J. Smit

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Effect of CYP3A perpetrators on ibrutinib exposure in healthy participants

J. Murphy, J. Snoeys, R. de Vries, 2015, Pharmacology research & perspectives.

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

J. Schellens, J. Beijnen, J. Schellens, 2000, Journal of the National Cancer Institute.

MIDAZOLAM AND CYCLOSPORIN A METABOLISM IN TRANSGENIC MICE WITH LIVER-SPECIFIC EXPRESSION OF HUMAN CYP3A4

J. Schellens, J. Beijnen, A. V. van Herwaarden, 2005, Drug Metabolism and Disposition.

Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry

L. A. Fenu, Vikash K. Sinha, A. Peer, 2011, Clinical pharmacokinetics.

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.

Ji-Ying Song, Jos H Beijnen, H. Rosing, 2007, The Journal of clinical investigation.

Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia.

P. de Knijff, R. Frants, L. Havekes, 1990, Atherosclerosis.

(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

R. Boellaard, A. Windhorst, C. Molthoff, 2003, Nuclear medicine and biology.

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

J. Beijnen, P. Borst, A. Sparreboom, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Treatment of combined hyperlipidemia with fluvastatin and gemfibrozil, alone or in combination, does not induce muscle damage.

G. Jansen, T. D. de Bruin, D. Erkelens, 1995, The American journal of cardiology.

Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with ‘refractoriness to treatment’: a cohort study

F. Weerkamp, C. D. de Groot, O. Visser, 2019, BMC Pregnancy and Childbirth.

Combined hyperlipidemia is associated with increased exercise-induced muscle protein release which is improved by triglyceride-lowering intervention.

T. D. de Bruin, D. Erkelens, J. Smit, 1999, Metabolism: clinical and experimental.

A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with Advanced Solid Tumors

J. Camm, R. Plummer, R. Cowan, 2013, Clinical Cancer Research.

Studies on megakaryopoiesis in patients with myelodysplasia and idiopathic thrombocytopenic purpura

E. Vellenga, J. V. D. van der Want, J. Smit, 2008 .

Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs.

D. Meijer, A. Schinkel, J. Smit, 1998, The Journal of pharmacology and experimental therapeutics.

CD27 is heterogeneously expressed in multiple myeloma: low CD27 expression in patients with high‐risk disease

F. Zhan, J. Shaughnessy, E. Vellenga, 2003, British journal of haematology.

AL amyloidosis treated with induction chemotherapy with VAD followed by high dose melphalan and autologous stem cell transplantation

B. Hazenberg, E. Vellenga, P. L. Jager, 2002, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Involvement of p-glycoprotein in the biliary and intestinal excretion of amphiphilic drugs: MDR gene knock out studies

J. Smit, D. K. Meijer, P. Borst, 1996 .

Pharmacokinetics of paroxetine, a selective serotonin reuptake inhibitor, in Grey parrots (Psittacus erithacus erithacus): influence of pharmaceutical formulation and length of dosing.

E. V. van Maarseveen, J. Fink-Gremmels, J. Smit, 2013, Journal of veterinary pharmacology and therapeutics.

Effects of HMG-CoA reductase inhibitors on growth and differentiation of cultured rat skeletal muscle cells.

J. Veerkamp, J. Smit, A. Benders, 1996, Biochimica et biophysica acta.

The antiperinuclear factor. 1. The diagnostic significance of the antiperinuclear factor for rheumatoid arthritis.

C. Aaij, J. Smit, T. Feltkamp, 1979, Annals of the rheumatic diseases.

Paraformaldehyde fixation in immunofluorescence and immunoelectron microscopy. Preservation of tissue and cell surface membrane antigens.

J. Smit, F. Décary, T. Feltkamp-Vroom, 1974, Journal of immunological methods.

Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone

E. Vellenga, E. Berg, J. Smit, 1994, British journal of haematology.

The antiperinuclear factor: II. A light microscopical and immunofluorescence study on the antigenic substrate.

C. Aaij, J. Smit, T. Feltkamp, 1980, Annals of the rheumatic diseases.

Effects of simvastatin and cholestyramine on bile lipid composition and gall bladder motility in patients with hypercholesterolaemia.

P. Portincasa, K. V. van Erpecum, G. P. van Berge‐Henegouwen, 1995, Gut.

Successful dissolution of cholesterol gallstone during treatment with pravastatin.

K. V. van Erpecum, D. Erkelens, J. Smit, 1992, Gastroenterology.

Role of macrophage colony-stimulating factor in the differentiation and expansion of monocytes and dendritic cells from CD34+ progenitor cells

E. Vellenga, J. Smit, D. Hendriks, 1999, Medical oncology.

Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura.

