S. Humphreys

发表

Postprandial substrate deposition in human forearm and adipose tissues in vivo.

S. Coppack, K. Frayn, K. Frayn, 1990, Clinical science.

Periprandial regulation of lipid metabolism in insulin-treated diabetes mellitus.

S. Coppack, K. Frayn, S. Humphreys, 1993, Metabolism: clinical and experimental.

The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank

F. Karpe, M. Neville, B. Fielding, 2005, Diabetologia.

Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.

G. Gibbons, S. Humphreys, B. Knight, 2003, Journal of lipid research.

Fatty Acid Metabolism in Patients with PPAR Mutations

S. O’Rahilly, F. Karpe, B. Fielding, 2008 .

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.

F. Haj, F. Karpe, T. Anthony, 2013, American journal of physiology. Endocrinology and metabolism.

The relationship of plasma acetate with glucose and other blood intermediary metabolites in non-diabetic and diabetic subjects.

V. Thursfield, S. Humphreys, T. Hockaday, 1989, Clinica chimica acta; international journal of clinical chemistry.

Femoral Adipose Tissue May Accumulate the Fat That Has Been Recycled as VLDL and Nonesterified Fatty Acids

F. Karpe, B. Fielding, L. Hodson, 2010, Diabetes.

Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast.

K. Frayn, S. Humphreys, Keith N Frayn, 2012, American journal of physiology. Endocrinology and metabolism.

Metabolic characteristics of human adipose tissue in vivo.

S. Coppack, K. Frayn, S. Humphreys, 1989, Clinical science.

Arteriovenous differences across human adipose and forearm tissues after overnight fast.

S. Coppack, K. Frayn, S. Humphreys, 1990, Metabolism: clinical and experimental.

Metabolic responses of forearm and adipose tissues to acute ethanol ingestion.

S. Coppack, K. Frayn, S. Humphreys, 1990, Metabolism: clinical and experimental.

Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.

S. Coppack, K. Frayn, K. Frayn, 1992, Metabolism: clinical and experimental.

Arterio-venous differences across human adipose tissue for mono-, di- and triacylglycerols before and after a high-fat meal

S. Shadid, B. Fielding, K. Frayn, 1995 .

Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue.

I. Macdonald, D. Matthews, J. Samra, 1996, The American journal of physiology.

Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity.

J. Samra, K. Frayn, R. Morris, 1996, Clinical science.

Clearance of lipoprotein remnant particles in adipose tissue and muscle in humans.

J. Samra, F. Karpe, K. Frayn, 1997, Journal of lipid research.

Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.

I. Macdonald, J. Samra, K. Frayn, 1998, The Journal of clinical endocrinology and metabolism.

Adipose tissue metabolism in the postprandial period: microdialysis and arteriovenous techniques compared.

P. Arner, K. Frayn, S. Humphreys, 1998, The American journal of physiology.

Fatty acid metabolism in patients with PPARgamma mutations.

S. O’Rahilly, F. Karpe, B. Fielding, 2008, The Journal of clinical endocrinology and metabolism.

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

F. Karpe, B. Fielding, L. Hodson, 2009, The Journal of clinical endocrinology and metabolism.

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

M. Neville, L. Hodson, K. Frayn, 2009, Diabetologia.

Prior exercise and postprandial substrate extraction across the human leg.

A. Hardman, K. Frayn, S. Humphreys, 2000, American journal of physiology. Endocrinology and metabolism.

Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals.

D. Maclaren, T. Reilly, K. Frayn, 1998, Journal of applied physiology.

Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects.

S. Coppack, K. Frayn, K. Frayn, 1995, The American journal of physiology.

Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes.

D. Dunger, C. Acerini, M. Marcovecchio, 2009, The Journal of clinical endocrinology and metabolism.

Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans.

F. Karpe, H. Vidal, G. Goossens, 2004, Obesity research.

Plasma acetate levels in response to intravenous fat or glucose/insulin infusions in diabetic and non-diabetic subjects.

