J. Takeda

发表

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

T. Hansen, O. Pedersen, G. Lathrop, 1996, Nature.

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

M. Stoffel, P. Froguel, H. Zouali, 1992, Nature.

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.

K. Clément, M. Stoffel, P. Froguel, 1994, The Journal of clinical investigation.

Mutations of the human glucokinase gene and diabetes mellitus

M. Stoffel, P. Froguel, G. Bell, 1993, Trends in Endocrinology & Metabolism.

A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones.

G. Bell, J. Takeda, H. Yano, 1993, Human molecular genetics.

Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3

T. Hori, H. Kasuya, Y. Seino, 2001, Cytogenetic and Genome Research.

Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells.

M. Seno, H. Yamada, H. Mashima, 1999, Diabetes.

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

M. Stoffel, P. Froguel, I. Weber, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Increased Expression of Endothelin B Receptor mRNA following Subarachnoid Hemorrhage in Monkeys

R. Macdonald, G. Bell, R. Macdonald, 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Screening of diabetes of youth for hepatocyte nuclear factor 1 mutations: clinical phenotype of HNF1β‐related maturity‐onset diabetes of the young and HNF1α‐related maturity‐onset diabetes of the young in Japanese

J. Takeda, Y. Horikawa, J. Takeda, 2014, Diabetic medicine : a journal of the British Diabetic Association.

Identification of a gain-of-function mutation in the HNF-1β gene in a Japanese family with MODY

Y. Matsuzawa, Q. Zhu, K. Yamagata, 2002, Diabetologia.

Identification of Glucokinase Mutations in Subjects With Gestational Diabetes Mellitus

C. L. Blackburn, M. Stoffel, C. Ober, 1993, Diabetes.

The polymorphism linked to the human insulin gene: its lack of association with either IDDM or NIDDM in Japanese.

Y. Seino, J. Takeda, T. Morita, 1986, Acta endocrinologica.

Negative regulation of human insulin gene expression by the 5′‐flanking region in non‐pancreatic cells

S. Ishii, F. Imamoto, J. Takeda, 1989, FEBS letters.

Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.

R. Espinosa, D. Steiner, S. Chan, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Genes Differentially Expressed in Canine Vasospastic Cerebral Arteries after Subarachnoid Hemorrhage

K. Takakura, T. Hori, I. Inoue, 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion

K. Polonsky, S. Seino, G. Bell, 1993, Diabetes.

Short term effects of glucose and arginine on the preproinsulin messenger ribonucleic acid level in the perfused rat pancreas: comparison with insulin secretion.

H. Imura, K. Tsuda, Y. Seino, 1989, Endocrinology.

Effects of oral glucose administration on preproinsulin mRNA in rats in vivo.

H. Imura, K. Tsuda, Y. Seino, 1986, Biochemical and biophysical research communications.

Gastric Inhibitory Polypeptide: Structure and ChromosomalLocalization of the Human Gene

R. Eddy, T. Shows, Yuichiro Yamada, 2008 .

Na-Pi cotransporter expressed during the differentiation of pancreatic AR42J cells.

H. Mashima, J. Takeda, I. Kojima, 2001, Diabetes.

Reduced levels of messenger ribonucleic acid for calcium channel, glucose transporter-2, and glucokinase are associated with alterations in insulin secretion in fasted rats.

K. Polonsky, S. Seino, J. Takeda, 1994, Endocrinology.

Sucrase-Isomaltase Gene Expression Is Inhibited by Mutant Hepatocyte Nuclear Factor (HNF)-1α and Mutant HNF-1β in Caco-2 Cells

G. Tsujimoto, K. Tsuda, J. Takeda, 2006 .

Inhibitory Effect of the Small Heterodimer Partner on Hepatocyte Nuclear Factor-4 Mediates Bile Acid-induced Repression of the Human Angiotensinogen Gene*

A. Fukamizu, M. Nangaku, H. Fujii, 2004, Journal of Biological Chemistry.

Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor.

