D. Knez

发表

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

S. Turk, D. Mengin-Lecreulx, C. Contreras-Martel, 2013, European journal of medicinal chemistry.

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

M. Anderluh, D. Blanot, H. Barreteau, 2014, European journal of medicinal chemistry.

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

M. Bajda, B. Malawska, S. Gobec, 2016, Molecules.

Synthesis of Indoline‐Based Benzhydroxamic Acids as Potential HDAC6 Inhibitors

O. De Wever, K. De Bosscher, S. Gobec, 2019, ChemistrySelect.

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.

B. Malawska, R. Sabaté, S. Gobec, 2019, European journal of medicinal chemistry.

Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.

K. Kieć‐Kononowicz, M. Kołaczkowski, B. Malawska, 2018, ACS chemical neuroscience.

Efficient synthesis and preliminary biological evaluations of trifluoromethylated imidazo[1,2-a]pyrimidines and benzimidazo[1,2-a]pyrimidines

S. Gobec, D. Knez, M. Akssira, 2019, New Journal of Chemistry.

From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.

Uroš Grošelj, S. Gobec, D. Knez, 2022, European journal of medicinal chemistry.

Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments

G. Keserű, B. Vértessy, A. Perczel, 2020, ChemBioChem.

Development of an in-vivo active reversible butyrylcholinesterase inhibitor

J. Kos, B. Malawska, M. Perše, 2016, Scientific Reports.

Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.

M. Kołaczkowski, B. Malawska, P. Bieńkowski, 2016, European journal of medicinal chemistry.

8-Hydroxyquinoline-based anti-Alzheimer multimodal agents

J. Kos, S. Gobec, Izidor Sosič, 2020, Monatshefte für Chemie - Chemical Monthly.

Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment

F. López-Muñoz, D. Hadjipavlou-Litina, I. Iriepa, 2022, Antioxidants.

Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1−42 Aggregation Inhibitors for Alzheimer's Disease Therapy

Oscar M. Bautista-Aguilera, M. Decker, B. Malawska, 2016, ChemMedChem.

Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads

G. Keserű, P. Ábrányi‐Balogh, G. Ferenczy, 2021, Cells.

Mur ligases inhibitors with azastilbene scaffold: expanding the structure-activity relationship.

H. Barreteau, S. Gobec, M. Hrast, 2021, Bioorganic & medicinal chemistry letters.

N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases

I. Iriepa, J. Marco-Contelles, S. Gobec, 2022, Molecules.

Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?

S. Gobec, M. Hrast, D. Knez, 2022, ACS medicinal chemistry letters.

Redox active or thiol reactive? Optimization of rapid screens to identify less evident nuisance compounds.

S. Gobec, Izidor Sosič, D. Knez, 2022, Drug discovery today.

Discovery of selective fragment-sized immunoproteasome inhibitors.

G. Keserű, P. Ábrányi‐Balogh, G. Ferenczy, 2021, European journal of medicinal chemistry.

Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors

G. Keserű, J. Ilaš, P. Ábrányi‐Balogh, 2022, Pharmaceuticals.

Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead.

M. Zorović, S. Pajk, M. Denic, 2022, European journal of medicinal chemistry.

N-alkylpiperidine carbamates as potential anti-Alzheimer's agents.

J. Kos, S. Gobec, D. Knez, 2020, European journal of medicinal chemistry.

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.

J. Kos, N. Coquelle, J. Colletier, 2018, Journal of medicinal chemistry.

Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.

M. Kołaczkowski, B. Malawska, S. Gobec, 2021, European journal of medicinal chemistry.

Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X.

J. Kos, S. Gobec, M. Hrast, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

M. Bajda, B. Malawska, O. Soukup, 2017, European journal of medicinal chemistry.

Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

M. Sastre, J. Llop, P. Ramos-Cabrer, 2021, Theranostics.

Structure-activity relationship study of tryptophan-based butyrylcholinesterase inhibitors.

Uroš Grošelj, S. Gobec, D. Knez, 2020, European journal of medicinal chemistry.

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

M. Zorović, N. Coquelle, J. Colletier, 2020, Journal of enzyme inhibition and medicinal chemistry.

Tryptophan-derived butyrylcholinesterase inhibitors as promising leads against Alzheimer's disease.

J. Kos, Uroš Grošelj, S. Gobec, 2019, Chemical communications.

Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.

J. Kos, N. Coquelle, J. Colletier, 2018, European journal of medicinal chemistry.

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

Oscar M. Bautista-Aguilera, B. Malawska, O. Soukup, 2016, Molecules.

Assessment of tractable cysteines by covalent fragments screening.

S. Grdadolnik, G. Keserű, B. Vértessy, 2020, Chembiochem : a European journal of chemical biology.

Pyrimido[1,2-b]indazole derivatives: Selective inhibitors of human monoamine oxidase B with neuroprotective activity.

J. Kos, S. Gobec, D. Knez, 2020, European journal of medicinal chemistry.

Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides

Uroš Grošelj, S. Gobec, M. Hrast, 2016, Molecular Diversity.

