D. Kikelj

发表

5‐Benzylidenethiazolidin‐4‐ones as Multitarget Inhibitors of Bacterial Mur Ligases

S. Turk, S. Grdadolnik, M. Filipič, 2010, ChemMedChem.

Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.

C. Contreras-Martel, D. Patin, D. Blanot, 2011, ACS medicinal chemistry letters.

Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.

S. Turk, D. Patin, D. Blanot, 2010, Journal of medicinal chemistry.

Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).

C. Contreras-Martel, D. Blanot, A. Dessen, 2011, Journal of medicinal chemistry.

Virtual screening for potential inhibitors of bacterial MurC and MurD ligases

G. Klebe, D. Blanot, Andreja Kovač, 2012, Journal of Molecular Modeling.

Novel potent and selective thrombin inhibitors based on a central 1,4-benzoxazin-3(4H)-one scaffold.

J. Ilaš, T. Tomašič, D. Kikelj, 2008, Journal of medicinal chemistry.

An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.

C. Pál, T. Révész, Ž. Skok, 2019, European journal of medicinal chemistry.

A New Cell‐Based AI‐2‐Mediated Quorum Sensing Interference Assay in Screening of LsrK‐Targeted Inhibitors

J. Ilaš, M. Anderluh, T. Tomašič, 2020, Chembiochem : a European journal of chemical biology.

Antimicrobial Activity of the Marine Alkaloids, Clathrodin and Oroidin, and Their Synthetic Analogues

Danijel Kikelj, Päivi Tammela, J. Ilaš, 2014, Marine drugs.

Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

C. Stevenson, D. Lawson, Ž. Skok, 2020, ACS medicinal chemistry letters.

Linker-switch approach towards new ATP binding site inhibitors of DNA gyrase B.

J. Ilaš, M. Anderluh, D. Kikelj, 2017, European journal of medicinal chemistry.

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.

J. Tytgat, J. Ilaš, S. Peigneur, 2017, European journal of medicinal chemistry.

Chemistry of 2‐Aminoimidazoles

J. Ilaš, D. Kikelj, Aleš Žula, 2016 .

Synthetic analogues of marine alkaloid clathrodin differently induce phosphatidylserine exposure in monocytic cancer cells then in cancer stem cell lines

C. Muller, T. Tomašič, Nace Zidar, 2016 .

N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation.

J. Ilaš, T. Šolmajer, T. Tomašič, 2015, Journal of medicinal chemistry.

A convenient strategy for synthesizing the Agelas alkaloids clathrodin, oroidin, and hymenidin and their (un)saturated linker analogs

J. Ilaš, D. Kikelj, Aleš Žula, 2014 .

Inhibition of biofilm formation by conformationally constrained indole-based analogues of the marine alkaloid oroidin.

G. Węgrzyn, J. Ilaš, M. Łoś, 2014, Bioorganic & medicinal chemistry letters.

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators.

D. Madge, J. Tytgat, J. Ilaš, 2014, European journal of medicinal chemistry.

Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells

J. Kos, Nace Zidar, D. Kikelj, 2014, Neuropharmacology.

Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P(1)-arginine mimetics.

A. Kranjc, D. Kikelj, L. P. Mašič, 2005, European journal of medicinal chemistry.

Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90.

L. Naesens, S. Liekens, T. Tomašič, 2020, Bioorganic chemistry.

Enantiomers of 2‐methyl‐ and 2,4‐dimethyl‐3‐oxo‐3,4‐dihydro‐2H‐1,4‐benzoxazine‐2‐carboxylic acid: Preparation by resolution, determination of absolute configuration, and Curtius rearrangement

D. Kikelj, I. Leban, Alenka Rutar, 1998 .

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

T. Tomašič, D. Kikelj, Lucija Peterlin Mašič, 2019, Medicinal research reviews.

Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism.

P. Dunkel, P. Mátyus, J. Ilaš, 2013, European journal of medicinal chemistry.

Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores.

J. Ilaš, D. Kikelj, U. Trstenjak, 2013, European journal of medicinal chemistry.

Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities.

D. Hadjipavlou-Litina, J. Ilaš, D. Kikelj, 2011, Bioorganic & Medicinal Chemistry Letters.

3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function.