E. Vellenga, J. V. D. van der Want, J. Smit, 2004, Blood.

Phase 1/1b Studies of UCB0599, an Oral Inhibitor of α‐Synuclein Misfolding, Including a Randomized Study in Parkinson's Disease

M. Bani, J. Smit, Stan Carson, 2022, Movement disorders : official journal of the Movement Disorder Society.

Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency.

G. Hammer, R. Auchus, J. Jiao, 2014, The Journal of clinical endocrinology and metabolism.

Interferon-α induction of lymphocytes containing parallel tubular structures

J. Smit, Y. Hoogeveen, N. Blom, 1988, Blut.

Heterozygous familial hypercholesterolaemia is associated with pathological exercise‐induced leakage of muscle proteins, which is not aggravated by simvastatin therapy

D. Erkelens, J. Smit, P. R. Bär, 1995, European journal of clinical investigation.

Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors

A. Schinkel, M. Huisman, J. Smit, 2000, AIDS.

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

Jos H Beijnen, J. Beijnen, N. Zelcer, 2002, AIDS.

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure.

O. van Tellingen, A. Schinkel, M. Huisman, 1999, The Journal of clinical investigation.

University of Groningen Studies on megakaryopoiesis in patients with myelodysplasia and idiopathic thrombocytopenic purpura Houwerzijl,

E. Vellenga, J. Smit, E. Houwerzijl, 2008 .

Mrp2 is essential for estradiol‐17β(β‐D ‐glucuronide)–induced cholestasis in rats

D. Meijer, J. Smit, Liyue Huang, 2000 .

Mrp2 is essential for estradiol-17beta(beta-D-glucuronide)-induced cholestasis in rats.

D. Meijer, L. Huang, J. Smit, 2000, Hepatology.

A comparison of the effects of simvastatin and pravastatin monotherapy on muscle histology and permeability in hypercholesterolaemic patients.

D. Erkelens, J. Smit, P. R. Bär, 1995, British journal of clinical pharmacology.

Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene

H. Koepsell, A. Schinkel, J. Jonker, 2001, Molecular and Cellular Biology.

Hb Fukuyama or alpha 2 beta(2)77(EF1)His----Tyr observed in an Indonesian female.

T. Huisman, J. Smit, J. B. Wilson, 1991, Hemoglobin.

Assessing Safety and Efficacy of Directed P-Glycoprotein Inhibition to Improve the Pharmacokinetic Properties of Saquinavir Coadministered with Ritonavir

J. Beijnen, A. Schinkel, M. Huisman, 2003, Journal of Pharmacology and Experimental Therapeutics.

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir.

J. Beijnen, A. Schinkel, M. Huisman, 2001, Molecular pharmacology.

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

D. Meijer, A. Schinkel, J. Smit, 1998, British journal of pharmacology.

Contribution of the murine mdr1a P‐glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption

D. Meijer, A. Schinkel, J. Smit, 1998, Hepatology.

Comparative pharmacokinetics and bioavailability of tapentadol following oral administration of immediate- and prolonged-release formulations.

J. Smit, R. Terlinden, J. Rengelshausen, 2013, International journal of clinical pharmacology and therapeutics.

Population Pharmacokinetics of Tapentadol Immediate Release (IR) in Healthy Subjects and Patients with Moderate or Severe Pain

J. Smit, P. Nandy, X. Xu, 2010, Clinical pharmacokinetics.

Effects of Acetaminophen, Naproxen, and Acetylsalicylic Acid on Tapentadol Pharmacokinetics: Results of Two Randomized, Open‐Label, Crossover, Drug‐Drug Interaction Studies

J. Smit, D. Upmalis, R. Terlinden, 2010, Pharmacotherapy.

Measurement of the collisional self-broadening of the cesium 6S 1/2→5D3/2 (689-nm) electric quadrupole transition

J. Smit, A. Andalkar, E. N. Fortson, 2004 .

The molecular basis for hepatobiliary transport of organic cations and organic anions.

G. Hooiveld, D. Meijer, P. Jansen, 1999, Pharmaceutical biotechnology.

6-Mercaptopurine, Still Valuable for the Palliative Treatment of Acute Myeloid Leukaemia

E. Vellenga, J. Smit, S. Daenen, 2001, Hematology.

Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications

J. Schellens, J. Beijnen, A. Schinkel, 2000, Annals of the New York Academy of Sciences.

Platelet production rate predicts the response to prednisone therapy in patients with idiopathic thrombocytopenic purpura

E. Vellenga, W. Sluiter, J. Smit, 2007, Annals of Hematology.

Phase 1b Study of Abiraterone Acetate Plus Prednisone and Docetaxel in Patients with Metastatic Castration-resistant Prostate Cancer.

