N. Sarapa

发表

Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers

Y. Pithavala, M. Garrett, B. Hee, 2010, Investigational New Drugs.

Unexpected pharmacokinetics of evofosfamide observed in phase III MAESTRO study.

N. Sarapa, J. Higgins, Jason Kim, 2018 .

Electrocardiographic Identification of Drug‐Induced QT Prolongation: Assessment by Different Recording and Measurement Methods

Borje Darpo, Nenad Sarapa, Wojciech Zareba, 2004, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Phase I study of anti-mesothelin antibody drug conjugate anetumab ravtansine (AR).

J. Nemunaitis, J. Bendell, K. Moore, 2016 .

Cardiac Safety Research Consortium: can the thorough QT/QTc study be replaced by early QT assessment in routine clinical pharmacology studies? Scientific update and a research proposal for a path forward.

M. Malik, P. Sager, C. Garnett, 2014, American heart journal.

The Application of Accelerator Mass Spectrometry to Absolute Bioavailability Studies in Humans: Simultaneous Administration of an Intravenous Microdose of 14C‐Nelfinavir Mesylate Solution and Oral Nelfinavir to Healthy Volunteers

Nenad Sarapa, R. C. Garner, N. Sarapa, 2005, Journal of clinical pharmacology.

Quality assessment of digital annotated ECG data from clinical trials by the FDA ECG warehouse

N. Sarapa, 2007, Expert opinion on drug safety.

Challenges of characterizing proarrhythmic risk due to QTc prolongation induced by nonadjuvant anticancer agents

N. Sarapa, M. Britto, 2008, Expert opinion on drug safety.

Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.

C. Garnett, F. Badilini, D. Karnad, 2014, British journal of clinical pharmacology.

Effect of rifampin on the pharmacokinetics of SU11248 in healthy volunteers

B. Houk, S. Misbah, J. Smeraglia, 2005 .

Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parameters.

Borje Darpo, Nenad Sarapa, Wojciech Zareba, 2003, Journal of electrocardiology.

Effect of axitinib on the QT interval in healthy volunteers

B. Houk, Y. Pithavala, M. Tortorici, 2015, Cancer Chemotherapy and Pharmacology.

Evaluation of the Effect of 5 QT‐Positive Drugs on the JTpeak Interval — An Analysis of ECGs From the IQ‐CSRC Study

W. Zareba, J. Couderc, J. Ferry, 2020, Journal of clinical pharmacology.

Novel Antibody Therapeutics Targeting Mesothelin In Solid Tumors

N. Sarapa, H. Dinter, B. Subramanyam, 2016, Clinical cancer drugs.

Clinical QTc Assessment in Oncology

N. Sarapa, M. Britto, 2016 .

Challenges of characterizing proarrhythmic risk due to QTc prolongation induced by nonadjuvant anticancer agents.

N. Sarapa, M. Britto, 2008, Expert opinion on drug safety.

Clinical Pharmacology Knowledge, Opportunities and Working Strengths (CPKNOWS): a competency model for pursuit of excellence in clinical pharmacology.

Michael G. M. Derks, K. Nieforth, B. Boutouyrie, 2013, British journal of clinical pharmacology.

Results From the IQ‐CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

C Garnett, N Sarapa, N. Stockbridge, 2015, Clinical pharmacology and therapeutics.

Lack of Effect of DX-619, a Novel Des-Fluoro(6)-Quinolone, on Glomerular Filtration Rate Measured by Serum Clearance of Cold Iohexol

R. Weitzman, Nanxiang Ge, N. Sarapa, 2007, Antimicrobial Agents and Chemotherapy.

The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor

N. Sarapa, K. Parivar, M. Britto, 2005, European Journal of Clinical Pharmacology.

Assessment of normal and tumor tissue uptake of MAG-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma

M. Rocchetti, P. Nygren, N. Sarapa, 2003, Cancer Chemotherapy and Pharmacology.

Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer.

Nenad Sarapa, Amita Joshi, René Bruno, 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody–Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors

J. Nemunaitis, J. Bendell, B. Childs, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Implications of methodological differences in digital electrocardiogram interval measurement.

