D. Hutchinson

发表

The FASEB Journal • Research Communication Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

C. Wahlestedt, J. Timmons, O. Larsson, 2022 .

Adrenoceptors in white, brown, and brite adipocytes

B. A. Evans, T. Bengtsson, D. Hutchinson, 2019, British journal of pharmacology.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

W. Shi, M. Busslinger, W. Alexander, 2016, Immunity.

The capacity of G protein-coupled receptors to modulate mammalian target of rapamycin (mTOR) activity is a newly emerging paradigm with the potential to link cell surface receptors with cell survival. Cardiomyocyte viability is linked to signaling pathways

Joanne Baltos, P. White, L. May, 2017 .

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for α- and β-adrenergic receptors

R. Summers, D. Hutchinson, M. Gibbs, 2010, Neuroscience.

Anti-Proteus activity of some South African medicinal plants : their potential for the prevention of rheumatoid arthritis

M. Fendt, S. Hintermann, D. Hoyer, 2013 .

The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism.

B. A. Evans, T. Bengtsson, R. Summers, 2010, Cellular signalling.

Mouse β3a‐ and β3b‐adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

B. A. Evans, T. Bengtsson, R. Summers, 2002 .

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

B. A. Evans, R. Summers, D. Hutchinson, 2017, British journal of pharmacology.

β2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle—ligand-directed signalling or a reflection of system complexity?

B. A. Evans, R. Summers, D. Hutchinson, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Peripheral modulation of the endocannabinoid system in metabolic disease.

A. McAinch, J. Headrick, D. Hryciw, 2018, Drug discovery today.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, R. Summers, 2017, Scientific Reports.

Agonist effects of zinterol at the mouse and human β3-adrenoceptor

T. Bengtsson, R. Summers, D. Hutchinson, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

B. A. Evans, T. Bengtsson, D. Hutchinson, 2019, British journal of pharmacology.

Mirabegron: potential off target effects and uses beyond the bladder

T. Bengtsson, D. Hutchinson, Nodi Dehvari, 2018, British journal of pharmacology.

GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors.

C. Wainwright, C. Lipina, R. Summers, 2021, Biochemical pharmacology.

Rosiglitazone and a β3-Adrenoceptor Agonist Are Both Required for Functional Browning of White Adipocytes in Culture

M. Pakzad, C. Nowell, B. A. Evans, 2018, Front. Endocrinol..

Themed section: molecular pharmacology of GPCRs

B. A. Evans, R. Summers, D. Hutchinson, 2012, British journal of pharmacology.

Ligand‐directed signalling at β‐adrenoceptors

B. A. Evans, R. Summers, D. Hutchinson, 2010, British journal of pharmacology.

The metabolic effects of mirabegron are mediated primarily by β3‐adrenoceptors

B. A. Evans, T. Bengtsson, R. Summers, 2020, Pharmacology research & perspectives.

Obesity , Diabetes and Energy Homeostasis BRL 37344 stimulates GLUT 4 translocation and glucose uptake in skeletal muscle via 2-adrenoceptors without causing classical receptor desensitization

B. A. Evans, T. Bengtsson, R. Summers, 2019 .

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization.

B. A. Evans, T. Bengtsson, R. Summers, 2019, American journal of physiology. Regulatory, integrative and comparative physiology.

The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake.

M. Pakzad, C. Nowell, B. A. Evans, 2018, Cellular signalling.

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin‐independent signaling pathway involving mechanistic target of rapamycin complex 2

B. A. Evans, T. Bengtsson, D. Hutchinson, 2017, Pharmacological research.

JCB_201403080 1..10

J. Chambard, T. Bengtsson, D. Hutchinson, 2014 .

β₁-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β₃-adrenergic receptor-knockout mice via nonshivering thermogenesis.

H. Hogberg, T. Bengtsson, D. Hutchinson, 2011, American Journal of Physiology. Endocrinology and Metabolism.

β-Adrenoceptors, but not α-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1

T. Bengtsson, D. Hutchinson, B. Cannon, 2005, Diabetologia.

α1- and β1-Adrenoceptor Signaling Fully Compensates for β3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake

T. Bengtsson, D. Hutchinson, J. Nedergaard, 2005 .

alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway.

