Zhenyuan Song

发表

Biomechanics and functionality of hepatocytes in liver cirrhosis.

Shan Sun, M. Cho, Zhenyuan Song, 2014, Journal of biomechanics.

Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice.

C. McClain, Zhenyuan Song, Y. J. Kang, 2004, The American journal of pathology.

Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease

J. Chen, Songtao Li, Zhenyuan Song, 2014, British journal of pharmacology.

Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease

C. McClain, I. Deaciuc, Zhenyuan Song, 2008, Hepatology.

S-Adenosylmethionine, cytokines, and alcoholic liver disease.

C. McClain, W. Watson, S. Barve, 2002, Alcohol.

Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism.

C. McClain, Zhenyuan Song, Y. J. Kang, 2011, The American journal of pathology.

Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport.

C. McClain, S. Uriarte, I. Deaciuc, 2007, Biochemical pharmacology.

S‐adenosylhomocysteine sensitizes to TNF‐α hepatotoxicity in mice and liver cells: A possible etiological factor in alcoholic liver disease

C. McClain, S. Uriarte, S. Barve, 2004, Hepatology.

Nuclear factor (erythroid‐derived 2)‐like 2 activation‐induced hepatic very‐low‐density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice

Songtao Li, Zhenyuan Song, Zhanxiang Zhou, 2014, Hepatology.

mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes

Jun Wang, Zhenyuan Song, Yingli Chen, 2020, Experimental biology and medicine.

Inositol requiring enzyme 1 alpha (IRE1a) links palmitate-induced mTOR activation and lipotoxicity in Hepatocytes.

Jun Wang, Zhenyuan Song, Yingli Chen, 2020, American journal of physiology. Cell physiology.

The TLR4‐IRE1α pathway activation contributes to palmitate‐elicited lipotoxicity in hepatocytes

Songtao Li, L. Ding, Zhenyuan Song, 2018, Journal of cellular and molecular medicine.

Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation.

C. McClain, I. Deaciuc, Zhenyuan Song, 2007, Basic & clinical pharmacology & toxicology.

Protection of nicotinic acid against oxidative stress-induced cell death in hepatocytes contributes to its beneficial effect on alcohol-induced liver injury in mice.

Songtao Li, Zhenyuan Song, Xiaobing Dou, 2013, The Journal of nutritional biochemistry.

Advances in alcoholic liver disease

C. McClain, S. Joshi‐Barve, Zhenyuan Song, 2004, Current gastroenterology reports.

Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes

Songtao Li, Zhenyuan Song, Ximei Zhang, 2013, PloS one.

Adipose tissue-liver axis in alcoholic liver disease.

Zhenyuan Song, Zhan-Xiang Zhou, Zhigang Wang, 2016, World journal of gastrointestinal pathophysiology.

Adipose Tissue Dysfunction and Alcoholic Liver Disease

Zhenyuan Song, 2015 .

Inhibition of ERK1/2 pathway suppresses adiponectin secretion via accelerating protein degradation by Ubiquitin-proteasome system: relevance to obesity-related adiponectin decline.

Songtao Li, Zhenyuan Song, Ximei Zhang, 2013, Metabolism: clinical and experimental.

S-Adenosylmethionine Protects against Acetaminophen-Induced Hepatotoxicity in Mice

C. McClain, Zhenyuan Song, Theresa S. Chen, 2004, Pharmacology.

Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction.

Songtao Li, Zhenyuan Song, Xiaobing Dou, 2017, Nutrition research.

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

Songtao Li, Changhao Sun, Zhenyuan Song, 2017, Hepatology.

Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice

Zhenyuan Song, Tong Yao, Zhigang Wang, 2010, Experimental biology and medicine.

Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease

T. Knudsen, C. McClain, S. Barve, 2008, Hepatology international.

Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver.

Zhenyuan Song, Tong Yao, Zhigang Wang, 2010, Alcoholism, clinical and experimental research.

Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model

C. McClain, L. Cai, Zhenyuan Song, 2007, Cardiovascular Toxicology.

Long- Term Management Of Alcoholic Liver Disease

C. McClain, L. Marsano, Zhenyuan Song, 2009 .

Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway.

G. Fantuzzi, Changhao Sun, Zhenyuan Song, 2011, American journal of physiology. Endocrinology and metabolism.

Mechanisms of non-alcoholic steatohepatitis.

C. McClain, S. Barve, I. Deaciuc, 2004, Alcohol.

ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1–TFAM signalling in alcoholic steatohepatitis

W. Guo, Wenlian Zhang, Zhaoli Sun, 2020, Gut.

Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis.

C. McClain, I. Deaciuc, Zhenyuan Song, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Inhibition of NF-κB activation by 4-hydroxynonenal contributes to liver injury in a mouse model of alcoholic liver disease.

