A. Remacle

发表

Quantitative profiling of protease specificity

P. Cieplak, J. Smith, B. Ratnikov, 2020, bioRxiv.

Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Cleaves C3b, an Essential Component of the Complement System*

A. Strongin, A. Remacle, D. Rozanov, 2004, Journal of Biological Chemistry.

Emerging roles for proteinases in cancer.

L. Devy, J. Foidart, A. Noël, 1997, Invasion & metastasis.

O-Glycosylation Regulates Autolysis of Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)*

A. Strongin, A. Remacle, D. Rozanov, 2006, Journal of Biological Chemistry.

Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy

J. Foidart, A. Noël, M. Polette, 2004, Virchows Archiv.

Gelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy

J. Foidart, A. Noël, M. Polette, 1994 .

Inflammatory Proprotein Convertase-Matrix Metalloproteinase Proteolytic Pathway in Antigen-presenting Cells as a Step to Autoimmune Multiple Sclerosis*

Jeffrey W. Smith, A. Strongin, Roy M. Williams, 2009, The Journal of Biological Chemistry.

Amino acid sequence conservation of the algesic fragment of myelin basic protein is required for its interaction with CDK5 and function in pain

A. Strongin, P. Cieplak, V. Shubayev, 2018, The FEBS journal.

Sex-Specific B Cell and Anti-Myelin Autoantibody Response After Peripheral Nerve Injury

A. Strongin, T. Yaksh, V. Shubayev, 2022, Frontiers in Cellular Neuroscience.

Amyelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

A. Strongin, T. Yaksh, V. Shubayev, 2020 .

B cell Activity and anti-MBP Autoantibody Response to Peripheral Nerve Injury is Sexually Dimorphic

A. Strongin, T. Yaksh, V. Shubayev, 2020 .

A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

A. Strongin, T. Yaksh, V. Shubayev, 2020, The Journal of Biological Chemistry.

A Femtomol Range FRET Biosensor Reports Exceedingly Low Levels of Cell Surface Furin: Implications for the Processing of Anthrax Protective Antigen

A. Strongin, Yingxiao Wang, Mingxing Ouyang, 2010, PloS one.

Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries

A. Strongin, D. Nam, A. Remacle, 2016, Proceedings of the National Academy of Sciences.

Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP

A. Strongin, R. Day, M. Fugère, 2006, Oncogene.

Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens*

Jeffrey W. Smith, A. Strongin, R. Liddington, 2007, Journal of Biological Chemistry.

Distinct Interactions with Cellular E-Cadherin of the Two Virulent Metalloproteinases Encoded by a Bacteroides fragilis Pathogenicity Island

A. Strongin, A. Remacle, S. Shiryaev, 2014, PloS one.

Tissue Inhibitor of Metalloproteinases-2 Binding to Membrane-type 1 Matrix Metalloproteinase Induces MAPK Activation and Cell Growth by a Non-proteolytic Mechanism*

A. Strongin, A. Galloway, D. Roses, 2008, Journal of Biological Chemistry.

Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.

J. Foidart, A. Noël, W. Stetler-Stevenson, 1992, Cancer research.

Membrane Type 1 Matrix Metalloproteinase-associated Degradation of Tissue Inhibitor of Metalloproteinase 2 in Human Tumor Cell Lines*

J. Foidart, A. Noël, C. Munaut, 2000, The Journal of Biological Chemistry.

Molecular interactions involving urokinase plasminogen activator (uPA), its receptor (uPAR) and its inhibitor, plasminogen activator inhibitor-1 (PAI-1), as new targets for tumour therapy

J. Foidart, A. Noël, C. Munaut, 1999 .

Assay of matrix metalloproteinases types 1, 2, 3 and 9 in breast cancer.

J. Foidart, A. Noël, M. Duffy, 1998, British Journal of Cancer.

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis

A. Strongin, P. Cieplak, A. Remacle, 2016, Oncotarget.

Matrix Metalloproteinase-14 Both Sheds Cell Surface Neuronal Glial Antigen 2 (NG2) Proteoglycan on Macrophages and Governs the Response to Peripheral Nerve Injury*

A. Strongin, V. Shubayev, A. Remacle, 2014, The Journal of Biological Chemistry.

Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface.

A. Strongin, Huimin Zhao, B. Kay, 2018, Cell chemical biology.

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

A. Strongin, R. Tsien, Yingxiao Wang, 2010, Cancer research.

Involvement of PA/plasmin system in the processing of pro‐MMP‐9 and in the second step of pro‐MMP‐2 activation

J. Foidart, A. Noël, H. Krell, 1997, FEBS letters.

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

Alex Y Strongin, Mingxing Ouyang, Nathan C Shaner, 2010, Cancer research.

Inhibition of stromal matrix metalloproteases: Effects on breast‐tumor promotion by fibroblasts

J. Foidart, A. Noël, A. Hajitou, 1998, International journal of cancer.

Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.

