G. Rychkov

发表

Targeting Ca2+ Signaling in the Initiation, Promotion and Progression of Hepatocellular Carcinoma

G. Barritt, Eunus S. Ali, G. Rychkov, 2020, Cancers.

ClC‐1 CHLORIDE CHANNEL: MATCHING ITS PROPERTIES TO A ROLE IN SKELETAL MUSCLE

E. Aromataris, G. Rychkov, Edoardo C Aromataris, 2006, Clinical and experimental pharmacology & physiology.

Expression and function of TRP channels in liver cells.

G. Barritt, G. Rychkov, 2011, Advances in experimental medicine and biology.

TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity

A. Page, S. Brierley, L. Blackshaw, 2011, The Journal of physiology.

Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel

D. Peet, M. Dallas, Johana Chicher, 2015, Journal of Cell Science.

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

I. Vetter, R. Lewis, A. Keramidas, 2017, Scientific Reports.

Mitochondrial uncoupler FCCP activates proton conductance but does not block store-operated Ca(2+) current in liver cells.

G. Barritt, E. Aromataris, J. Castro, 2010, Archives of biochemistry and biophysics.

A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid.

G. Barritt, E. Aromataris, J. Castro, 2009, The Biochemical journal.

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

G. Melino, Sharad Kumar, A. Voss, 2011, Nature communications.

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress

G. Lukács, Haijin Xu, G. Rychkov, 2022, Cellular and molecular life sciences : CMLS.

Ubr1-induced selective endophagy/autophagy protects against the endosomal and Ca2+-induced proteostasis disease stress

G. Lukács, Haijin Xu, G. Rychkov, 2021, Cellular and Molecular Life Sciences.

Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

D. Craik, David John Adams, Q. Kaas, 2018, British journal of pharmacology.

STORE‐OPERATED Ca2+ CHANNELS AND MICRODOMAINS OF Ca2+ IN LIVER CELLS

G. Barritt, E. Aromataris, J. Castro, 2009, Clinical and experimental pharmacology & physiology.

Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential

D. Peet, Yagnesh Nagarajan, G. Rychkov, 2017, Pharmaceuticals.

TRPs as mechanosensitive channels

G. Barritt, G. Rychkov, 2005, Nature Cell Biology.

Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors

G. Barritt, G. Rychkov, R. Gregory, 2001 .

Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors.

G. Barritt, G. Rychkov, R. Gregory, 2001, The Biochemical journal.

Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells.

G. Barritt, H. Brereton, M. L. Harland, 2001, Biochimica et biophysica acta.

Glucagon activates Ca2+ and Cl− channels in rat hepatocytes

G. Barritt, E. Aromataris, G. Rychkov, 2006, The Journal of physiology.

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca(2+) signalling in steatotic hepatocytes.

G. Barritt, Eunus S. Ali, G. Rychkov, 2016, Biochimica et biophysica acta.

TRPC1 Ca(2+)-permeable channels in animal cells.

G. Barritt, G. Rychkov, 2007, Handbook of experimental pharmacology.

The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.

D. Corey, A. Page, G. Holtmann, 2009, Gastroenterology.

Concentration and pH dependence of skeletal muscle chloride channel ClC‐1.

T. Jentsch, G. Rychkov, A. Bretag, 1996, The Journal of physiology.

Arachidonic acid inhibits the store-operated Ca2+ current in rat liver cells.

G. Barritt, G. Rychkov, T. Litjens, 2005, The Biochemical journal.

Involvement of Helices at the Dimer Interface in ClC-1 Common Gating

G. Rychkov, A. Bretag, Michael D. Duffield, 2003, The Journal of general physiology.

Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.

Paul E. Miller, R. Feil, S. Brierley, 2018, JCI insight.

Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes.

G. Barritt, G. Rychkov, E. Kheradpezhouh, 2018, Biochemical and biophysical research communications.

Adult Human Dental Pulp Stem Cells Differentiate Toward Functionally Active Neurons Under Appropriate Environmental Cues

S. Gronthos, S. Shi, G. Rychkov, 2008, Stem cells.

Neurogenic potential of dental pulp stem cells isolated from murine incisors

D. O’Carroll, G. Rychkov, S. Koblar, 2014, Stem Cell Research & Therapy.

Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

G. Barritt, G. Rychkov, E. Kheradpezhouh, 2015, Redox biology.

TRPM2 channels mediate acetaminophen-induced liver damage

G. Barritt, Linlin Ma, G. Rychkov, 2014, Proceedings of the National Academy of Sciences.

Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+ Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+ Channel Orai1*

H. Rieger, C. Peinelt, K. Dörr, 2012, The Journal of Biological Chemistry.

Mutations of the Ca -sensing Stromal Interaction Molecule STIM1 Regulate Ca Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca Channel Orai1*

H. Rieger, C. Peinelt, K. Dörr, 2012 .

The predominant role of IP₃ type 1 receptors in activation of store-operated Ca²+ entry in liver cells.

