A. Siwkowski

发表

Antisense oligonucleotide therapy for TTR amyloidosis

M. Benson, B. Monia, B. Kluve-Beckerman, 2011, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

A. Siwkowski, T. P. Prakash, H. Gaus, 2010, Journal of medicinal chemistry.

An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.

M. Egli, A. Watt, P. S. Pallan, 2010, Journal of the American Chemical Society.

Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate

S. Crooke, W. Lima, A. Siwkowski, 2007, Molecular Pharmacology.

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-α in Two Murine Models of Colitis

K. Myers, B. Baker, K. Madsen, 2003, Journal of Pharmacology and Experimental Therapeutics.

Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.

R. Griffey, D. Corey, B. Monia, 2010, Journal of medicinal chemistry.

Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes.

L. M. Alvarez-Salas, J. DiPaolo, A. Siwkowski, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2'-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN.

R. Geary, J. Matson, A. Siwkowski, 2009, Biochemical pharmacology.

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

A. Siwkowski, T. P. Prakash, H. Gaus, 2008, Nucleic acids symposium series.

Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis.

K. Myers, B. Baker, K. Madsen, 2003, The Journal of pharmacology and experimental therapeutics.

Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma.

Shuling Guo, Seng H. Cheng, Canwen Jiang, 2010, International immunology.

Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals.

D. Witchell, A. Siwkowski, T. P. Prakash, 2009, Journal of medicinal chemistry.

Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids.

R. Griffey, M. Manoharan, C. Bennett, 2006, Journal of medicinal chemistry.

Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid.

R. Griffey, M. Manoharan, B. Monia, 2005, Journal of Medicinal Chemistry.

Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing.

B. Monia, C. Bennett, M. Maier, 2004, Nucleic acids research.

Pharmacokinetic/Pharmacodynamic Properties ofPhosphorothioate 2'-O-(2-Methoxyethyl)-ModifiedAntisense Oligonucleotides in Animals and Man

A. Levin, R. Yu, R. Geary, 2007 .

Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells.

L. Chappell, B. Baker, A. Siwkowski, 1999, Nucleic acids research.

Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo.

E. Lesnik, M. Manoharan, B. Monia, 2003, Antisense & nucleic acid drug development.

Mutational analysis of loops 1 and 5 of the hairpin ribozyme.

R. Shippy, A. Siwkowski, A. Hampel, 1998, Biochemistry.

Analysis of hairpin ribozyme base mutations in loops 2 and 4 and their effects on cis-cleavage in vitro.

R. Shippy, A. Siwkowski, A. Hampel, 1997, Biochemistry.

The sCYMV1 hairpin ribozyme: targeting rules and cleavage of heterologous RNA

M. Young, A. Siwkowski, J. Rappaport, 1999, Gene Therapy.

Discovery and analysis of antisense oligonucleotide activity in cell culture.

B. Monia, E. Koller, B. Baker, 2001, Methods.

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

B. Monia, A. Siwkowski, G. Hung, 2006, Nucleic acids research.

Antisense oligonucleotides: efficient synthesis of 2'-O-methoxyethyl phosphorothioate oligonucleotides using 4,5-dicyanoimidazole. Are these oligonucleotides comparable to those synthesized using 1H-tetrazole as coupling activator?

W. Lima, A. Siwkowski, V. Ravikumar, 2006, Bioorganic & medicinal chemistry.

Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression.

J. Pober, B. Monia, L. Madge, 2004, Molecular pharmacology.

Alteration of hairpin ribozyme specificity utilizing PCR.

A. Siwkowski, M. Altschuler, S. Galasinski, 1994, PCR methods and applications.

Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides.

A. Siwkowski, T. P. Prakash, H. Gaus, 2010, Journal of medicinal chemistry.

Design of the hairpin ribozyme for targeting specific RNA sequences.

M. Deyoung, A. Siwkowski, S. Galasinski, 1997, Methods in molecular biology.

Design, targeting, and initial screening of sTRSV-derived hairpin ribozymes for optimum helix 1 length and catalytic efficiency in vitro.

R. Shippy, K. Khalili, P. Klotman, 2004, Methods in molecular biology.

Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression

J. Pober, B. Monia, L. Madge, 2004 .

Screening for important base identities in the hairpin ribozyme by in vitro selection for cleavage.

A. Siwkowski, M. Humphrey, A. Hampel, 1998, BioTechniques.

Antisense Oligonucleotide Blockade of Tumor Necrosis Factor-(cid:1) in Two Murine Models of Colitis

K. Myers, B. Baker, K. Madsen, 2002 .