Jingshan Shen

发表

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors.

Weiliang Zhu, Kaixian Chen, Hualiang Jiang, 2011, Journal of medicinal chemistry.

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Hualiang Jiang, Yechun Xu, M. Zheng, 2012, Journal of medicinal chemistry.

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

Jianhua He, Di Liu, Christopher J Vavricka, 2010, Nature Structural &Molecular Biology.

Synthesis of novel analogues of zanamivir as neuraminidase inhibitors

Qingjie Zhao, Zheng Liu, Jingshan Shen, 2010 .

An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride

Xiangrui Jiang, Chunhui Wu, Jingshan Shen, 2015 .

Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2017, Bioorganic & medicinal chemistry.

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.

Xiaomin Luo, Kaixian Chen, Hualiang Jiang, 2018 .

Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2

H. Aisa, Yuan-Chao Xie, Jingshan Shen, 2021, Bioorganic & Medicinal Chemistry.

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Zhen Wang, Zheng Liu, Guanghui Tian, 2009, Bioorganic & medicinal chemistry letters.

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts.

H. Aisa, Chang-Liang Sun, Xiangrui Jiang, 2019, The Journal of organic chemistry.

One step stereoselective synthesis of oxazoline-fused saccharides and their conversion into the corresponding 1,2-cis glycosylamines bearing various protected groups.

Weiliang Zhu, Kaixian Chen, Zhijian Xu, 2021, Organic & biomolecular chemistry.

Practical and Highly Efficient Synthesis of Remdesivir from GS-441524

Jingshan Shen, H. Aisa, T. Hu, 2022, ACS omega.

Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate.

H. Aisa, Guanghui Tian, Jingshan Shen, 2021, The Journal of organic chemistry.

A neighboring group participation strategy: facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-d-arabino-γ-lactone

Xiangrui Jiang, Guanghui Tian, Jingshan Shen, 2015 .

New process for the preparation of nitroorotsyre

Rolf Dach, Jin Suo, Yi Zhu, 2010 .

Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium.

Weiliang Zhu, Kaixian Chen, Bo Li, 2022, Journal of medicinal chemistry.

Synthesis of CBD and Its Derivatives Bearing Various C4'-side Chains with a Late-Stage Diversification Method.

H. Aisa, Chang-Liang Sun, Jingshan Shen, 2019, The Journal of organic chemistry.

Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs

Jingshan Shen, Yumin Zhang, T. Hu, 2022, Tetrahedron Letters.

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor

Xi Cheng, Xinheng He, H. Xu, 2022, Cell.

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.

Wei-Chang Fu, H. Sarau, J. Foley, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and antiviral activity of 2′‐deoxy‐6′‐substituted carbocyclic nucleosides

Jingshan Shen, T. Hu, Shuang Guo, 2021, Chemical biology & drug design.

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Gengfu Xiao, Lei-ke Zhang, Jingshan Shen, 2022, Signal Transduction and Targeted Therapy.

Optimized Synthesis of a Key Intermediate of Nirmatrelvir

Jingshan Shen, F. Zhu, H. Aisa, 2022, Organic Process Research & Development.

Overman rearrangement and Pomeranz-Fritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents.

Weiliang Zhu, Kaixian Chen, Zhijian Xu, 2013, European journal of medicinal chemistry.

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.

Jingshan Shen, Jianfeng Li, Guangxin Xia, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of PDE5 Inhibitory Activity of Novel Pyrido[2′,1′:5,1]pyrazolo[4,3‐d]pyrimidin‐4‐one Derivatives

Guanghui Tian, Jingshan Shen, Ya-bing Wei, 2007 .

Facile Synthesis of Benzimidazoles via N-Arylamidoxime Cyclization

Jingshan Shen, T. Hu, F. Zhu, 2022, ACS omega.

A Facile Route of Synthesis for Making Flibanserin

Yang He, Feipu Yang, Chunhui Wu, 2016 .

Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group

Xiangrui Jiang, Jingshan Shen, Dehui Jiang, 2021 .

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism

Weiliang Zhu, Jiye Shi, Zhijian Xu, 2016 .

A practical and enantioselective synthesis of tapentadol

Xiangrui Jiang, Guanghui Tian, Jingshan Shen, 2012 .

Metal-free quinolylation of the primary amino groups of amino acid derivatives and peptides with dihydrooxazolo[3,2-a]quinoliniums

Weiliang Zhu, Kaixian Chen, Z. Miao, 2019, Green Chemistry.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

Hualiang Jiang, Shuyang Zhang, Gengfu Xiao, 2020, bioRxiv.

Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics.

Yang He, Feipu Yang, Chunhui Wu, 2020, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.

Jian Ding, Jing-kang Shen, Zhen Wang, 2013, Bioorganic & medicinal chemistry.

Stereoselective Synthesis of 2-Deoxy-2-disubstituted ribonolactones Through a TiCl4-Mediated Evans-Aldol Reaction

Xiangrui Jiang, Yang He, Guan Wang, 2022, Tetrahedron Letters.

An improved preparation process for gemcitabine

Xiangrui Jiang, Jingshan Shen, Jianfeng Li, 2008 .

One-Pot Synthesis of Molnupiravir from Cytidine

Jingshan Shen, H. Aisa, T. Hu, 2022, Organic Process Research & Development.

Sildenafil promotes adipogenesis through a PKG pathway.

Jingshan Shen, Xiaoyun Sun, Heyao Wang, 2010, Biochemical and biophysical research communications.

PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells

Jingshan Shen, Xiaoyun Sun, Heyao Wang, 2012, Journal of cellular biochemistry.

Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.

Cheng Luo, Mingyue Zheng, Kaixian Chen, 2014, Journal of medicinal chemistry.

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism

Weiliang Zhu, Jiye Shi, Zhijian Xu, 2016, Synthesis.

Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase‐4 Inhibitors

Weiliang Zhu, Qiang Shao, Xiangrui Jiang, 2015, Archiv der Pharmazie.

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2016, Bioorganic & medicinal chemistry letters.

The complete synthesis of favipiravir from 2-aminopyrazine

Jingshan Shen, Mingshuo Xu, Shuang Guo, 2019, Chemical Papers.

An improved synthesis of telmisartan via the copper-catalyzed cyclization of o-haloarylamidines

Chang-Liang Sun, Jingshan Shen, F. Zhu, 2020, RSC advances.

Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor

Xiangrui Jiang, Guanghui Tian, Jingshan Shen, 2020 .

Synthesis of Impurities of Pramipexole Dihydrochloride

Xiangrui Jiang, Feipu Yang, Jingshan Shen, 2016 .

TPN10466 ameliorates Concanavalin A‐induced autoimmune hepatitis in mice via inhibiting ERK/JNK/p38 signaling pathway

Xiangrui Jiang, Jingshan Shen, Changsheng Du, 2023, European journal of immunology.

Artemisinin derivative TPN10466 suppresses immune cell migration and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.

Ningning Li, Xiangrui Jiang, Jingshan Shen, 2022, Cellular immunology.

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Weiliang Zhu, Hualiang Jiang, Yechun Xu, 2019, Journal of medicinal chemistry.

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.

Xiaomin Luo, Kaixian Chen, Hualiang Jiang, 2018, European journal of medicinal chemistry.

Water-promoted Synthesis of Stereoselective Oxazoline-fused Saccharides and Construction for 1, 2-cis Glycosylamines of Multi-modifications of Polyhydroxyl groups

Weiliang Zhu, Kaixian Chen, Zhijian Xu, 2020 .

Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety

H. Su, Lei-ke Zhang, Xiangrui Jiang, 2023, Bioorganic & medicinal chemistry.

Design, Synthesis, in vitro Evaluation of a New Pyrrolo[1,2‐ a ]thiazolo[5,4‐ d ]pyrimidinone Derivatives as Cholinesterase Inhibitors Against Alzheimer's Disease

H. Aisa, Yi Li, Jingshan Shen, 2022, Journal of Heterocyclic Chemistry.

Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents.

Qi Guo, Xiangrui Jiang, Jingshan Shen, 2019, Bioorganic & medicinal chemistry.

Facile synthesis of 2-C-methyl-d-arabino-γ-1,4-lactones and mechanism study

Jingshan Shen, T. Hu, Shuang Guo, 2018 .

Industry-Oriented Route Evaluation and Process Optimization for the Preparation of Brexpiprazole

H. Aisa, Jingshan Shen, J. Suo, 2019, Organic Process Research & Development.

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.

Guan Wang, Weiliang Zhu, Zhijian Xu, 2014, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2

H. Su, Lei-ke Zhang, Xiangrui Jiang, 2023, European journal of medicinal chemistry.

Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2

Rui Li, Xiangrui Jiang, Jingshan Shen, 2023, European Journal of Medicinal Chemistry.

New and Practical Synthesis of N‐(3‐Cyano‐7‐ethoxy‐4‐oxo‐1,4‐dihydroquinolin‐6‐yl)acetamide

Hongbin Sun, Jingshan Shen, Rongxia Zhang, 2014 .

New Synthesis of N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide

Xiangrui Jiang, Jingshan Shen, Weiming Chen, 2014 .

Synthesis of N-(3-Cyano-7-ethoxy-1,4-dihydro-4-oxoquinolin-6-yl)acetamide

Xiangrui Jiang, Zheng Liu, Jingshan Shen, 2011 .

A New and Improved Process for N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide

Xiangrui Jiang, Zheng Liu, Jingshan Shen, 2012 .

WITHDRAWN: Design, synthesis and biological evaluation of 3-substituted-4-anilinequinoline as EGFR tyrosine kinase inhibitors.

Jian Ding, Jingshan Shen, Jianfeng Li, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of N‐(3‐Cyano‐7‐ethoxy‐1,4‐dihydro‐4‐oxoquinolin‐6‐yl)acetamide.

Xiangrui Jiang, Zheng Liu, Jingshan Shen, 2012 .

IMPROVED TOTAL SYNTHESIS OF RACEMIC RUTAMARIN

Xiangrui Jiang, Hongbin Sun, Jingshan Shen, 2010 .

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Hualiang Jiang, Yechun Xu, Jingge Ren, 2013, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of Artemisinin derivatives as potential MS agents.

Hanxi Yang, Xiangrui Jiang, Jingshan Shen, 2022, Bioorganic & medicinal chemistry letters.

Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial

W. Wang, Lei-ke Zhang, Xiangrui Jiang, 2023, The Lancet regional health. Western Pacific.

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Gengfu Xiao, Yan Zhang, H. Su, 2023, Nature communications.

Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety.

Xiangrui Jiang, Yang He, Chunhui Wu, 2023, European journal of medicinal chemistry.

Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

Zhi Chen, Zhen Wang, Weiliang Zhu, 2010, J. Chem. Inf. Model..

Synthesis of Telmisartan Via Oxidative Cyclization

Rui Li, Xiangrui Jiang, Jingshan Shen, 2022, SSRN Electronic Journal.