S. Humphreys, A. Akanji, L. Ng, 1988, Clinica chimica acta; international journal of clinical chemistry.

Plasma leptin is influenced by diet composition and exercise

F. Karpe, A. Hardman, K. Frayn, 2003, International Journal of Obesity.

Urinary albumin excretion in pregnancy

S. Humphreys, C. Redman, H. Dhar, 1986 .

A “futile cycle” induced by thiazolidinediones in human adipose tissue?

F. Karpe, H. Vidal, D. Langin, 2003, Nature Medicine.

Substrate Utilization by the Failing Human Heart by Direct Quantification Using Arterio-Venous Blood Sampling

T. Betts, F. Karpe, L. Hodson, 2009, PloS one.

Human triacylglycerol-rich lipoprotein subfractions as substrates for lipoprotein lipase.

S. Coppack, K. Frayn, R. Fisher, 1995, Clinica chimica acta; international journal of clinical chemistry.

Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy

T. Funahashi, Y. Matsuzawa, F. Karpe, 2005, Diabetologia.

Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.

D. Dunger, R. Hovorka, L. Chassin, 2009, American journal of physiology. Endocrinology and metabolism.

Exercise Prevents the Accumulation of Triglyceride-Rich Lipoproteins and Their Remnants Seen When Changing to a High-Carbohydrate Diet

F. Karpe, A. Hardman, K. Frayn, 2001, Arteriosclerosis, thrombosis, and vascular biology.

Fasting plasma triacylglycerol concentrations predict adverse changes in lipoprotein metabolism after a normal meal

S. Coppack, K. Frayn, R. Fisher, 1994, British Journal of Nutrition.

Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism.

I. Macdonald, J. Samra, K. Frayn, 1996, The American journal of physiology.

Glycerol and lactate uptake in human forearm.

S. Coppack, K. Frayn, S. Humphreys, 1991, Metabolism: clinical and experimental.

Release of individual fatty acids from human adipose tissue in vivo after an overnight fast.

J. Samra, B. Fielding, K. Frayn, 1996, Journal of lipid research.

Change in plasma acetate levels in diabetic subjects on mixed high fiber diets.

S. Humphreys, T. Hockaday, A. Akanji, 1989, The American journal of gastroenterology.

Effects of adrenaline infusion on the interstitial environment of subcutaneous adipose tissue as studied by microdialysis.

I. Macdonald, J. Samra, K. Frayn, 1996, Clinical science.

Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

F. Karpe, B. Fielding, L. Hodson, 2010, American journal of physiology. Endocrinology and metabolism.

Inhibition of cholesterol absorption associated with a PPARα-dependent increase in ABC binding cassette transporter A1 in mice Published, JLR Papers in Press, August 1, 2003. DOI 10.1194/jlr.M300042-JLR200

G. Gibbons, S. Humphreys, B. Knight, 2003, Journal of Lipid Research.

Micro-method for preparing perchloric extracts of blood.

K. Frayn, S. Humphreys, K. N. Frayn, 1988, Clinical chemistry.

Adipose tissue metabolism in the postprandial period: microdialysis and arteriovenous techniques compared.

P. Arner, K. Frayn, S. Humphreys, 1998, American journal of physiology. Endocrinology and metabolism.

The Measurement of Plasma Acetate by a Manual or Automated Technique in Diabetic and Non-Diabetic Subjects

R. Smith, S. Humphreys, T. Hockaday, 1986, Annals of clinical biochemistry.

Inhibition of the fibrinolytic and fibrinogenolytic activity of plasminogen activators in vitro by the antidotes ϵ-aminocaproic acid, tranexamic acid and aprotinin

S. Humphreys, J. Hearn, R. Standring, 1992 .

Micro-Method for Measurement of Sub-Nanomole Amounts of Triacylglycerol

K. Frayn, R. Fisher, S. Humphreys, 1990, Annals of clinical biochemistry.

Separation of lipoprotein fractions by ultracentrifugation: investigation of analytical recovery with sequential flotation and density gradient procedures.

