R. Lesyk

发表

Recent developments with rhodanine as a scaffold for drug discovery

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2017, Expert opinion on drug discovery.

2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule

J. Handzlik, R. Lesyk, Kamila Buzun, 2022, International journal of molecular sciences.

Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential.

N. Finiuk, R. Lesyk, A. Kryshchyshyn-Dylevych, 2021, Bioorganic & medicinal chemistry.

5‐Arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones with selective inhibitory activity against some leukemia cell lines

S. Kubicek, R. Kralovics, R. Lesyk, 2020, Archiv der Pharmazie.

Thiazolidinone-Related Heterocyclic Compounds as Potential Antitrypanosomal Agents

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2020, Azoles - Synthesis, Properties, Applications and Perspectives [Working Title].

Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds.

M. Hajdúch, P. Džubák, R. Lesyk, 2020, Bioorganic & medicinal chemistry letters.

Synthesis of indoline-thiazolidinone hybrids with antibacterial and antifungal activities

R. Konechna, O. Korniychuk, Y. Konechnyi, 2020 .

Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents

D. Kaminskyy, R. Lesyk, M. Mishchenko, 2020, Scientia Pharmaceutica.

Thiazolidinone/thiazole based hybrids - New class of antitrypanosomal agents.

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2019, European journal of medicinal chemistry.

Isothiochromenothiazoles-A Class of Fused Thiazolidinone Derivatives with Established Anticancer Activity That Inhibits Growth of Trypanosoma brucei brucei.

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2018, Scientia pharmaceutica.

4-Thiazolidones: Centenarian History, Current Status and Perspectives for Modern Organic and Medicinal Chemistry

R. Lesyk, B. Zimenkovsky, 2004 .

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives.

D. Kaminskyy, R. Lesyk, B. Zimenkovsky, 2009, European journal of medicinal chemistry.

Synthesis of pyrazoline-thiazolidinone hybrids with trypanocidal activity.

R. Lesyk, P. Grellier, B. Zimenkovsky, 2014, European journal of medicinal chemistry.

Study of antineoplastic action of novel isomeric derivatives of 4-thiazolidinone.

M. Fil, R. Stoika, R. Lesyk, 2014, Ukrainian biochemical journal.

5-Ene-4-thiazolidinones – An efficient tool in medicinal chemistry

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2017, European Journal of Medicinal Chemistry.

One-Pot Synthesis of 5-Ene-4-aminothiazol-2(5H)-ones and Chromeno[2,3-d]thiazol-2-ones

D. Kaminskyy, R. Lesyk, A. Gzella, 2017, Synlett.

3D-MoRSE descriptors explained.

Oleg Devinyak, Roman Lesyk, R. Lesyk, 2014, Journal of molecular graphics & modelling.

In silico identification and biochemical validation of plausible molecular targets of 4-thiazolidinone derivative Les-3833 as a potential anticancer agent

R. Lesyk, I. Subtelna, L. Kоbylinska, 2021, The Ukrainian Biochemical Journal.

QSAR Analysis of Antimicrobial Activity of 4‐thiazolidone Derivatives

E. Muratov, V. Kuz'min, A. Artemenko, 2009 .

Synthesis and Biological Activity Evaluation of Novel 5-Methyl-7-phenyl-3H-thiazolo[4,5-b]pyridin-2-ones

Y. Konechnyi, R. Lesyk, A. Lozynskyi, 2021, Scientia Pharmaceutica.

Biodistribution and Anticancer Characteristics of Les-3833, A Novel 4-thiazolidinone-Based Lead Compound

R. Stoika, R. Lesyk, S. Vari, 2020, Scientia Pharmaceutica.

Changes in Energy Consumption, Economic Growth and Aspirations for Energy Independence: Sectoral Analysis of Uses of Natural Gas in Ukrainian Economy

R. Lesyk, O. Yemelyanov, A. Symak, 2019 .

Application of the 2(5H)furanone motif in the synthesis of new thiopyrano[2,3-d]thiazoles via the hetero-Diels–Alder reaction and related tandem processes

Svyatoslav Polovkovych, R. Lesyk, A. Gzella, 2016 .

Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor.

