K. Blease

发表

Late Breaking Abstract - Evaluation of the JNK inhibitor, CC-90001, in a phase 1b pulmonary fibrosis trial

B. Bennett, P. Schafer, S. Greenberg, 2017 .

Bone induction by AdBMP-2/collagen implants.

K. Blease, R. Schreiber, A. Ambrosio, 2005, The Journal of bone and joint surgery. American volume.

Therapeutic use of chemokines.

S. Kunkel, A. Matsukawa, C. Hogaboam, 2000, Current pharmaceutical design.

IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2

S. Kunkel, C. Hogaboam, K. Blease, 2001, Inflammation Research.

Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus.

S. Kunkel, C. Hogaboam, K. Blease, 2002, American journal of physiology. Lung cellular and molecular physiology.

Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murine model of fungal asthma

S. Kunkel, C. Hogaboam, K. Blease, 2000, Inflammation Research.

Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury.

K. Blease, D. Nikolic-Paterson, F. Ma, 2016, The American journal of pathology.

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Y. Satoh, B. Bennett, D. Giegel, 2012, Bioorganic & medicinal chemistry letters.

Delivery of FGF genes to wound repair cells enhances arteriogenesis and myogenesis in skeletal muscle.

L. Chandler, K. Blease, G. Pierce, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis

K. Blease, D. Nikolic-Paterson, F. Ma, 2011, Laboratory Investigation.

Targeting kinases in asthma

K. Blease, 2005, Expert opinion on investigational drugs.

Lipoteichoic acid inhibits lipopolysaccharide-induced adhesion molecule expression and IL-8 release in human lung microvascular endothelial cells.

K. Blease, P. Hellewell, A. Burke-Gaffney, 1999, Journal of immunology.

Human Lung Microvascular Endothelial Molecule Expression and IL-8 Release in Lipopolysaccharide-Induced Adhesion Lipoteichoic Acid inhibits

K. Blease, Yan Chen, P. Hellewell, 1999 .

TNF-α Potentiates C5a-Stimulated Eosinophil Adhesion to Human Bronchial Epithelial Cells: A Role for α5β1 Integrin1

K. Blease, P. Hellewell, A. Hartnell, 2002, The Journal of Immunology.

CXCR2 Is Necessary for the Development and Persistence of Chronic Fungal Asthma in Mice1

C. Hogaboam, K. Blease, J. Schuh, 2002, The Journal of Immunology.

Expression and Functional Consequences of Cytokine- or Lipopolysaccharide-Induced Adhesion Molecule Expression on Human Lung Microvascular Endothelial Cells

K. Blease, P. Hellewell, A. Burke-Gaffney, 1998 .

Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells.

I. Adcock, K. Blease, P. Hellewell, 1998, American journal of respiratory cell and molecular biology.

Chemokines and their role in airway hyper-reactivity

S. Kunkel, C. Hogaboam, K. Blease, 2000, Respiratory research.

Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2−/− Mice1

T. Standiford, S. Kunkel, C. Hogaboam, 2000, The Journal of Immunology.

The role of CC chemokine receptor 5 (CCR5) and RANTES/CCL5 during chronic fungal asthma in mice1

C. Hogaboam, K. Blease, J. Schuh, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus.

T. Standiford, S. Kunkel, C. Hogaboam, 2000, The American journal of pathology.

Intrapulmonary targeting of RANTES/CCL5‐responsive cells prevents chronic fungal asthma

H. Brühl, M. Mack, C. Hogaboam, 2003, European Journal of Immunology.

Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma1

J. Westwick, S. Kunkel, C. Hogaboam, 2001, The Journal of Immunology.

Integrin 1 β 5 α Cells : A Role for Adhesion to Human Bronchial Epithelial Potentiates C 5 a-Stimulated Eosinophil

K. Blease, P. Hellewell, A. Hartnell, 2002 .

Fungal-Induced Allergic Airway Disease in IL-13 Fusion Cytotoxin Ameliorates Chronic

R. Puri, C. Hogaboam, K. Blease, 2013 .

IL-13 Fusion Cytotoxin Ameliorates Chronic Fungal-Induced Allergic Airway Disease in Mice1

R. Puri, B. Joshi, C. Hogaboam, 2001, The Journal of Immunology.

Modulation of cell adhesion molecule expression and function on human lung microvascular endothelial cells by inhibition of phosphodiesterases 3 and 4

K. Blease, P. Hellewell, A. Burke-Gaffney, 1998, British journal of pharmacology.

MicePersistence of Chronic Fungal Asthma in CXCR2 Is Necessary for the Development and

C. Hogaboam, K. Blease, J. Schuh, 2002 .

Airway Remodeling Is Absent in CCR1−/− Mice During Chronic Fungal Allergic Airway Disease1

T. Standiford, S. Kunkel, C. Hogaboam, 2000, The Journal of Immunology.

Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma.

R. Puri, M. Kaplan, S. Kunkel, 2002, The American journal of pathology.

Emerging treatments for asthma

K. Blease, H. Raymon, A. Lewis, 2003, Expert opinion on emerging drugs.

Antifungal and Airway Remodeling Roles for Murine Monocyte Chemoattractant Protein-1/CCL2 During Pulmonary Exposure to Asperigillus fumigatus Conidia1

T. Standiford, S. Kunkel, C. Hogaboam, 2001, The Journal of Immunology.

Type 1/type 2 cytokine paradigm and the progression of pulmonary fibrosis.

S. Kunkel, C. Hogaboam, S. Chensue, 2001, Chest.

Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs

D. Brenner, J. Lachowicz, A. Gurney, 2020, PloS one.

Small molecule inhibitors of cell signaling: novel future therapeutics for asthma and chronic obstructive pulmonary diseases.

K. Blease, H. Raymon, 2003, Current opinion in investigational drugs.

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.

P. Schafer, K. Blease, J. Leisten, 2009, Journal of medicinal chemistry.

Conidia Asperigillus fumigatus to Protein-1 / CCL 2 During Pulmonary Exposure Murine Monocyte Chemoattractant Antifungal and Airway Remodeling Roles for Kunkel

T. Standiford, S. Kunkel, C. Hogaboam, 2001 .

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Chin-Chun Lu, L. Hamann, M. Rolfe, 2018, Nature Chemical Biology.

The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

R. Owens, M. Merriman, P. Hughes, 1996, British journal of pharmacology.

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.

Philip Chamberlain, Y. Satoh, B. Bennett, 2012, Bioorganic & medicinal chemistry letters.

SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma

M. Kersten, A. Kater, J. Guikema, 2022, Molecular oncology.

Chemokines and cytokines: axis and allies in asthma and allergy.

S. Kunkel, C. Hogaboam, K. Blease, 2003, Cytokine & growth factor reviews.

Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001.

Y. Satoh, B. Bennett, D. Mortensen, 2021, Journal of medicinal chemistry.

A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney.

K. Blease, D. Nikolic-Paterson, F. Ma, 2016, Life sciences.

Cytokines and chemokines in allergic bronchopulmonary aspergillosis (ABPA) and experimental Aspergillus-induced allergic airway or asthmatic disease.

C. Hogaboam, K. Blease, J. Schuh, 2003, Frontiers in bioscience : a journal and virtual library.

Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005.

E. Hur, Lisa Morrison, B. Bennett, 2021, Journal of medicinal chemistry.

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

K. Blease, D. Nikolic-Paterson, F. Ma, 2015, International journal of experimental pathology.

A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation

K. Miyazawa, B. Bennett, L. LeBrun, 2016, PloS one.