D. Alagille

发表

Identification and in vivo evaluation of a fluorine-18 rolipram analogue, [(18) F]MNI-617, as a radioligand for PDE4 imaging in mammalian brain.

R. Baldwin, G. Tamagnan, O. Barret, 2016, Journal of labelled compounds & radiopharmaceuticals.

A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Modulators

P. Conn, G. Tamagnan, D. Alagille, 2006, Molecular Pharmacology.

A Close Structural Analog of 2-Methyl-6-(phenylethynyl)-pyridine Acts as a Neutral Allosteric Site Ligand on Metabotropic Glutamate Receptor Subtype 5 and Blocks the Effects of Multiple Allosteric Modulators

P. Jeffrey Conn, David Alagille, P. Conn, 2005, Molecular Pharmacology.

A close structural analog of MPEP acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

P. Conn, Y. Nong, G. Tamagnan, 2005 .

Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity.

B. Roth, R. Baldwin, J. Wroblewski, 2005, Bioorganic & medicinal chemistry.

Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP.

David Alagille, Bryan L Roth, B. Roth, 2005, Bioorganic & medicinal chemistry letters.

Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series.

R. Baldwin, P. Conn, G. Tamagnan, 2011, Bioorganic & medicinal chemistry letters.

Functionalization at Position 3 of the Phenyl Ring of the Potent mGluR5 Noncompetitive Antagonists MPEP.

B. Roth, R. Baldwin, J. Wroblewski, 2005 .

In vivo evaluation of [¹²³I]mZIENT as a SPECT radioligand for the serotonin transporter.

J. Seibyl, K. Cosgrove, M. Goodman, 2012, Nuclear medicine and biology.

PRECLINICAL AND CLINICAL PROPERTIES OF [123I]ABC577: A NOVEL RADIOIODINATED SPECT AGENT FOR IMAGING B-AMYLOID IN THE BRAIN

D. Jennings, J. Seibyl, K. Marek, 2014, Alzheimer's & Dementia.

Design, synthesis and biological evaluation of new thalidomide analogues as TNF-α and IL-6 production inhibitors.

L. Favot, D. Alagille, Cécile Croix, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of positron emission tomography radiotracers targeting serotonin 4 receptors in brain: [18F]MNI-698 and [18F]MNI-699.

J. Seibyl, R. Baldwin, G. Tamagnan, 2013, Bioorganic & medicinal chemistry letters.

Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes.

J. Trojanowski, J. Seibyl, K. Marek, 2019, Brain : a journal of neurology.

Convenient synthesis of 18F-radiolabeled R-(-)-N-n-propyl-2-(3-fluoropropanoxy-11-hydroxynoraporphine.

R. Baldwin, J. Neumeyer, G. Tamagnan, 2014, Journal of labelled compounds & radiopharmaceuticals.

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

G. Kerchner, J. Seibyl, K. Marek, 2019, European Journal of Nuclear Medicine and Molecular Imaging.

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Yi Su, J. Perlmutter, Hongjun Jin, 2016, Pharmacology research & perspectives.

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Yi Su, J. Perlmutter, Hongjun Jin, 2016, Pharmacology research & perspectives.

Brain distribution of BZM055, an analog of fingolimod (FTY720), in human

D. Jennings, J. Seibyl, K. Marek, 2012 .

Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).

Tsuyoshi Ishii, S. Gay, G. Tamagnan, 2022, European journal of medicinal chemistry.

Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging.

Steven H. Liang, Keith A. Johnson, N. Vasdev, 2014, MedChemComm.

Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.

R. Baldwin, P. Conn, G. Tamagnan, 2006, Journal of medicinal chemistry.

Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques.

A. Levey, M. Goodman, G. Tamagnan, 2010, ACS medicinal chemistry letters.

6‐[123I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D4 receptor: synthesis and in vivo evaluation in a nonhuman primate

J. Seibyl, K. Cosgrove, J. Staley, 2008 .

Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB)

Steven H. Liang, N. Vasdev, Daniel L. Yokell, 2015 .

Erratum to “Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series” [Bioorg. Med. Chem. Lett. 21 (2011) 3243–3247]

R. Baldwin, P. Conn, G. Tamagnan, 2012 .

Automated one-step radiosynthesis of the CB1 receptor imaging agent [(18) F]MK-9470.

R. Baldwin, R. Hargreaves, G. Tamagnan, 2014, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of 5- and 6-substituted 2-(4-dimethylaminophenyl)-1,3-benzoxazoles and their in vitro and in vivo evaluation as imaging agents for amyloid plaque.

Sven H. Hausner, K. Cosgrove, J. Staley, 2009, Bioorganic & medicinal chemistry letters.

Crystal structure of 2-(3-methoxyphenylethynyl)-6-methylpyridine, C15H13NO, M-MPEP – a mGluR5 antagonist

R. Baldwin, C. Incarvito, G. Tamagnan, 2004 .

Crystal structure of 2-(3-methoxyphenylethynyl)-6-methylpyridine, C15H13NO, M-MPEP- a mGluR5 antagonist

R. Baldwin, C. Incarvito, G. Tamagnan, 2004 .

One-step synthesis of 2-arylbenzothiazole (‘BTA’) and -benzoxazole precursors for in vivo imaging of β-amyloid plaques

R. Baldwin, G. Tamagnan, D. Alagille, 2005 .

Design and Synthesis of Indole and Tetrahydroisoquinoline Hydantoin Derivatives as Human Chymase Inhibitors

G. Ferry, J. Boutin, P. Renard, 2004, Journal of enzyme inhibition and medicinal chemistry.

2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.