G. Barritt, J. Castro, G. Rychkov, 2011, Biochimica et biophysica acta.

entry in liver cells

J. Castro, G. Rychkov, T. Litjens, 2011 .

Store-operated Ca(2+) channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells.

G. Barritt, E. Aromataris, J. Castro, 2008, Biochimica et biophysica acta.

Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells.

G. Barritt, E. Aromataris, J. Castro, 2007, The Biochemical journal.

Orai1‐ and Orai2‐, but not Orai3‐mediated ICRAC is regulated by intracellular pH

G. Barritt, S. Brierley, Linlin Ma, 2021, The Journal of physiology.

Orai1- and Orai2-, but not Orai3-mediated ICRAC is regulated by intracellular pH

G. Barritt, S. Brierley, Linlin Ma, 2020, bioRxiv.

Properties of Orai1 mediated store‐operated current depend on the expression levels of STIM1 and Orai1 proteins

G. Barritt, Linlin Ma, G. Rychkov, 2009, The Journal of physiology.

Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease.

G. Barritt, G. Rychkov, Eunüs S. Ali, 2017, Advances in experimental medicine and biology.

Ca(2+) -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology.

G. Barritt, G. Rychkov, Jinglong Chen, 2008, Biochimica et biophysica acta.

Selective spider toxins reveal a role for Nav1.1 channel in mechanical pain

A. Basbaum, D. Julius, C. Stucky, 2016, Nature.

TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

G. Barritt, Eunus S. Ali, G. Rychkov, 2021, Antioxidants.

Functional complementation of truncated human skeletal-muscle chloride channel (hClC-1) using carboxyl tail fragments.

B. P. Hughes, G. Rychkov, A. Bretag, 2006, The Biochemical journal.

Movement of hClC-1 C-termini during common gating and limits on their cytoplasmic location.

Linlin Ma, Jie Zheng, G. Rychkov, 2011, The Biochemical journal.

Inter-subunit communication and fast gate integrity are important for common gating in hClC-1.

C. Bagley, G. Rychkov, A. Bretag, 2010, The international journal of biochemistry & cell biology.

Modulation of the gating of ClC‐1 by S‐(–) 2‐(4‐chlorophenoxy) propionic acid

G. Rychkov, A. Bretag, S. Bryant, 1999, British journal of pharmacology.

pH‐Dependent Interactions of Cd2+ and a Carboxylate Blocker with the Rat ClC‐1 Chloride Channel and Its R304E Mutant in the Sf‐9 Insect Cell Line

B. P. Hughes, G. Rychkov, A. Bretag, 1997, The Journal of physiology.

Oxygen‐sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth

G. Rychkov, M. L. Roberts, I. C. McMillen, 1998, The Journal of physiology.

Identifying the Ion Channels Responsible for Signaling Gastro-Intestinal Based Pain

S. Brierley, L. Blackshaw, A. Harrington, 2010, Pharmaceuticals.

NaV1.1 inhibition can reduce visceral hypersensitivity.

A. Basbaum, P. Pasricha, G. King, 2018, JCI insight.

Tetrodotoxin-sensitive voltage-gated sodium channels regulate bladder afferent responses to distension

S. Brierley, A. Harrington, G. Rychkov, 2018, Pain.

Characterization of three myotonia‐associated mutations of the CLCN1 chloride channel gene via heterologous expression

B. P. Hughes, N. Laing, G. Rychkov, 2004, Human mutation.

Extracellular cGMP, the downstream effector released in response to linaclotide-induced activation of guanylate cyclase-C, reduces excitability of murine and human dorsal root ganglion neurons

S. Brierley, C. Kurtz, J. Castro, 2014 .

Permeation and Block of the Skeletal Muscle Chloride Channel, ClC-1, by Foreign Anions

T. Jentsch, G. Rychkov, A. Bretag, 1998, The Journal of general physiology.

Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels

I. McMillen, G. Rychkov, D. Keating, 2004, The Journal of physiology.

Functional study of cytoplasmic loops of human skeletal muscle chloride channel, hClC-1.

Linlin Ma, G. Rychkov, A. Bretag, 2009, The international journal of biochemistry & cell biology.

Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma.

G. Barritt, Eunus S. Ali, G. Rychkov, 2019, Cell calcium.

Effects of water flow on transmembrane ionic currents in neurons of Helix pomatia and in squid giant axons.

