eCAM.

PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn

Yi-Tao Wang, Ling Huang, H. Bi, 2013, Evidence-based complementary and alternative medicine : eCAM.

Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.

Yi-Tao Wang, Ling Huang, Min Huang, 2013, Journal of ethnopharmacology.

Antitumor Activity and Mechanism of Robustic Acid from Dalbergia benthami Prain via Computational Target Fishing

Dianpeng Li, Ling Huang, Wenyu Tian, 2020, Molecules.

Amphioxus SARM Involved in Neural Development May Function as a Suppressor of TLR Signaling

A. Xu, Shengfeng Huang, Xin Tao, 2010, The Journal of Immunology.

Natural products as sources of new lead compounds for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, Tao Su, 2013, Current topics in medicinal chemistry.

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo.

Jinhui Hu, Xingshu Li, Ling Huang, 2016, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease.

Yadan Huang, Hai-bin Luo, Jinhui Hu, 2018, ACS chemical neuroscience.

Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

Xiang Gao, Baili Chen, Ling Huang, 2021, Pharmacology research & perspectives.

Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.

Xingshu Li, Ling Huang, F. Mao, 2012, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease.

Xingshu Li, Ling Huang, Bo-Chi Wang, 2015, Journal of medicinal chemistry.

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.

Xingshu Li, Ling Huang, Jianwen Chen, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.

Xingshu Li, Ling Huang, Zonghua Luo, 2010, Bioorganic & medicinal chemistry.

The Archaic Roles of the Amphioxus NF-κB/IκB Complex in Innate Immune Responses

A. Xu, Jie Zhang, Shangwu Chen, 2013, The Journal of Immunology.

A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, Z. Du, 2013, European journal of medicinal chemistry.

O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry.

Rapid and simultaneous measurement of midazolam, 1'-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity.

Ling Huang, H. Bi, G. Zhong, 2011, Journal of pharmaceutical and biomedical analysis.

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents.

B. An, Xingshu Li, Ling Huang, 2017, Journal of medicinal chemistry.

Correlation between Antioxidant Activities and Phenolic Contents of Radix Angelicae Sinensis (Danggui)

Xican Li, Ling Huang, Ling Huang, 2009, Molecules.

Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia.

Steven H. Liang, Ruibo Wu, Hai-bin Luo, 2020, Journal of medicinal chemistry.

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.

Xingshu Li, Ling Huang, Hui Miao, 2014, European journal of medicinal chemistry.

Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.

Yang Sun, Hai-Bin Luo, Xingshu Li, 2013, Journal of medicinal chemistry.

Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.

Xingshu Li, Ling Huang, Zonghua Luo, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.

Hai-bin Luo, Xingshu Li, Ling Huang, 2013, Journal of medicinal chemistry.

Chiral Cu(II) complex catalyzed enantioselective addition of phenylacetylene to N-aryl arylimines

A. Chan, Xingshu Li, Ling Huang, 2007 .

The synthesis of chiral N-tosylatedaminoimine ligands and their application in enantioselective addition of phenylacetylene to imines

A. Chan, Xingshu Li, Ling Huang, 2007 .

Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease

Xingshu Li, Ling Huang, F. Mao, 2015, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Bioorganic & medicinal chemistry.

Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.

Xingshu Li, Xingshu Li, Ling Huang, 2010, Bioorganic & medicinal chemistry letters.

The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol

Xingshu Li, Ling Huang, Zonghua Luo, 2011 .

A convenient synthesis of (R)-salmeterol via Rh-catalyzed asymmetric transfer hydrogenation

A. Chan, Xingshu Li, Ling Huang, 2008 .

The asymmetric synthesis of (R,R)-formoterol via transfer hydrogenation with polyethylene glycol bound Rh catalyst in PEG2000 and water.

Xingshu Li, Ling Huang, Wenjun Shan, 2009, Chirality.

Design, synthesis, and biological evaluation of benzoselenazole-stilbene hybrids as multi-target-directed anti-cancer agents.

Xingshu Li, Ling Huang, F. Mao, 2015, European journal of medicinal chemistry.

Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.

Ruibo Wu, Zhihong Liu, Xingshu Li, 2015, Dalton transactions.

Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease.

Jinhui Hu, Tingting Pan, Xingshu Li, 2018, MedChemComm.

Dual functional cholinesterase and MAO inhibitors for the treatment of Alzheimer’s disease: synthesis, pharmacological analysis and molecular modeling of homoisoflavonoid derivatives

Xingshu Li, Ling Huang, Zechen Wang, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and Biological Evaluation of Selenium-Containing 4-Anilinoquinazoline Derivatives as Novel Antimitotic Agents.

A. Chan, Jinhui Hu, B. An, 2018, Journal of medicinal chemistry.

Effect of Alpinia officinarum Hance alcohol extracts on primary dysmenorrheal.

Jun-Qing Zhang, Ling Huang, Yinfeng Tan, 2016, Asian Pacific journal of tropical medicine.

N-butanol fraction of Entada phaseoloides ethanol extract inhibits hepatocellular carcinoma HepG2 cell proliferation by inducing apoptosis.

Qian Wu, Ling Huang, Qibing Liu, 2014, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation.

Xingshu Li, Ling Huang, Wenjun Shan, 2011, European journal of medicinal chemistry.

Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model

Jian-Dong Huang, Sookja K. Chung, Xingshu Li, 2012, Neurobiology of Aging.