Convenient syntheses of orthogonally protected aminocyclopentitols from aldopentoses

S. Gobec, M. Hrast, D. Knez, 2015 .

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents

M. Bajda, B. Malawska, S. Gobec, 2018, Molecules.

2’-Hydroxy-4’,5’-dimethyl-4-dimethylaminochalcone, a novel fluorescent flavonoid with capacity to detect aluminium in cells and modulate Alzheimer’s disease targets

Laureano L. Sabatier, M. Ferreira-Gomes, L. Gavernet, 2021 .

Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice

S. Gobec, D. Knez, M. Wagner, 2023, Pharmaceuticals.

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

J. Kos, M. Denic, J. Marco-Contelles, 2023, Acta pharmaceutica Sinica. B.

Biological Evaluation of 8-Hydroxyquinolines as Multi-Target Directed Ligands for Treating Alzheimer's Disease.

J. Kos, S. Gobec, Izidor Sosič, 2019, Current Alzheimer research.

ProBiS-Dock: A Hybrid Multitemplate Homology Flexible Docking Algorithm Enabled by Protein Binding Site Comparison

Janez Konc, D. Janežič, Blaž Škrlj, 2022, J. Chem. Inf. Model..

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

J. Kos, M. Bajda, B. Malawska, 2018, ACS chemical neuroscience.

Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.

K. Wanner, G. Höfner, B. Malawska, 2021, European journal of medicinal chemistry.

New antagonists of toll-like receptor 7 discovered through 3D ligand-based virtual screening

S. Turk, U. Švajger, S. Gobec, 2014, Medicinal Chemistry Research.

Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors

A. Rotter, J. Kos, Urša Pečar Fonović, 2022, International journal of molecular sciences.

LiSiCA: A Software for Ligand-Based Virtual Screening and Its Application for the Discovery of Butyrylcholinesterase Inhibitors

Dusanka Janezic, Janez Konc, Damijan Knez, 2015, J. Chem. Inf. Model..

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.

Janez Konc, D. Janežič, I. Mlinarič-Raščan, 2016, Angewandte Chemie.

Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy

J. Kos, J. Završnik, B. Turk, 2022, Cellular and Molecular Life Sciences.

Cell models for Alzheimer's and Parkinson's disease: At the interface of biology and drug discovery.

J. Kos, S. Gobec, D. Knez, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Identification and characterization of the novel reversible and selective cathepsin X inhibitors

J. Kos, S. Gobec, D. Knez, 2017, Scientific Reports.

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

Janez Konc, J. Kos, I. Mangialavori, 2020, Journal of medicinal chemistry.

Synthesis and Initial Characterization of a Reversible, Selective 18F-Labeled Radiotracer for Human Butyrylcholinesterase

M. Decker, S. Gobec, D. Knez, 2021, Molecular Imaging and Biology.

Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease.

M. Sova, S. Gobec, D. Knez, 2017, Future medicinal chemistry.

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.

J. Kos, N. Coquelle, J. Colletier, 2017, Bioorganic & medicinal chemistry.

Cathepsin B inhibitors: Further exploration of the nitroxoline core.

J. Kos, S. Gobec, Izidor Sosič, 2018, Bioorganic & medicinal chemistry letters.

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.

N. Coquelle, J. Colletier, Janez Mravljak, 2015, Bioorganic & medicinal chemistry.

Multitarget 2′-hydroxychalcones as potential drugs for the treatment of neurodegenerative disorders and their comorbidities

S. Gobec, D. Knez, S. Žakelj, 2021, Neuropharmacology.

WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors

György G. Ferenczy, Damijan Knez, Stanislav Gobec, 2021, Journal of Computer-Aided Molecular Design.

Screening of Big Pharma’s Library against Various in-house Biological Targets

S. Gobec, M. Hrast, D. Knez, 2022, Molecules.

Indoles and 1-(3-(benzyloxy)benzyl)piperazines: Reversible and selective monoamine oxidase B inhibitors identified by screening an in-house compound library.

J. Kos, S. Gobec, M. Hrast, 2021, Bioorganic chemistry.

Structure of recombinant human butyrylcholinesterase in complex with a coumarin-based fluorescent probe linked to sulfonamide type inhibitor.

M. Zorović, N. Coquelle, J. Colletier, 2020 .

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta

M. Bajda, B. Malawska, S. Gobec, 2016, Molecules.

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

M. Sova, S. Gobec, D. Knez, 2021, Molecules.

Human Butyrylcholinesterase complexed with N-Propargyliperidines

J. Kos, N. Coquelle, J. Colletier, 2018 .

Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.

Janez Konc, D. Janežič, I. Mlinarič-Raščan, 2016, Angewandte Chemie.

Exploring the aryl esterase catalysis of paraoxonase-1 through solvent kinetic isotope effects and phosphonate-based isosteric analogues of the tetrahedral reaction intermediate.

S. Gobec, D. Knez, J. Stojan, 2014, Biochimie.

New antagonists of toll-like receptor 7 discovered through 3D ligand-based virtual screening

S. Turk, U. Švajger, S. Gobec, 2014, Medicinal Chemistry Research.