S. Kubicek, R. Kralovics, R. Lesyk, 2020, Blood.

Study of 1,3-dipolar cycloaddition of amino-acid azomethines and Juglone

R. Lesyk, A. Gzella, V. Novikov, 2020 .

Computational Search for Possible Mechanisms of 4‐Thiazolidinones Anticancer Activity: The Power of Visualization

R. Lesyk, B. Zimenkovsky, D. Havrylyuk, 2014, Molecular informatics.

Targeting of the pro-oxidant-antioxidant balance in vitro and in vivo by 4-thiazolidinone-based chemotherapeutics with anticancer potential

R. Lesyk, R. Stoika, O. Klyuchivska, 2019, The Ukrainian Biochemical Journal.

Development of Rational Strategy for Selective COX-2 Inhibitors Searching as Potential Anticancer Drugs

R. Lesyk, Vasyl Atamanyuk, M. Senthilraja, 2012 .

Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one

A. Nowaczyk, R. Lesyk, A. Gzella, 2014, Journal of Molecular Modeling.

Recycling of expired paracetamol-containing drugs as source of useful reagents for an organic synthesis

R. Lesyk, A. Lozynskyi, L. Lesyk, 2019, Journal of Applied Pharmaceutical Science.

Synthesis and in vivo evaluation of pyrazoline-thiazolidin-4-one hybrid Les-5581 as a potential non-steroidal anti-inflammatory agent

R. Lesyk, S. Holota, R. Vynnytska, 2019, Biopolymers and Cell.

New 5-substituted thiazolo[3,2-b][1,2,4]triazol-6-ones: synthesis and anticancer evaluation.

R. Lesyk, A. Gzella, S. Holota, 2007, European journal of medicinal chemistry.

Molecular Design, Synthesis, and Properties of Surface-Active Comb-Like PEG-Containing Polymers and Derived Supramolecular Structures for Drug Delivery

M. Šlouf, N. Finiuk, R. Lesyk, 2021, Biomedical Nanomaterials.

Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents

N. Finiuk, R. Lesyk, A. Gzella, 2022, Molecules.

Effect of Experimental Hypergomocysteinemia and its Correction by Choline and Vitamin D on the Biochemical Indicators of the Famale rats

R. Lesyk, O. Kutelmakh, M. Lutsyuk, 2019, Experimental and Clinical Physiology and Biochemistry.

4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms

N. Finiuk, R. Stoika, R. Lesyk, 2017, Croatian medical journal.

Anticancer properties of 4-thiazolidinone derivatives depend on peroxisome proliferator-activated receptor gamma (PPARγ).

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2017, European journal of medicinal chemistry.

Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives

M. Fil, R. Stoika, R. Lesyk, 2012 .

Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides.

R. Lesyk, Alysha G. Elliott, J. Zuegg, 2020, European journal of medicinal chemistry.

Screening of antioxidant and anti-inflammatory activities among thiopyrano[2,3-d]thiazoles

D. Kaminskyy, R. Lesyk, A. Lozynskyi, 2015 .

New 4-thiazolidinone-based molecules Les-2769 and Les-3266 as possible PPARγ modulators.

R. Lesyk, K. A. Szychowski, Bartosz Skóra, 2022, Bioorganic chemistry.

Study of novel anticancer 4-thiazolidinone derivatives.

D. Kaminskyy, R. Lesyk, K. A. Szychowski, 2017, Chemico-biological interactions.

Search for Imbalance Mechanisms of the Metabolic Indicators and Natural Detoxification at the Action of New 4-thiazolidinone Derivatives Possessing Anti-neoplastic Activity

R. Lesyk, B. Zimenkovsky, L. Kobylinska, 2016 .

Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation.

N. Finiuk, R. Lesyk, A. Kryshchyshyn-Dylevych, 2022, European journal of medicinal chemistry.

Increased antitumor efficiency and reduced negative side effects of 4-thiazolidinone derivatives in complexes with PEG-containing polymeric nanocarrier

R. Stoika, R. Lesyk, B. Zimenkovsky, 2018 .

Nitric oxide as the main multifunctional regulator of immunocompetent and endothelial cells

R. Lesyk, M. Kolishetska, O. V. Sadlyak, 2017 .

1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3-d]thiazoles as Potential Biologically Active Compounds

N. Finiuk, Svyatoslav Polovkovych, R. Lesyk, 2022, Molecules.

Proton tautomerism and stereoisomerism of 4-amino-1,3-thiazol-2(5H)-one derivatives bearing substituents with opposite electronic effects: synthesis, structure and spectroscopic studies

M. Jaskólski, A. Łapiński, R. Lesyk, 2022, Journal of Molecular Structure.

Synthesis, structure and evaluation of anticancer activity of 4-amino-1,3-thiazolinone/pyrazoline hybrids

M. Jaskólski, R. Lesyk, A. Gzella, 2021 .

Synthesis of new structurally diverse thiazolidinone-derived compounds based on reaction of isorhodanine with ortho-substituted aldehydes, α-keto- and β-aroylacrylic acids