Songtao Li, Zhenyuan Song, Xiaobing Dou, 2012, The American journal of pathology.

Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Inhibition of NF-B Activation by 4-Hydroxynonenal Contributes to Liver Injury in a Mouse Model of Alcoholic Liver Disease

Songtao Li, Zhenyuan Song, Xiaobing Dou, 2012 .

Silymarin protects against acute ethanol-induced hepatotoxicity in mice.

C. McClain, I. Deaciuc, X. Ji, 2006, Alcoholism, clinical and experimental research.

Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease.

C. McClain, S. Uriarte, S. Joshi‐Barve, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease.

C. McClain, S. Joshi‐Barve, S. Barve, 2005, Alcoholism, clinical and experimental research.

Dysregulated cytokine metabolism in alcoholic liver disease

C. McClain, S. Barve, I. Deaciuc, 2004 .

Abrogation of Nuclear Factor-κB Activation Is Involved in Zinc Inhibition of Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production and Liver Injury

J. T. Saari, C. McClain, Zhenyuan Song, 2004 .

Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease.

C. McClain, S. Barve, I. Deaciuc, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Prevention of Alterations in Intestinal Permeability Is Involved in Zinc Inhibition of Acute Ethanol-Induced Liver Damage in Mice

C. McClain, Zhenyuan Song, Y. J. Kang, 2003, Journal of Pharmacology and Experimental Therapeutics.

A Critical Involvement of Oxidative Stress in Acute Alcohol-Induced Hepatic TNF-α Production

C. McClain, Zhenyuan Song, Y. J. Kang, 2003 .

Monocyte activation in alcoholic liver disease.

C. McClain, S. Barve, I. Deaciuc, 2002, Alcohol.

Tetrathiomolybdate Protects against Bile Duct Ligation-Induced Cholestatic Liver Injury and Fibrosis

C. McClain, G. Arteel, S. Barve, 2008, Journal of Pharmacology and Experimental Therapeutics.

Cysteine aggravates palmitate-induced cell death in hepatocytes.

Zhenyuan Song, Xiaobing Dou, Tong Yao, 2011, Life sciences.

Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system.

C. McClain, W. Watson, I. Deaciuc, 2011, Biochimica et biophysica acta.

Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress.

J. T. Saari, C. McClain, Zhenyuan Song, 2005, The American journal of pathology.

Zinc Supplementation Inhibits Hepatic Apoptosis in Mice Subjected to a Long-Term Ethanol Exposure

Jie Liu, C. McClain, Zhenyuan Song, 2008, Experimental biology and medicine.

Cardiac Metallothionein Induction Plays the Major Role in the Prevention of Diabetic Cardiomyopathy by Zinc Supplementation

J. T. Saari, S. Prabhu, L. Cai, 2006, Circulation.

Danshen protects against early-stage alcoholic liver disease in mice via inducing PPARα activation and subsequent 4-HNE degradation

L. Ding, Zhenyuan Song, Xiaobing Dou, 2017, PloS one.

Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration.

C. McClain, Zhenyuan Song, Y. J. Kang, 2008, American Journal of Pathology.

4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin–proteasome degradation

Zhenyuan Song, C. Braunschweig, Chen Shen, 2011, Molecular and Cellular Endocrinology.

Lessons from large-scale gene profiling of the liver in alcoholic liver disease.

C. McClain, I. Deaciuc, Zhenyuan Song, 2005, Hepatology research : the official journal of the Japan Society of Hepatology.

A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production.

C. McClain, Zhenyuan Song, Y. J. Kang, 2003, The American journal of pathology.

Zinc supplementation reverses alcohol‐induced steatosis in mice through reactivating hepatocyte nuclear factor‐4α and peroxisome proliferator‐activated receptor‐α

Jie Liu, C. McClain, Zhenyuan Song, 2009, Hepatology.

Homocysteine inhibits adipogenesis in 3T3-L1 preadipocytes

Zhenyuan Song, Tong Yao, Zhigang Wang, 2011, Experimental biology and medicine.

Involvement and mechanism of DGAT2 upregulation in the pathogenesis of alcoholic fatty liver disease

Zhenyuan Song, Tong Yao, Zhigang Wang, 2010, Journal of Lipid Research.

Preservation of Hepatocyte Nuclear Factor-4α Is Associated with Zinc Protection Against TNF-α Hepatotoxicity in Mice

C. McClain, Zhenyuan Song, Y. J. Kang, 2007, Experimental biology and medicine.

Dietary Zinc Deficiency Exaggerates Ethanol-Induced Liver Injury in Mice: Involvement of Intrahepatic and Extrahepatic Factors

C. McClain, Zhenyuan Song, Zhanxiang Zhou, 2013, PloS one.

Interactions of cytokines, S‐adenosylmethionine, and S‐adenosylhomocysteine in alcohol‐induced liver disease and immune suppression

C. McClain, S. Joshi‐Barve, S. Barve, 2006, Journal of gastroenterology and hepatology.

Upregulation of 4-Hydroxynonenal Contributes to the Negative Effect of n-6 Polyunsaturated Fatty Acid on Alcohol-Induced Liver Injury and Hepatic Steatosis.