A. Strongin, M. Pellecchia, J. Stebbins, 2012, Cancer research.

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

A. Strongin, V. Shubayev, A. Remacle, 2015, Journal of Neuroinflammation.

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain

A. Strongin, V. Shubayev, A. Remacle, 2012, Journal of Neuroinflammation.

Biochemical Characterization of the Cellular Glycosylphosphatidylinositol-linked Membrane Type-6 Matrix Metalloproteinase*

A. Strongin, M. Pellecchia, Ilian A Radichev, 2010, The Journal of Biological Chemistry.

High levels of TIMP‐2 correlate with adverse prognosis in breast cancer

A. Noël, E. McDermott, N. O’higgins, 2000, International journal of cancer.

The MMP-9/TIMP-1 Axis Controls the Status of Differentiation and Function of Myelin-Forming Schwann Cells in Nerve Regeneration

A. Strongin, A. Mizisin, V. Shubayev, 2012, PloS one.

Substrate Cleavage Analysis of Furin and Related Proprotein Convertases

Piotr Cieplak, Michal Lebl, Robert Day, 2008, Journal of Biological Chemistry.

Epigenetic Control of the Invasion-promoting MT1-MMP/MMP-2/TIMP-2 Axis in Cancer Cells*

A. Strongin, A. Remacle, A. Chernov, 2009, Journal of Biological Chemistry.

High-Throughput Multiplexed Peptide-Centric Profiling Illustrates Both Substrate Cleavage Redundancy and Specificity in the MMP Family.

Piotr Cieplak, David A. Routenberg, Muskan Kukreja, 2015, Chemistry & biology.

Peptide Sequence Region That is Essential for the Interactions of the Enterotoxigenic Bacteroides fragilis Metalloproteinase II with E-cadherin.

A. Strongin, P. Cieplak, A. Remacle, 2014, Journal of proteolysis.

Substrate Cleavage Profiling Suggests a Distinct Function of Bacteroides fragilis Metalloproteinases (Fragilysin and Metalloproteinase II) at the Microbiome-Inflammation-Cancer Interface*

A. Strongin, P. Čapek, P. Cieplak, 2013, The Journal of Biological Chemistry.

Membrane type I-matrix metalloproteinase (MT1-MMP) is internalised by two different pathways and is recycled to the cell surface

Gillian Murphy, A. Remacle, G. Murphy, 2003, Journal of Cell Science.

Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island

A. Strongin, R. Liddington, P. Cieplak, 2014, The FEBS Journal.

Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism.

A. Strongin, P. Cieplak, V. Shubayev, 2018, The Biochemical journal.

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.

A. Strongin, R. Liddington, P. Cieplak, 2010, The international journal of biochemistry & cell biology.

Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Exhibits an Important Intracellular Cleavage Function and Causes Chromosome Instability*

A. Strongin, A. Osterman, S. Boyd, 2005, Journal of Biological Chemistry.

Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain

A. Strongin, T. Yaksh, V. Shubayev, 2017, Brain, Behavior, and Immunity.

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1–MMP

A. Strongin, P. Cieplak, N. Behrendt, 2013, Oncogenesis.

Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells.

A. Strongin, Ilian A Radichev, Wenhong Zhu, 2009, The Biochemical journal.

The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP)

A. Strongin, A. Remacle, D. Rozanov, 2005, Journal of Cell Science.

The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury

A. Strongin, V. Shubayev, A. Remacle, 2015, Journal of Neuroinflammation.

Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency.

A. Strongin, R. Day, M. Fugère, 2006, Archives of biochemistry and biophysics.

Non-destructive and Selective Imaging of the Functionally Active, Pro-invasive Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Enzyme in Cancer Cells*

A. Strongin, A. Remacle, V. Golubkov, 2013, The Journal of Biological Chemistry.

Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury

A. Strongin, V. Shubayev, A. Remacle, 2018, Journal of neuroinflammation.

Matrix Metalloproteinase (MMP) Proteolysis of the Extracellular Loop of Voltage-gated Sodium Channels and Potential Alterations in Pain Signaling*

A. Strongin, P. Cieplak, V. Shubayev, 2015, The Journal of Biological Chemistry.

Autocatalytic Activation of the Furin Zymogen Requires Removal of the Emerging Enzyme's N-Terminus from the Active Site

A. Strongin, B. Stec, R. Day, 2009, PloS one.

A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples.

A. Strongin, V. Shubayev, A. Remacle, 2018, Journal of immunological methods.

Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.

A. Strongin, M. Duffy, S. Krajewski, 2006, Cancer research.

Timp‐2 binding with cellular MT1‐MMP stimulates invasion‐promoting MEK/ERK signaling in cancer cells

A. Strongin, A. Noel, A. Remacle, 2009, International journal of cancer.

Non-destructive and Selective Imaging of the Functionally Active, Pro-invasive Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Enzyme in Cancer Cells*

A. Strongin, A. Remacle, V. Golubkov, 2013, The Journal of Biological Chemistry.

Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth.

A. Strongin, M. Pellecchia, J. Stebbins, 2012, Cancer research.

Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases*

A. Strongin, B. Stec, Ilian A Radichev, 2011, The Journal of Biological Chemistry.

Timp‐2 binding with cellular MT1‐MMP stimulates invasion‐promoting MEK/ERK signaling in cancer cells

A. Strongin, A. Noel, A. Remacle, 2009, International journal of cancer.

Dynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs)

B. Stec, Ilian A Radichev, A. Remacle, 2011 .