J. Ilaš, D. Kikelj, M. Stegnar, 2008, Journal of medicinal chemistry.

Peptides and pseudopeptides incorporating D‐Phe–Pro–Arg and Arg–Gly–Asp lead sequences as potential antithrombotic agents

J. Ilaš, F. Hudecz, D. Kikelj, 2008, Journal of peptide science : an official publication of the European Peptide Society.

Utility of PFA-100 closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro.

M. Dolenc, D. Kikelj, M. Božič, 2007, Clinical chemistry and laboratory medicine.

Design and structure-activity relationship of thrombin inhibitors with an azaphenylalanine scaffold: potency and selectivity enhancements via P2 optimization.

T. Šolmajer, A. Zega, D. Kikelj, 2001, Bioorganic & medicinal chemistry.

Design and synthesis of novel platelet fibrinogen receptor antagonists with 2H-1,4-benzoxazine-3(4H)-one scaffold. A systematic study.

M. Anderluh, M. Dolenc, D. Kikelj, 2005, European journal of medicinal chemistry.

The synthesis of alternative diketopiperazines as potential RGD mimetics

R. Kiss, J. Ilaš, A. Csámpai, 2006, Journal of peptide science : an official publication of the European Peptide Society.

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

M. Gütschow, J. Ilaš, Anna Beckmann, 2016, Pharmaceuticals.

Searching new structural scaffolds for BRAF inhibitors. An integrative study using theoretical and experimental techniques.

R. Enriz, Sergio E Alvarez, J. Jampílek, 2019, Bioorganic chemistry.

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels

D. Madge, J. Tytgat, J. Ilaš, 2014, Marine drugs.

Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold.

J. Ilaš, D. Kikelj, M. Ilić, 2012, European journal of medicinal chemistry.

Novel thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics: optimization via modification of P1 and P3 moieties.

J. Ilaš, A. Kranjc, D. Kikelj, 2004, Bioorganic & medicinal chemistry letters.

Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.

T. Šolmajer, D. Kikelj, J. Stojan, 2004, European journal of medicinal chemistry.

Selective 3-amino-2-pyridinone acetamide thrombin inhibitors incorporating weakly basic partially saturated heterobicyclic P1-arginine mimetics.

A. Kranjc, T. Šolmajer, D. Kikelj, 2003, Bioorganic & medicinal chemistry letters.

Novel thrombin inhibitors incorporating non-basic partially saturated heterobicyclic P1-arginine mimetics.

T. Šolmajer, D. Kikelj, M. Stegnar, 2003, Bioorganic & Medicinal Chemistry Letters.

A Convenient Synthesis of Trans-2-alkyl-octahydro-2H-1,4-benzoxazin-3-ones

D. Kikelj, U. Urleb, S. Pečar, 1989 .

Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines

J. Kos, Nace Zidar, D. Kikelj, 2011, Radiology and oncology.

2-Aminoimidazoles in medicinal chemistry.

J. Ilaš, D. Kikelj, Aleš Žula, 2013, Mini reviews in medicinal chemistry.

Design, synthesis, and biological evaluation of 1‐ethyl‐3‐(thiazol‐2‐yl)urea derivatives as Escherichia coli DNA gyrase inhibitors

J. Ilaš, T. Tomašič, Nace Zidar, 2018, Archiv der Pharmazie.

New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors.

J. Ilaš, T. Tomašič, Nace Zidar, 2019, MedChemComm.

Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks

J. Ilaš, I. Kovačević, D. Secci, 2021, ACS omega.

Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues

P. Pristovsek, D. Kikelj, U. Urleb, 1992 .

A Convenient Method for the Methylation of Alkyl Dicyanoacetates

R. Neidlein, D. Kikelj, 1989 .

A pentacyclic condensation product from 2,4-dimethyl-7-nitro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylic acid

J. Ilaš, D. Kikelj, N. Lah, 2008 .

Recent Progress in Diaryl Ether Synthesis

D. Kikelj, R. Frlan, 2006 .

Recent advances in the discovery of tissue factor/factor VIIa inhibitors and dual inhibitors of factor VIIa/factor Xa.

