David Brühlmann

发表

Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures.

Thomas K. Villiger, Rudiyanto Gunawan, H. Broly, 2017, Metabolic engineering.

Generation of site‐distinct N‐glycan variants for in vitro bioactivity testing

M. Sauer, H. Broly, M. Jordan, 2019, Biotechnology and bioengineering.

Glycosylation flux analysis reveals dynamic changes of intracellular glycosylation flux distribution in Chinese hamster ovary fed-batch cultures

Thomas K. Villiger, Rudiyanto Gunawan, H. Broly, 2017, bioRxiv.

Cell culture media supplemented with raffinose reproducibly enhances high mannose glycan formation.

M. Sauer, H. Broly, F. Kalman, 2017, Journal of biotechnology.

Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing

Hervé Broly, David Brühlmann, Jonathan Souquet, 2019, Science Advances.

Tailoring recombinant protein quality by rational media design

Hervé Broly, David Brühlmann, Markus Sauer, 2015, Biotechnology progress.

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed‐batch systems

Jean-Marc Bielser, Hervé Broly, David Brühlmann, 2016, Biotechnology progress.

Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality

Hervé Broly, Michael Sokolov, David Brühlmann, 2017, Biotechnology and bioengineering.

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction

Massimo Morbidelli, Hervé Broly, Michael Sokolov, 2020, Biotechnology progress.

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

Massimo Morbidelli, Jean-Marc Bielser, Dominik Rothenhäusler, 2017, Biotechnology progress.