C. Lerner

发表

Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure

P. Hajduk, K. Longenecker, V. Stoll, 2005, Protein Science.

Structure-activity relationships of novel potent MurF inhibitors.

David D. Anderson, P. Hajduk, R. Clark, 2004, Bioorganic & medicinal chemistry letters.

An Ultraefficient Affinity-Based High-Throughout Screening Process: Application to Bacterial Cell Wall Biosynthesis Enzyme MurF

K. Comess, Hua Tang, D. Burns, 2006, Journal of biomolecular screening.

Structure‐based Optimization of MurF Inhibitors

David D. Anderson, P. Hajduk, K. Longenecker, 2006, Chemical biology & drug design.

ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens.

Renaldo Mendoza, Jun Chen, P. Hajduk, 2005, Journal of the American Chemical Society.

Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.

Jean M. Severin, Rolf Wagner, Vincent S Stoll, 2004, Journal of medicinal chemistry.

Pleiotropic changes resulting from depletion of Era, an essential GTP‐binding protein in Escherichia coli

M. Inouye, C. Lerner, 1991, Molecular microbiology.

Novel Antibacterial Class

Xiaoan Ruan, N. Soni, Philip J. Merta, 2003, Antimicrobial Agents and Chemotherapy.

The Escherichia coli Ras-like protein (Era) has GTPase activity and is essential for cell growth.

M. Inouye, J. Ahnn, C. Lerner, 1988, Oncogene.

High Throughput Screen for Inhibitors of Bacterial DNA Topoisomerase I Using the Scintillation Proximity Assay

X. Xuei, C. Lerner, A. Mackinnon, 1996 .

Isolation of subtilisin pro-sequence mutations that affect formation of active protease by localized random polymerase chain reaction mutagenesis.

M. Inouye, T. Kobayashi, C. Lerner, 1990, The Journal of biological chemistry.

Synthesis of yeast cell wall glucan and evidence for glucan metabolism in a Saccharomyces cerevisiae whole cell system.

R. Goldman, C. Lerner, M. Coen, 1994, Microbiology.

DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones

C. Lerner, A. Saiki, C. Chen, 1999, Antimicrobial Agents and Chemotherapy.

Localized random polymerase chain reaction mutagenesis.

M. Inouye, C. Lerner, 1994, Methods in molecular biology.

Bacillus subtilis Pyrimidine Biosynthetic (pyr)

R. Switzer, C. Lerner, B. T. Stephenson, 2022 .

Structure oftheBacillus subtilis Pyrimidine Biosynthetic (pyr) GeneCluster

C. Lerner, B. T. Stephenson, 1987 .

Stimuli that induce production of Candida albicans extracellular aspartyl proteinase.

C. Lerner, R. Goldman, Claude G. Lerner, 1993, Journal of general microbiology.

Application of a fluorogenic substrate in the assay of proteolytic activity and in the discovery of a potent inhibitor of Candida albicans aspartic proteinase.

C. Lerner, J. Capobianco, R. Goldman, 1992, Analytical biochemistry.

Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.

N. Soni, R. Clark, Y. Gu, 2004, Bioorganic & medicinal chemistry letters.

Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency

Xiaoan Ruan, Philip J. Merta, C. Lerner, 2005, Antimicrobial Agents and Chemotherapy.

Low copy number plasmids for regulated low-level expression of cloned genes in Escherichia coli with blue/white insert screening capability.

M. Inouye, C. Lerner, M Inouye, 1990, Nucleic acids research.

Nucleoside diphosphate kinase from Escherichia coli; its overproduction and sequence comparison with eukaryotic enzymes.

S. Inouye, M. Inouye, C. Lerner, 1991, Gene.

Location of the gene (ndk) for nucleoside diphosphate kinase on the physical map of the Escherichia coli chromosome

S. Inouye, M. Inouye, C. Lerner, 1991, Journal of bacteriology.

Cold-sensitive conditional mutations in Era, an essential Escherichia coli GTPase, isolated by localized random polymerase chain reaction mutagenesis.

M. Inouye, C. Lerner, P. Gulati, 1995, FEMS microbiology letters.

Characterization of the autophosphorylation of Era, an essential Escherichia coli GTPase

M. Inouye, T. Shimamoto, C. Lerner, 1994, Molecular microbiology.

From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae

P. Hajduk, K. Comess, Liping Yu, 2007, Chemical biology & drug design.

Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity

M. Inouye, C. Lerner, P. March, 1995, Journal of bacteriology.

Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae

Liping Yu, J. Mack, C. Lerner, 2003, Protein science : a publication of the Protein Society.

Cold-sensitive growth and decreased GTP-hydrolytic activity from substitution of Pro17 for Val in Era, an essential Escherichia coli GTPase

M. Inouye, J. Ahnn, C. Lerner, 1992 .

Cold-sensitive growth and decreased GTP-hydrolytic activity from substitution of Pro17 for Val in Era, an essential Escherichia coli GTPase.

M. Inouye, J. Ahnn, C. Lerner, 1992, FEMS Microbiology Letters.

Solution structure and function of a conserved protein SP14.3 encoded by an essential Streptococcus pneumoniae gene.

A. Gunasekera, E. Olejniczak, S. Fesik, 2001, Journal of molecular biology.

Antibacterial drug discovery in the post-genomics era.

C. Lerner, B. Beutel, 2002, Current drug targets. Infectious disorders.

A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic Resonance-Based Screening

P. Hajduk, Xiaoan Ruan, S. Fesik, 2002, Journal of biomolecular screening.

A Strategy for Discovery of Novel Broad-Spectrum Antibacterials Using a High-Throughput Streptococcus pneumoniae Transcription/Translation Screen

L. Traphagen, U. Warrior, N. Soni, 2004, Journal of biomolecular screening.

Structure of the Bacillus subtilis pyrimidine biosynthetic (pyr) gene cluster

R. Switzer, C. Lerner, B. T. Stephenson, 1987, Journal of bacteriology.

Cloning and structure of the Bacillus subtilis aspartate transcarbamylase gene (pyrB).

R. Switzer, C. Lerner, 1986, The Journal of biological chemistry.

Resonance-Based Screening A Strategy for High-Throughput Assay Development Using Leads Derived from Nuclear Magnetic

P. Hajduk, Xiaoan Ruan, S. Fesik, 2013 .