A. Kranjc, D. Kikelj, L. Peterlin-Mašič, 2005, Current pharmaceutical design.

Recent advances in the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones and 3,4-dihydro-2H-1,4-benzoxazines

J. Ilaš, M. Dolenc, D. Kikelj, 2005 .

Novel Pyrazinone and Pyridinone Thrombin Inhibitors Incorporating Weakly Basic Heterobicyclic P1-Arginine Mimetics.

A. Kranjc, D. Kikelj, L. P. Mašič, 2005 .

Synthesis of 2-amino-7,8-dihydro-6(5 H )-quinazolinone, 2,4-diamino-7,8-dihydro-6(5 H )-quinazolinone, 5,6,7,8-tetrahydro-2,6-quinazoline-diamine and 5,6,7,8-tetrahydro-2,4,6-quinazolinetriamine derivatives

D. Kikelj, Aleš Obreza, A. Krbavčič, 2000 .

Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.

J. Ilaš, M. Anderluh, T. Šolmajer, 2015, Journal of medicinal chemistry.

A general synthetic approach to novel conformationally restricted arginine side chain mimetics

D. Kikelj, P. Marinko, L. Peterlin-Mašič, 2002 .

Synthesis of 2‐Amino‐7,8‐dihydro‐6(5H)‐quinazolinone, 2,4‐Diamino‐7,8‐dihydro‐6(5H)‐quinazolinone, 5,6,7,8‐Tetrahydro‐2,6‐quinazolinediamine and 5,6,7,8‐Tetrahydro‐2,4,6‐quinazolinetriamine Derivatives.

D. Kikelj, Aleš Obreza, A. Krbavčič, 2000 .

A general synthesis of novel conformationally restricted arginine side-chain mimetics

D. Kikelj, L. P. Mašič, 2000 .

Convergent Domino Knoevenagel Hetero-DielsAlder and Domino Oxidation Hetero-DielsAlder Reactions Encountered in an Unexpected Formation of Novel 5-Aryl-1H-pyrano[2,3-d]pyrimidine-2,4(3H,5H)-diones and 5-Aryl-2,3-dihydro-2-thioxo-1H-pyrano[2,3-d]pyrimidin-4(5H)-ones

Nace Zidar, D. Kikelj, 2011 .

Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors.

J. Ilaš, T. Tomašič, D. Kikelj, 2017, European journal of medicinal chemistry.

Design, synthesis, biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C, a crucial enzyme involved in biosynthesis of the mycobacterial cell wall.

G. Besra, R. Appelberg, U. Švajger, 2007, European journal of medicinal chemistry.

Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall.

G. Besra, Janez Mravljak, S. Gobec, 2004, Bioorganic & medicinal chemistry letters.

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.

Ž. Skok, J. Ilaš, T. Tomašič, 2020, Bioorganic chemistry.

Convergent Domino Knoevenagel Hetero‐Diels—Alder and Domino Oxidation Hetero‐Diels—Alder Reactions Encountered in an Unexpected Formation of Novel 5‐Aryl‐1H‐pyrano[2,3‐d]pyrimidine‐2,4(3H,5H)‐diones and 5‐Aryl‐2,3‐dihydro‐2‐thioxo‐1H‐pyrano[2,3‐d]pyrimidin‐4(5H)‐ones.

Nace Zidar, D. Kikelj, 2011 .

Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators

D. Madge, J. Tytgat, M. Anderluh, 2014, Medicinal Chemistry Research.

Preparation and Reactivity of 5-benzylidenebarbituric and 5-benzylidene-2-thiobarbituric Acids.

Nace Zidar, D. Kikelj, 2011, Acta chimica Slovenica.

Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones.

T. Tomašič, Nace Zidar, D. Kikelj, 2010, European journal of medicinal chemistry.

Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery

J. Ilaš, T. Tomašič, Nace Zidar, 2020, ACS omega.

A convenient synthesis of 3,4-dihydro-1,4-benzoxazin-2-ones

Nace Zidar, D. Kikelj, 2008 .

Advances in the Synthesis of Morpholin-3-ones and Morpholin-2-ones

J. Ilaš, D. Kikelj, U. Trstenjak, 2012 .

Influence of chirality of the preceding acyl moiety on the cis/trans ratio of the proline peptide bond.

S. Grdadolnik, G. Giester, D. Kikelj, 2001, The Journal of organic chemistry.

Novel state-dependent voltage-gated sodium channel modulators, based on marine alkaloids from Agelas sponges.