T. Bengtsson, D. Hutchinson, 2005, Endocrinology.

THE JANUS* FACES OF ADRENOCEPTORS: FACTORS CONTROLLING THE COUPLING OF ADRENOCEPTORS TO MULTIPLE SIGNAL TRANSDUCTION PATHWAYS

B. A. Evans, R. Summers, D. Hutchinson, 2004, Clinical and experimental pharmacology & physiology.

Annual Scientific Meeting of ASCEPT 2003 THE JANUS* FACES OF ADRENOCEPTORS: FACTORS CONTROLLING THE COUPLING OF ADRENOCEPTORS TO MULTIPLE SIGNAL TRANSDUCTION PATHWAYS

B. A. Evans, R. Summers, D. Hutchinson, 2004 .

Acute β-adrenoceptor mediated glucose clearance in brown adipose tissue; a distinct pathway independent of functional insulin signaling

T. Bengtsson, D. Hutchinson, Alice Åslund, 2019, Molecular metabolism.

β1‐Adrenoceptors compensate for β3‐adrenoceptors in ileum from β3‐adrenoceptor knock‐out mice

B. A. Evans, R. Summers, D. Hutchinson, 2001, British journal of pharmacology.

b 1-Adrenoceptors compensate for b 3-adrenoceptors in ileum from b 3-adrenoceptor knock-out mice 1

B. A. Evans, R. Summers, D. Hutchinson, 2001 .

β2-Adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP

T. Bengtsson, D. Hutchinson, D. L. Yamamoto, 2006, Diabetologia.

Beta-adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1.

T. Bengtsson, D. Hutchinson, B. Cannon, 2005, Diabetologia.

The β3-Adrenoceptor Agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and Antagonist (S)-N-[4-[2-[[3-[3-(Acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) Activate Diff

B. A. Evans, R. Summers, D. Hutchinson, 2008, Molecular Pharmacology.

Effect of β1/β2‐adrenoceptor blockade on β3‐adrenoceptor activity in the rat cremaster muscle artery

F. Britton, T. Murphy, S. Sandow, 2021, British journal of pharmacology.

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors.

B. A. Evans, R. Summers, D. Hutchinson, 2004, European journal of pharmacology.

Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

J. Chambard, T. Bengtsson, D. Hutchinson, 2014, The Journal of cell biology.

Quantification of Functional Selectivity at the Human α1A-Adrenoceptor

A. Christopoulos, B. A. Evans, R. Summers, 2011, Molecular Pharmacology.

Quantification of Functional Selectivity at the Human (cid:1) 1A -Adrenoceptor □ S

A. Christopoulos, R. Summers, D. Hutchinson, 2011 .

DNAM-1 expression marks an alternative program of NK cell maturation.

F. Souza-Fonseca-Guimaraes, Camille Guillerey, N. Huntington, 2015, Cell reports.

Ligand-Directed Signaling at the β3-Adrenoceptor Produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) Relative to Receptor Agonists

B. A. Evans, R. Summers, D. Hutchinson, 2007, Molecular Pharmacology.

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

B. A. Evans, R. Summers, D. Hutchinson, 2016, Naunyn-Schmiedeberg's Archives of Pharmacology.

Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse β3-Adrenoceptor*

B. A. Evans, T. Bengtsson, R. Summers, 2012, The Journal of Biological Chemistry.

CB1 Ligand AM251 Induces Weight Loss and Fat Reduction in Addition to Increased Systemic Inflammation in Diet-Induced Obesity

A. McAinch, D. Hryciw, K. Jenkin, 2022, International journal of molecular sciences.

Role of β‐adrenoceptors in glucose uptake in astrocytes using β‐adrenoceptor knockout mice

R. Summers, D. Hutchinson, Masaaki Sato, 2011, British journal of pharmacology.

Evidence for Pleiotropic Signaling at the Mouse β3-Adrenoceptor Revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol Oxalate]

A. Christopoulos, B. A. Evans, R. Summers, 2005, Journal of Pharmacology and Experimental Therapeutics.

Evidence for pleiotropic signalling at the mouse β 3-adrenoceptor revealed by SR 59230 A

A. Christopoulos, B. A. Evans, R. Summers, 2004 .

β2‐Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C‐terminal tail

J. Nevzorova, B. A. Evans, T. Bengtsson, 2012, British journal of pharmacology.

β2‐ and β3‐Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement?