R. Baldwin, G. Tamagnan, D. Alagille, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cycloheptal[b]indoles.

D. Alagille, B. Joseph, S. Léonce, 2000, Chemical & pharmaceutical bulletin.

Total synthesis of the marine cytotoxic caulibugulones A–D

R. Baldwin, G. Tamagnan, D. Alagille, 2004 .

Rational Design, Pharmacomodulation, and Synthesis of Dual 5-Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [(18)F]-PET Imaging in a Primate Brain.

A. Bojarski, G. Satała, A. Chartier, 2015, Journal of medicinal chemistry.

One-Step Synthesis of 2-Arylbenzothiazole (“BTA”) and -benzoxazole Precursors for in vivo Imaging of β-Amyloid Plaques.

R. Baldwin, G. Tamagnan, D. Alagille, 2005 .

Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [¹⁸F]MNI-698.

J. Seibyl, G. Tamagnan, O. Barret, 2014, Nuclear medicine and biology.

The phosphodiesterase 10 positron emission tomography tracer, [18F]MNI-659, as a novel biomarker for early Huntington disease.

D. Jennings, J. Seibyl, J. Friedman, 2014, JAMA neurology.

Development and In Vivo Preclinical Imaging of Fluorine-18-Labeled Synaptic Vesicle Protein 2A (SV2A) PET Tracers

Christine M Sandiego, Olivier Barret, David Alagille, 2018, Molecular Imaging and Biology.

Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

M. Mintun, D. Jennings, J. Seibyl, 2017, The Journal of Nuclear Medicine.

Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys

J. Seibyl, M. Laruelle, G. Tamagnan, 2014, The Journal of Nuclear Medicine.

Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor.

F. Oury-Donat, F. Barth, G. Tamagnan, 2014, Bioorganic & medicinal chemistry letters.

Preclinical properties and human in vivo assessment of 123 I-ABC577 as a novel SPECT agent for imaging amyloid-β

D. Jennings, J. Seibyl, K. Marek, 2015, Brain : a journal of neurology.

In Vivo Assessment and Dosimetry of 2 Novel PDE10A PET Radiotracers in Humans: 18F-MNI-659 and 18F-MNI-654

Olivier Barret, Gilles Tamagnan, John Seibyl, 2014, The Journal of Nuclear Medicine.

Synthesis of benzo[5,6]cyclohepta[b]indol-6-one derivatives

D. Alagille, B. Joseph, C. Rousseau, 1999 .

A convenient preparation of furo[2,3-b]indoles by conjugated addition of organomagnesium reagents to 2-hydroxyindolylidenemalonates

P. Joseph-Nathan, M. S. Morales-Ríos, D. Alagille, 2003 .

A Convenient Preparation of Furo[2,3-b]indoles by Conjugated Addition of Organomagnesium Reagents to 2-Hydroxyindolylidenemalonates.

P. Joseph-Nathan, M. S. Morales-Ríos, D. Alagille, 2003 .

Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.

T. Wichmann, Y. Smith, J. Votaw, 2011, Brain : a journal of neurology.

Characterization in Humans of 18F-MNI-444, a PET Radiotracer for Brain Adenosine 2A Receptors

D. Jennings, J. Seibyl, M. Laruelle, 2015, The Journal of Nuclear Medicine.

Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase

J. Seibyl, G. Tamagnan, O. Barret, 2021, European Journal of Nuclear Medicine and Molecular Imaging.

Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers.

J. Seibyl, K. Cosgrove, J. Staley, 2010, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates

Jenna M. Sullivan, J. Seibyl, G. Tamagnan, 2021, The Journal of Nuclear Medicine.

Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with 123I‐INER

J. Seibyl, K. Cosgrove, J. Kordower, 2013, Synapse.

Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropanes

R. Baldessarini, R. Innis, R. Baldwin, 2006 .

Kinetic Modeling, Test–Retest, and Dosimetry of 123I-MNI-420 in Humans

D. Jennings, J. Seibyl, I. Zubal, 2013, The Journal of Nuclear Medicine.

In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.

J. Seibyl, K. Cosgrove, J. Kordower, 2013, Nuclear medicine and biology.

Synthesis and in vivo Evaluation of Fluorine‐18 and Iodine‐123 Pyrazolo[4,3‐e]‐1,2,4‐triazolo[1,5‐c]pyrimidine Derivatives as PET and SPECT Radiotracers for Mapping A2A Receptors

R. Baldwin, G. Tamagnan, O. Barret, 2016, ChemMedChem.

Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging

D. Jennings, J. Seibyl, K. Marek, 2016, Neurology.

FIRST-IN-HUMAN PET STUDIES WITH THE NEXT GENERATION TAU AGENT 18-F PI-2620 IN ALZHEIMER’S DISEASE, PROGRESSIVE SUPRANUCLEAR PALSY, AND CONTROLS

J. Seibyl, K. Marek, L. Dinkelborg, 2017, Alzheimer's & Dementia.

A NOVEL CLASS OF POSITIVE ALLOSTERIC MODULATORS OF mGluR1 INTERACT WITH A SITE DISTINCT FROM THAT OF NEGATIVE ALLOSTERIC MODULATORS

P. Conn, G. Tamagnan, D. Alagille, 2006 .

Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.

F. Tarazi, R. Baldessarini, J. Seibyl, 2007, Bioorganic & medicinal chemistry letters.

2-Arylimidazo[2,1-b]benzothiazoles: a new family of amyloid binding agents with potential for PET and SPECT imaging of Alzheimer's brain.

R. Baldwin, G. Tamagnan, D. Alagille, 2011, Bioorganic & medicinal chemistry letters.

Radiation dosimetry and biodistribution of [18F]PF-05270430, a radiotracer for phosphodiesterase 2A (PDE2A) in rhesus macaques and humans

D. Jennings, J. Seibyl, K. Marek, 2018 .