J. Stephan

发表

An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth

M. Yaylaoglu, Zhaoshi Jiang, Grégoire Pau, 2014, Genes & development.

Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.

P. Giresi, J. Settleman, Kuan-Bei Chen, 2017, Cancer cell.

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.

Christian Wiesmann, Pamela Chan, Ping Wu, 2009, The Journal of clinical investigation.

High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

H. Koeppen, S. Scales, J. M. Elliott, 2007, British journal of haematology.

Cell and Antibody Engineering: New Tools for Antigen and Therapeutic Antibody Discovery

J. Stephan, P. Roberts, J. Mather, 2000 .

Membrane display and functional analysis of juxtacrine ligand-receptor signaling.

D. Lawrence, L. Komuves, S. Marsters, 2015, BioTechniques.

Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.

J. Settleman, W. Sandoval, G. Hatzivassiliou, 2016, Cell metabolism.

Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection.

G. Frantz, A. Ebens, H. Koeppen, 2009, Cancer research.

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

Z. Modrušan, I. Mellman, H. Koeppen, 2018, The Journal of cell biology.

A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice.

G. Frantz, K. Hillan, J. Stinson, 2002, American Journal of Pathology.

non-Hodgkin lymphoma Antibody-drug conjugates targeted to CD79 for the treatment of

A. Ebens, S. Ross, M. J. Cole, 2013 .

Antibody-drug conjugates targeted to CD 79 for the treatment of non-Hodgkin ’ s lymphoma Antibody drug conjugates targeted to CD 79

A. Ebens, S. Ross, M. J. Cole, 2007 .

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma.

A. Ebens, S. Ross, M. J. Cole, 2006, Blood.

Proteomic analyses identify a novel role for EZH2 in the initiation of cancer cell drug tolerance.

A. Masselot, D. Arnott, R. Pitti, 2020, Journal of proteome research.

Regulation of Sertoli cell IL-1 and IL-6 production in vitro

B. Jégou, J. Stephan, V. Syed, 1997, Molecular and Cellular Endocrinology.

PFKFB3 and insulin signalling

D. James, B. Parker, J. Krycer, 2015 .

A Putative New Melatonin Binding Site in Sheep Brain, MTx: Preliminary Observations and Characteristics

J. Boutin, P. Delagrange, J. Leprince, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Source, catabolism and role of the tetrapeptide N-acetyl-ser-asp-lys-Pro within the testis.

J. Toppari, B. Jégou, J. Wdzieczak‐Bakala, 2000, Journal of cell science.

Distribution and function of the adhesion molecule BEN during rat development.

J. Stephan, P. Roberts, L. Bald, 1999, Developmental biology.

Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design

F. Fages, P. Delagrange, J. Stephan, 2022, PLoS Comput. Biol..

Albumin Stimulates the Accumulation of Extracellular Matrix in Renal Tubular Epithelial Cells

R. Rabkin, E. Filvaroff, J. Stephan, 2004, American Journal of Nephrology.

D. French, L. Powell-Braxton, J. Stephan, 2022 .

Ultrasensitive detection of cellular protein interactions using bioluminescence resonance energy transfer quantum dot‐based nanoprobes

D. Sobek, Gabriel A. Quiñones, J. Stephan, 2012, Journal of cellular biochemistry.

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).

Zhaoyang Wen, Brigitte Maurer, Vickie Tsui, 2012, Journal of medicinal chemistry.

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

Thijs J. Hagenbeek, M. Shibuya, I. Kasman, 2010, Cell.

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

D. Lawrence, S. Marsters, A. Ashkenazi, 2012, Molecular cell.

fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis.

P. Marker, G. Cunha, J. Stephan, 2001, Developmental biology.

An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.

Marie Evangelista, M. Belvin, J. Zha, 2012, Cancer research.

Production, characterization and pharmacokinetic properties of antibodies with N-linked Mannose-5 glycans

Marcella Yu, R. Bayer, J. Stephan, 2012, mAbs.

Nucleic acid capture assay, a new method for direct quantitation of nucleic acids.

P. Jhurani, M. Vasser, M. Jakobsen, 2003, Nucleic acids research.

Antibodies against the gH/gL/UL128/UL130/UL131 Complex Comprise the Majority of the Anti-Cytomegalovirus (Anti-CMV) Neutralizing Antibody Response in CMV Hyperimmune Globulin

R. Vandlen, B. Feierbach, J. Stephan, 2012, Journal of Virology.

Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway.