D. Kaminskyy, R. Lesyk, A. Gzella, 2020 .

Antimicrobial and cytotoxic activities of thiazolo[4,5-b]pyridine derivatives

N. Finiuk, Y. Konechnyi, R. Lesyk, 2021 .

4-Thiazolidinone-Bearing Hybrid Molecules in Anticancer Drug Design

R. Lesyk, K. Bielawski, A. Bielawska, 2022, International journal of molecular sciences.

rel-2-[4-Chloro-2-[(5R,6R,7S)-6-[5-(4-methoxyphenyl)-3-(2-naphthyl)-3,4-dihydropyrazole-2-carbonyl]-5-methyl-2-oxo-3,5,6,7-tetrahydrothiopyrano[2,3-d]thiazol-7-yl]phenoxy]acetic Acid

R. Lesyk, I. Yushyn, S. Holota, 2022, Molbank.

Anticancer 5‐arylidene‐2‐(4‐hydroxyphenyl)aminothiazol‐4(5H)‐ones as tubulin inhibitors

P. Džubák, R. Lesyk, A. Kryshchyshyn-Dylevych, 2022, Archiv der Pharmazie.

Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues

R. Lesyk, A. Lozynskyi, M. Mishchenko, 2021, Scientia Pharmaceutica.

Synthesis and antiinflammatory activity of some 2-arylamino-2-thiazoline-4-ones.

R. Lesyk, I. Subtelna, I. Nektegayev, 2003, Acta poloniae pharmaceutica.

Characterization of Phytochemical Components of Crocus sativus Leaves: A New Attractive By-Product

L. Ivanauskas, R. Lesyk, I. Bezruk, 2021, Scientia Pharmaceutica.

The synthesis of 4-thiazolidinone derivatives using 2-(4-R-2-formylphenoxy)-N-(R’-phenyl)acetamides and their anti-inflammatory activity

T. Yushchenko, R. Lesyk, N. Voloshchuk, 2015 .

Fused Thiopyrano[2,3-d]thiazole Derivatives as Potential Anticancer Agents

A. Kryshchyshyn, R. Lesyk, D. Atamanyuk, 2012, Scientia pharmaceutica.

A new domino-Knoevenagel–hetero-Diels–Alder reaction

A. Kryshchyshyn, R. Lesyk, A. Gzella, 2008 .

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids

R. Lesyk, D. Havrylyuk, O. Roman, 2016, European Journal of Medicinal Chemistry.

Synthesis and evaluation of biological activity of 1-[2-amino-4-methylthiazol-5-yl]-3-arylpropenones

Y. Konechnyi, R. Lesyk, A. Lozynskyi, 2021, Biopolymers and Cell.

Unexpected synthesis of azepino[4,3,2- cd ]indoles from 4-aminoindoles

R. Lesyk, A. Gzella, M. Garazd, 2017 .

Synthesis and cytotoxicity of new thiazolo[4,5-b]pyridine-2(3H)-one derivatives based on α,β-unsaturated ketones and α-ketoacids

R. Lesyk, A. Gzella, L. Radko, 2018, Chemical Papers.

Cyclocondensation of Thioamides and Haloacetic Acid Derivatives Provides Only 4-Thiazolidinones; Isomeric 5-Thiazolidinones Were Not observed

D. Kaminskyy, R. Lesyk, A. Gzella, 2014 .

Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety.

R. Lesyk, A. Gzella, B. Zimenkovsky, 2010, European journal of medicinal chemistry.

Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies.

K. Kieć‐Kononowicz, F. Jensen, R. Lesyk, 2006, Bioorganic & medicinal chemistry.

Isothiocoumarin-3-carboxylic acid derivatives: synthesis, anticancer and antitrypanosomal activity evaluation.

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2014, European journal of medicinal chemistry.

Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

R. Lesyk, A. Gzella, B. Zimenkovsky, 2009, European journal of medicinal chemistry.

Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles.

R. Lesyk, P. Grellier, D. Atamanyuk, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity.

K. Kieć‐Kononowicz, R. Lesyk, A. Gzella, 2010, Bioorganic & medicinal chemistry.

An overview on 1,2,4-triazole and 1,3,4-thiadiazole derivatives as potential anesthesic and anti-inflammatory agents

R. Lesyk, A. Lozynskyi, S. Shtrygol’, 2022, ScienceRise: Pharmaceutical Science.

trans-Aconitic acid-based hetero-Diels-Alder reaction in the synthesis of thiopyrano[2,3-d][1,3]thiazole derivatives

R. Lesyk, A. Gzella, P. Grellier, 2017 .

Synthesis of fused thiopyrano[2,3- d ][1,3]thiazoles via hetero-Diels–Alder reaction related tandem and domino processes

R. Lesyk, A. Gzella, V. Matiychuk, 2015 .

Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity.

