E. Koyama

发表

A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes.

K. Chiba, T. Ishizaki, T. Kawashiro, 1998, The Journal of pharmacology and experimental therapeutics.

Simple and sensitive determination of timolol in human plasma and urine by high-performance liquid chromatography with ultraviolet detection.

T. Ishizaki, E. Koyama, T. Yamada, 1990, Journal of chromatography.

Dual sorption model for the nonlinear percutaneous permeation kinetics of timolol.

E. H. Twizell, E H Twizell, E. Koyama, 1993, Journal of pharmaceutical sciences.

Skin irritation induced by topically applied timolol.

E. Koyama, K. Kubota, K. Yasuda, 1991, British journal of clinical pharmacology.

Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes.

K. Chiba, T. Ishizaki, H. Echizen, 1994, The Journal of pharmacology and experimental therapeutics.

Effects of genetic defects in the CYP2C19 gene on the N‐demethylation of imipramine, and clinical outcome of imipramine therapy

K. Chiba, T. Ishizaki, S. Morinobu, 1997, Psychiatry and clinical neurosciences.

Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans.

Norifumi Sakai, M. Ui, E. Koyama, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora.

M. Ui, E. Koyama, K. Kitazawa, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs.

T Ishizaki, K Chiba, K. Chiba, 1997, The Journal of pharmacology and experimental therapeutics.

An in vitro study on the metabolism and possible drug interactions of rokitamycin, a macrolide antibiotic, using human liver microsomes.

T. Ishizaki, X. J. Zhao, E. Koyama, 1999, Drug metabolism and disposition: the biological fate of chemicals.

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation.

K. Chiba, T. Ishizaki, E. Koyama, 1994, British journal of clinical pharmacology.

Simultaneous High‐Performance Liquid Chromatography‐Electrochemical Detection Determination of Imipramine, Desipramine, Their 2‐Hydroxylated Metabolites, and Imipramine N‐Oxide in Human Plasma and Urine: Preliminary Application to Oxidation Pharmacogenetics

K. Chiba, T. Ishizaki, E. Koyama, 1993, Therapeutic Drug Monitoring.

Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients.

K. Chiba, T. Ishizaki, S. Morinobu, 1996, Journal of clinical psychopharmacology.

Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S‐mephenytoin 4′‐hydroxylation

K. Chiba, T. Ishizaki, E. Koyama, 1995, Clinical pharmacology and therapeutics.

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.

K. Chiba, T. Ishizaki, E. Koyama, 1996, The Journal of pharmacology and experimental therapeutics.

A random walk method for percutaneous drug absorption pharmacokinetics: application to repeated administration of a therapeutic timolol patch.

E. Koyama, K Kubota, E Koyama, 1991, Journal of pharmaceutical sciences.