Y. Matsuzawa, N. Iwasaki, K. Yamagata, 1999, Biochemical and biophysical research communications.

Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with maturity-onset diabetes of the young

Y. Matsuzawa, Q. Zhu, K. Yamagata, 2000, Diabetologia.

Comparative effect of somatostatin-14 and somatostatin-28 on glucagon-induced glycogenolysis from the perfused rat liver.

H. Imura, K. Tsuda, Y. Seino, 1988, Metabolism: clinical and experimental.

Regulation of Glucose-Transporter Gene Expression by Insulin in Cultured Human Fibroblasts

A. Kosaki, M. Okamoto, Y. Yoshimasa, 1988, Diabetes.

Mutations in the hepatocyte nuclear factor-1α gene (MODY3) are not a major cause of early-onset non-insulin-dependent (type 2) diabetes mellitus in Japanese

T. Utsugi, S. Yamada, H. Nishigori, 1998, Journal of Human Genetics.

Effect of the α2-blocker DG-5128 on insulin and somatostatin release from the isolated perfused rat pancreas

H. Imura, K. Tsuda, Y. Seino, 1987 .

Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption.

B. Kirschner, G. Bell, R. Taub, 1996, The Journal of clinical investigation.

Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain.

S. Vannucci, I. Simpson, J. Takeda, 1992, Biochemical and biophysical research communications.

Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues.

S. Seino, G. Bell, O. Blondel, 1993, The Journal of biological chemistry.

Restriction fragment length polymorphism (RFLP) of the human insulin receptor gene in Japanese: its possible usefulness as a genetic marker

S. Seino, H. Imura, Y. Yoshimasa, 1986, Diabetologia.

Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.

P. Froguel, M. Vaxillaire, G. Velho, 1993, The Journal of biological chemistry.

T130I mutation in HNF-4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects

Y. Matsuzawa, Q. Zhu, Y. Horikawa, 2003, Diabetologia.

Identification of missense mutations in the hepatocyte nuclear factor-3β gene in Japanese subjects with late-onset Type II diabetes mellitus

Y. Matsuzawa, Q. Zhu, K. Yamagata, 2000, Diabetologia.

5 – Prohormone of Human Motilin

H. Imura, Y. Seino, J. Takeda, 1990 .

Effect of mutations in HNF-1α and HNF-1β on the transcriptional regulation of human sucrase–isomaltase in Caco-2 cells

G. Tsujimoto, K. Tsuda, J. Takeda, 2004 .

Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins

C. Nelson, D. Loh, R. Sen, 1990, Molecular and cellular biology.

Multiple tachykinins are produced and secreted upon post-translational processing of the three substance P precursor proteins, alpha-, beta-, and gamma-preprotachykinin. Expression of the preprotachykinins in AtT-20 cells infected with vaccinia virus recombinants.

C. Rice, J. Krause, M. MacDonald, 1989, The Journal of biological chemistry.

Sequence of an intestinal cDNA encoding human motilin precursor

K. Tanaka, H. Imura, Y. Seino, 1987, FEBS letters.

Nestin-positive Cells in Adult Pancreas Express Amylase and Endocrine Precursor Cells

S. Toyokuni, Yuichiro Yamada, Y. Seino, 2005, Pancreas.

Human pancreatic Beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13

T. Shows, M. Stoffel, G. Bell, 1992, Diabetologia.

Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.

G. Bell, O. Blondel, J. Takeda, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Identification of a novel gene, OASIS, which encodes for a putative CREB/ATF family transcription factor in the long-term cultured astrocytes and gliotic tissue.

T. Tsukamoto, H. Kiyosawa, M. Tojo, 1999, Brain research. Molecular brain research.

Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat.

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

Rapid Publication Organization of the Human GLUT2 (Pancreatic p-Cell and Hepatocyte) Glucose Transporter Gene

G. Bell, J. Takeda, T. Kayano, 1993 .

Erratum: Human glucokinase gene: Isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin- dependent (type 2) diabetes mellitus (Proc. Natl. Acad. Sci. USA (August 15, 1992) 89 (7698-7702))

M. Stoffel, P. Froguel, I. Weber, 1992 .

Degradation and conversion of somatostatin in normal and diabetic rats in vivo and in vitro.