R. Lesyk, A. Gzella, B. Zimenkovsky, 2012, Journal of medicinal chemistry.

Synthesis and Anticancer Activity of Novel Nonfused Bicyclic Thiazolidinone Derivatives

R. Lesyk, B. Zimenkovsky, D. Havrylyuk, 2009 .

New 5-substituted thiazolo[3,2-b][1,2,4]triazol-6-ones: synthesis and anticancer evaluation.

R. Lesyk, A. Gzella, S. Holota, 2007, European journal of medicinal chemistry.

Synthesis and anti-leukemic activity of pyrrolidinedione-thiazolidinone hybrids

R. Kralovics, D. Kaminskyy, A. Kryshchyshyn, 2020 .

Synthesis and Anticancer and Antiviral Activities of New 2‐Pyrazoline‐Substituted 4‐Thiazolidinones

R. Lesyk, B. Zimenkovsky, D. Havrylyuk, 2013 .

Thiazolidinone motif in anticancer drug discovery. Experience of DH LNMU medicinal chemistry scientific group

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2011 .

Induction of Cyp450 enzymes by 4-thiazolidinone-based derivatives in 3T3-L1 cells in vitro

K. Rybczyńska-Tkaczyk, D. Kaminskyy, R. Lesyk, 2020, Naunyn-Schmiedeberg's Archives of Pharmacology.

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates

D. Kaminskyy, R. Lesyk, L. Zaprutko, 2011, Scientia pharmaceutica.

Biologically active 4-thiazolidinones: a review of QSAR studies and QSAR modeling of antitumor activity.

R. Lesyk, B. Zimenkovsky, O. Devinyak, 2013, Current topics in medicinal chemistry.

Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives

R. Lesyk, M. Garazd, Y. Garazd, 2016, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

Synthesis and anticancer activity of 6-heteroarylcoumarins.

R. Lesyk, M. Garazd, Y. Garazd, 2015, European journal of medicinal chemistry.

Synthesis, antioxidant and antimicrobial activities of novel thiopyrano[2,3-d]thiazoles based on aroylacrylic acids

D. Kaminskyy, R. Lesyk, A. Lozynskyi, 2017, Molecular Diversity.

Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro- and enterotoxicity on the stress model in rats

R. Lesyk, I. Fomenko, T. Bondarchuk, 2021 .

Synthesis and Biological Activity Evaluation of Polyfunctionalized Anthraquinonehydrazones

R. Lesyk, A. Lozynskyi, O. Karpenko, 2020 .

Hydrogen Sulfide Releasing 2-Mercaptoacrylic Acid-Based Derivative Possesses Cytoprotective Activity in a Small Intestine of Rats with Medication-Induced Enteropathy

R. Lesyk, A. Lozynskyi, I. Fomenko, 2017, Scientia pharmaceutica.

Arylidene Pyruvic Acids Motif in the Synthesis of New 2H,5H-Chromeno[4′,3′:4,5]thiopyrano[2,3-d]thiazoles via Tandem Hetero-Diels–Alder-Hemiacetal Reaction

R. Lesyk, A. Gzella, A. Lozynskyi, 2015 .

Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones.

A. Bast, G. D. den Hartog, D. Kaminskyy, 2016, European journal of medicinal chemistry.

Modified Coumarins. 38. Synthesis and Cytotoxicity of 6-Pyrazolinylcoumarins

R. Lesyk, M. Garazd, Y. Garazd, 2016, Chemistry of Natural Compounds.

SYNTHESIS AND ANTITUMOR ACTIVITY OF NOVEL 2-THIOXO-4-THIAZOLIDINONES WITH BENZOTHIAZOLE MOIETIES

C. Davila, R. Lesyk, B. Zimenkovsky, 2009 .

Facile one-pot synthesis of 5-aryl/heterylidene-2-(2-hydroxyethyl- and 3-hydroxypropylamino)-thiazol-4-ones via catalytic aminolysis

R. Lesyk, A. Gzella, O. Karpenko, 2017 .

An efficient method for the transformation of 5-ylidenerhodanines into 2,3,5-trisubstituted-4-thiazolidinones

D. Kaminskyy, R. Lesyk, Dmytro Khyluk, 2012 .

Synthesis, Antibacterial and Antifungal Activity of New 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine Quaternary Salts

R. Lesyk, Alysha G. Elliott, J. Zuegg, 2021, Molecules.

SYNTHESIS AND ANTICANCER ACTIVITY OF ISATIN, OXADIAZOLE AND 4-THIAZOLIDINONE BASED CONJUGATES

R. Lesyk, M. Lelyukh, D. Havrylyuk, 2015 .

Anticancer cytotoxicity of indole-thiazolidinone hybrids, in silico study of mechanisms of their action

N. Finiuk, R. Lesyk, A. Kryshchyshyn-Dylevych, 2022, Biopolymers and Cell.

Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

R. Lesyk, N. D. Obushak, R. Kutsyk, 2006, Pharmaceutical Chemistry Journal.

Synthesis of new potential anticancer agents based on 4-thiazolidinone and oleanane scaffolds

O. Kazakova, D. Kaminskyy, R. Lesyk, 2011, Medicinal Chemistry Research.

Synthesis of Fused Thiopyrano[2,3‐d][1,3]thiazoles via hetero‐Diels—Alder Reaction Related Tandem and Domino Processes.

