A. Zega

发表

5‐Benzylidenethiazolidin‐4‐ones as Multitarget Inhibitors of Bacterial Mur Ligases

S. Turk, S. Grdadolnik, M. Filipič, 2010, ChemMedChem.

Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.

C. Contreras-Martel, D. Patin, D. Blanot, 2011, ACS medicinal chemistry letters.

Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.

S. Turk, D. Patin, D. Blanot, 2010, Journal of medicinal chemistry.

Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).

C. Contreras-Martel, D. Blanot, A. Dessen, 2011, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of N‐Acylhydrazones as Inhibitors of MurC and MurD Ligases

I. Chopra, J. Bostock, D. Blanot, 2008, ChemMedChem.

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.

B. Joris, S. Grdadolnik, C. Contreras-Martel, 2011, European journal of medicinal chemistry.

NMR Methods for Identification of False Positives in Biochemical Screens.

A. Zega, 2017, Journal of medicinal chemistry.

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.

C. Pál, T. Révész, Ž. Skok, 2019, European journal of medicinal chemistry.

Data on biosynthesis of BPAF glucuronide, enzyme kinetics of BPAF glucuronidation, and molecular modeling

M. Finel, T. Tomašič, A. Zega, 2018, Data in brief.

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

C. Stevenson, D. Lawson, Ž. Skok, 2020, ACS medicinal chemistry letters.

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

J. Mainardi, S. Magnet, M. Arthur, 2013, European journal of medicinal chemistry.

Evaluation of endocrine activities of ellagic acid and urolithins using reporter gene assays.

T. Tomašič, A. Zega, Lucija Peterlin Mašič, 2019, Chemosphere.

Design and structure-activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization.

T. Šolmajer, A. Zega, D. Kikelj, 2001, Bioorganic & medicinal chemistry.

Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited

C. Contreras-Martel, D. Blanot, A. Dessen, 2016, PloS one.

Kinetic mechanism of Enterococcus faeciumd-aspartate ligase.

J. Mainardi, S. Magnet, D. Blanot, 2019, Biochimie.

New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors.

J. Ilaš, T. Tomašič, Nace Zidar, 2019, MedChemComm.

Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks

J. Ilaš, I. Kovačević, D. Secci, 2021, ACS omega.

Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite.

M. Finel, A. Carino, S. Marchianò, 2019, Chemosphere.

Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models.

A. Zega, U. Urleb, M. Božič, 2005, Thrombosis and haemostasis.

Metabolism-directed optimisation of antithrombotics: the prodrug principle.

J. César, A. Zega, L. Peterlin-Mašič, 2006, Current pharmaceutical design.

Azapeptides as pharmacological agents.

A. Zega, 2005, Current medicinal chemistry.

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.

Ž. Skok, J. Ilaš, T. Tomašič, 2020, Bioorganic chemistry.

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

Stanislav Gobec, Christopher Randall, Martina Hrast, 2012, PloS one.

Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery

J. Ilaš, T. Tomašič, Nace Zidar, 2020, ACS omega.

Catalytic Stereoconvergent Synthesis of Homochiral β-CF3, β-SCF3, and β-OCF3 Benzylic Alcohols

Pavel A. Dub, T. Tomašič, A. Zega, 2022, ACS organic & inorganic Au.

Molecular interactions of 1,4-dihydropyridine derivatives with selected organic solvents : A volumetric, spectroscopic and computational study

S. Srčič, J. Mavri, A. Zega, 2008 .

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

C. Pál, T. Révész, Ž. Skok, 2020, Pharmaceutics.

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

C. Pál, Ž. Skok, J. Ilaš, 2019, ChemMedChem.

Identification of Herbarium Whole‐Leaf Samples of Epilobium Species by ATR‐IR Spectroscopy

S. Kreft, A. Zega, Simona Strgulc Krajšek, 2008, Chemistry & biodiversity.

Rational design of balanced dual-targeting antibiotics with limited resistance

C. Pál, T. Révész, B. Kintses, 2020, PLoS biology.

Thrombin inhibitors built on an azaphenylalanine scaffold.

T. Šolmajer, A. Zega, U. Urleb, 2004, Bioorganic & medicinal chemistry letters.

ATP-binding site of bacterial enzymes as a target for antibacterial drug design.

T. Tomašič, A. Zega, L. P. Mašič, 2011, Journal of medicinal chemistry.

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

L. Pardo, J. Tytgat, S. Peigneur, 2021, Medicinal research reviews.

Applicability of the OECD 455 in-vitro assay for determination of hERa agonistic activity of isoflavonoids.

P. Horký, P. Mladěnka, A. Zega, 2019, Toxicology and applied pharmacology.

Shape optimization and characterization of polysaccharide beads prepared by ionotropic gelation

M. Bogataj, O. Planinšek, A. Mrhar, 2008 .

Evaluation of Michael-type acceptor reactivity of 5-benzylidenebarbiturates, 5-benzylidenerhodanines, and related heterocycles using NMR.

J. Plavec, T. Tomašič, Nace Zidar, 2014, Acta Chimica Slovenica.

Azaphenylalanine-based serine protease inhibitors induce caspase-mediated apoptosis.

Tina Batista Napotnik, I. Mlinarič-Raščan, A. Zega, 2009, European journal of pharmacology.

Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases

S. Grdadolnik, D. Patin, H. Barreteau, 2019, Journal of enzyme inhibition and medicinal chemistry.

New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.

C. Contreras-Martel, D. Patin, D. Blanot, 2011, European journal of medicinal chemistry.

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents

J. Ilaš, T. Tomašič, Nace Zidar, 2019, Expert opinion on therapeutic patents.

Second generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.

C. Pál, R. Enriz, Ž. Skok, 2020, Future medicinal chemistry.

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Guido V. Janssen, C. Pál, L. Pardo, 2023, Journal of medicinal chemistry.

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Guido V. Janssen, B. Birnir, C. Stevenson, 2023, Journal of medicinal chemistry.

New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

C. Pál, T. Révész, Ž. Skok, 2021, European journal of medicinal chemistry.

Surface analysis of powder binary mixtures with ATR FTIR spectroscopy.

O. Planinšek, S. Srčič, A. Zega, 2006, International journal of pharmaceutics.

False positives in the early stages of drug discovery.

Stanislav Gobec, S. Gobec, A. Zega, 2010, Current medicinal chemistry.

Hydrogen-Bonding Ability of Noyori–Ikariya Catalysts Enables Stereoselective Access to CF3-Substituted syn-1,2-Diols via Dynamic Kinetic Resolution

M. Huš, A. Zega, Matic Lozinšek, 2023, ACS catalysis.

Simple and effective preparation of amino sulfonylureas from amino acids: application to the synthesis of amino sulfonylurea-containing peptidomimetics

A. Zega, R. Šink, 2008 .

Direct thrombin inhibitors built on the azaphenylalanine scaffold provoke degranulation of mast cells

A. Zega, M. Oblak, U. Urleb, 2006, Thrombosis and Haemostasis.

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates.

Ž. Skok, J. Ilaš, T. Tomašič, 2019, Bioorganic chemistry.

ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.

Ž. Skok, J. Ilaš, T. Tomašič, 2023, European journal of medicinal chemistry.

Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens

D. Lawson, M. Czikkely, J. Ilaš, 2023, ACS Omega.