K. Cheng

发表

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human.

M. Yarmush, E. Novik, T. Maguire, 2009, Biochemical pharmacology.

Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.

Li Xiao, Michael R. Ziebell, Charles A. Lesburg, 2011, Biochemical pharmacology.

Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability.

V. Madison, K. Cheng, C. Lesburg, 2008, Protein engineering, design & selection : PEDS.

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.

V. Pazienza, K. Abid, F. Negro, 2006, The Journal of antimicrobial chemotherapy.

In vitro antiviral activity of SCH 446211 ( SCH 6 ) , a novel inhibitor of the hepatitis C virus NS 3 serine protease

V. Pazienza, K. Abid, F. Negro, 2006 .

Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma.

Walter A. Korfmacher, R. Morrison, F. G. Njoroge, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3α-hydroxysteroid dehydrogenase

M. New, K. Cheng, K. Cheng, 1993, The Journal of Steroid Biochemistry and Molecular Biology.

Purification and characterization of two constitutive forms of rat liver microsomal cytochrome P-450.

J. Schenkman, K. Cheng, 1982, The Journal of biological chemistry.

Amino-terminal sequence analysis of six cytochrome P-450 isozymes purified by monoclonal antibody directed immunopurification.

H. Krutzsch, K. Cheng, H. Gelboin, 1984, Biochemical and biophysical research communications.

Association of D222G substitution in haemagglutinin of 2009 pandemic influenza A (H1N1) with severe disease.

W. Lim, K. Cheng, Gannon C.K. Mak, 2010, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans.

R. Morrison, F. G. Njoroge, K. Cheng, 2008, Biochemical pharmacology.

Structure-activity relationship (SAR) development and discovery of potent indole-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

A novel class of highly potent irreversible hepatitis C virus NS5B polymerase inhibitors.

B. Feld, J. Duca, F. G. Njoroge, 2012, Journal of medicinal chemistry.

Towards the second generation of Boceprevir: Dithianes as an alternative P2 substituent for 2,2-dimethyl cycloproyl proline in HCV NS3 protease inhibitors.

X. Tong, R. Doll, Zhuyan Guo, 2010, Bioorganic & medicinal chemistry letters.

Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.

X. Tong, F. G. Njoroge, K. Cheng, 2009, Bioorganic & medicinal chemistry letters.

Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.

F. G. Njoroge, K. Cheng, J. Pichardo, 2008, Bioorganic & medicinal chemistry.

Ultra-performance liquid chromatography/tandem mass spectrometric determination of testosterone and its metabolites in in vitro samples.

Walter A. Korfmacher, K. Cheng, Xiaoming Cui, 2006, Rapid communications in mass spectrometry : RCM.

Structure and tissue-specific expression of the aldo-keto reductase superfamily.

K. Cheng, K. Qin, 1994, Biochemistry.

A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.

K. Cheng, Ronald E. White, Y. Lau, 2002, Journal of pharmacological and toxicological methods.

Structural comparison of monoclonal antibody immunopurified pulmonary and hepatic cytochrome P-450 from 3-methylcholanthrene-treated rats.

K. Cheng, H. Gelboin, S. S. Park, 1986, Biochemical pharmacology.

Chiral supercritical fluid chromatography/tandem mass spectrometry for the simultaneous determination of pindolol and propranolol in metabolic stability samples.

L. Favreau, K. Cheng, Y. Hsieh, 2005, Rapid communications in mass spectrometry : RCM.

Steroid 21-hydroxylase deficiency: genotype may not predict phenotype.

M. New, R. Wilson, R. C. Wilson, 1995, The Journal of clinical endocrinology and metabolism.

Hepatitis B virus large surface protein is not secreted but is immunogenic when selectively expressed by recombinant vaccinia virus

B. Moss, G. Smith, K. Cheng, 1986, Journal of virology.

Distribution of 3α-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans

K. Cheng, M. Khanna, K. Qin, 1995, The Journal of Steroid Biochemistry and Molecular Biology.

Metabolism of progesterone and estradiol by microsomes and purified cytochrome P-450 RLM3 and RLM5.

J. Schenkman, K. Cheng, 1984, Drug metabolism and disposition: the biological fate of chemicals.

Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450.

H. Krutzsch, K. Cheng, H. Gelboin, 1986, Biochemistry.

Discovery of novel orally active ureido NPY Y5 receptor antagonists.