R. Summers, D. Hutchinson, M. Gibbs, 2007 .

β3‐Adrenoceptor regulation and relaxation responses in mouse ileum

B. A. Evans, R. Summers, D. Hutchinson, 2000, British journal of pharmacology.

Microsoft Word-95101209-file00

Christopoulos, B. A. Evans, R. Summers, 2010 .

Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep.

D. Walker, F. Wong, D. Hutchinson, 2018, Journal of applied physiology.

Shikonin Increases Glucose Uptake in Skeletal Muscle Cells and Improves Plasma Glucose Levels in Diabetic Goto-Kakizaki Rats

C. Östenson, M. Wilcke, T. Bengtsson, 2011, PloS one.

Beta2- and beta3-adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement?

R. Summers, D. Hutchinson, M. Gibbs, 2007, Journal of neurochemistry.

Rapid Turnover of Glycogen in Memory Formation

D. Hutchinson, M. Gibbs, 2012, Neurochemical Research.

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: potential utility in treatment of diabetes and heart disease.

T. Bengtsson, R. Summers, D. Hutchinson, 2008, Pharmacology & therapeutics.

CIS is a potent checkpoint in NK cell–mediated tumor immunity

Laura F. Dagley, S. Li, W. Shi, 2016, Nature Immunology.

Astrocytic involvement in learning and memory consolidation

Leif Hertz, L. Hertz, D. Hutchinson, 2008, Neuroscience & Biobehavioral Reviews.

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Laura F. Dagley, Melissa J. Davis, Joseph Cursons, 2019, Science Signaling.

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Suzanne L. Miller, R. Summers, D. Hutchinson, 2009, International Journal of Developmental Neuroscience.

Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase.

M. Wilcke, T. Bengtsson, D. Hutchinson, 2007, Cellular signalling.

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

R. Summers, D. Hutchinson, M. Gibbs, 2008, Brain Research Bulletin.

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.

B. A. Evans, T. Bengtsson, D. Hutchinson, 2016, Molecular nutrition & food research.

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

P. Sexton, P. Wookey, D. Hutchinson, 2019, BMC Cancer.

Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle

T. Bengtsson, R. Summers, D. Hutchinson, 2014, Diabetes.

Pharmacophore‐guided Virtual Screening to Identify New β3‐adrenergic Receptor Agonists

O. Nureki, D. Schuster, D. Hutchinson, 2021, Molecular informatics.

G protein coupled receptor 18: A potential role for endocannabinoid signaling in metabolic dysfunction.

A. McAinch, D. Hryciw, A. Simcocks, 2016, Molecular nutrition & food research.

&agr;1A‐Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Joanne Baltos, P. White, L. May, 2018, Biochemical pharmacology.

Role of β-Adrenoceptors in Memory Consolidation: β3-Adrenoceptors Act on Glucose Uptake and β2-Adrenoceptors on Glycogenolysis

R. Summers, D. Hutchinson, M. Gibbs, 2008, Neuropsychopharmacology.

Role of beta-adrenoceptors in memory consolidation: beta3-adrenoceptors act on glucose uptake and beta2-adrenoceptors on glycogenolysis.

R. Summers, D. Hutchinson, M. Gibbs, 2008, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Memory Processing in the Avian Hippocampus Involves Interactions between β-Adrenoceptors, Glutamate Receptors, and Metabolism

D. Bowser, R. Summers, D. Hutchinson, 2008, Neuropsychopharmacology.

AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: mediation by alpha1-adrenoceptors causing glucose uptake.

T. Bengtsson, D. Hutchinson, 2006, Diabetes.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Jingbo Xiao, J. Marugan, ossain, 2017, Scientific Reports.