G. Rychkov, S. Ayrapetyan, M. A. Suleymanyan, 1988, Comparative biochemistry and physiology. A, Comparative physiology.

Structural and stoichiometric determinants of Ca2+ release-activated Ca2+ (CRAC) channel Ca2+-dependent inactivation.

David P. Wilson, G. Barritt, G. Rychkov, 2014, Biochimica et biophysica acta.

Glu¹⁰⁶ in the Orai1 pore contributes to fast Ca²⁺-dependent inactivation and pH dependence of Ca²⁺ release-activated Ca²⁺ (CRAC) current.

David P. Wilson, G. Rychkov, N. Scrimgeour, 2012, The Biochemical journal.

Zinc inhibits human ClC‐1 muscle chloride channel by interacting with its common gating mechanism

G. Rychkov, A. Bretag, M. Roberts, 2005, The Journal of physiology.

Temperature dependence of human muscle ClC‐1 chloride channel

G. Rychkov, A. Bretag, B. Bennetts, 2001, The Journal of physiology.

Oxygen‐sensing pathway for SK channels in the ovine adrenal medulla

P. Giacomin, G. Rychkov, D. Keating, 2005, Clinical and experimental pharmacology & physiology.

Oxygen sensitivity in the sheep adrenal medulla: role of SK channels.

G. Rychkov, D. Keating, M. L. Roberts, 2001, American journal of physiology. Cell physiology.

The contribution of voltage-gated Ca2+ currents to K+ channel activation during ovine adrenal chromaffin cell development

G. Rychkov, D. Keating, M. Roberts, 2009, International Journal of Developmental Neuroscience.

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH

G. Barritt, G. Rychkov, F. H. Zhou, 2017, Scientific Reports.

Plasma membrane Ca2+ release–Activated Ca2+ channels with a high selectivity for Ca2+ identified by patch‐clamp recording in rat liver cells

G. Barritt, H. Brereton, M. L. Harland, 2001, Hepatology.

Fast and slow gating of CLC-1: differential effects of 2-(4-chlorophenoxy) propionic acid and dominant negative mutations.

B. P. Hughes, E. Aromataris, G. Rychkov, 2001, Molecular pharmacology.

Steatosis inhibits liver cell store-operated Ca²⁺ entry and reduces ER Ca²⁺ through a protein kinase C-dependent mechanism.

G. Barritt, Eunus S. Ali, G. Rychkov, 2015, The Biochemical journal.

Analysis of carboxyl tail function in the skeletal muscle Cl- channel hClC-1.

B. P. Hughes, Linlin Ma, G. Rychkov, 2008, The Biochemical journal.

Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH

G. Barritt, G. Rychkov, F. H. Zhou, 2017, Scientific Reports.

Cytoplasmic ATP-sensing Domains Regulate Gating of Skeletal Muscle ClC-1 Chloride Channels*

M. Parker, C. Morton, D. Stapleton, 2005, Journal of Biological Chemistry.

Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC‐1: effects on permeation and gating

G. Rychkov, A. Bretag, M. Pusch, 2001, The Journal of physiology.

Characteristics of skeletal muscle chloride channel C1C-1 and point mutant R304E expressed in Sf-9 insect cells.

B. P. Hughes, G. Rychkov, A. Bretag, 1996, Biochimica et biophysica acta.

ATP and vasopressin activate a single type of store-operated Ca2+ channel, identified by patch-clamp recording, in rat hepatocytes.

G. Barritt, G. Rychkov, T. Litjens, 2005, Cell calcium.

Measurement of the CRAC Channel Fast Ca2+-Dependent Inactivation (FCDI).

G. Rychkov, 2018, Methods in molecular biology.

Fast Ca2+‐dependent inactivation of the store‐operated Ca2+ current (ISOC) in liver cells: a role for calmodulin

G. Barritt, M. L. Harland, G. Rychkov, 2004, The Journal of physiology.

Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons.

Philip Poronnik, Sharad Kumar, J. Ekberg, 2014, The Biochemical journal.

pH-dependent interactions ofCd2" anda carboxylate blocker withtheratC0C-1chloride channel anditsR304Emutant intheSf-9insect cell line

B. P. Hughes, G. Rychkov, A. Bretag, 2011 .

Functional Effects of Epilepsy Associated KCNT1 Mutations Suggest Pathogenesis via Aberrant Inhibitory Neuronal Activity

G. Rubboli, L. Dibbens, G. Rychkov, 2022, International journal of molecular sciences.

ClC‐1 CHLORIDE CHANNEL: MATCHING ITS PROPERTIES TO A ROLE IN SKELETAL MUSCLE

E. Aromataris, G. Rychkov, 2006, Clinical and experimental pharmacology & physiology.