E. Joshi

发表

Improvement in ADMET Prediction with Multitask Deep Featurization.

Evan N. Feinberg, V. Pande, A. Cheng, 2020, Journal of medicinal chemistry.

2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton

T. Macdonald, E. Joshi, E. Joshi, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Development of LC-MS/MS-based receptor occupancy tracers and positron emission tomography radioligands for the nociceptin/orphanin FQ (NOP) receptor.

S. D. Kahl, D. Mudra, M. Statnick, 2012, Journal of medicinal chemistry.

Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

E. Nisenbaum, P. Zanotti-Fregonara, S. Zoghbi, 2012, European Journal of Nuclear Medicine and Molecular Imaging.

Prediction Accuracy of Production ADMET Models as a Function of Version: Activity Cliffs Rule

R. Sheridan, M. Tudor, E. Joshi, 2022, J. Chem. Inf. Model..

The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.

J. Metzger, K. Maloney, E. Joshi, 2017, Bioorganic & medicinal chemistry letters.

Efficiency gains in tracer identification for nuclear imaging: can in vivo LC-MS/MS evaluation of small molecules screen for successful PET tracers?

Thomas J. Raub, Stuart Morton, C. Mitch, 2014, ACS chemical neuroscience.

Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.

D. McKinzie, S. D. Kahl, J. Witkin, 2014, Journal of medicinal chemistry.

Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1).

Patrick J. Curran, Mee Ra Heo, M. Augustin, 2020, ACS medicinal chemistry letters.

Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas.

T. Macdonald, E. Joshi, A. M. Deveau, 2008, Bioorganic & medicinal chemistry letters.

Development of quantitative systems pharmacology and toxicology models within consortia: experiences and lessons learned through DILIsym development

Hugh A. Barton, Gary Eichenbaum, Brett A. Howell, 2016 .

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Talakad G. Lohith, L. Gantert, E. Hostetler, 2016, The Journal of Nuclear Medicine.

Discovery of 6-(Fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

Talakad G. Lohith, S. Melquist, L. Gantert, 2016, Journal of medicinal chemistry.

Discovery of a potent, dual serotonin and norepinephrine reuptake inhibitor.

Kirk W. Johnson, G. Stephenson, J. Shah, 2013, ACS medicinal chemistry letters.

In vitro metabolism of 2-acetylbenzothiophene: relevance to zileuton hepatotoxicity.

Elizabeth M Joshi, M. Chordia, T. Macdonald, 2004, Chemical research in toxicology.

Experimental error, kurtosis, activity cliffs, and methodology: What limits the predictivity of QSAR models?

Meir Glick, Robert P Sheridan, Yuting Xu, 2020, Journal of chemical information and modeling.

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.

Andreas Verras, Robert P Sheridan, J Christopher Culberson, 2017, Journal of medicinal chemistry.

Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.

M. Chordia, J. Linden, T. Macdonald, 2004, Bioorganic & medicinal chemistry letters.

Step Change Improvement in ADMET Prediction with PotentialNet Deep Featurization pdf

Vijay S. Pande, Alan C. Cheng, Robert Sheridan, 2019, ArXiv.