H. Imura, K. Tsuda, Y. Seino, 1988, Canadian journal of physiology and pharmacology.

Increase in liver glucose transporter mRNA levels during rat liver regeneration.

S. Seino, Y. Fukuda, H. Imura, 1990, Biochemical and biophysical research communications.

Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

M. Stoffel, J. Sturis, K. Polonsky, 1995, Diabetes.

Alternative splicing of human inwardly rectifying K+ channel ROMK1 mRNA.

M. L. Le Beau, L. Philipson, G. Bell, 1994, Molecular pharmacology.

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.

J. Beckmann, M. Permutt, M. Stoffel, 1993, The New England journal of medicine.

Advances in Brief Cloning of Human Telomerase Catalytic Subunit ( hTERT ) Gene Promoter and Identification of Proximal Core Promoter Sequences Essential for Transcriptional Activation in Immortalized and Cancer Cells

M. Yutsudo, S. Kyo, M. Takakura, 1999 .

Expression of OASIS, a CREB/ATF family transcription factor, in CNS lesion and its transcriptional activity.

A. Wanaka, J. Takeda, Tetsuji Mori, 2002, Brain research. Molecular brain research.

Exon‐intron organization, expression, and chromosomal localization of the human motilin gene

R. Eddy, T. Shows, G. Bell, 1989, FEBS letters.

Effect of vitamin D on gastrin and gastric somatostatin secretion from the isolated perfused rat stomach.

K. Tsuda, Y. Seino, J. Takeda, 1988, Life sciences.

Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.

M. L. Le Beau, G. Bell, K. Yamagata, 1995, Genomics.

Identification of a new case of hepatocyte nuclear factor-1β mutation with highly varied phenotypes

M. Ono, Y. Horikawa, J. Takeda, 2004, Diabetologia.

Expression of the CRE-BP1 transcriptional regulator binding to the cyclic AMP response element in central nervous system, regenerating liver, and human tumors.

C. Tanaka, S. Ishii, H. Imura, 1991, Oncogene.

Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.

J. Takeda, K. Yasuda, H. Yano, 1993, Molecular pharmacology.

Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.

M. Yutsudo, S. Kyo, M. Takakura, 1999, Cancer research.

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

G. Bell, T. Reisine, J. Takeda, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.

S. Seino, G. Bell, J. Takeda, 1992, Nucleic acids research.

Sequence Analysis and Expressional Regulation of Messenger RNAs Encoding β Subunits of Follicle-Stimulating Hormone and Luteinizing Hormone in the Red-Bellied Newt, Cynops pyrrhogaster1

J. Takeda, H. Tomura, Shigeyasu Tanaka, 2002 .

Regional distribution of neuropeptide γ and other tachykinin peptides derived from the substance P gene in the rat

J. Krause, J. Takeda, Y. Takeda, 1990, Regulatory Peptides.

Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.

Y. Matsuzawa, M. Kanamori, D. Moore, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F).

M. L. Le Beau, A. Fernald, S. Yamada, 1998, Genomics.

Mutation analysis of NR0B2 among 1545 Danish men identifies a novel c.278G>A (p.G93D) variant with reduced functional activity

O. Pedersen, J. Takeda, H. Tomura, 2004, Human mutation.

Genomewide-linkage and haplotype-association studies map intracranial aneurysm to chromosome 7q11.

K. Takakura, T. Nakajima, T. Hori, 2001, American journal of human genetics.

Gene expression profile in rat pancreatic islet and RINm5F cells.

M. Muramatsu, L. Jin, Y. Horikawa, 2005, Journal of molecular endocrinology.

Gene expression profile in rat pancreatic islet and RINm 5 F cells

M. Muramatsu, L. Jin, Y. Horikawa, 2005 .

Structure and function of mammalian facilitative sugar transporters.

G I Bell, C. Burant, G. Bell, 1993, The Journal of biological chemistry.

Fructose transporter in human spermatozoa and small intestine is GLUT5.