J. Stephan, 2014, Methods in enzymology.

Cell-based siRNA screens highlight triple-negative breast cancer cell epigenetic vulnerability

A. Walsh, F. Perez, J. Camonis, 2021 .

Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes.

R. Soriano, P. Williams, R. Vandlen, 2004, Endocrinology.

Filling the drug discovery gap: is high-content screening the missing link?

Thierry Dorval, J. Stephan, T. Dorval, 2018, Current opinion in pharmacology.

Nucleic Acid Capture Assay: A Novel High- Throuhgput Method for Direct Mrna Quantitation

L. Zheng, P. Tsai, J. Stephan, 2005 .

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

J. Settleman, D. Kirkpatrick, J. Stephan, 2014, Oncotarget.

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Vickie Tsui, Frederick Cohen, Harvey Wong, 2009, Journal of medicinal chemistry.

Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway.

B. Jégou, M. Parvinen, C. Bardin, 1995, Endocrinology.

In vitro regulation of an inducible-type NO synthase in the rat seminiferous tubule cells.

B. Jégou, J. Stephan, F. Bauché, 1998, Biology of reproduction.

Gene expression profiling during hibernation in the European hamster

Jean A Boutin, Célia Gautier, Damien Valour, 2018, Scientific Reports.

Nitric oxide production by Sertoli cells in response to cytokines and lipopolysaccharide.

B. Jégou, J. Stephan, F. Bauché, 1995, Biochemical and biophysical research communications.

Preclinical pharmacokinetics of MFGR1877A, a human monoclonal antibody to FGFR3, and prediction of its efficacious clinical dose for the treatment of t(4;14)-positive multiple myeloma

A. Kamath, J. Qing, J. Stephan, 2012, Cancer Chemotherapy and Pharmacology.

High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes.

Jean A Boutin, O. Nosjean, J. Boutin, 2016, American journal of physiology. Heart and circulatory physiology.

A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.

M. Sliwkowski, D. Danilenko, C. Eigenbrot, 2011, Cancer cell.

Development of a frozen cell array as a high-throughput approach for cell-based analysis.

Jean Philippe Stephan, Silvia Schanz, Anne Wong, 2002, The American journal of pathology.

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs

R. Bourgon, J. Settleman, M. Merchant, 2016, Nature Communications.

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

Zhijun Tang, Z. Modrušan, J. Zha, 2008, Molecular Cancer Therapeutics.

Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma

A. Ebens, T. Januario, S. Prabhu, 2010, Leukemia.

Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination.

A. Ebens, S. Prabhu, F. Jacobson, 2008, Bioconjugate chemistry.

Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates.

J. Stephan, W. Wong, K. Kozak, 2011, Bioanalysis.

Identification and Analysis of In Vivo VEGF Downstream Markers Link VEGF Pathway Activity with Efficacy of Anti-VEGF Therapies

Matthew J. Brauer, C. James, P. Hegde, 2013, Clinical Cancer Research.

Interleukin-1, interleukin-6 and the germ cell-Sertoli cell cross-talk.

B. Jégou, J. Stephan, E. Gomez, 1995, Reproduction, fertility, and development.

Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor

R. Weaver, C. Porter, M. Scanlon, 2021, bioRxiv.

Selective cloning of cell surface proteins involved in organ development: epithelial glycoprotein is involved in normal epithelial differentiation.

J. Stephan, P. Roberts, L. Bald, 1999, Endocrinology.

Defining the Ligand Specificity of the Deleted in Colorectal Cancer (DCC) Receptor

M. Tessier-Lavigne, Lino C. Gonzalez, Bernd J. Wranik, 2014, PloS one.

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway*

D. James, James Lee, B. Parker, 2015, The Journal of Biological Chemistry.

Application of a new wall-less plate technology to complex multistep cell-based investigations using suspension cells.

Hyunjae Lee, N. Jeon, Sudong Kim, 2013, Blood.

The Sertoli cell-germ cell interactions and the seminiferous tubule interleukin-1 and interleukin-6 system.

B. Jégou, J. Stephan, C. Piquet-Pellorce, 2000, Results and problems in cell differentiation.

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

M. Dennis, J. Stephan, Elizabeth Drake, 2011, mAbs.