A. O’Neill

发表

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

S. Turk, D. Mengin-Lecreulx, C. Contreras-Martel, 2013, European journal of medicinal chemistry.

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

M. Anderluh, D. Blanot, H. Barreteau, 2014, European journal of medicinal chemistry.

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

I. Chopra, A. O’Neill, Ian Chopra, 2010, Nature Reviews Microbiology.

Characterization of the Epidemic European Fusidic Acid-Resistant Impetigo Clone of Staphylococcus aureus

I. Chopra, R. Skov, A. O’Neill, 2007, Journal of Clinical Microbiology.

Distribution of Fusidic Acid Resistance Determinants in Methicillin-Resistant Staphylococcus aureus

I. Chopra, R. Skov, A. O’Neill, 2010, Antimicrobial Agents and Chemotherapy.

A Fusidic Acid-Resistant Epidemic Strain of Staphylococcus aureus Carries the fusB Determinant, whereas fusA Mutations Are Prevalent in Other Resistant Isolates

I. Chopra, A. O’Neill, A. Larsen, 2004, Antimicrobial Agents and Chemotherapy.

Molecular basis of fusB‐mediated resistance to fusidic acid in Staphylococcus aureus

I. Chopra, A. O’Neill, 2006, Molecular microbiology.

Increased mutability of Pseudomonas aeruginosa in biofilms.

I. Chopra, K. Miller, J. Bostock, 2008, The Journal of antimicrobial chemotherapy.

Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress

I. Chopra, A. O’Neill, V. Ryder, 2012, PloS one.

Zinc oxide nanoparticle-coated films: fabrication, characterization, and antibacterial properties

Yulong Ding, Yunhong Jiang, A. O’Neill, 2015, Journal of Nanoparticle Research.

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement.

J. Frère, I. Chopra, L. Czaplewski, 2008, The Lancet. Infectious diseases.

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

J. Mainardi, S. Magnet, M. Arthur, 2013, European journal of medicinal chemistry.

Activity-directed expansion of a series of antibacterial agents.

S. Warriner, A. Nelson, A. O’Neill, 2020, Chemical communications.

Discovery and development of new anti-bacterial drugs

I. Chopra, A. O’Neill, L. Hesse, 2002 .

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa

K. Marchal, N. Verstraeten, M. Fauvart, 2016, PloS one.

Biological Properties of Novel Antistaphylococcal Quinoline-Indole Agents

I. Chopra, G. Cuny, K. Miller, 2003, Antimicrobial Agents and Chemotherapy.

Potential for repurposing the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents for topical application

A. O’Neill, Victoria E Lee, 2019, The Journal of antimicrobial chemotherapy.

Redox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agents

J. Cove, A. O’Neill, E. Eady, 2014, The Journal of antimicrobial chemotherapy.

Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

A. Jirgensons, C. Randall, A. O’Neill, 2016, Antimicrobial Agents and Chemotherapy.

Creating a framework to align antimicrobial resistance (AMR) research with the global guidance: a viewpoint.

Jessica Mitchell, A. O’Neill, R. King, 2022, The Journal of antimicrobial chemotherapy.

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus

A. Jirgensons, W. Goessens, J. Hays, 2016, Antimicrobial Agents and Chemotherapy.

Impaired alanine transport or exposure to D-cycloserine increases the susceptibility of MRSA to β-lactam antibiotics

F. Cava, P. Fey, Fareha Razvi, 2019, bioRxiv.

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

I. Chopra, A. O’Neill, J. Hurdle, 2003, The Journal of antimicrobial chemotherapy.

Structural basis of resistance to lincosamide, streptogramin A, and pleuromutilin antibiotics by ABCF ATPases in Gram-positive pathogens

Daniel N. Wilson, Z. Ignatova, G. Atkinson, 2020, bioRxiv.

Anti-staphylococcal activity and mode of action of clofazimine.

I. Chopra, K. Miller, A. O’Neill, 2004, The Journal of antimicrobial chemotherapy.

Molecular Mechanisms of Antibiotic Resistance – Part II

A. O’Neill, Liam K R Sharkey, Liam K. R. Sharkey, 2019, Bacterial Resistance to Antibiotics – From Molecules to Man.

Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus.

J. Cove, I. Chopra, A. O’Neill, 2001, The Journal of antimicrobial chemotherapy.

Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus.