R. Lesyk, A. Gzella, V. Matiychuk, 2016 .

Drug design: 4-thiazolidinones applications. Part 1. Synthetic routes to the drug-like molecules

R. Lesyk, 2020, Journal of Medical Science.

Screening of spiro-substituted thiopyrano[2,3-d]thiazoles for their cytotoxic action on tumor cells

N. Finiuk, R. Lesyk, R. Stoika, 2017 .

Evaluation of Anticancer and Antibacterial Activity of Four 4-Thiazolidinone-Based Derivatives

D. Kaminskyy, R. Lesyk, A. Kryshchyshyn-Dylevych, 2022, Molecules.

Synthesis and anticancer activity evaluation of 3-(4-oxo-2-thioxothiazolidin-5-yl)-1H-indole-carboxylic acids derivatives

R. Lesyk, A. Kryshchyshyn-Dylevych, M. Garazd, 2020 .

Synthesis and evaluation of anticancer activity of 5-ylidene-4- aminothiazol-2(5H)-one derivatives.

D. Kaminskyy, R. Lesyk, A. Gzella, 2015, Medicinal chemistry (Shariqah (United Arab Emirates)).

Trends in research of antitrypanosomal agents among synthetic heterocycles.

D. Kaminskyy, A. Kryshchyshyn, R. Lesyk, 2014, European journal of medicinal chemistry.

Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.

R. Lesyk, L. Zaprutko, Justyna Żwawiak, 2009, European journal of medicinal chemistry.

Autophagy Modulators in Cancer Therapy

R. Lesyk, Kamila Buzun, Agnieszka Gornowicz, 2021, International journal of molecular sciences.

Synthesis and anticancer activity of novel thiopyrano[2,3-d]thiazole-based compounds containing norbornane moiety

R. Lesyk, B. Zimenkovsky, D. Atamanyuk, 2008 .

The application of anthraquinone-based triazenes as equivalents of diazonium salts in reaction with methylene active compounds

R. Lesyk, A. Lozynskyi, R. Vynnytska, 2018 .

Synthesis and evaluation of anti-yellow fever virus activity of new 6-aryl-3-R-amino-1,2,4-triazin-5(4H)-ones.

I. Komarov, R. Lesyk, Y. Novodvorskyi, 2023, European journal of medicinal chemistry.

Arylidene pyruvic acids motif in the synthesis of new thiopyrano[2,3-d]thiazoles as potential biologically active compounds

R. Lesyk, A. Lozynskyi, B. Zimenkovsky, 2015 .

Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity.

R. Lesyk, A. Gzella, P. Grellier, 2019, Bioorganic chemistry.

Synthesis and Anticancer Activity of Isatin‐Based Pyrazolines and Thiazolidines Conjugates

R. Lesyk, B. Zimenkovsky, D. Havrylyuk, 2011, Archiv der Pharmazie.

EFFECTS OF 4-THIAZOLIDINONE DERIVATIVES LES-2658 AND LES-1205 ON SLEEP - WAKEFULNESS CYCLE IN KINDLED RATS

R. Lesyk, O. Pinyazhko, S. Myronenko, 2017 .

Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety

R. Lesyk, B. Zimenkovsky, D. Atamanyuk, 2013, Scientia pharmaceutica.

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry

R. Lesyk, A. Lozynskyi, O. Roman, 2018, Scientia pharmaceutica.

Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds.

R. Hodges, Y. Vassetzky, V. Ribrag, 2014, Bioorganic & medicinal chemistry.

Putative anticancer potential of novel 4-thiazolidinone derivatives: cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats

R. Stoika, R. Lesyk, R. Panchuk, 2016, Croatian medical journal.

Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones

D. Smee, R. Lesyk, P. Grellier, 2013, European Journal of Medicinal Chemistry.

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

N. Finiuk, R. Stoika, D. Kaminskyy, 2016, European journal of medicinal chemistry.

Crotonic, cynnamic, and propiolic acids motifs in the synthesis of thiopyrano[2,3-d][1,3]thiazoles via hetero-Diels–Alder reaction and related tandem processes

