S. Paoletta

发表

Exploring a 2-Naphthoic Acid Template for the Structure-Based Design of P2Y14 Receptor Antagonist Molecular Probes

Kyle A. Brown, R. Stevens, K. Jacobson, 2014, ACS chemical biology.

Agonist-bound structure of the human P2Y12 receptor

Hualiang Jiang, R. Stevens, K. Jacobson, 2014, Nature.

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Steven M. Moss, Hualiang Jiang, R. Stevens, 2014, Nature.

Two disparate ligand-binding sites in the human P2Y1 receptor

Hualiang Jiang, R. Stevens, K. Jacobson, 2015, Nature.

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

Silvia Paoletta, Kenneth A. Jacobson, K. Jacobson, 2014, PloS one.

Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses

K. Jacobson, S. Paoletta, Antonella Ciancetta, 2017, J. Chem. Inf. Model..

Screening of herbal constituents for aromatase inhibitory activity.

P. Hylands, D. Wildeboer, S. Paoletta, 2008, Bioorganic & medicinal chemistry.

Computational studies to predict or explain GPCR polypharmacology

K. Jacobson, S. Costanzi, S. Paoletta, 2015 .

Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A2A Adenosine Receptor Antagonists

Stefano Moro, Ettore Novellino, Sandro Cosconati, 2013, J. Chem. Inf. Model..

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.

S. Moro, S. Federico, G. Spalluto, 2012, Biochemical pharmacology.

Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders

K. Jacobson, C. Gachet, P. Ohlmann, 2016, Hämostaseologie.

Targeting p300/CBP in lethal prostate cancer

Suzanne, Jane Worthington, N. Tunariu, 2021 .

Targeting p300/CBP axis in lethal prostate cancer.

N. Tunariu, K. Knudsen, Jian Ning, 2021, Cancer discovery.

Fluorescent ligands for adenosine receptors.

S. Moro, S. Federico, G. Spalluto, 2013, Bioorganic & medicinal chemistry letters.

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.

S. Moro, C. Martini, S. Paoletta, 2011, Journal of medicinal chemistry.

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

S. Moro, K. Klotz, S. Federico, 2011, Bioorganic & medicinal chemistry.

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A3 Adenosine Receptor Agonists

Steven M. Moss, K. Jacobson, Zhang-Guo Gao, 2014, Journal of medicinal chemistry.

Title: Targeting p300/CBP in lethal prostate cancer. Running title: Targeting p300/CBP in lethal prostate cancer

N. Tunariu, K. Knudsen, Jian Ning, 2020 .

Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.

K. Jacobson, C. Gachet, P. Ohlmann, 2015, Blood.

associated with bleeding diathesis receptor variant, 12 Identification of a new dysfunctional platelet P2Y

K. Jacobson, C. Gachet, P. Ohlmann, 2014 .

A Novel Generalized 3D‐QSAR Model of Camptothecin Analogs

S. Moro, M. Bacilieri, S. Paoletta, 2011, Molecular informatics.

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.

Silvia Paoletta, Steven M. Moss, Kenneth A Jacobson, 2013, Journal of medicinal chemistry.

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor

K. Jacobson, A. T. Nguyen, Joanne Baltos, 2016, Molecular Pharmacology.

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.

K. Jacobson, Zhang-Guo Gao, J. Auchampach, 2015, ACS medicinal chemistry letters.

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.

Steven M. Moss, K. Jacobson, F. Deflorian, 2012, Journal of medicinal chemistry.

Photomodulation of G Protein-Coupled Adenosine Receptors by a Novel Light-Switchable Ligand

F. Ciruela, K. Jacobson, J. Hernando, 2014, Bioconjugate chemistry.

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

R. Stevens, K. Jacobson, V. Katritch, 2015, Molecular Pharmacology.

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.

S. Moro, K. Klotz, S. Federico, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.

S. Moro, K. Klotz, S. Federico, 2011, Journal of medicinal chemistry.

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.

S. Moro, K. Klotz, S. Federico, 2010, Journal of medicinal chemistry.

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.

Steven M. Moss, K. Jacobson, S. van Calenbergh, 2014, Bioorganic & medicinal chemistry.

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold.

E. Uriarte, S. Moro, K. Klotz, 2012, Biochemical pharmacology.

Species differences and mechanism of action of A3 adenosine receptor allosteric modulators

K. Jacobson, A. IJzerman, Zhang-Guo Gao, 2018, Purinergic Signalling.

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

Qiang Zhao, Stefano Moro, Christa E. Müller, 2015, Journal of Computer-Aided Molecular Design.

Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.

K. Jacobson, E. Kiselev, S. Paoletta, 2015, Bioorganic & medicinal chemistry.

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors☆

K. Jacobson, Zhang-Guo Gao, E. Kiselev, 2014, Computational and structural biotechnology journal.

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.

Steven M. Moss, K. Jacobson, Zhang-Guo Gao, 2014, ACS medicinal chemistry letters.

Nucleotides Acting at P 2 Y Receptors : Connecting Structure and Function

R. Stevens, K. Jacobson, V. Katritch, 2015 .

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example.

S. Moro, K. Klotz, S. Federico, 2019, MedChemComm.

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.

Silvia Paoletta, Kenneth A Jacobson, K. Jacobson, 2015, MedChemComm.

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.

K. Jacobson, Zhang-Guo Gao, S. Paoletta, 2012, ACS medicinal chemistry letters.

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.

S. Moro, Erika Morizzo, K. Varani, 2009, Journal of medicinal chemistry.

Computational studies to predict or explain G protein coupled receptor polypharmacology.

Stefano Costanzi, Silvia Paoletta, Kenneth A Jacobson, 2014, Trends in pharmacological sciences.

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.

S. Moro, K. Klotz, S. Federico, 2012, Journal of medicinal chemistry.

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry.

S. Moro, S. Federico, G. Spalluto, 2012, Biochemical pharmacology.

Programmable Nanoscaffolds That Control Ligand Display to a G-Protein-Coupled Receptor in Membranes To Allow Dissection of Multivalent Effects

Steven M. Moss, S. Durell, K. Jacobson, 2014, Journal of the American Chemical Society.

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

S. Moro, K. Klotz, S. Federico, 2011, Bioorganic & medicinal chemistry.

Characterisation of CCS1477: A novel small molecule inhibitor of p300/CBP for the treatment of castration resistant prostate cancer.

K. Knudsen, S. Paoletta, Jonathan Shannon, 2017 .