J. Trias

发表

Peptide Deformylase in Staphylococcus aureus: Resistance to Inhibition Is Mediated by Mutations in the Formyltransferase Gene

P. Margolis, C. Hackbarth, D. Young, 2000, Antimicrobial Agents and Chemotherapy.

Varespladib (A-002), a Secretory Phospholipase A2 Inhibitor, Reduces Atherosclerosis and Aneurysm Formation in ApoE−/− Mice

Heather L Rick, J. Trias, P. Eacho, 2009, Journal of cardiovascular pharmacology.

N- and C-terminal modifications of negamycin.

Sampathkumar Anandan, D. Patel, C. Hackbarth, 2003, Bioorganic & medicinal chemistry letters.

Specificity of the glucose channel formed by protein D1 of Pseudomonas aeruginosa.

H. Nikaido, J. Trias, E. Rosenberg, 1988, Biochimica et biophysica acta.

Permeability of the cell wall of Mycobacterium smegmatis

R. Benz, J. Trias, Joaquim Trias, 1994, Molecular microbiology.

Evidence of Segregation of a Quinolone Antibiotic in Dipalmitoylphosphatidylcholine Environment

J. Trias, K. Keough, J. Hernández-Borrell, 1996 .

Neutrophil chemotaxis by pathogen‐associated molecular patterns – formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus

R. Landmann, S. A. Kristian, G. Matteoli, 2006, Cellular microbiology.

Novel oxazolidinone-quinolone hybrid antimicrobials.

J. Gage, C. Parker, D. Patel, 2003, Bioorganic & medicinal chemistry letters.

Varespladib methyl in cardiovascular disease

R. Rosenson, J. Trias, H. Fraser, 2010, Expert opinion on investigational drugs.

Characterization of the channel formed by the mycobacterial porin in lipid bilayer membranes. Demonstration of voltage gating and of negative point charges at the channel mouth.

R. Benz, J. Trias, 1993, The Journal of biological chemistry.

Alpha-substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents.

D. Chen, Z. Yuan, R. Jain, 2003, Bioorganic & medicinal chemistry letters.

Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue.

Masahiro Wakao, J. Ellman, J. Trias, 2003, Bioorganic & medicinal chemistry letters.

Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane

H. Nikaido, N. Masuda, J. Trias, 1993, Antimicrobial Agents and Chemotherapy.

Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem

V. Jarlier, J. Trias, E. Cambau, 1995, Antimicrobial agents and chemotherapy.

Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications.

E. Gordon, Shaoqing Chen, S. Donadio, 2003, Bioorganic & medicinal chemistry letters.

6-Fluoroquinolone–liposome interactions: fluorescence quenching study using iodide

J. Trias, J. Hernández-Borrell, M. Montero, 1998 .

Porins in the cell wall of mycobacteria.

R. Benz, V. Jarlier, J. Trias, 1992, Science.

Varespladib Inhibits Secretory Phospholipase A2 in Bronchoalveolar Lavage of Different Types of Neonatal Lung Injury

G. Conti, E. Capoluongo, J. Trias, 2012, Journal of clinical pharmacology.

Mining bacterial cell wall biosynthesis with new tools: multitarget screens.

Zhengyu Yuan, J. Trias, 1999, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Brown pigmentation in Serratia marcescens cultures associated with tyrosine metabolism.

J. Guinea, M. Viñas, J. Trias, 1989, Canadian journal of microbiology.

Induction of Yellow Pigmentation in Serratia marcescens

J. Guinea, J. Trias, Joaquim Trias, 1988, Applied and environmental microbiology.

Deformylase as a novel antibacterial target.

Z. Yuan, R. White, Zhengyu Yuan, 2001, Drug discovery today.

New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.

D. Patel, C. Hackbarth, Zhengyu Yuan, 2003, Bioorganic & medicinal chemistry letters.

Innovative approaches to novel antibacterial drug discovery.