I. Chopra, K. Miller, A. O’Neill, 2004, The Journal of antimicrobial chemotherapy.

Structure-based ligand design of novel bacterial RNA polymerase inhibitors.

C. Fishwick, A. Johnson, I. Chopra, 2011, ACS medicinal chemistry letters.

Escherichia coli Mutators Present an Enhanced Risk for Emergence of Antibiotic Resistance during Urinary Tract Infections

I. Chopra, K. Miller, A. O’Neill, 2004, Antimicrobial Agents and Chemotherapy.

Antibacterial activity and mode of action of tert-butylhydroquinone (TBHQ) and its oxidation product, tert-butylbenzoquinone (TBBQ).

J. Cove, I. Chopra, R. Bojar, 2013, The Journal of antimicrobial chemotherapy.

A platform for detecting cross-resistance in antibacterial drug discovery

C. Randall, A. O’Neill, L. H. Galarion, 2021, The Journal of antimicrobial chemotherapy.

Staphylococcus aureus SH1000 and 8325‐4: comparative genome sequences of key laboratory strains in staphylococcal research

A. O’Neill, 2010, Letters in applied microbiology.

Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.

I. Chopra, A. O’Neill, 2002, The Journal of antimicrobial chemotherapy.

Target protection as a key antibiotic resistance mechanism

Daniel N. Wilson, G. Atkinson, V. Hauryliuk, 2020, Nature Reviews Microbiology.

Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight.

A. O’Neill, Liam K R Sharkey, Liam K. R. Sharkey, 2018, ACS infectious diseases.

Resistance during Urinary Tract Infections Enhanced Risk for Emergence of Antibiotic Mutators Present an Escherichia coli

I. Chopra, K. Miller, A. O’Neill, 2003 .

Delayed Development of Linezolid Resistance in Staphylococcus aureus following Exposure to Low Levels of Antimicrobial Agents

E. Ingham, I. Chopra, M. Wilcox, 2008, Antimicrobial Agents and Chemotherapy.

Loss of Function of the GdpP Protein Leads to Joint β-Lactam/Glycopeptide Tolerance in Staphylococcus aureus

A. O’Neill, J. Griffiths, 2011, Antimicrobial Agents and Chemotherapy.

Lack of Evidence for Involvement of Hypermutability in Emergence of Vancomycin-Intermediate Staphylococcus aureus

I. Chopra, A. O’Neill, 2003, Antimicrobial Agents and Chemotherapy.

Algorithm-driven activity-directed expansion of a series of antibacterial quinazolinones.

S. Warriner, D. Derks, A. O’Neill, 2022, Organic & biomolecular chemistry.

Ellipticines and 9-acridinylamines as inhibitors of D-alanine:D-alanine ligase.

Janez Konc, D. Janežič, I. Chopra, 2011, Bioorganic & medicinal chemistry.

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

Stanislav Gobec, Christopher Randall, Martina Hrast, 2012, PloS one.

The role of mutators in the emergence of antibiotic-resistant bacteria.

I. Chopra, K. Miller, A. O’Neill, 2003, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes.

I. Chopra, K. Miller, A. O’Neill, 2002, The Journal of antimicrobial chemotherapy.

An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis

C. Randall, A. O’Neill, L. H. Galarion, 2023, The Journal of antimicrobial chemotherapy.

Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections.

I. Chopra, A. O’Neill, J. Hurdle, 2004, The Journal of antimicrobial chemotherapy.

Exploiting current understanding of antibiotic action for discovery of new drugs

I Chopra, L Hesse, A J O'Neill, 2002, Symposium series.

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

M. Rodnina, W. Wintermeyer, S. Homans, 2012, Proceedings of the National Academy of Sciences.

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

Yulong Ding, David W. York, Malcolm Povey, 2010 .

Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms

N. Jackson, C. Randall, A. O’Neill, 2015, The Journal of antimicrobial chemotherapy.

Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance

I. Chopra, A. O’Neill, V. Savage, 2013, Antimicrobial Agents and Chemotherapy.

The Target of Daptomycin Is Absent from Escherichia coli and Other Gram-Negative Pathogens

I. Chopra, C. Randall, A. O’Neill, 2012, Antimicrobial Agents and Chemotherapy.

Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens

C. Randall, A. O’Neill, Jennifer L. Cottell, 2017, The Journal of antimicrobial chemotherapy.

Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin

I. Chopra, A. O’Neill, Ian Chopra, 2001, Antimicrobial Agents and Chemotherapy.

RNA Polymerase Inhibitors with Activity against Rifampin-Resistant Mutants of Staphylococcus aureus

C. Fishwick, I. Chopra, A. O’Neill, 2000, Antimicrobial Agents and Chemotherapy.

Consequences of daptomycin-mediated membrane damage in Staphylococcus aureus.