F. Badilini, N. Sarapa, 2006, Journal of electrocardiology.

Pharmacokinetic Changes in Patients With Oedema

M. Huic, N. Sarapa, F. Plavšić, 1995, Clinical pharmacokinetics.

A phase I, randomized, open-label study of the multiple-dose pharmacokinetics of vemurafenib in patients with BRAFV600E mutation-positive metastatic melanoma

A. Joe, P. Munster, A. Daud, 2013, Cancer Chemotherapy and Pharmacology.

Detection of Clinically Significant QTc Prolongation in Phase I Studies in Healthy Participants: Comparison of 2 Semiautomated QT Measurement Methods

B. Tyl, N. Sarapa, S. Francom, 2009, Journal of clinical pharmacology.

Quantitative Performance of E‐Scribe Warehouse in Detecting Quality Issues With Digital Annotated ECG Data From Healthy Subjects

Nenad Sarapa, Justin L Mortara, Barry D Brown, 2008, Journal of clinical pharmacology.

Exploratory IND: a new regulatory strategy for early clinical drug development in the United States.

N Sarapa, N. Sarapa, 2007, Ernst Schering Research Foundation workshop.

Prediction of overall survival or progression free survival by disease control rate at week 8 is independent of ethnicity: Western versus Chinese patients with first‐line non‐small cell lung cancer treated with chemotherapy with or without bevacizumab

A. Joshi, N. Sarapa, R. Bruno, 2014, Journal of clinical pharmacology.

Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors

A. Tolcher, J. Nemunaitis, K. Bhalla, 2015, Cancer Chemotherapy and Pharmacology.

The IQ‐CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

Charles Benson, Borje Darpo, Nenad Sarapa, 2014, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Risk management and eligibility criteria for QTc assessment in patients with advanced cancer

H. Fingert, M. Varterasian, N. Sarapa, 2005 .

Valdecoxib, a COX‐2‐Specific Inhibitor, Does Not Affect Cardiac Repolarization

N. Sarapa, S. Cox, M. Britto, 2003, Journal of clinical pharmacology.

Impaired T‐Amplitude Adaptation to Heart Rate Characterizes IKr Inhibition in the Congenital and Acquired Forms of the Long QT Syndrome

A. Moss, W. Zareba, J. Couderc, 2007, Journal of cardiovascular electrophysiology.

Analyses of Dynamic Beat‐to‐Beat QT–TQ Interval (ECG Restitution) Changes in Humans under Normal Sinus Rhythm and Prior to an Event of Torsades de Pointes during QT Prolongation Caused by Sotalol

Nenad Sarapa, Fabio Badilini, Wojciech Zareba, 2007, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

Ritonavir 100 mg Does Not Cause QTc Prolongation in Healthy Subjects: A Possible Role as CYP3A Inhibitor in Thorough QTc Studies

N. Sarapa, D. Nickens, M. Amantea, 2008, Clinical pharmacology and therapeutics.

Comparison of QTinno, a fully automated electrocardiographic analysis program, to semiautomated electrocardiographic analysis methods in a drug safety study in healthy subjects.

P. Kowey, I. Gussak, L. Hadzievski, 2009, Journal of electrocardiology.

Investigating the effect of sotalol on the repolarization intervals in healthy young individuals.

Nenad Sarapa, Wojciech Zareba, Jean-Philippe Couderc, 2008, Journal of electrocardiology.

Contrasting Time‐ and Rate‐Based Approaches for the Assessment of Drug‐Induced QT Changes

F. Badilini, P. Maison-Blanche, A. Leenhardt, 2007, Journal of clinical pharmacology.

Comparison of QTinno, a fully automated electrocardiographic analysis program, to semiautomated electrocardiographic analysis methods in a drug safety study in healthy subjects.

P. Kowey, I. Gussak, L. Hadzievski, 2009, Journal of electrocardiology.

Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors

A. Tolcher, J. Nemunaitis, K. Bhalla, 2015, Cancer Chemotherapy and Pharmacology.