D. Barak

发表

Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking.

K. Jacobson, T. K. Harden, J. Boyer, 2001, Journal of medicinal chemistry.

Constitutive Activation of A3 Adenosine Receptors by Site-Directed Mutagenesis

K. Jacobson, Zhang-Guo Gao, D. Barak, 2001 .

Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor*

K. Jacobson, C. Müller, Zhang-Guo Gao, 2002, The Journal of Biological Chemistry.

Engineering of A3 adenosine and P2Y nucleotide receptors and their ligands

K. Jacobson, Zhang-Guo Gao, D. Barak, 2003, Drug development research.

The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase.

Avigdor Shafferman, Dov Barak, N. Ariel, 2002, Biochemistry.

Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions.

N. Greig, Qian-sheng Yu, A. Shafferman, 2009, The Biochemical journal.

The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers.

A. Shafferman, Y. Karton, B. Velan, 2005, Chemico-biological interactions.

Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents.

A. Shafferman, B. Velan, A. Ordentlich, 2005, Chemico-biological interactions.

Orchestration of the functional subsites in the acetylcholinesterase active center – contribution to catalytic perfection and high reactivity toward specific ligands

N. Ariel, A. Shafferman, B. Velan, 2005 .

Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

N. Ariel, A. Shafferman, S. Cohen, 1992, The EMBO journal.

New M1 Agonists: Selective Signaling, Neurotrophic-Like and Cognitive Effects — Implications in the Treatment of Alzheimer’s Disease

D. Gurwitz, Z. Vogel, A. Fisher, 1995 .

Rigid analogs of acetylcholine can be m1-selective agonists: implications for a rational treatment strategy in Alzheimer's disease

D. Gurwitz, Z. Vogel, A. Fisher, 1992 .

New Muscarinic Agonists with Special Emphasis on AF102B

C. Fraser, D. Gurwitz, A. Fisher, 1991 .

Constitutive activation of A(3) adenosine receptors by site-directed mutagenesis.

K. Jacobson, Zhang-Guo Gao, D. Barak, 2001, Biochemical and biophysical research communications.

Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE

N. Ariel, A. Shafferman, B. Velan, 1998 .

Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.

N. Ariel, A. Shafferman, B. Velan, 1995, Biochemistry.

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket.

N. Ariel, A. Shafferman, S. Cohen, 1993, The Journal of biological chemistry.

The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors.

N. Ariel, A. Shafferman, B. Velan, 1998, The Biochemical journal.

Carbocation-Mediated Processes in Biocatalysts. Contribution of Aromatic Moieties

A. Shafferman, B. Velan, H. Benschop, 1997 .

Acetylcholinesterase Catalysis - Protein Engineering Studies

N. Ariel, A. Shafferman, B. Velan, 1992 .

RIBOSE MODIFIED NUCLEOSIDES AND NUCLEOTIDES AS LIGANDS FOR PURINE RECEPTORS

S. Moro, K. Jacobson, X. Ji, 2001, Nucleosides, nucleotides & nucleic acids.

Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray‐ionization mass spectrometry

A. Shafferman, B. Velan, R. Barak, 1997, FEBS letters.

Surprising findings from the functional analysis of human acetylcholinesterase adducts of Alzheimer’s disease drugs

N. Ariel, A. Shafferman, B. Velan, 2004 .

Structural and Functional Correlates of Human Acetylcholinesterase Mutants for Evaluating Alzheimer’s Disease Treatments

N. Ariel, A. Shafferman, B. Velan, 2002 .

Contribution of the Active Center Functional Architecture to AChE Reactivity Toward Substrates and Inhibitors

N. Ariel, A. Shafferman, B. Velan, 1998 .

Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases

N. Ariel, S. Reuveny, A. Shafferman, 1995 .

Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?

N. Ariel, A. Shafferman, B. Velan, 2001, Biochemistry.

Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase.

A. Shafferman, B. Velan, R. Barak, 2000, Biochemistry.

Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers.

N. Ariel, A. Shafferman, B. Velan, 1999, Biochemistry.

Engineering resistance to ‘aging’ of phosphylated human acetylcholinesterase Role of hydrogen bond network in the active center

N. Ariel, A. Shafferman, B. Velan, 1993, FEBS letters.

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

N. Ariel, A. Shafferman, S. Cohen, 1992, The Journal of biological chemistry.

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

N. Ariel, J. Sussman, I. Silman, 2000, Acta crystallographica. Section D, Biological crystallography.

Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase*

B Velan, N. Ariel, A. Shafferman, 1998, The Journal of Biological Chemistry.

Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE.

A. Shafferman, Y. Karton, B. Velan, 2004, Biochemistry.

The Architecture of Human Acetylcholinesterase Active Center Probed by Interactions with Selected Organophosphate Inhibitors

B Velan, N. Ariel, A. Shafferman, 1996, The Journal of Biological Chemistry.

Structural Determinants of A3 Adenosine Receptor Activation: Nucleoside Ligands at the Agonist/Antagonist Boundary

Kenneth A. Jacobson, Carl R. Johnson, Dov Barak, 2002 .

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Carl R. Johnson, Dov Barak, Kenneth A Jacobson, 2002, Journal of medicinal chemistry.

Selective Signaling via Unique Ml Muscarinic Agonists a

M. Segal, D. Gurwitz, Z. Vogel, 1993, Annals of the New York Academy of Sciences.

Aging of phosphylated human acetylcholinesterase: catalytic processes mediated by aromatic and polar residues of the active centre.

N. Ariel, A. Shafferman, B. Velan, 1996, The Biochemical journal.

Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?

Avigdor Shafferman, Dov Barak, A. Shafferman, 2004, Biochemistry.

Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.

N. Ariel, A. Shafferman, B. Velan, 1994, The EMBO journal.

A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.

J L Sussman, I Silman, J. Sussman, 1999, Chemico-biological interactions.

Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

N. Ariel, A. Shafferman, B. Velan, 1994, The Journal of biological chemistry.

Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase (*)

N. Ariel, A. Shafferman, B. Velan, 1995, The Journal of Biological Chemistry.

The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.

A. Shafferman, B. Velan, A. Ordentlich, 1994, The Journal of biological chemistry.

Flexibility versus "rigidity" of the functional architecture of AChE active center.

N. Greig, A. Shafferman, B. Velan, 2008, Chemico-biological interactions.

Structural investigation of protein kinase C inhibitors.

R. Rein, M. Shibata, D. Barak, 1991, Journal of molecular structure.

Homology model-assisted elucidation of binding sites in GPCRs.

Anat Levit, Dov Barak, Masha Y Niv, 2012, Methods in molecular biology.

Functional requirements for the optimal catalytic configuration of the AChE active center.

A. Shafferman, B. Velan, A. Ordentlich, 2005, Chemico-biological interactions.

Crystal Structures of “Aged” Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase

J. Sussman, I. Silman, M. Harel, 1998 .

What can be Learned from the use of HuAChE Mutants for Evaluation of Potential Alzheimer’s Drugs

N. Ariel, A. Shafferman, B. Velan, 1998 .

Structural modifications of the Ω loop in human acetylcholinesterase

N. Ariel, A. Shafferman, B. Velan, 1996 .

Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy.

N. Ariel, Y. Ashani, B. P. Doctor, 1993, Biochemistry.

Molecular Models for Human AChE and its Phosphonylation Products

N. Ariel, A. Shafferman, B. Velan, 1992 .

Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

J. Sussman, I. Silman, M. Harel, 1999, Biochemistry.

Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.

K. Jacobson, S. van Calenbergh, Zhang-Guo Gao, 2001, Journal of medicinal chemistry.

Catalytic activity of aminoacyl tRNA synthetases and its implications for the origin of life. I. Aminoacyl adenylate formation in tyrosyl tRNA synthetase

R. Rein, M. Shibata, D. Barak, 1991, Journal of Molecular Evolution.

Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.

Dov Barak, Kenneth A Jacobson, K. Jacobson, 2009, Journal of medicinal chemistry.

Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives.

A. Shafferman, B. Velan, A. Ordentlich, 1996, Molecular pharmacology.

DIRECTED EVOLUTION OF ABACTERIAL PESTICIDES DEGRADING ENZYME

B. Velan, A. Ordentlich, D. Barak, 1999 .

Function-specific blockage of M1 and M3 muscarinic acetylcholine receptors by VX and echothiophate

D. Barak, Z. Pittel, Y. Segall, 2006, Brain Research.

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

N. Ariel, J. Sussman, I. Silman, 2000, Acta crystallographica. Section D, Biological crystallography.

Aging of somanyl-acetylcholinesterase adducts: facts and models.

N. Ariel, A. Shafferman, B. Velan, 1997, The Biochemical journal.