Jinghua Yu

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Shuling Guo, B. Monia, S. Booten, 2014, Nucleic acids research.

27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith–Lemli–Opitz syndrome: a novel metabolic pathway

F. Porter, C. Wassif, Jinghua Yu, 2003, Steroids.

The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate*

Y. Li, S. Wright, J. Schaeffer, 2002, The Journal of Biological Chemistry.

Phenylguanidines as selective nonpeptide melanocortin-5 receptor antagonists.

Beth A. Fleck, A. Foster, Chen Chen, 2004, Journal of medicinal chemistry.

Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump*

S. Wright, P. Meinke, F. Peláez, 2003, The Journal of Biological Chemistry.

Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.

John Calvin Reed, M. Dawson, J. Fontana, 2012, Journal of medicinal chemistry.

Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity

John Calvin Reed, M. Andreeff, D. Hansel, 2018, Oncotarget.

The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia.

G. Beaton, Jinghua Yu, S. Malany, 2010, Bioorganic & medicinal chemistry letters.

Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia.

G. Beaton, Jinghua Yu, S. Malany, 2010, Bioorganic & medicinal chemistry letters.

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

M. Bradbury, F. Jovic, G. Beaton, 2009, Journal of medicinal chemistry.

Normal Development of Mice Lacking Metablastin (P19), a Phosphoprotein Implicated in Cell Cycle Regulation*

U. Schubart, W. Edelmann, Jinghua Yu, 1996, The Journal of Biological Chemistry.

Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity*

S. Wright, P. Meinke, Jinghua Yu, 2002, The Journal of Biological Chemistry.

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Richard G. Lee, Sue Murray, T. P. Prakash, 2019, Nucleic acids research.

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

F. Rigo, C. Bennett, Tae-Won Kim, 2019, Nucleic acids research.

The Farnesoid X Receptor Controls Gene Expression in a Ligand- and Promoter-selective Fashion*

N. de Pedro, S. Wright, F. Peláez, 2004, Journal of Biological Chemistry.

Identification of a PCSK9-LDLR disruptor peptide with in vivo function.

V. Subramanian, G. Spraggon, A. Koch, 2021, Cell chemical biology.

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

T. P. Prakash, Jinghua Yu, Audrey Low, 2016, Bioorganic & medicinal chemistry letters.

Solution structure of a consensus stem-loop D RNA domain that plays important roles in regulating translation and replication in enteroviruses and rhinoviruses.

R. Andino, Z. Du, T. James, 2004, Biochemistry.

Synthesis and Antisense Properties of 2′‐O‐(2S‐Methoxypropyl)‐RNA‐Modified Gapmer Antisense Oligonucleotides

S. Pandey, T. P. Prakash, Jinghua Yu, 2014, ChemMedChem.

A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.

T. P. Prakash, Jinghua Yu, E. Swayze, 2016, Bioorganic & medicinal chemistry letters.

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

S. Booten, S. Murray, M. Graham, 2016, Journal of medicinal chemistry.

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

T. P. Prakash, Jinghua Yu, Audrey Low, 2015, Bioorganic & medicinal chemistry letters.

NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA.

R. Andino, Z. Du, T. James, 2004, Biochemistry.

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.

John Calvin Reed, M. Dawson, J. Fontana, 2011, Journal of medicinal chemistry.

Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.

F. Rigo, T. P. Prakash, Jinghua Yu, 2018, Bioorganic & medicinal chemistry letters.

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

T. P. Prakash, Jinghua Yu, Audrey Low, 2015, Bioconjugate chemistry.

Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

M. Egli, Jinghua Yu, E. Swayze, 2012, Biochemistry.

Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.

M. Egli, A. Watt, T. P. Prakash, 2011, Journal of the American Chemical Society.

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

J. Backer, J. McIlroy, Jinghua Yu, 1998, Molecular and Cellular Biology.

Synthesis and biophysical characterization of R-6'-Me-α-L-LNA modified oligonucleotides.

Jinghua Yu, E. Swayze, P. Seth, 2011, Bioorganic & medicinal chemistry letters.