D. Madge, T. Tomašič, D. Kikelj, 2013, European journal of medicinal chemistry.

A convenient synthesis of 4-aminomethyl-4,5,6,7-tetrahydro-1,3-benzothiazole arginine side-chain mimetics

D. Kikelj, A. Krbavčič, P. Marinko, 2001 .

Synthesis of alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates as peptidomimetic building blocks

D. Kikelj, P. Štefanić, Katja Turnšek, 2003 .

Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities.

Danijel Kikelj, Marko Anderluh, J. Ilaš, 2005, Journal of medicinal chemistry.

Synthesis of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors

S. Gobec, D. Kikelj, R. Frlan, 2007 .

Synthesis and antiproliferative activity of 2-(([1,2,4]triazolo[4,3-b]- pyridazin-6-yloxy)methyl)-2,4-dimethyl-3,4-dihydro-2Hbenzo[b][1,4]oxazine derivatives

P. Mátyus, J. Ilaš, S. Liekens, 2011 .

Studies towards the Synthesis of Alkyl N‐(4‐Nitrophenyl)‐3/2‐oxomorpholine‐2/3‐carboxylates

J. Ilaš, D. Kikelj, U. Trstenjak, 2013 .

Synthesis of alkyl N-(4-nitrophenyl)-3/2-oxomorpholine-2/3-carboxylates by rhodium(II) acetate catalyzed O–H and N–H carbene insertion

J. Ilaš, D. Kikelj, U. Trstenjak, 2013 .

Discovery of Benzothiazole Scaffold-Based DNA Gyrase B Inhibitors.

J. Ilaš, T. Tomašič, D. Kikelj, 2016, Journal of medicinal chemistry.

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation

C. Pál, T. Révész, Ž. Skok, 2020, Pharmaceutics.

Dual Escherichia coli DNA Gyrase A and B Inhibitors with Antibacterial Activity

C. Pál, Ž. Skok, J. Ilaš, 2019, ChemMedChem.

Fluconazole Cocrystals with Dicarboxylic Acids

Odon Planinšek, Danijel Kikelj, Janez Plavec, 2010 .

New lipophilic phthalimido- and 3-phenoxybenzyl sulfonates: Inhibition of antigen 85C mycolyltransferase activity and cytotoxicity

G. Besra, M. Filipič, Andreja Kovač, 2006, Journal of enzyme inhibition and medicinal chemistry.

Design, Synthesis, and Evaluation of Novel Tyrosine‐Based DNA Gyrase B Inhibitors

J. Ilaš, D. Kikelj, R. Frlan, 2017, Archiv der Pharmazie.

Synthesis and Evaluation of N‐Phenylpyrrolamides as DNA Gyrase B Inhibitors

J. Ilaš, T. Tomašič, Nace Zidar, 2018, ChemMedChem.

Overcoming problems of poor drug penetration into bacteria: challenges and strategies for medicinal chemists

Nace Zidar, D. Kikelj, Davide Benedetto Tiz, 2018, Expert opinion on drug discovery.

Rational design of balanced dual-targeting antibiotics with limited resistance

C. Pál, T. Révész, B. Kintses, 2020, PLoS biology.

Dual inhibitors of human DNA topoisomerase II and other cancer-related targets.

Ž. Skok, J. Ilaš, Nace Zidar, 2020, Journal of medicinal chemistry.

Recent progress in the discovery and development of DNA gyrase B inhibitors.

J. Ilaš, D. Kikelj, Michaela Barančoková, 2018, Future medicinal chemistry.

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis.

P. Dunkel, P. Mátyus, J. Ilaš, 2012, European journal of medicinal chemistry.

MurD enzymes from different bacteria: evaluation of inhibitors.

S. Turk, M. Hervé, D. Mengin-Lecreulx, 2012, Biochemical pharmacology.

Analogues of the Lignan Pinoresinol as Novel Lead Compounds for P-glycoprotein (P-gp) Inhibitors.