Songtao Li, Zhenyuan Song, Xiaobing Dou, 2022, Journal of agricultural and food chemistry.

S-adenosylmethionine (SAMe) protects against acute alcohol induced hepatotoxicity in mice.

C. McClain, S. Barve, Zhenyuan Song, 2003, The Journal of nutritional biochemistry.

S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes.

C. McClain, S. Uriarte, S. Barve, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

M. Kyba, Congcong He, G. Shu, 2022, bioRxiv.

S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptor.

C. McClain, S. Uriarte, R. Sahoo, 2005, Biochimica et biophysica acta.

4‐Hydroxynonenal‐induced apoptosis in rat hepatic stellate cells: Mechanistic approach

C. McClain, I. Deaciuc, W. D. de Villiers, 2007, Journal of gastroenterology and hepatology.

Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe).

C. McClain, S. Uriarte, S. Barve, 2004, Cytokine.

Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice

Songtao Li, Zhenyuan Song, Li Zhou, 2021, Frontiers in Pharmacology.

Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation.

Yong Zeng, Songtao Li, Zhenyuan Song, 2015, Biochimica et biophysica acta.

ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development.

Jun Wang, Zhaoli Sun, Zhenyuan Song, 2020, Journal of hepatology.

Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition.

C. McClain, S. Joshi‐Barve, S. Barve, 2007, The Journal of nutritional biochemistry.

tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation.

Songtao Li, Changhao Sun, Shan Sun, 2014, Biochimica et biophysica acta.

Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial.

K. Varady, L. Tussing-Humphreys, Zhenyuan Song, 2022, Cell metabolism.

Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.

G. Fantuzzi, Zhenyuan Song, Zhanxiang Zhou, 2010, American journal of physiology. Gastrointestinal and liver physiology.

Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice

Bing Zhang, Zhenyuan Song, Zhiwei Bao, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury.

C. McClain, Zhenyuan Song, Y. J. Kang, 2004, The American journal of pathology.

Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease

Songtao Li, L. Ding, Linfeng Hu, 2018, Experimental & Molecular Medicine.

The Notch-Pdgfrβ axis suppresses brown adipocyte progenitor differentiation in early postnatal mice

Shaolei Xiong, Yuwei Jiang, B. Layden, 2023, bioRxiv.

Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice.

C. McClain, Zhenyuan Song, Y. J. Kang, 2007, Experimental biology and medicine.

Genetically prolonged beige fat in male mice confers long-lasting metabolic health

M. Kyba, Congcong He, G. Shu, 2023, Nature communications.

Editorial: Alcohol Consumption and Liver Diseases: From Pathology to Phytotherapy

Songtao Li, P. Yao, Zhenyuan Song, 2022, Frontiers in Pharmacology.

Reply to: "NNMT aggravates hepatic steatosis but alleviates liver injury in alcoholic liver disease" and "Two sides of NNMT in alcoholic and nonalcoholic fatty liver development".

Jun Wang, Zhenyuan Song, Qing Song, 2021, Journal of hepatology.

Nicotinamide N-methyltransferase (NNMT) upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes.

Jun Wang, Yuwei Jiang, Zhenyuan Song, 2021, American journal of physiology. Cell physiology.

Differential roles of insulin receptor in adipocyte progenitor cells in mice

Shaolei Xiong, Yuwei Jiang, Zhenyuan Song, 2023, Molecular and Cellular Endocrinology.

mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease

C. Liew, Songtao Li, N. Nieto, 2023, Hepatology communications.

Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease

Songtao Li, L. Ding, Linfeng Hu, 2018, Experimental & Molecular Medicine.

Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes

C. McClain, S. Uriarte, S. Joshi‐Barve, 2005, Cell Death and Differentiation.

Inhibition of PARP Activity Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice

Bing Zhang, Liu Yang, Zhenyuan Song, 2017 .

Songtao Li, Zhenyuan Song, Zhanxiang Zhou, 2014, Hepatology.

Inhibition of adiponectin production by homocysteine: A potential mechanism for alcoholic liver disease

C. McClain, I. Deaciuc, Zhenyuan Song, 2008, Hepatology.

4-Hydroxynonenal differentially regulates adiponectin gene expression and secretion via activating PPARγ and accelerating ubiquitin–proteasome degradation

Zhenyuan Song, C. Braunschweig, Chen Shen, 2012, Molecular and Cellular Endocrinology.