W. Greenlee, A. Stamford, C. Farley, 2008, Bioorganic & medicinal chemistry letters.

Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate.

F. G. Njoroge, K. Cheng, S. Agrawal, 2014, ACS medicinal chemistry letters.

Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.

X. Tong, A. McPhail, A. Arasappan, 2010, Journal of medicinal chemistry.

The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.

Walter A. Korfmacher, W. Greenlee, D. Tulshian, 2009, Bioorganic & medicinal chemistry letters.

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.

Zhuyan Guo, Frank Bennett, X. Tong, 2010, Bioorganic & medicinal chemistry letters.

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:

Weiying Yang, Zhuyan Guo, Andrea Hart, 2006, Journal of medicinal chemistry.

Characterisation and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan.

Y. Chuang, K. Cheng, L-T Wu, 2006, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Peptide-specific antibodies employed in determining the interspecies immunological cross-reactivity of haemopexin.

U. Muller-eberhard, W. Maloy, K. Cheng, 1988, Comparative biochemistry and physiology. B, Comparative biochemistry.

Selective synthesis and secretion of particles composed of the hepatitis B virus middle surface protein directed by a recombinant vaccinia virus: induction of antibodies to pre-S and S epitopes

B. Moss, K. Cheng, 1987, Journal of virology.

Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo.

R. Morrison, K. Cheng, Ronald E. White, 2005, Journal of pharmacological and toxicological methods.

Rapid deoxyribonucleic acid analysis by allele-specific polymerase chain reaction for detection of mutations in the steroid 21-hydroxylase gene.

M. New, R. C. Wilson, K. Cheng, 1995, The Journal of clinical endocrinology and metabolism.

Prenatal treatment and diagnosis of congenital adrenal hyperplasia owing to steroid 21-hydroxylase deficiency.

M. New, R. Wilson, R. C. Wilson, 1995, The Journal of clinical endocrinology and metabolism.

Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

X. Tong, A. Arasappan, K. Cheng, 2009, Bioorganic & medicinal chemistry.

NADPH-cytochrome P-450 reductase is not a component of the liver microsomal steroid 5-alpha reductase.

A. Y. Lu, K. Cheng, R. Wang, 1989, Biochemical and biophysical research communications.

Testosterone metabolism by cytochrome P-450 isozymes RLM3 and RLM5 and by microsomes. Metabolite identification.

J. Schenkman, K. Cheng, J B Schenkman, 1983, The Journal of biological chemistry.

Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography-tandem mass spectrometry.

Walter A. Korfmacher, K. Ng, Gangfeng Wang, 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.

Weiying Yang, Frank Bennett, Jesse Wong, 2010, ACS medicinal chemistry letters.

Application and interpretation of hPXR screening data: Validation of reporter signal requirements for prediction of clinically relevant CYP3A4 inducers.

R. Morrison, K. Cheng, Richard A Morrison, 2008, Biochemical pharmacology.

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

R. Sparkes, K. Cheng, S. Belkin, 1995, Genomics.

Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.

S. Tamura, S. Kemp, M. Lim-Wilby, 2006, Journal of medicinal chemistry.

Monoclonal antibody-directed analysis of cytochrome P-450.

K. Cheng, H. Gelboin, S. S. Park, 1986, Advances in experimental medicine and biology.

Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009-2011.

W. Lim, K. Cheng, Gannon C.K. Mak, 2011, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

Dissection of cytochrome P-450 isozymes (RLM) from fractions of untreated rat liver microsomal proteins.

J. Schenkman, K. Cheng, W. Backes, 1982, Biochemical and biophysical research communications.

Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.

Weiying Yang, Frank Bennett, X. Tong, 2009, Journal of medicinal chemistry.

A histidine residue at the active site of avian liver phosphoenolpyruvate carboxykinase.

K. Cheng, T. Nowak, 1989, The Journal of biological chemistry.

Prediction of oral drug absorption in humans – from cultured cell lines and experimental animals

K. Cheng, Cheng Li, K-C Cheng, 2008 .

Molecular Cloning and Expression of Rat Liver 3α-Hydroxysteroid Dehydrogenase

P. C. White, K. Cheng, K. Cheng, 1991 .

Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors.

Robert Chase, Sony Agrawal, X. Tong, 2008, Biochemical pharmacology.