R. Lesyk, A. Gzella, V. Matiychuk, 2014 .

Evaluation of 5-[(Z)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent

R. Lesyk, A. Lozynskyi, M. Mishchenko, 2022, Scientia Pharmaceutica.

Psychotropic properties of a potential anticonvulsant of 5-[(Z)-(4-nitrobenzylidene)]-2- (thiazol-2-ylimino)-4-thiazolidinone

R. Lesyk, A. Lozynskyi, M. Mishchenko, 2021, News of Pharmacy.

Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones as Possible Anticancer Agents

R. Lesyk, A. Gzella, A. Cherkas, 2021, Molecules.

Investigation of anticancer and anti-parasitic activity of thiopyrano[2,3-d]thiazoles bearing norbornane moiety

D. Kaminskyy, R. Lesyk, P. Grellier, 2017 .

Synthesis and anticancer activity in vitro of isothiochromeno[3,4-d]thiazole derivatives

R. Lesyk, B. Zimenkovsky, Anna Kryshchyshyn, 2008 .

Enhanced Proapoptotic Effects of Water Dispersed Complexes of 4-Thiazolidinone-Based Chemotherapeutics with a PEG-Containing Polymeric Nanocarrier

R. Stoika, R. Lesyk, B. Zimenkovsky, 2019, Nanoscale Research Letters.

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells

R. Stoika, R. Lesyk, R. Panchuk, 2017, Croatian medical journal.

Development of Predictive QSAR Models of 4‐Thiazolidinones Antitrypanosomal Activity Using Modern Machine Learning Algorithms

Anna Kryshchyshyn, Oleg Devinyak, Danylo Kaminskyy, 2018, Molecular informatics.

Comparison of dual acting drugs and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis

R. Lesyk, D. Havrylyuk, I. Fomenko, 2011 .

EVALUATION OF NOVEL 4-THIAZOLIDINONE-BASED DERIVATIVES AS POSSIBLE CYTOPROTECTIVE AGENTS AGAINST STRESS MODEL IN RATS

R. Lesyk, I. Ilkiv, O. Sklyarov, 2017 .

The influence of novel 4-thiazolidinone derivaties in cytoprotective mechanisms of small intestine under nsaid-induced damage

R. Lesyk, I. Ilkiv, O. Sklyarov, 2016 .

Synthesis of New Schiff Bases and Polycyclic Fused Thiopyranothiazoles Containing 4,6‐Dichloro‐1,3,5‐Triazine Moiety

Svyatoslav Polovkovych, R. Lesyk, B. Zimenkovsky, 2013 .

Cell immunity of laboratory animals under the influence of 5-indolylmethylene rhodanine-3-carboxylic/sulphonic acid derivative

R. Konechna, O. Korniychuk, Y. Konechnyi, 2021 .

Synthesis and evaluation of biological activity of rhodanine-pyrazoline hybrid molecules with 2-(2,6-dichlorophenylamino)-phenylacetamide fragment

R. Lesyk, P. Grellier, A. Lozynskyi, 2020, Biopolymers and Cell.

Changes of nitric oxide system and lipid peroxidation parameters in the digestive system of rats under conditions of acute stress, and use of nonsteroidal anti-inflammatory drugs

R. Lesyk, I. Fomenko, T. Bondarchuk, 2015 .

Synthesis and biological activity evaluation of new thiazolidinone-diclofenac hybrid molecules

R. Lesyk, P. Grellier, A. Lozynskyi, 2020 .

Synthesis and cytotoxicity of new 2-oxo-7-phenyl-2,3-dihydrothiazolo[4,5-b]pyridine-5-carboxylic acid amides

R. Stoika, R. Lesyk, A. Gzella, 2019, Phosphorus, Sulfur, and Silicon and the Related Elements.

Use of lectins as vector molecules for delivery of drugs to cells and tissues. Report 2.

R. Lesyk, R. Stoika, A. Lozynskyi, 2019, Biopolymers and Cell.

Comparative Investigation of Amino Acids Content in the Dry Extracts of Juno bucharica, Gladiolus Hybrid Zefir, Iris Hungarica, Iris Variegata and Crocus Sativus Raw Materials of Ukrainian Flora

L. Ivanauskas, R. Lesyk, I. Bezruk, 2020, Scientia Pharmaceutica.

BODIPY-Based Nanomaterials—Sensing and Biomedical Applications

T. Goslinski, R. Lesyk, L. Sobotta, 2022, Applied Sciences.

Multi-Targeting Anticancer Activity of a New 4-Thiazolidinone Derivative with Anti-HER2 Antibodies in Human AGS Gastric Cancer Cells

R. Lesyk, Agnieszka Gornowicz, R. Czarnomysy, 2023, International journal of molecular sciences.

4-Thiazolidinone-based derivatives rescue TNAα-inhibited osteoblast differentiation in mouse mesenchymal precursor cells

