Zhongqi Shen

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2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase in

Ping Chen, A. Doweyko, Derek J. Norris, 2006, Journal of medicinal chemistry.

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.

D. Cheney, Ping Chen, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

Responses of seven wetlands carbon sources and sinks to permafrost degradation in Northeast China

Zhongqi Shen, Chang-cheng Mu, L. Han, 2022, Journal of Soils and Sediments.

Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck).

Ping Chen, A. Doweyko, R. Moquin, 2003, Bioorganic & medicinal chemistry letters.

Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117.

A. Doweyko, S. Spergel, R. Moquin, 2003, Bioorganic & medicinal chemistry letters.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.

D. Cheney, E. Iwanowicz, J. Barrish, 2003, Bioorganic & medicinal chemistry letters.

Novel diamide-based inhibitors of IMPDH.

Henry H. Gu, E. Iwanowicz, M. Witmer, 2002, Bioorganic & medicinal chemistry letters.

Network Pharmacology and Molecular Docking Analyses Unveil the Mechanisms of Yiguanjian Decoction against Parkinson's Disease from Inner/Outer Brain Perspective

Zhongqi Shen, Mengdie Yu, Shaozhi Zhang, 2022, BioMed research international.

Novel inhibitors of cell adhesion molecule expression

Zhongqi Shen, Dharmpal S. Dodd, N. Graber, 1996 .

A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.

Henry H. Gu, E. Iwanowicz, W. Pitts, 2002, Organic letters.

The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists.

M. Day, T. Comery, S. Grauer, 2010, Journal of medicinal chemistry.

A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

Ping Chen, J. Barrish, Zhongqi Shen, 2000 .

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

J. Y. Roberge, Ping Chen, A. Doweyko, 2002, Bioorganic & medicinal chemistry letters.

A biomimetic-like radical approach to furanoditerpenes

Zhongqi Shen, A. Ribeiro, Ming Wang, 1995 .

Total Synthesis of d,l-Isospongiadiol: An Intramolecular Radical Cascade Approach to Furanoditerpenes.

Zhongqi Shen, A. Ribeiro, Yongzhen Zhang, 1996, The Journal of organic chemistry.

Trichosanthin inhibits T cell activation by interfering with the recruitment of ZAP-70 to CD3 ζ chain

Zhongqi Shen, Jian Hong, P. Lu, 1998, Cell Research.

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Bioorganic & medicinal chemistry letters.

Research Progress on the Pharmacodynamic Mechanisms of Sini Powder against Depression from the Perspective of the Central Nervous System

Zhongqi Shen, Mengdie Yu, Zhenfei Dong, 2023, Medicina.

Chapter 6 Support Vector Machine Aided Non-linear QSAR study of binding affinity of Serotonin reuptake inhibitors – Antidepressants 6 . 1

Zhongqi Shen, 2016 .

3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.

Ping Chen, Derek J. Norris, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.

E. Iwanowicz, J. Barrish, D. Hollenbaugh, 2002, Bioorganic & medicinal chemistry letters.

Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Journal of medicinal chemistry.

Responses of seven wetlands carbon sources and sinks to permafrost degradation in Northeast China

Zhongqi Shen, Chang-cheng Mu, L. Han, 2022, Journal of Soils and Sediments.

Synthesis and structure-activity relationship of novel lactam-fused chroman derivatives having dual affinity at the 5-HT(1A) receptor and the serotonin transporter.

B. Harrison, W. Childers, Zhongqi Shen, 2010, Bioorganic & medicinal chemistry letters.