J. C. Crispín

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Moderate and severe neutropenia in patients with systemic lupus erythematosus.

J. Sánchez-Guerrero, D. Martínez-Baños, J. C. Crispín, 2006, Rheumatology.

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

J. C. Crispín, I. Madera-Salcedo, Giovanna Flores-Mendoza, 2021, Frontiers in Immunology.

Gene-function studies in SLE.

J. C. Crispín, F. Rosetti, Abigail de la Cruz, 2019, Current opinion in rheumatology.

The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus.

J. Alcocer-Varela, J. C. Crispín, J. Alcocer‐Varela, 2007, Autoimmunity reviews.

Rheumatologic manifestations of diabetes mellitus.

J. Alcocer-Varela, J. C. Crispín, J. Alcocer‐Varela, 2003, The American journal of medicine.

t cells as therapeutic targets in systemic lupus erythematosus

G. Tsokos, V. Kyttaris, J. C. Crispín, 2010 .

T cells as therapeutic targets in SLE

G. Tsokos, V. Kyttaris, J. C. Crispín, 2010, Nature Reviews Rheumatology.

PPP 2 R 2 B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases

J. Alcocer-Varela, O. Mutchinick, J. C. Crispín, 2019 .

Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling

T. Rauen, G. Tsokos, V. Kyttaris, 2014, Proceedings of the National Academy of Sciences.

Quantification of regulatory T cells in patients with systemic lupus erythematosus.

J. Alcocer-Varela, J. C. Crispín, Araceli Martínez, 2003, Journal of autoimmunity.

Immunoregulatory defects in patients with systemic lupus erythematosus in clinical remission

D. Alarcón-Segovia, J. Alcocer-Varela, Y. Richaud-Patin, 2003, Lupus.

T cells

J. C. Crispín, F. Rosetti, J. Crispín, 2019, Systemic Lupus Erythematosus.

Chapter 13 – T Cells

J. C. Crispín, Noé Rodríguez-Rodríguez, F. Rosetti, 2016 .

The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway.

J. C. Crispín, I. Madera-Salcedo, G. Fragoso, 2020, Clinical immunology.

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice.

V. Kuchroo, A. Sharpe, G. Tsokos, 2013, Arthritis and rheumatism.

SLE-Associated Defects Promote Altered T Cell Function.

G. Tsokos, J. C. Crispín, A. Suárez-Fueyo, 2017, Critical reviews in immunology.

Serine/threonine phosphatase PP2A is essential for optimal B cell function.

J. Manis, A. Sharabi, G. Tsokos, 2020, JCI insight.

Chapter 9 – T Cells

G. Tsokos, J. C. Crispín, J. Crispín, 2013 .

How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype.

G. Tsokos, V. Kyttaris, Y. Juang, 2008, Trends in immunology.

B cells contribute to ischemia/reperfusion-mediated tissue injury.

G. Tsokos, T. Tedder, J. C. Crispín, 2009, Journal of autoimmunity.

De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients: A Place for Interaction?

J. Alcocer-Varela, J. C. Crispín, J. Alberú, 2012, Journal of transplantation.

Regulatory T cells as modulators of B cell antibody production.

J. C. Crispín, J. Crispín, 2011, Clinical immunology.

Expression of PD-1/PD-L1 and PD-L2 in peripheral T-cells from non-small cell lung cancer patients

A. Cardona, O. Arrieta, J. C. Crispín, 2017, Oncotarget.

Programmed Cell Death 1 and Helios Distinguish TCR-αβ+ Double-Negative (CD4−CD8−) T Cells That Derive from Self-Reactive CD8 T Cells

G. Tsokos, D. Barouch, J. C. Crispín, 2015, The Journal of Immunology.

Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses IL-2 Production and Regulatory T Cell Activity in Lupus

G. Tsokos, K. Ichinose, T. Koga, 2012, The Journal of Immunology.

Novel molecular targets in the treatment of systemic lupus erythematosus.

G. Tsokos, J. C. Crispín, J. Crispín, 2008, Autoimmunity reviews.

Pathogenesis of lupus

G. Tsokos, J. C. Crispín, J. Crispín, 2011 .

Protein phosphatase 2A is requisite for the function of regulatory T cells this access benefits you. Your story matters

G. Tsokos, M. Tsokos, J. C. Crispín, 2016 .

Lessons from Sjögren’s syndrome etiopathogenesis: Novel cellular and molecular targets

J. C. Crispín, G. Hernández-Molina, F. Rosetti, 2015 .

Systemic lupus erythematosus induced by therapy with interferon-beta in a patient with multiple sclerosis.

J. C. Crispín, E. Díaz-Jouanen, J. Crispín, 2005, Lupus.

IL-17 in Systemic Lupus Erythematosus The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

G. Tsokos, J. C. Crispín, J. Crispín, 2010 .

Programmed Cell Death 1 and Helios Distinguish TCR-ab Double-Negative (CD4CD8) T Cells That Derive from Self-Reactive CD8 T Cells

G. Tsokos, J. C. Crispín, Noé Rodríguez-Rodríguez, 2015 .

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus

T. Rauen, G. Tsokos, Mindy S Lo, 2012, Proceedings of the National Academy of Sciences.

Pro‐inflammatory self‐reactive T cells are found within murine TCR‐αβ+CD4−CD8−PD‐1+ cells

J. McCluskey, G. Tsokos, A. Corbett, 2016, European journal of immunology.

Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV.

G. Tsokos, Y. Juang, K. Ichinose, 2011, Arthritis and rheumatism.

Systemic lupus erythematosus: new molecular targets

G. Tsokos, V. Kyttaris, Y. Juang, 2007, Annals of the rheumatic diseases.

TCR‐α/β CD4− CD8− double negative T cells arise from CD8+ T cells

G. Tsokos, J. C. Crispín, Giovanna Flores-Mendoza, 2020, Journal of leukocyte biology.

cAMP-responsive Element Modulator α (CREMα) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3+CD4−CD8− T Cells in Health and Disease*

T. Rauen, G. Tsokos, V. Kyttaris, 2013, The Journal of Biological Chemistry.

Orbital and periorbital inflammation in VEXAS syndrome

J. C. Crispín, P. Grayson, E. Martín-Nares, 2022, Scandinavian journal of rheumatology.

Editorial: New biomarkers for the diagnosis and treatment of systemic lupus erythematosus

A. Perl, N. Agmon-Levin, J. C. Crispín, 2022, Frontiers in Immunology.

CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity.

F. Tacke, D. Foell, T. Rauen, 2012, Journal of molecular cell biology.

KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3+ regulatory T cells in MRL/lpr mice

G. Tsokos, T. Koga, J. C. Crispín, 2014, Autoimmunity.

Pyridostigmine reduces mortality of patients with severe SARS-CoV-2 infection: A phase 2/3 randomized controlled trial

D. Manzur-Sandoval, J. C. Crispín, S. Valdés-Ferrer, 2022, Molecular Medicine.

Neurocysticercosis: local and systemic immune-inflammatory features related to severity

J. C. Crispín, G. Fragoso, E. Sciutto, 2012, Medical Microbiology and Immunology.