R. Stoika, R. Lesyk, D. Havrylyuk, 2017 .

Screening study of new thiazolidinone derivatives for anticonvulsant activity

R. Lesyk, A. Lozynskyi, M. Mishchenko, 2020, Zaporozhye Medical Journal.

5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3-d][1,3]thiazole Core

R. Lesyk, B. Zimenkovsky, D. Atamanyuk, 2014 .

Assessment of the Technological Changes Impact on the Sustainability of State Security System of Ukraine

R. Lesyk, O. Yemelyanov, A. Symak, 2018 .

The Pharmacophore Model for the Antistaphylococcal Activity Screening Among Thiazolidinone-Related Structures

R. Lesyk, S. Holota, A. Lozynskyi, 2020 .

Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).

P. Džubák, N. Finiuk, Svyatoslav Polovkovych, 2023, European journal of medicinal chemistry.

Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms.

M. Cazzola, D. Vertommen, C. Pecquet, 2022, Blood.

Design, synthesis, and anticancer evaluation of nitrobenzoxadiazole-piperazine hybrids as potent pro-apoptotic agents

R. Lesyk, Xinya Han, Qian Chen, 2023, Tetrahedron.

5-Year Trends in QSAR and its Machine Learning Methods.

R. Lesyk, O. Devinyak, Oleg T Devinyak, 2016, Current computer-aided drug design.

4-thiazolidinone-based derivatives rosiglitazone and pioglitazone affect the expression of antioxidant enzymes in different human cell lines.

D. Kaminskyy, R. Lesyk, A. Kryshchyshyn-Dylevych, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Fused Triazole-Azepine Hybrids as Potential Non-Steroidal Antiinflammatory Agents

R. Lesyk, S. Holota, A. Demchenko, 2023, Scientia Pharmaceutica.

N-(3-Cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-[[5-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide

R. Lesyk, R. Vynnytska, I. Yushyn, 2021, Molbank.

Manganic encephalopathy due to “ephedrone” abuse

S. Fahn, R. Lesyk, Iryna Komnatska, 2007, Movement disorders : official journal of the Movement Disorder Society.

Metal Nanoparticle-Flavonoid Connections: Synthesis, Physicochemical and Biological Properties, as Well as Potential Applications in Medicine

T. Goslinski, R. Lesyk, Dariusz T. Mlynarczyk, 2023, Nanomaterials.

Anticancer properties of 5Z-(4-fluorobenzylidene)-2-(4-hydroxyphenylamino)-thiazol-4-one

D. Kaminskyy, R. Lesyk, K. A. Szychowski, 2019, Scientific reports.

The novel pyrazolin-5-one bearing thiazolidin-4-ones: synthesis, characterization and biological evaluation

R. Lesyk, S. Holota, I. Nektegayev, 2021, Biopolymers and Cell.

Thiopyrano[2,3-d]thiazole structures as promising scaffold with anticancer potential.

N. Finiuk, R. Lesyk, R. Stoika, 2022, Chemico-biological interactions.

Study of 1,2,4-triazole-3(5)-thiol Behavior in Reactions with 1-phenyl-1H-pyrrole-2,5-dione Derivatives and 3-bromodihydrofuran-2(3H)-one and Antimicrobial Activity of Products

R. Lesyk, A. Gzella, R. Kutsyk, 2020, Chemistry Proceedings.

Features of antimicrobial activity of some 5-aminomethylene-2-thioxo-4-thiazolidinones

R. Lesyk, S. Holota, R. Kutsyk, 2019, Biopolymers and Cell.

Synthesis of 4-(2H-[1,2,4]-Triazol-5-ylsulfanyl)-1,2-dihydropyrazol-3-one via Ring-Switching Hydrazinolysis of 5-Ethoxymethylidenethiazolo [3,2-b][1,2,4]triazol-6-one

R. Lesyk, A. Gzella, O. Karpenko, 2018, Molbank.

Synthesis and evaluation of antitrypanosomal activity of some thiosemicarbazide derivatives of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

U. Holzgrabe, R. Lesyk, A. Gzella, 2018, Synthetic Communications.

Tandem hetero-Diels–Alder-hemiacetal reaction in the synthesis of new chromeno[4′,3′:4,5]thiopyrano[2,3-d]thiazoles

R. Lesyk, A. Gzella, V. Matiychuk, 2017 .

Synthesis and Anticancer Activity Evaluation of 5-[2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-thiazolidinones

R. Lesyk, Kamila Buzun, A. Kryshchyshyn-Dylevych, 2021, Molecules.

Structure–anticancer activity relationships among 4-azolidinone-3-carboxylic acids derivatives