C. Burant, G. Bell, N. Davidson, 1992, The Journal of biological chemistry.

Genetic variation in the hepatocyte nuclear factor (HNF)-3alpha gene does not contribute to maturity-onset diabetes of the young in Japanese.

Y. Seino, H. Nishigori, J. Takeda, 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Gastric inhibitory polypeptide: structure and chromosomal localization of the human gene.

R. Eddy, T. Shows, G. Bell, 1989, Molecular endocrinology.

Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle

R. Spielman, P. Concannon, G. Bell, 1996, Diabetologia.

Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.

Suzuki, K. Tanaka, Y. Seino, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.

Toshihiro Tanaka, T. Nakajima, S. Hunt, 2003, American journal of human genetics.

Linkage Analysis of Acute Insulin Secretion With GLUT2 and Glucokinase in Pima Indians and the Identification of a Missense Mutation in GLUT2

C. Bogardus, W. Knowler, D. B. Thompson, 1994, Diabetes.

Organization of the Human GLUT2 (Pancreatic β-Cell and Hepatocyte) Glucose Transporter Gene

G. Bell, J. Takeda, T. Kayano, 1993, Diabetes.

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.

A. Hattersley, M. Stoffel, P. Froguel, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.

T. Reisine, J. Takeda, H. Yano, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mutations in the Glucokinase Gene are not a Major Cause of Late‐onset Type 2 (Non‐insulin‐dependent) Diabetes Mellitus in Japanese subjects

G. Bell, J. Takeda, S. Nishi, 1994, Diabetic medicine : a journal of the British Diabetic Association.

Human fructose-1,6-bisphosphatase gene (FBP1): exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency.

M. Stoffel, M. L. Le Beau, G. Bell, 1995, Genomics.

Molecular cloning, structural characterization and functional expression of the human substance P receptor.

K. B. Chou, J. Krause, J. Takeda, 1991, Biochemical and biophysical research communications.

Mutant HNF-1α and mutant HNF-1β identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells

G. Tsujimoto, K. Tsuda, Tetsuro Matsunaga, 2006 .

Localization of huntingtin-interacting protein-2 (Hip-2) mRNA in the developing mouse brain

A. Wanaka, J. Takeda, Y. Honma, 1999, Journal of Chemical Neuroanatomy.

A novel dominant-negative mutation of the hepatocyte nuclear factor-1alpha gene in Japanese early-onset type 2 diabetes.

J. Takeda, M. Okubo, T. Murase, 2000, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Identification of mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins.

T. Takumi, T. Ogata, N. Iwatani, 1999, Diabetes.

High frequency of mutations in the HNF-1α gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance

Y. Horikawa, J. Takeda, H. Tomura, 2002, Diabetologia.

Use of 33P-labeled primer increases the sensitivity and specificity of mRNA differential display.

J. Takeda, Y. Tokuyama, 1995, BioTechniques.

Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients

T. Saibara, S. Seino, Y. Horikawa, 2008, Human mutation.

Analysis of Tachykinin Peptide Family Gene Expression Patterns by Combined High-Performance Liquid Chromatography–Radioimmunoassay

J. Krause, J. Takeda, Y. Takeda, 1991 .

Localization of the kappa opioid receptor gene to human chromosome band 8q11.2.

R. Espinosa, M. L. Le Beau, G. Bell, 1994, Genomics.

Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys.

R. Macdonald, G. Bell, R. Macdonald, 1996, Neurosurgery.

Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.

G. Bell, É. Brot-Laroche, J. Takeda, 1994, The Biochemical journal.

Expression profile of mRNAs from human pancreatic islet tumors.

O. Ohara, R. Kikuno, L. Jin, 2003, Journal of molecular endocrinology.

Effect of truncal vagotomy on GIP release induced by intraduodenal glucose or fat in dogs.

J. Utsunomiya, H. Imura, Y. Seino, 1985, Digestion.

Effect of the alpha 2-blocker DG-5128 on insulin and somatostatin release from the isolated perfused rat pancreas.

H. Imura, K. Tsuda, Y. Seino, 1987, Life Science.