J. Tremblay

发表

A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice.

D. Schmidt, Lianfa Shi, H. Feng, 2014, The Journal of infectious diseases.

A heterohexameric protein consisting of six linked single-domain antibodies is highly protective for BoNT/A, BoNT/B and BoNT/E exposures

M. Debatis, C. Shoemaker, J. Awata, 2021, bioRxiv.

Use of VHH antibodies for the development of antigen detection test for visceral leishmaniasis

R. Fujiwara, L. Bueno, C. Shoemaker, 2018, Parasite immunology.

A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

Saul Tzipori, David T. Curiel, Gillian Beamer, 2016, Clinical and Vaccine Immunology.

of Veterinary Biotechnology; Key Laboratory of Urban Agriculture (South) Ministry of

S. Tzipori, D. Schmidt, D. Curiel, 2016 .

Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases.

G. Oyler, C. Shoemaker, M. Jin, 2010, Toxicon : official journal of the International Society on Toxinology.

Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin*

N. Mantis, C. Shoemaker, J. Tremblay, 2013, The Journal of Biological Chemistry.

Toxin That Passively Protect Mice from Ricin H AntibodiesHSingle Domain Camelid V Stepwise Engineering of Heterodimeric Immunology :

N. Mantis, C. Shoemaker, J. Tremblay, 2013 .

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

Patrick M. Wright, Leonard A. Smith, S. Tzipori, 2012, PloS one.

Adenovirus Vector Expressing Stx1/Stx2-Neutralizing Agent Protects Piglets Infected with Escherichia coli O157:H7 against Fatal Systemic Intoxication

S. Tzipori, D. Curiel, M. Debatis, 2014, Infection and Immunity.

and 2 Mice against Challenge with Shiga Toxins 1 Agent and an Effector Antibody Protect A Single VHH-Based Toxin-Neutralizing

M. Debatis, G. Beamer, J. Tremblay, 2014 .

A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

S. Tzipori, M. Debatis, G. Beamer, 2013, Infection and Immunity.

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

D. Curiel, M. Debatis, I. Dmitriev, 2014, PloS one.

Adenoviral targeting using genetically incorporated camelid single variable domains

D. Curiel, C. Shoemaker, J. Tremblay, 2014, Laboratory Investigation.

Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.

M. Yoder, G. M. Helmkamp, J. Tremblay, 2005, Biochemistry.

Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody.

S. Seaman, D. Curiel, I. Dmitriev, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Generation of a phage-display library of single-domain camelid VH H antibodies directed against Chlamydomonas reinhardtii antigens, and characterization of VH Hs binding cell-surface antigens.

Julian N. Rosenberg, G. Oyler, D. Weeks, 2013, The Plant journal : for cell and molecular biology.

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection*

Allison J. Greaney, S. Leppla, M. Moayeri, 2016, The Journal of Biological Chemistry.

A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model*

S. Leppla, M. Moayeri, C. Shoemaker, 2015, The Journal of Biological Chemistry.

Mechanism of interaction of PITPalpha with membranes: conformational changes in the C-terminus associated with membrane binding.

Jay R. Unruh, J. Tremblay, Carey K. Johnson, 2005, Archives of biochemistry and biophysics.

Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

M. Debatis, C. Shoemaker, Celinia A. Ondeck, 2022, Scientific Reports.

Intramuscular delivery of formulated RNA encoding six linked single-domain antibodies is highly protective for exposures to three Botulinum neurotoxin serotypes

J. Awata, J. Tremblay, J. Mukherjee, 2022 .

Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies*

N. Mantis, C. Shoemaker, J. Tremblay, 2015, The Journal of Biological Chemistry.

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin

D. Volkin, N. Mantis, C. Shoemaker, 2017, Clinical and Vaccine Immunology.

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Non-Neutralizing Single Domain Antibodies on Ricin Toxin's Enzymatic and Binding Subunits

D. Volkin, N. Mantis, C. Shoemaker, 2017 .

X-ray analysis of crystals of rat phosphatidylinositol-transfer protein with bound phosphatidylcholine.

M. Yoder, G. M. Helmkamp, J. Tremblay, 1999, Acta crystallographica. Section D, Biological crystallography.

CEREBROSIDE MAY BE FALSELY IDENTIFIED AS A SOLUBLE ‘BRAIN SPECIFIC PROTEIN’

M. Simon, J. Tremblay, S. Barondes, 1974, Journal of neurochemistry.

Engineered E. coli for the targeted deposition of therapeutic payloads to sites of disease

H. Ploegh, W. Garrett, J. Glickman, 2022 .

Structure of a Multifunctional Protein

M. Yoder, G. M. Helmkamp, J. Tremblay, 2001, The Journal of Biological Chemistry.

Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins

M. Debatis, C. Shoemaker, A. Da'dara, 2017, PLoS neglected tropical diseases.

Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats.

J. DeGnore, C. Shoemaker, J. Sepúlveda, 2010, International journal for parasitology.

Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium.

S. Tzipori, C. Shoemaker, J. Tremblay, 2021, International journal for parasitology.

Both isoforms of mammalian phosphatidylinositol transfer protein are capable of binding and transporting sphingomyelin.

G. M. Helmkamp, J. Tremblay, Hong Li, 2002, Biochimica et biophysica acta.

Limited Proteolysis of Rat Phosphatidylinositol Transfer Protein by Trypsin Cleaves the C Terminus, Enhances Binding to Lipid Vesicles, and Reduces Phospholipid Transfer Activity*

J. Tremblay, L. Yarbrough, Helmkamp M. George, 1996, The Journal of Biological Chemistry.

Engineered Escherichia coli for the in situ secretion of therapeutic nanobodies in the gut.

H. Ploegh, W. Garrett, J. Glickman, 2023, Cell host & microbe.

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917

Neel S. Joshi, S. Tzipori, M. Osburne, 2021, bioRxiv.

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

S. Leppla, D. Curiel, M. Debatis, 2016, Clinical and Vaccine Immunology.

Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies

S. Tzipori, M. Debatis, V. Vigdorovich, 2023, bioRxiv.

Single-domain antibodies pinpoint potential targets within Shigella invasion plasmid antigen D of the needle tip complex for inhibition of type III secretion

S. Tzipori, C. Shoemaker, W. Picking, 2017, The Journal of Biological Chemistry.

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

K. Lam, C. Shoemaker, Edwin J. Vazquez-Cintron, 2020, Cell reports.

Modifications of cysteine residues in the solution and membrane-associated conformations of phosphatidylinositol transfer protein have differential effects on lipid transfer activity.

G. M. Helmkamp, H. Li, J. Tremblay, 2001, Biochemistry.

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function

K. Lam, C. Shoemaker, Edwin J. Vazquez-Cintron, 2020, Toxins.

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

K. Lam, C. Shoemaker, J. Tremblay, 2023, Nature communications.

Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits

N. Mantis, C. Shoemaker, J. Tremblay, 2021, Infection and immunity.

Adenovirus Vector Expressing Stx1/Stx2-Neutralizing Agent Protects Piglets Infected with Escherichia coli O157:H7 against Fatal Systemic Intoxication

S. Tzipori, D. Curiel, M. Debatis, 2014, Infection and Immunity.

Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies

K. Lam, J. Tremblay, K. Perry, 2022, PLoS pathogens.