D. Kaminskyy, R. Lesyk, 2010 .

2-[N-(2,4-Dimethoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate

R. Lesyk, A. Gzella, V. Horishny, 2013, Acta crystallographica. Section E, Structure reports online.

Compounding in Ukraine: Assessment of the Risks for the Ointment’s Quality by the FMECA Method

L. Ivanauskas, R. Lesyk, V. Georgiyants, 2022, Scientia Pharmaceutica.

Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides

R. Lesyk, A. Lozynskyi, B. Zimenkovsky, 2014, Scientia pharmaceutica.

Synthesis and evaluation of the anticancer activity of some semisynthetic derivatives of rutaecarpine and evodiamine

P. Džubák, R. Lesyk, M. Garazd, 2021, Synthetic Communications.

4-thiazolidinone-based derivatives do not affect differentiation of mouse embryo fibroblasts (3T3-L1 cell line) into adipocytes.

D. Kaminskyy, R. Lesyk, A. Kryshchyshyn-Dylevych, 2021, Chemico-biological interactions.

Synthesis and structure elucidation of thiopyrano[2,3-d]thiazole-6-carbonitriles as adducts of Michael reaction

R. Lesyk, A. Gzella, A. Lozynskyi, 2022, Journal of Molecular Structure.

3-Phenylpropanal and citral in the multicomponent synthesis of novel thiopyrano[2,3-d]thiazoles

Svyatoslav Polovkovych, R. Lesyk, A. Gzella, 2022, Results in Chemistry.

Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives.

R. Lesyk, A. Gzella, M. Kowiel, 2014, Acta crystallographica. Section C, Structural chemistry.

2-[7-(3,5-Dibromo-2-hydroxyphenyl)-6-ethoxycarbonyl-2-oxo-5H-2,3,6,7-tetrahydrothiopyrano[2,3-d][1,3]thiazol-6-yl]acetic acid ethanol monosolvate

R. Lesyk, A. Gzella, M. Kowiel, 2012, Acta crystallographica. Section E, Structure reports online.

Synthesis, anticancer and antiviral activities of novel thiopyrano[2,3-d]thiazole-6-carbaldehydes

R. Lesyk, A. Gzella, A. Lozynskyi, 2016 .

Crotonic, Cynnamic, and Propiolic Acids Motifs in the Synthesis of Thiopyrano[2,3‐d][1,3]thiazoles via hetero‐Diels—Alder Reaction and Related Tandem Processes.

R. Lesyk, A. Gzella, V. Matiychuk, 2014 .

Morphology of the Micelles Formed by a Comb-Like PEG-Containing Copolymer Loaded with Antitumor Substances with Different Water Solubilities

V. Garamus, R. Lesyk, N. Mitina, 2020 .

Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity

R. Stoika, R. Lesyk, R. Panchuk, 2017 .

3-[5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl]-propionic Acid as a Potential Polypharmacological Agent

Y. Konechnyi, R. Lesyk, A. Lozynskyi, 2023, Scientia Pharmaceutica.

Evaluation of the Adaptability of the Ukrainian Economy to Changes in Prices for Energy Carriers and to Energy Market Risks

Olexandr Yemelyanov, Roman Lesyk, Anastasiya Symak, 2018, Energies.

New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents

R. Konechna, Y. Konechnyi, R. Lesyk, 2023, Biopolymers and Cell.

Pyrrolidinedione-thiazolidinone hybrid molecules with potent cytotoxic effect in squamous cell carcinoma SCC-15 cells.

N. Finiuk, R. Lesyk, R. Stoika, 2023, Bioorganic & medicinal chemistry.

Anticancer properties of 5Z-(4-fluorobenzylidene)-2-(4-hydroxyphenylamino)-thiazol-4-one

D. Kaminskyy, R. Lesyk, K. A. Szychowski, 2019, Scientific Reports.

Comparative analysis of the impact of retabolil, derived tiopiranotiazolu (substance LES-2222) and testosterone propionate on protein metabolism in the body of rats at food deprivation

R. Lesyk, N. Koropetska, D. Ostapiv, 2015 .

The Chemical Inhibitors of Endocytosis: From Mechanisms to Potential Clinical Applications

N. Finiuk, Y. Vassetzky, R. Lesyk, 2023, Cells.

5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells.

N. Finiuk, R. Stoika, D. Kaminskyy, 2016, European journal of medicinal chemistry.

Preliminary evaluation of thiazolidinone- and pyrazoline-related heterocyclic derivatives as potential antimalarial agents

R. Lesyk, P. Grellier, Anna P. Kryshchyshyn-Dylevych, 2020 .

Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity.

R. Lesyk, A. Gzella, B. Zimenkovsky, 2009, European journal of medicinal chemistry.