K. Frayn, R. Fisher, G. Gibbons, 1994, Clinica chimica acta; international journal of clinical chemistry.

Carbohydrate metabolism in human adipose tissue in vivo

S. Coppack, K. Frayn, S. Humphreys, 1989 .

Carbohydrate metabolism in insulin resistance: glucose uptake and lactate production by adipose and forearm tissues in vivo before and after a mixed meal.

Jennifer J. Pointon, S. Coppack, K. Frayn, 1996, Clinical science.

The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes

F. Karpe, M. Laville, B. Fielding, 2004, Diabetologia.

Plasma triacylglycerol extraction in human adipose tissue in vivo: effects of glucose ingestion and insulin infusion.

S. Coppack, K. Frayn, S. Humphreys, 1989, European journal of clinical nutrition.

The storage stability and concentration of acetoacetate differs between blood fractions.

L. Hodson, S. Humphreys, C. Pramfalk, 2014, Clinica chimica acta; international journal of clinical chemistry.

Plasma mono-, di- and triacylglycerol measurements in a study of fat uptake by human adipose tissue in vivo.

S. Shadid, B. Fielding, K. Frayn, 1995, Biochemical Society transactions.

The use of microdialysis to monitor rapid changes in glucose concentration.

K. Frayn, J. Bugler, S. Humphreys, 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Immediate metabolic availability of dietary fat in combination with carbohydrate.

A. Griffiths, B. Fielding, K. Frayn, 1994, The American journal of clinical nutrition.

Stability of Plasma Glucose during Storage

K. Frayn, K. Frayn, S. Humphreys, 1990, Annals of clinical biochemistry.

Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects

D. Matthews, K. Frayn, S. Humphreys, 1998, British Journal of Nutrition.

Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet.

B. Fielding, K. Frayn, S. Humphreys, 2000, The American journal of clinical nutrition.

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.

K. Frayn, G. Olivecrona, P. Sutton, 2011, American journal of physiology. Endocrinology and metabolism.

Metabolic responses to isoenergetic meals containing different proportions of carbohydrate and fat

T Reilly, K N Frayn, D. Maclaren, 1997, British Journal of Nutrition.

Selection of oral microbial adhesion antagonists using biotinylated Streptococcus sanguis and a human mixed oral microflora.

I. Marlow, S. Humphreys, Y. Guan, 2001, Archives of oral biology.

Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects.

D. Dunger, P. Murgatroyd, A. Sleigh, 2009, Clinical science.

Regulation of lipid metabolism in adipose tissue during early starvation.

K N Frayn, I. Macdonald, J. Samra, 1996, The American journal of physiology.

Metabolic Signatures of Human Adipose Tissue Hypoxia in Obesity

F. Karpe, L. Hodson, K. Frayn, 2013, Diabetes.

Cohort Profile Cohort Profile : The Oxford Biobank

F. Karpe, M. Neville, S. Vasan, 2018 .

Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity

Fredrik Karpe, F. Karpe, M. Neville, 2010, Diabetes.

Adipose tissue fatty acid metabolism in insulin-resistant men

F. Karpe, B. Fielding, H. Tornqvist, 2008, Diabetologia.

Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization.

S. Coppack, B. Fielding, K. Frayn, 1995, Advances in enzyme regulation.

Physiological and metabolic responses to a hill walk.

D. Maclaren, T. Reilly, P. Ainslie, 2002, Journal of applied physiology.

Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men

T. Willson, P. Hegde, S. O’Rahilly, 2008, Diabetes.

Subcutaneous adipose tissue metabolism studied by local catheterization.

S. Coppack, K. Frayn, S. Humphreys, 1993, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase concentrations.

J. Samra, F. Karpe, K. Frayn, 1998, Journal of lipid research.

Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose.