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

B. A. Evans, R. Summers, D. Hutchinson, 2018, Journal of molecular endocrinology.

Factors influencing biased agonism in recombinant cells expressing the human α1A‐adrenoceptor

B. A. Evans, R. Summers, D. Hutchinson, 2017, British journal of pharmacology.

Agonist effects of zinterol at the mouse and human beta(3)-adrenoceptor.

T. Bengtsson, R. Summers, D. Hutchinson, 2006, Naunyn-Schmiedeberg's Archives of Pharmacology.

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake.

T. Bengtsson, D. Hutchinson, J. Nedergaard, 2005, Endocrinology.

Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways.

B. A. Evans, T. Bengtsson, R. Summers, 2002, British Journal of Pharmacology.

Orthosteric Binding of ρ-Da1a, a Natural Peptide of Snake Venom Interacting Selectively with the α1A-Adrenoceptor

Elodie Marcon, D. Servent, B. Gilquin, 2013, PloS one.

Functional Domains of the Mouse β3-Adrenoceptor Associated with Differential G Protein Coupling

Ű. Langel, B. A. Evans, T. Bengtsson, 2005, Journal of Pharmacology and Experimental Therapeutics.

Functional domains of the mouse beta(3)-adrenoceptor associated with differential G-protein coupling.

B. A. Evans, R. Summers, D. Hutchinson, 2007, Biochemical Society transactions.

Rapid Turnover of Glycogen in Memory Formation

D. Hutchinson, M. Gibbs, 2012, Neurochemical Research.

α2‐Adrenoceptors activate noradrenaline‐mediated glycogen turnover in chick astrocytes

R. Summers, D. Hutchinson, Jon Merlin, 2011, Journal of neurochemistry.

β2-Adrenoceptor-mediated regulation of glucose uptake in skeletal muscle—ligand-directed signalling or a reflection of system complexity?

B. A. Evans, R. Summers, D. Hutchinson, 2013, Naunyn-Schmiedeberg's Archives of Pharmacology.

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

P. Sexton, P. Wookey, D. Hutchinson, 2019, BMC Cancer.

b3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

B. A. Evans, T. Bengtsson, R. Summers, 2002 .

Treatment of Diet-Induced Obese Rats with CB2 Agonist AM1241 or CB2 Antagonist AM630 Reduces Leptin and Alters Thermogenic mRNA in Adipose Tissue

A. McAinch, D. Hryciw, K. Jenkin, 2023, International journal of molecular sciences.

Therapeutic blockade of Activin-A improves NK cell function and anti-tumor immunity

Laura F. Dagley, Melissa J. Davis, Joseph Cursons, 2018, bioRxiv.

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

B. A. Evans, T. Bengtsson, D. Hutchinson, 2019, British journal of pharmacology.

Response to Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle. Diabetes 2014;63:4115–4129

T. Bengtsson, R. Summers, D. Hutchinson, 2014, Diabetes.

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.

M. Busslinger, W. Alexander, S. Carotta, 2016, Immunity.

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

Evans, B. A. Evans, R. Summers, 2018, Journal of molecular endocrinology.

Interaction with Caveolin-1 Modulates G Protein Coupling of Mouse β3-Adrenoceptor*

B. A. Evans, T. Bengtsson, R. Summers, 2012, The Journal of Biological Chemistry.

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Suzanne L. Miller, R. Summers, D. Hutchinson, 2009, International Journal of Developmental Neuroscience.

The metabolic effects of mirabegron are mediated primarily by β 3 -adrenoceptors

B. A. Evans, T. Bengtsson, D. Hutchinson, 2020 .

Mirabegron

T. Bengtsson, D. Hutchinson, Nodi Dehvari, 2017, Reactions Weekly.

Ligand‐directed signalling at β‐adrenoceptors

B. A. Evans, D. Hutchinson, Masaaki Sato, 2010 .

Targeting G protein‐coupled receptors for heart failure treatment

A. T. Nguyen, L. May, R. Ritchie, 2023, British journal of pharmacology.