E. Gordon, J. Trias, 1997, Current opinion in biotechnology.

Outer membrane protein D2 catalyzes facilitated diffusion of carbapenems and penems through the outer membrane of Pseudomonas aeruginosa

H. Nikaido, J. Trias, 1990, Antimicrobial Agents and Chemotherapy.

In vitro antistaphylococcal activity of dalbavancin, a novel glycopeptide.

C. Hackbarth, J. Trias, B. Goldstein, 2005, The Journal of antimicrobial chemotherapy.

N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

J. Koehn, D. Patel, P. Margolis, 2002, Antimicrobial Agents and Chemotherapy.

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.

Z. Ni, D. Chen, Z. Yuan, 2000, Biochemistry.

The role of combichem in antibiotic discovery.

J. Trias, 2001, Current opinion in microbiology.

Lack of additive effect between mechanisms of resistance to carbapenems and other beta-lactam agents inPseudomonas aeruginosa

V. Jarlier, J. Trias, C. Dib, 1995, European Journal of Clinical Microbiology and Infectious Diseases.

Protein D2 channel of the Pseudomonas aeruginosa outer membrane has a binding site for basic amino acids and peptides.

H. Nikaido, J. Trias, 1990, The Journal of biological chemistry.

Isolation from urine of two Serratia marcescens strains excreting a diffusible yellow pigment.

J. Guinea, M. Viñas, J. Trias, 1987, Journal of general microbiology.

Conformationally restricted analogs of deoxynegamycin.

Shihai Gu, Sampathkumar Anandan, D. Patel, 2004, Bioorganic & medicinal chemistry letters.

Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitumβ‐lactamase genes cloned from a natural isolate and a high‐level β‐lactamase producer

J. Frère, B. Joris, G. Orefici, 1994, Molecular microbiology.

Diffusion of beta-lactam antibiotics into proteoliposomes reconstituted with outer membranes of isogenic imipenem-susceptible and -resistant strains of Enterobacter cloacae.

L. Gutmann, J. Trias, E. Collatz, 1992, Journal of general microbiology.

Regulation of the alpha-galactosidase activity in Streptococcus pneumoniae: characterization of the raffinose utilization system.

C. Rosenow, J. Trias, M. Maniar, 1999, Genome research.

Targeting metalloenzymes: a strategy that works.

P. Margolis, Zhengyu Yuan, Richard J. White, 2003, Current opinion in pharmacology.

A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs

M. Fernández, J. Trias, H. Fraser, 2009, BMC cardiovascular disorders.

Decreased outer membrane permeability in imipenem-resistant mutants of Pseudomonas aeruginosa

H. Nikaido, J. Trias, R. Lévesque, 1989, Antimicrobial Agents and Chemotherapy.

Peptide Deformylase Inhibitors as Antibacterial Agents: Identification of VRC3375, a Proline-3-Alkylsuccinyl Hydroxamate Derivative, by Using an Integrated Combinatorial and Medicinal Chemistry Approach

Z. Ni, D. Chen, Z. Yuan, 2004, Antimicrobial Agents and Chemotherapy.

A method for the enrichment of auxotrophic mutants of Serratia marcescens with the antibiotic azthreonam

J. Guinea, J. Trias, M. Viñas, 1987 .

Novel antibacterial azetidine lincosamides.

Wen Wang, J. Trias, M. Gordeev, 2008, Bioorganic & medicinal chemistry letters.

D-Ala-D-lac binding is not required for the high activity of vancomycin dimers against vancomycin resistant enterococci.

J. Ellman, R. Jain, J. Trias, 2003, Journal of the American Chemical Society.

Resistance of Streptococcus pneumoniaeto Deformylase Inhibitors Is Due to Mutations indefB

P. Margolis, C. Hackbarth, Wen Wang, 2001, Antimicrobial Agents and Chemotherapy.

Resistance of Streptococcus pneumoniaeto Deformylase Inhibitors Is Due to Mutations indefB

P. Margolis, C. Hackbarth, Wen Wang, 2001, Antimicrobial Agents and Chemotherapy.