J. Bülow, K. Frayn, L. Simonsen, 1999, Journal of lipid research.

Peripheral triacylglycerol extraction in the fasting and post-prandial states.

S. Coppack, K. Frayn, K. Frayn, 1991, Clinical science.

Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition.

S. Coppack, S. Shadid, B. Fielding, 1994, The American journal of physiology.

Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations.

G. Reid, B. Fielding, K. Frayn, 2000, The British journal of nutrition.

Chylomicrons are the preferred substrate for lipoprotein lipase in vivo.

S. Coppack, K. Frayn, R. Fisher, 1991, Biochemical Society transactions.

Mono- and di-acylglycerol concentrations in human plasma in relation to lipoprotein lipase activity.

B. Fielding, K. Frayn, S. Humphreys, 1993, Biochemical Society transactions.

Mono-, di- and triacylglycerol concentrations in human plasma: effects of heparin injection and of a high-fat meal.

B. Fielding, K. Frayn, S. Humphreys, 1993, Clinica chimica acta; international journal of clinical chemistry.

Regulation of human metabolism by hypoxia-inducible factor

Kieran Clarke, Fredrik Karpe, Peter A. Robbins, 2010, Proceedings of the National Academy of Sciences.

Disturbances in the normal regulation of SREBP-sensitive genes in PPARα-deficient mice

G. Gibbons, S. Humphreys, B. Knight, 2001 .

Urinary albumin excretion in pregnancy.

C. Redman, S. Humphreys, H. Dhar, 1986, British journal of obstetrics and gynaecology.

Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.

G. Gibbons, S. Humphreys, B. Knight, 2001, Journal of lipid research.

Fuel selection in white adipose tissue

S. Coppack, K. Frayn, S. Humphreys, 1995, Proceedings of the Nutrition Society.

Possible importance of glycogen in human adipose tissue.

S. Coppack, K. Frayn, S. Humphreys, 1989, Biochemical Society Transactions.

Physiological, metabolic, and performance implications of a prolonged hill walk: influence of energy intake.

D. Maclaren, T. Reilly, P. Ainslie, 2003, Journal of applied physiology.

Energy balance, metabolism, hydration, and performance during strenuous hill walking: the effect of age.

D. Maclaren, T. Reilly, K. Westerterp, 2002, Journal of applied physiology.

of a prolonged hill walk: influence of energy intake Physiological, metabolic, and performance implications

T. Reilly, P. Ainslie, K. Frayn, 2015 .

Effects of insulin on human adipose tissue metabolism in vivo.

T D Hockaday, S. Coppack, K. Frayn, 1989, Clinical science.

Net carbon flux across subcutaneous adipose tissue after a standard meal in normal-weight and insulin-resistant obese subjects.

S. Coppack, K. Frayn, S. Humphreys, 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Is the Growth Hormone Concentration Regulated by the Morning Rise in the Plasma Cortisol Concentration?

D. Matthews, K. Frayn, S. Humphreys, 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Energy balance, metabolism, hydration, and performance during strenuous hill walking: the effect of age.

K. Westerterp, P. Ainslie, K. Frayn, 2002, Journal of applied physiology.

Fatty Acid Metabolism in Patients with PPAR gamma Mutations

S. O’Rahilly, F. Karpe, B. Fielding, 2008 .

Effects of Acute Administration of Doxazosin on Fasting and Postprandial Haemodynamics and Lipid Metabolism in Healthy Subjects

D. Matthews, F. Karpe, K. Frayn, 2002, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Fatty acid metabolism in patients with PPARgamma mutations.

S. O’Rahilly, F. Karpe, B. Fielding, 2008, The Journal of clinical endocrinology and metabolism.

Regulation of human metabolism by hypoxia-inducible factor

Thomas G. Smith, F. Formenti, K. Clarke, 2010, Proceedings of the National Academy of Sciences.