T. Mikkaichi

发表

Farnesoid X receptor, hepatocyte nuclear factors 1α and 3β are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene

T. Rikiyama, T. Abe, M. Unno, 2006, Journal of Gastroenterology.

Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

T. Izumi, T. Mikkaichi, K. Abe, 2014, Pharmaceutical Research.

Liver-selective distribution in rats supports the importance of active uptake into the liver via organic anion transporting polypeptides (OATPs) in humans.

T. Izumi, T. Mikkaichi, D. Nakai, 2015, Drug metabolism and pharmacokinetics.

SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation.

E. Mishima, T. Abe, S. Ito, 2009, Journal of the American Society of Nephrology : JASN.

Design and evaluation of an extended-release matrix tablet formulation; the combination of hypromellose acetate succinate and hydroxypropylcellulose

T. Mikkaichi, H. Minami, Shuichi Yada, 2016, Asian journal of pharmaceutical sciences.

Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3 Published, JLR Papers in Press, March 13, 2006.

T. Abe, M. Unno, T. Hishinuma, 2006, Journal of Lipid Research.

Expression of organic anion transporting polypeptide E (OATP-E) in human placenta.

T. Suzuki, T. Abe, M. Unno, 2003, Placenta.

Simultaneous quantification of prostaglandins, isoprostane and thromboxane in cell-cultured medium using gas chromatography-mass spectrometry.

T. Hishinuma, H. Tsukamoto, M. Mizugaki, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Evaluation of the therapeutic index of a novel phosphodiesterase 4B-selective inhibitor over phosphodiesterase 4D in mice.

Satoshi Nakamura, T. Mikkaichi, H. Maeda, 2013, Journal of pharmacological sciences.

Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors.

Mizuki Takahashi, S. Sasaki, T. Mikkaichi, 2014, Bioorganic & medicinal chemistry letters.

Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.

Mizuki Takahashi, S. Sasaki, Tomoko Takahashi, 2013, Bioorganic & medicinal chemistry letters.

Transport of estrone 3-sulfate mediated by organic anion transporter OATP4C1: estrone 3-sulfate binds to the different recognition site for digoxin in OATP4C1.

T. Abe, T. Hishinuma, N. Mano, 2010, Drug Metabolism and Pharmacokinetics.

Distribution of rat organic anion transporting polypeptide-E (oatp-E) in the rat eye.

H. Tomita, Takashi Suzuki, H. Sasano, 2003, Investigative ophthalmology & visual science.

The organic anion transporter (OATP) family.

Tsuyoshi Mikkaichi, T. Abe, S. Ito, 2004, Drug metabolism and pharmacokinetics.

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.

T. Abe, S. Ito, M. Unno, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Identification and characterization of novel rat and human gonad-specific organic anion transporters.

T. Abe, S. Ito, M. Unno, 2003, Molecular endocrinology.

Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.

E. Kamiyama, T. Mikkaichi, D. Nakai, 2010, Life sciences.

Integrated Approach of In Vivo and In Vitro Evaluation of the Involvement of Hepatic Uptake Organic Anion Transporters in the Drug Disposition in Rats Using Rifampicin as an Inhibitor

T. Izumi, T. Mikkaichi, K. Abe, 2013, Drug Metabolism and Disposition.

DMD051052 1442..1449

T. Izumi, T. Mikkaichi, K. Abe, 2013 .

Edoxaban Transport via P-Glycoprotein Is a Key Factor for the Drug’s Disposition

H. Masumoto, T. Izumi, T. Mikkaichi, 2014, Drug Metabolism and Disposition.

Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K

T. Mikkaichi, N. Yamamura, Ken-ichi Itokawa, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Establishment of a clinically relevant specification for dissolution testing using physiologically based pharmacokinetic (PBPK) modeling approaches.

Takafumi Kato, Takuya Miyano, Hiroshi Nakagawa, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Identifying determinants of persistent MRSA bacteremia using mathematical modeling

Alexander Hoffmann, Michael R. Yeaman, Tsuyoshi Mikkaichi, 2019, PLoS Comput. Biol..

Quantitative analysis of an impact of P-glycoprotein on edoxaban's disposition using a human physiologically based pharmacokinetic (PBPK) model.

Takako Shimizu, T. Izumi, T. Mikkaichi, 2021, International journal of pharmaceutics.

T. Izumi, T. Mikkaichi, K. Abe, 2015, Pharmaceutical Research.

DMD054866 520..528

H. Masumoto, T. Mikkaichi, T. Imaoka, 2014 .

Expression of organic anion transporting polypeptide E (OATP-E) in human placenta.

T. Abe, J. Sugawara, T. Onogawa, 2003 .

Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.

Mizuki Takahashi, S. Sasaki, Tomoko Takahashi, 2013, Bioorganic & medicinal chemistry.