I. Chopra, K. Miller, A. O’Neill, 2008, The Journal of antimicrobial chemotherapy.

The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

I. Chopra, Linda B Oyama, J. Bostock, 2013, The Journal of antimicrobial chemotherapy.

Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques

I. Chopra, A. O’Neill, 2004, Expert opinion on investigational drugs.

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

C. Fishwick, K. Simmons, I. Chopra, 2009, Molecular microbiology.

ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal Protection

T. Edwards, A. O’Neill, Liam K. R. Sharkey, 2016, mBio.

Transcriptional Signature following Inhibition of Early-Stage Cell Wall Biosynthesis in Staphylococcus aureus

J. Hinds, I. Chopra, K. Gould, 2009, Antimicrobial Agents and Chemotherapy.

This is an author produced version of Impact of exposure of methicillin-resistant Staphylococcus aureus to polyhexanide in vitro and in vivo.

C. Manzano, P. François, J. Schrenzel, 2018 .

Impact of Exposure of Methicillin-Resistant Staphylococcus aureus to Polyhexanide In Vitro and In Vivo

C. Manzano, P. François, J. Schrenzel, 2017, Antimicrobial Agents and Chemotherapy.

Transposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.

A. O’Neill, Katy L. Blake, 2013, The Journal of antimicrobial chemotherapy.

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

Daniel N. Wilson, Z. Ignatova, G. Atkinson, 2021, Nature Communications.

Molecular Genetic and Structural Modeling Studies of Staphylococcus aureus RNA Polymerase and the Fitness of Rifampin Resistance Genotypes in Relation to Clinical Prevalence

C. Fishwick, I. Chopra, T. Huovinen, 2006, Antimicrobial Agents and Chemotherapy.

Structure of the 70S Ribosome from the Human Pathogen Acinetobacter baumannii in Complex with Clinically Relevant Antibiotics

N. Ranson, T. Edwards, A. O’Neill, 2020, Structure.

Population Diversification in Staphylococcus aureus Biofilms May Promote Dissemination and Persistence

I. Chopra, A. O’Neill, V. Savage, 2013, PloS one.

Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents

I. Chopra, A. O’Neill, J. Hurdle, 2005, Antimicrobial Agents and Chemotherapy.

Analysis of Mupirocin Resistance and Fitness in Staphylococcus aureus by Molecular Genetic and Structural Modeling Techniques

C. Fishwick, E. Ingham, I. Chopra, 2004, Antimicrobial Agents and Chemotherapy.

Emergence and maintenance of resistance to fluoroquinolones and coumarins in Staphylococcus aureus: predictions from in vitro studies.

I. Chopra, A. O’Neill, A. Vickers, 2007, The Journal of antimicrobial chemotherapy.

Antimicrobial activity and mechanisms of resistance to cephalosporin P1, an antibiotic related to fusidic acid.

I. Chopra, J. Bostock, A. O’Neill, 2002, The Journal of antimicrobial chemotherapy.

Acquired Nisin Resistance in Staphylococcus aureus Involves Constitutive Activation of an Intrinsic Peptide Antibiotic Detoxification Module

C. Randall, A. O’Neill, Arya Gupta, 2018, mSphere.

Selection of resistance by antimicrobial coatings in the healthcare setting.

