P. Wijnker

发表

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue

L. Carrier, T. Eschenhagen, Alexander Dutsch, 2019, Scientific Reports.

Chapter 6 A novel HCM mutation in cardiac troponin T primarily alters cross-bridge kinetics and increases the energetic cost of tension generation in human cardiac tissue

C. Poggesi, Steven B Marston, C. Redwood, 2014 .

Phosphorylation of protein kinase C sites Ser42/44 decreases Ca(2+)-sensitivity and blunts enhanced length-dependent activation in response to protein kinase A in human cardiomyocytes.

C. D. dos Remedios, J. van der Velden, P. Wijnker, 2014, Archives of biochemistry and biophysics.

PKCα-Specific Phosphorylation of the Troponin Complex in Human Myocardium: A Functional and Proteomics Analysis

Pingbo Zhang, C. D. dos Remedios, J. V. Van Eyk, 2013, PloS one.

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

F. T. ten Cate, C. D. dos Remedios, C. Poggesi, 2013, Circulation research.

Mutation-specific pathology and treatment of hypertrophic cardiomyopathy in patients, mouse models and human engineered heart tissue.

J. van der Velden, P. Wijnker, 2020, Biochimica et biophysica acta. Molecular basis of disease.

GSK3&bgr; Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human: Short Communication

Jeroen A. A. Demmers, C. D. dos Remedios, S. Sadayappan, 2012, Circulation research.

Translational investigation of electrophysiology in hypertrophic cardiomyopathy

Jussi T. Koivumäki, L. Carrier, T. Eschenhagen, 2021, Journal of molecular and cellular cardiology.

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

H. Katus, O. Müller, F. Weinberger, 2014, Nature Communications.

The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

A. Biggeri, D. Ward, C. D. dos Remedios, 2018, The Journal of general physiology.

S‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

D. Dobrev, S. Sadayappan, I. Wittig, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.

Pingbo Zhang, C. D. dos Remedios, J. V. Van Eyk, 2015, Journal of molecular and cellular cardiology.

Comparison of the effects of a truncating and a missense MYBPC3 mutation on contractile parameters of engineered heart tissue.

L. Carrier, A. Eder, T. Eschenhagen, 2016, Journal of molecular and cellular cardiology.

Low expression of the K280N TNNT2 mutation is sufficient to increase basal myofilament activation in human hypertrophy cardiomyopathy

C. D. dos Remedios, B. Knollmann, C. Redwood, 2022, Journal of molecular and cellular cardiology plus.

Triggering of the dsRNA Sensors TLR3, MDA5, and RIG-I Induces CD55 Expression in Synovial Fibroblasts

P. Tak, J. Hamann, P. Wijnker, 2012, PloS one.

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.

C. D. dos Remedios, J. van der Velden, P. Wijnker, 2013, American journal of physiology. Heart and circulatory physiology.

ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

C. D. dos Remedios, M. Michels, D. Kuster, 2015, Proceedings of the National Academy of Sciences.

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.

James B. Hu, P. Doevendans, J. Sluijter, 2020, Cell stem cell.

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.

D. Kuster, P. Wijnker, J. Velden, 2019, Antioxidants & redox signaling.

Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension

M. Goumans, M. Humbert, A. Casali, 2017, Circulation.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium

C. D. dos Remedios, F. Müller, W. Schmitz, 2011, Journal of Muscle Research and Cell Motility.

Protein phosphatase 2A affects myofilament contractility in non-failing but not in failing human myocardium Paul J. M. WijnkerPeter BoknikUlrich GergsFrank U. Muller • Joachim NeumannCris dos RemediosWilhelm SchmitzJurgen R. Sindermann • Ger J. M. StienenJolanda van der VeldenUwe Kirchhefer

P. Wijnker, J. Sindermann, 2011 .

Development of a 3-Dimensional Model to Study Right Heart Dysfunction in Pulmonary Arterial Hypertension: First Observations

M. Goumans, H. Bogaard, A. Llucià-Valldeperas, 2021, Cells.

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation.

Vasco Sequeira, C. D. dos Remedios, J. van der Velden, 2014, American journal of physiology. Heart and circulatory physiology.

NOX2, p22phox and p47phox are Targeted to the Nuclear Pore Complex in Ischemic Cardiomyocytes Colocalizing with Local Reactive Oxygen Species

W. Paulus, M. Fornerod, H. Niessen, 2011, Cellular Physiology and Biochemistry.

Troponin I phosphorylation in human myocardium in health and disease

J. van der Velden, P. Wijnker, G. Stienen, 2014, Netherlands Heart Journal.

Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

H. Katus, O. Müller, F. Weinberger, 2014, Nature Communications.

Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium–glucose cotransporter 2 inhibitors

C. Remme, J. van der Velden, C. Zuurbier, 2024, Cardiovascular research.