D. Petrylak, E. Posadas, S. Tagawa, 2016, European urology.

Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level

D. Meijer, J. Smit, R. Oosting, 1998, British journal of pharmacology.

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan-Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors.

J. Tabernero, A. Italiano, J. Soria, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The effect of cyclosporine on haematological parameters in patients with paroxysmal nocturnal haemoglobinuria

E. Vellenga, J. Smit, G. V. van Imhoff, 1995, British journal of haematology.

Polymorphic mononuclear neutrophils CD64 index for diagnosis of sepsis in postoperative surgical patients and critically ill patients

J. Smit, B. Loef, P. McLaughlin, 2012, Clinical chemistry and laboratory medicine.

Health effects of therapeutic use of 131I in hyperthyroidism.

E. Pauwels, M. Bourguignon, J. Smit, 2000, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

Piet Borst, J. Beijnen, P. Borst, 1996, British journal of pharmacology.

EDITORIAL REVIEW: Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors

A. Schinkel, M. Huisman, J. Smit, 2022 .

In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity

J. Snoeys, A. Bernard, J. Jiao, 2016, Drug Metabolism and Disposition.

IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES TO ASSESS THE EFFECT OF ABIRATERONE ACETATE , ABIRATERONE , AND METABOLITES OF ABIRATERONE ON CYP 2 C 8 ACTIVITYa

J. Snoeys, A. Bernard, J. Jiao, 2016 .

Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study.

J. Friedberg, I. Flinn, Y. Oki, 2014, The Lancet. Oncology.

Stable isotope-labelled intravenous microdose for absolute bioavailability and effect of grapefruit juice on ibrutinib in healthy adults.

Juthamas Sukbuntherng, Jan Snoeys, L. D. De Zwart, 2016, British journal of clinical pharmacology.

Effects of alcohol consumption on pharmacokinetics, efficacy, and safety of fluvastatin.

T. D. de Bruin, D. Erkelens, J. Smit, 1995, The American journal of cardiology.

Cholesterol synthesis inhibitors in cholesterol gallstone disease.

J. Smit, G. P. vanBerge-Henegouwen, K. Vanerpecum, 1996, Scandinavian journal of gastroenterology. Supplement.

Predictive value of cord blood hematological indices and hemoglobin Barts for the detection of heterozygous alpha-thalassemia-2 in an African-Caribbean population.

M. Volmer, J. Smit, R. van Veen, 1999, Clinical chemistry.

Association between fluid management and dilutional coagulopathy in severe postpartum haemorrhage: a nationwide retrospective cohort study

F. Weerkamp, C. D. de Groot, O. Visser, 2018, BMC Pregnancy and Childbirth.

Gold probe choice in simultaneous detection of human lymphocyte surface antigens at the ultrastructural level.

J. Smit, Y. Hoogeveen, N. Blom, 1988, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Phase Ib study combining ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with CD20-positive B-cell non-Hodgkin lymphoma (NHL).

J. Friedberg, I. Flinn, Y. Oki, 2013 .

Transport mechanisms for cationic drugs and proteins in kidney, liver and intestine: implication for drug interactions and cell-specific drug delivery.

D. de Zeeuw, P. Meier, D. Meijer, 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Predicting Oral Clearance in Humans

L. A. Fenu, Luca A. Fenu, Stefan S. De Buck, 2008, Clinical pharmacokinetics.

Pharmacokinetic evaluation of tapentadol extended-release tablets in healthy subjects.

J. Smit, P. Zannikos, M. Etropolski, 2013, Journal of opioid management.

Basic haemoglobinopathy diagnostics in Dutch laboratories; providing an informative test result

E. Bakker, J. Smit, P. Giordano, 2013, International journal of laboratory hematology.

Excretory mechanisms for cationic drugs: role of p-glycoprotein and other organic cation transporters

J. Smit, 1997 .

In Vitro and In Vivo Drug-Drug Interaction Studies to Assess the Effect of Abiraterone Acetate, Abiraterone, and Metabolites of Abiraterone on CYP2C8 Activity

J. Snoeys, J. Jiao, J. Monbaliu, 2016, Drug Metabolism And Disposition.

The antiperinuclear factor. 1. The diagnostic significance of the antiperinuclear factor for rheumatoid arthritis.

C. Aaij, J. Smit, T. Feltkamp, 1979, Annals of the rheumatic diseases.

Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects

P. Reitmeir, J. Smit, D. Upmalis, 2012, PAIN®.

Rheumatoid arthritis associated with transient gamma 2-heavy chain disease

T. Ockhuizen, M. V. Leeuwen, J. Smit, 2004, Rheumatology International.

A biclonal origin of two monoclonal proteins, IgG3(kappa) and IgA1(lambda), from a single patient.

T. Ockhuizen, J. Smit, G. Steen, 1979, Immunology.