H. Mikolajek

发表

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

Vincent A. Voelz, Matthew F. D. Hurley, R. Glen, 2020, bioRxiv.

Plays a Key Role in Its Substrate Specificity of Eukaryotic Elongation Factor 2 Kinase A Conserved Loop in the Catalytic Domain

C. Proud, H. Mikolajek, C. E. Moore, 2014 .

A Conserved Loop in the Catalytic Domain of Eukaryotic Elongation Factor 2 Kinase Plays a Key Role in Its Substrate Specificity

C. Proud, H. Mikolajek, C. E. Moore, 2014, Molecular and Cellular Biology.

Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains

C. Proud, H. Mikolajek, J. Werner, 2011, The Biochemical journal.

Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana.

J. Cooper, S. Wood, R. Gill, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Production and Crystallization of Nanobodies in Complex with the Receptor Binding Domain of the SARS-CoV-2 Spike Protein.

R. Owens, J. Naismith, H. Mikolajek, 2022, Bio-protocol.

The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1

T. Elliott, L. Douglas, H. Mikolajek, 2018, The Journal of Biological Chemistry.

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival

C. Proud, G. Thomas, Jianling Xie, 2015, Molecular and Cellular Biology.

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

C. Proud, Xuemin Wang, Justin W. Kenney, 2015, Molecular and Cellular Biology.

Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes

R. Owens, M. Vendruscolo, D. Clare, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

E. Salah, C. Schofield, A. Tumber, 2022, Journal of medicinal chemistry.

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.

J. Cooper, S. Wood, N. Rashid, 2009, Journal of structural biology.

Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.

J. Cooper, Q. Bashir, A. Coker, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Ivan G. Costa, Vincent A. Voelz, Matthew F. D. Hurley, 2021, Cell Stem Cell.

VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline

J. Sanchez-Weatherby, C. Lobley, T. Sørensen, 2019, Journal of synchrotron radiation.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

Jordan J. Clark, R. Owens, J. Stewart, 2021, Nature Communications.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Characterization of recombinantly expressed matrilin VWA domains

M. Paulsson, H. Mikolajek, R. Wagener, 2015, Protein expression and purification.

A Structure of a Collagen VI VWA Domain Displays N and C Termini at Opposite Sides of the Protein

M. Paulsson, H. Mikolajek, R. Wagener, 2014, Structure.

Structural basis of ligand specificity in the human pentraxins, C‐reactive protein and serum amyloid P component

S. Wood, V. E. Pye, M. Pepys, 2011, Journal of molecular recognition : JMR.

2β-deoxy-Kdo is an inhibitor of the Arabidopsis thaliana CMP-2-Keto-3-deoxymanno-octulosonic acid synthetase, the enzyme required for activation of Kdo prior to incorporation into rhamnogalacturonan II.

H. Mikolajek, J. Werner, A. Marchant, 2013, Molecular plant.

Marine picocyanobacterial PhnD1 shows specificity for various phosphorus sources but likely represents a constitutive inorganic phosphate transporter

R. Owens, I. Paulsen, Deepa Varkey, 2023, The ISME journal.

Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2

R. Owens, D. Stuart, D. Clare, 2020, Nature Structural & Molecular Biology.

Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors

David D. L. Minh, Vincent A. Voelz, Matthew F. D. Hurley, 2023, bioRxiv.

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

T. Katoh, E. Salah, C. Schofield, 2023, Nature Chemistry.

High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei.

J. Cooper, S. Wood, G. Fox, 2006, Journal of molecular biology.

Insights into the mechanism of pyrrole polymerization catalysed by porphobilinogen deaminase: high-resolution X-ray studies of the Arabidopsis thaliana enzyme.

J. Cooper, S. Wood, R. Gill, 2013, Acta crystallographica. Section D, Biological crystallography.

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi‐functional c‐di‐GMP regulator

I. Tews, C. Keevil, H. Mikolajek, 2014, FEBS letters.

Crystallization and preliminary X-ray diffraction analysis of BipD, a virulence factor from Burkholderia pseudomallei

J. Cooper, S. Wood, R. Gill, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia

C. Proud, Xuemin Wang, Justin W. Kenney, 2015, Molecular and Cellular Biology.

Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.

J. Cooper, S. Wood, N. Rashid, 2009, Journal of structural biology.

H. Mikolajek, J. Werner, A. Marchant, 2013, Molecular plant.

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Ivan G. Costa, Vincent A. Voelz, Matthew F. D. Hurley, 2021, Cell Stem Cell.