T. Tomašič, D. Kikelj, Lucija Peterlin Mašič, 2018, ACS medicinal chemistry letters.

The Synthesis of Spin - Labeled Imipramine Analogs

D. Kikelj, S. Pečar, A. Krbavčič, 1984 .

Peptidomimetic Thrombin Inhibitors

D. Kikelj, 2003, Pathophysiology of Haemostasis and Thrombosis.

Synthesis of Phthalimido‐Desmuramylpeptide Analogues as Potential Immunomodulating Agents

D. Kikelj, U. Urleb, S. Pečar, 1995, Archiv der Pharmazie.

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.

S. Fiorucci, T. Tomašič, D. Kikelj, 2014, Journal of medicinal chemistry.

New N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity.

C. Pál, Ž. Skok, J. Ilaš, 2018, European journal of medicinal chemistry.

Evaluation of Michael-type acceptor reactivity of 5-benzylidenebarbiturates, 5-benzylidenerhodanines, and related heterocycles using NMR.

J. Plavec, T. Tomašič, Nace Zidar, 2014, Acta Chimica Slovenica.

Azaphenylalanine-based serine protease inhibitors induce caspase-mediated apoptosis.

Tina Batista Napotnik, I. Mlinarič-Raščan, A. Zega, 2009, European journal of pharmacology.

Pig liver esterase catalyzed hydrolysis of dimethyl and diethyl 2-methyl-2-(o-nitrophenoxy)malonates

D. Kikelj, M. Breznik, 1997 .

Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1H-indoles.

D. Passarella, L. Dalla Via, D. Secci, 2020, ACS medicinal chemistry letters.

New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.

C. Contreras-Martel, D. Patin, D. Blanot, 2011, European journal of medicinal chemistry.

ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents

J. Ilaš, T. Tomašič, Nace Zidar, 2019, Expert opinion on therapeutic patents.

Benzoxazine Series of Histidine Kinase Inhibitors as Potential Antimicrobial Agents with Activity against Enterococci

Nace Zidar, D. Kikelj, Vesna Cvitković Špik, 2009, Chemotherapy.

Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity

J. Ilaš, D. Kikelj, Aleš Žula, 2018, Marine drugs.

Multitarget antithrombotic drugs.

J. Ilaš, D. Kikelj, M. Ilić, 2011, Current Topics in Medicinal Chemistry.

Ligand- and Structure-Based Virtual Screening for Clathrodin-Derived Human Voltage-Gated Sodium Channel Modulators

Tihomir Tomasic, Basil Hartzoulakis, Nace Zidar, 2013, J. Chem. Inf. Model..

Second generation 4,5,6,7-tetrahydrobenzo[d]thiazoles as novel DNA gyrase inhibitors.

C. Pál, R. Enriz, Ž. Skok, 2020, Future medicinal chemistry.

Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.

S. Grdadolnik, D. Blanot, Andreja Kovač, 2011, European journal of medicinal chemistry.

Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase.

D. Blanot, Andreja Kovač, S. Gobec, 2009, Bioorganic & medicinal chemistry letters.

A 1:1 cocrystal of fluconazole with salicylic acid.

D. Kikelj, N. Lah, I. Leban, 2011, Acta crystallographica. Section C, Crystal structure communications.

Discovery of a New Potent N-(piperidin-4-yl)-1H-pyrrole-2-carboxamide Inhibitor of Adenylyl Cyclase of G. lamblia. Biological Evaluation and Molecular Modeling Studies.

R. Enriz, C. Davio, M. Anderluh, 2021, ChemMedChem.

Recent Advances in the Synthesis of 2H‐1,4‐Benzoxazin‐3‐(4H)‐ones and 3,4‐Dihydro‐2H‐1,4‐benzoxazines

J. Ilaš, M. Dolenc, D. Kikelj, 2005 .

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Guido V. Janssen, C. Pál, L. Pardo, 2023, Journal of medicinal chemistry.

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Guido V. Janssen, B. Birnir, C. Stevenson, 2023, Journal of medicinal chemistry.

New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

C. Pál, T. Révész, Ž. Skok, 2021, European journal of medicinal chemistry.

Inhibition of Hepatitis C Replication by Targeting the Molecular Chaperone Hsp90: Synthesis and Biological Evaluation of 4,5,6,7‐Tetrahydrobenzo[1,2‐d]thiazole Derivatives

V. Lohmann, P. Schult, T. Tomašič, 2019, ChemMedChem.

Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening

Nace Zidar, D. Kikelj, M. Rogers, 2016, Assay and drug development technologies.