The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors

B. An, Xingshu Li, Ling Huang, 2016 .

The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors.

B. An, Xingshu Li, Ling Huang, 2017, Bioorganic & medicinal chemistry.

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer's disease.

Xingshu Li, Ling Huang, Zhiren Wang, 2015, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.

Wenjun Zhang, Ling Huang, Jinchun Song, 2015, Bioorganic & medicinal chemistry letters.

Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood.

Yang Hu, Wenwen Zhu, Ling Huang, 2015, Bioanalysis.

Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents

Ziying Li, Ling Huang, Zhaoyang Qi, 2021, Bioorganic & Medicinal Chemistry Letters.

Synthesis and evaluation of selenium-containing indole chalcone and diarylketone derivatives as tubulin polymerization inhibition agents.

A. Chan, Jinhui Hu, B. An, 2017, Organic & biomolecular chemistry.

Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.

Xingshu Li, Ling Huang, Zonghua Luo, 2014, Bioorganic & medicinal chemistry.

A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells.

Jinhui Hu, Xingshu Li, Ling Huang, 2015, Biochemical pharmacology.

The design, synthesis and evaluation of selenium-containing 4-anilinoquinazoline hybrids as anticancer agents and a study of their mechanism.

A. Chan, J. Tang, Jinhui Hu, 2018, Organic & biomolecular chemistry.

Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer’s disease

Hai-Bin Luo, Yinuo Wu, Hai-bin Luo, 2016, Scientific Reports.

Regulation of Human Pregnane X Receptor and its Target Gene Cytochrome P450 3A by Praeruptorin A Isolated from the Herbal Medicine Peucedanum praeruptorum

Yi-Tao Wang, Jun-Qing Zhang, Ling Huang, 2013, Planta Medica.

Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease

Zhiren Wang, Xingshu Li, Ling Huang, 2016 .

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.

Xingshu Li, Ling Huang, Feng He, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and evaluation of multitarget-directed selenium-containing clioquinol derivatives for the treatment of Alzheimer's disease.

Xingshu Li, Ling Huang, F. Mao, 2014, ACS chemical neuroscience.

Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer's disease.

Jinhui Hu, Tingting Pan, B. An, 2018, Bioorganic & medicinal chemistry.

Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.

Haibin Luo, Jinhui Hu, Tingting Pan, 2019, Bioorganic & medicinal chemistry letters.

Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.

Xingshu Li, Xu Wang, Xingshu Li, 2011, Bioorganic & medicinal chemistry.

New multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol.

Xingshu Li, Ling Huang, F. Mao, 2014, Organic & biomolecular chemistry.

Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.

Xingshu Li, Xingshu Li, Ling Huang, 2011, Bioorganic & medicinal chemistry.

Study of the upregulation of the activity of cytochrome P450 3A isoforms by Astragalus injection and Astragalus granules in rats and in cells

Ling Huang, H. Bi, Min Huang, 2013, European Journal of Drug Metabolism and Pharmacokinetics.

Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.

A. Chan, Xiaoping Yang, Jinhui Hu, 2018, Journal of medicinal chemistry.

Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease.

Xingshu Li, Ling Huang, Zonghua Luo, 2012, Journal of medicinal chemistry.

Selective Catalytic Reduction of NO by Methane on Copper Catalysts: the Effects of Modifying the Catalysts with Acids on γ-alumina

J. Lou, Chang‐Mao Hung, Ling Huang, 2003 .

Synthesis, in vitro and in vivo evaluation of new hybrids of millepachine and phenstatin as potent tubulin polymerization inhibitors.

B. An, Xingshu Li, Ling Huang, 2017, Organic & biomolecular chemistry.

Two new cassane-type diterpenes from the seeds of Caesalpinia crista

Ling Huang, Qibing Liu, Qiao-Qin Xu, 2015, Journal of Asian natural products research.

Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models

Jing Jin, Ling Huang, H. Bi, 2013, Acta Pharmacologica Sinica.

KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a

J. Yun, W. Jia, Jian Li, 2013, Cell Death and Disease.

Discovery of Highly Specific Catalytic-Site-Targeting Fluorescent Probes for Detecting Lysosomal PDE10A in Living Cells.

Hai-bin Luo, Lehui Xiao, Zhe Li, 2021, ACS chemical biology.

Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aβ aggregation and antioxidant activity.

Xingshu Li, Ling Huang, Jun Yan, 2013, Bioorganic & medicinal chemistry.

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.

Xingshu Li, Ling Huang, Jianwen Chen, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of dual pharmacology β2-adrenoceptor agonists and PDE4 inhibitors.

Xingshu Li, Ling Huang, Wenjun Shan, 2014, Bioorganic & medicinal chemistry letters.

Study of the upregulation of the activity of cytochrome P450 3A isoforms by Astragalus injection and Astragalus granules in rats and in cells

Ling Huang, H. Bi, Min Huang, 2012, European Journal of Drug Metabolism and Pharmacokinetics.

Design, Synthesis, and Evaluation of Dihydropyranopyrazole Derivatives as Novel PDE2 Inhibitors for the Treatment of Alzheimer’s Disease

Haibin Luo, Zhe Li, Yi-You Huang, 2021, Molecules.

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.

Xingshu Li, Ling Huang, Hui Miao, 2014, European journal of medicinal chemistry.