Studies on an intermediate phase Al5P5O20(OH)2·C6H18N2·3H2O and its transformation to AlPO-HDA

Jinghua Yu, Da Xu, Caijin Li, 2004 .

Validation of the DNA Methylation Landscape of TFF1/TFF2 in Gastric Cancer

Haiyang Xie, Shusen Zheng, Jinghua Yu, 2022, Cancers.

Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: potential therapeutics for type II diabetes.

Soumitra S Ghosh, C. Anderson, N. Ede, 2003, The Journal of organic chemistry.

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

S. Crooke, T. P. Prakash, Jinghua Yu, 2021, Nucleic acids research.

Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.

M. Bradbury, G. Beaton, Jinghua Yu, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA.

P. Herdewijn, M. Egli, A. Jazayeri, 2012, The Journal of organic chemistry.

Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs.

S. Hanessian, Tianyuan Zhou, Jinghua Yu, 2016, Bioorganic & medicinal chemistry.

Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.

S. Crooke, T. P. Prakash, Jinghua Yu, 2021, ACS medicinal chemistry letters.

Mapping the Active Site of CD59

R. Abagyan, V. Nussenzweig, Jinghua Yu, 1997, The Journal of experimental medicine.

Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells*

J. Segall, J. Condeelis, J. Backer, 2000, The Journal of Biological Chemistry.

NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.

Yu Cao, Hu Zhou, Weiwei Gao, 2010, Cancer cell.

N-terminal Domains of the Class IA Phosphoinositide 3-Kinase Regulatory Subunit Play a Role in Cytoskeletal but Not Mitogenic Signaling*

J. Segall, J. Backer, S. Yip, 2001, The Journal of Biological Chemistry.

Specific Recognition of the C-rich Strand of Human Telomeric DNA and the RNA Template of Human Telomerase by the First KH Domain of Human Poly(C)-binding Protein-2*

R. Andino, Yihong Chen, Z. Du, 2004, Journal of Biological Chemistry.

Human Kininogen Gene Is Transactivated by the Farnesoid X Receptor*

R. Blevins, Theresa Zhang, N. de Pedro, 2003, Journal of Biological Chemistry.

Novel benzothiophene H1-antihistamines for the treatment of insomnia.

Siobhan Malany, Bin-Feng Li, M. Bradbury, 2010, Bioorganic & medicinal chemistry letters.

Identification of the Individual Residues That Determine Human CD59 Species Selective Activity*

R. Abagyan, B. Morgan, Jinghua Yu, 1999, The Journal of Biological Chemistry.

Diabetes reversal by inhibition of the low molecular weight tyrosine phosphatase

R. Liddington, N. Bottini, T. Mustelin, 2017, Nature chemical biology.

Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.

A. Bobkov, M. Dawson, D. Wolf, 2013, MedChemComm.

Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.

Siobhan Malany, Michael Hedrick, Jenny Wen, 2009, Bioorganic & Medicinal Chemistry Letters.

Extending the family of UNCG-like tetraloop motifs: NMR structure of a CACG tetraloop from coxsackievirus B3.

R. Andino, Z. Du, T. James, 2003, Biochemistry.

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets.

S. Wright, Jinghua Yu, J. Cui, 2004, DNA and cell biology.

A 5' beta-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription.

J. Yu, J. Slightom, Jinghua Yu, 1994, Gene.

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.

J. Backer, C. Wjasow, J. Yu, 1998, The Journal of biological chemistry.

Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)

Yan Deng, Jinghua Yu, Q. Chang, 2023, Frontiers in Pharmacology.

1h, 13c, and 15N NMR backbone assignments and chemical-shift-derived secondary structure of glutamine-binding protein of Escherichia coli

N. Tjandra, J. Lukin, C. Ho, 1997, Journal of biomolecular NMR.

Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase

J. Backer, C. Wjasow, Jinghua Yu, 1998, The Journal of Biological Chemistry.

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H₁-antihistamines for insomnia.

Joe A. Tran, G. Beaton, Jinghua Yu, 2012, Bioorganic & medicinal chemistry letters.

Characterization of novel selective H1-antihistamines for clinical evaluation in the treatment of insomnia.

M. Bradbury, F. Jovic, G. Beaton, 2009, Journal of medicinal chemistry.