New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel.

J. Tytgat, S. Peigneur, T. Tomašič, 2023, European journal of medicinal chemistry.

Benzothiazole-based Compounds in Antibacterial Drug Discovery.

T. Tomašič, D. Kikelj, L. P. Mašič, 2017, Current medicinal chemistry.

A Convenient Synthesis of 4-Benzyl-2-(2-(4-oxo-2-thioxothiazolidin-5-ylidene)ethyl)-2H-1,4-benzoxazin-3(4H)-ones and 5-(2-(4-Benzyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)ethylidene)thiazolidine-2,4-diones

Nace Zidar, D. Kikelj, J. Kladnik, 2009 .

A convenient synthesis of 3,4-dihydro-2-methyl-3-oxo-2H-1,4-benzoxazine-2-carboxylic acids and 3,4-dihydro-2-methyl-3-oxo-2H-pyrido[3,2-b]-1, 4-oxazine-2-carboxylic acid

D. Kikelj, U. Urleb, U. Žbontar, 1993 .

Multitarget cardiovascular drugs.

D. Kikelj, U. Trstenjak, 2011, Current Medicinal Chemistry.

Diethylstilbestrol-scaffold-based pregnane X receptor modulators.

S. Fiorucci, T. Tomašič, D. Kikelj, 2015, European journal of medicinal chemistry.

From Indazole Derivatives

D. Kikelj, 2004 .

Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates.

Ž. Skok, J. Ilaš, T. Tomašič, 2019, Bioorganic chemistry.

New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase.

J. Ilaš, T. Tomašič, Nace Zidar, 2016, European journal of medicinal chemistry.

A synthesis of alkyl 4-alkyl-2-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-2-carboxylates

J. Plavec, D. Kikelj, N. Lah, 2001 .

A Synthesis of Alkyl 4‐Alkyl‐2‐hydroxy‐3‐oxo‐3,4‐dihydro‐2H‐1,4‐benzoxazine‐2‐carboxylates.

J. Plavec, D. Kikelj, N. Lah, 2010 .

Ring Opening of 2‐(Benzylamino)‐2H‐1,4‐benzoxazin‐3(4H)‐ones and 2‐Bromo‐2H‐1,4‐benzoxazin‐3(4H)‐ones

J. Ilaš, D. Kikelj, 2008 .

Selective Alkylation of 3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazine-2-Carboxylates

D. Kikelj, Alenka Rutar, 1998 .

Marine alkaloid oroidin analogues with antiviral potential: A novel class of synthetic compounds targeting the cellular chaperone Hsp90

T. Tomašič, D. Kikelj, P. Tammela, 2017, Chemical biology & drug design.

Synthesis and biological evaluation of piperazine derivatives as novel isoform selective voltage-gated sodium (Nav) 1.3 channel modulators

D. Madge, J. Tytgat, M. Anderluh, 2015, Medicinal Chemistry Research.

Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

J. Ilaš, G. Ubeaud‐Séquier, C. Muller, 2015 .

Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors.

J. Ilaš, T. Tomašič, Nace Zidar, 2017, Bioorganic & medicinal chemistry.

ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.

Ž. Skok, J. Ilaš, T. Tomašič, 2023, European journal of medicinal chemistry.

Contents Vol. 55, 2009

Jianhua Shen, H. Kayed, J. Kleeff, 2009, Chemotherapy.

Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens

D. Lawson, M. Czikkely, J. Ilaš, 2023, ACS Omega.

Ligand- and Structure-Based Virtual Screening for Clathrodin-Derived Human Voltage-Gated Sodium Channel Modulators

D. Madge, J. Tytgat, S. Peigneur, 2013, J. Chem. Inf. Model..

Bazedoxifene-scaffold-based mimetics of solomonsterols A and B as novel pregnane X receptor antagonists.

S. Fiorucci, T. Tomašič, D. Kikelj, 2014, Journal of medicinal chemistry.

Conformationally tailored N-[(2-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl)carbonyl]proline templates as molecular tools for the design of peptidomimetics. Design and synthesis of fibrinogen receptor antagonists.

J. Plavec, M. Anderluh, D. Kikelj, 2004, Organic & biomolecular chemistry.