Hong Cheng

发表

Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition

D. Wiederschain, C. Winter, J. Pollard, 2017, PloS one.

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Marc W. Kirschner, Feng Cong, Craig Mickanin, 2009, Nature.

Circ_0001955 plays a carcinogenic role in breast cancer via positively regulating GLUT1 via decoying miR‐1299

Shengrong Sun, Hong Cheng, Sijie Kuang, 2022, Thoracic cancer.

Induction of apoptosis by 7-piperazinethylchrysin in HCT-116 human colon cancer cells.

Kun Hu, Jie Ren, Hong Cheng, 2012, Oncology reports.

Synthesis and antitumor activity of formononetin nitrogen mustard derivatives.

Kun Hu, Jie Ren, Xin Chen, 2012, European journal of medicinal chemistry.

Synthesis and cytotoxicity of novel chrysin derivatives

Kun Hu, Jie Ren, Hong Cheng, 2011, Medicinal Chemistry Research.

4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6.

Rajiv Chopra, Sunkyu Kim, Ming Xu, 2010, Journal of medicinal chemistry.

Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (IDH1) via Disruption of a Metal Binding Network by an Allosteric Small Molecule

Dietmar Hoffmann, Jean-Pierre Marquette, Magali Mathieu, 2014, The Journal of Biological Chemistry.

Studies of heterocyclic compounds. VIII. Synthesis, anti‐inflammatory and antiallergic activities of n‐alkyl‐2,3,4,9‐tetrahydrofuro[2,3‐b]quinoline‐3,4‐diones and related compounds

S. Kuo, Li‐Jiau Huang, Hong Cheng, 1991 .

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Q. Gao, I. Cornella-Taracido, C. García-echeverría, 2018, Cell chemical biology.

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.

Paul N. Mortenson, M. Congreve, R. Cheng, 2012, ACS medicinal chemistry letters.

PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.

S. Gross, Q. Gao, D. Wiederschain, 2014, Blood.

suppression of STAT 5 activation and degradation of MYC oncogene PIM inhibitors target CD 25-positive AML cells through concomitant

S. Gross, Q. Gao, D. Wiederschain, 2014 .

Combination of PIM and JAK2 inhibitors synergistically suppresses cell proliferation and overcomes drug resistance of myeloproliferative neoplasms

D. Wiederschain, C. García-echeverría, C. Lengauer, 2014, Oncotarget.

[Effects of Wogonin on Apoptosis,Invasion,Migration and Wnt/β-Catenin Signaling Pathway of Gastric Cancer Cells SGC7901].

Hong Cheng, Xiao-Hui Wang, Ying Wei, 2016, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.

Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches

Q. Gao, D. Wiederschain, C. García-echeverría, 2013, The Journal of Biological Chemistry.

SAR439859, a Novel Selective Estrogen Receptor Degrader (SERD), Demonstrates Effective and Broad Antitumor Activity in Wild-Type and Mutant ER-Positive Breast Cancer Models

Joon Sang Lee, C. García-echeverría, L. Debussche, 2020, Molecular Cancer Therapeutics.

Abstract 4648: In vitro characterization of spiro-oxindole-based modulators of the MDM2-p53 interaction and their interspecies selectivity.

Shaomeng Wang, J. Watters, C. García-echeverría, 2012 .

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer.

M. Mathieu, C. García-echeverría, M. Levit, 2019, Journal of medicinal chemistry.

Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer

C. García-echeverría, C. Winter, L. Debussche, 2018, Endocrinology.

Abstract A226: Mechanism of action of iniparib: Stimulation of reactive oxygen species (ROS) production in an iniparib-sensitive breast cancer cell line.

D. Bergstrom, J. Watters, J. Pollard, 2011 .

[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.

D. Chin, W. Shao, Yun Feng, 2012, Journal of medicinal chemistry.

A Robust Multiplex Mass Spectrometric Assay for Screening Small-Molecule Inhibitors of CD73 with Diverse Inhibition Modalities

R. Gregory, S. Licht, P. Ferrari, 2018, SLAS discovery : advancing life sciences R & D.

Abstract 5468: SAR650984, a humanized anti-CD38 antibody potently modulates intracellular and extracellular nucleotide levels of cancer cells

Shujia Dai, T. Cai, S. Licht, 2014 .