F. Schreiber, H. Jenssen, A. Ivask, 2020, The Journal of hospital infection.

Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure

J. Parkhill, J. Wright, C. Randall, 2019, mBio.

Mutagenesis Mapping of the Protein-Protein Interaction Underlying FusB-Type Fusidic Acid Resistance

T. Edwards, A. O’Neill, G. Cox, 2013, Antimicrobial Agents and Chemotherapy.

Genetic Basis of Resistance to Fusidic Acid in Staphylococci

I. Chopra, G. Kahlmeter, A. O’Neill, 2007, Antimicrobial Agents and Chemotherapy.

Intrinsic Novobiocin Resistance in Staphylococcus saprophyticus

I. Chopra, A. O’Neill, A. Vickers, 2007, Antimicrobial Agents and Chemotherapy.

Target protection as a key antibiotic resistance mechanism

G. Atkinson, A. O’Neill, D. Wilson, 2020, Nature Reviews Microbiology.

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA

L. Hurst, S. Sheppard, A. Lubben, 2018, Genome Biology.

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci

N. Ranson, G. Atkinson, T. Edwards, 2022, Nucleic acids research.

Activity of and Development of Resistance to Corallopyronin A, an Inhibitor of RNA Polymerase

C. Fishwick, I. Chopra, M. McPhillie, 2011, Antimicrobial Agents and Chemotherapy.

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin

J. Sutton, C. Rayner, R. Seipke, 2017, Scientific Reports.

Further Characterization of Bacillus subtilis Antibiotic Biosensors and Their Use for Antibacterial Mode-of-Action Studies

I. Chopra, A. O’Neill, Katherine R. Mariner, 2011, Antimicrobial Agents and Chemotherapy.

Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase

Colin W. G. Fishwick, C. Fishwick, I. Chopra, 2010, Antimicrobial Agents and Chemotherapy.

High prevalence of resistance to fusidic acid in clinical isolates of Staphylococcus epidermidis.

I. Chopra, A. O’Neill, F. McLaws, 2008, The Journal of antimicrobial chemotherapy.

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

Lona Mody, I. Chopra, L. Mody, 2005, The Journal of antimicrobial chemotherapy.

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance

A. Zhuravleva, G. Thompson, A. O’Neill, 2016, Scientific Reports.

Zeocin resistance suppresses mutation in hypermutable Escherichia coli.

I. Chopra, K. Miller, J. Bostock, 2003, Microbiology.

In Vitro Studies Indicate a High Resistance Potential for the Lantibiotic Nisin in Staphylococcus aureus and Define a Genetic Basis for Nisin Resistance

C. Randall, A. O’Neill, Katy L. Blake, 2011, Antimicrobial Agents and Chemotherapy.

Design, Synthesis and Microbiological Evaluation of Novel Compounds as Potential Staphylococcus aureus Phenylalanine tRNA Synthetase Inhibitors.

M. Wootton, C. Simons, A. O’Neill, 2018, Egyptian Journal of Chemistry.

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage

K. Marchal, M. Fauvart, J. Michiels, 2018, Front. Microbiol..

Evolution of extended-spectrum beta-lactamases in a MutS-deficient Pseudomonas aeruginosa hypermutator.

I. Chopra, K. Miller, J. Bostock, 2006, The Journal of antimicrobial chemotherapy.

A framework to assess the terrestrial risk of antibiotic resistance from antibiotics in slurry or manure amended soils

A. O’Neill, L. Carter, Felicity C. T. Elder, 2023, Environmental Science: Advances.

Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus

P. Long, J. Hinds, P. Taylor, 2011, International Journal of Astrobiology.

Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis

A. O’Neill, Louise Kime, Merianne Mohamad, 2023, The Journal of antimicrobial chemotherapy.

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

C. Fishwick, I. Chopra, A. O’Neill, 2009, The Journal of antimicrobial chemotherapy.

Complete nucleotide sequence of pGO1, the prototype conjugative plasmid from the Staphylococci.

A. O’Neill, A J O'Neill, J A Caryl, 2009, Plasmid.

Use of Mutator Strains for Characterization of Novel Antimicrobial Agents

I. Chopra, A. O’Neill, 2001, Antimicrobial Agents and Chemotherapy.

Hidden antibiotic resistance fitness costs revealed by GWAS-based epistasis analysis

L. Hurst, S. Sheppard, A. Lubben, 2017, bioRxiv.

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide)

A. O’Neill, N. Ooi, 2016, The Journal of Antibiotics.

Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent

J. Cove, A. O’Neill, E. Eady, 2016, The Journal of antimicrobial chemotherapy.

An Engineered Escherichia coli Community for Studying Quorum Sensing

F. Goycoolea, A. O’Neill, Justin E Clarke, 2023, SynBio.

Increased mutability of Pseudomonas aeruginosa in biofilms.

I. Chopra, K. Miller, J. Bostock, 2008, The Journal of antimicrobial chemotherapy.