H. Nagase

发表

Studies on Fungicides. XXII. Reaction of Dimethyl Acetylenedicarboxylate with Dithiocarbamates, Thiolcarbamates, Thiosemicarbazides and Thiosemicarbazones

H. Nagase, 1973 .

Properties of TAN-67, a nonpeptide δ-opioid receptor agonist, at cloned human δ-and μ-opioid receptors

V. Hruby, R. Knapp, H. Yamamura, 1995 .

Degradation of collagen in lung tissue slices exposed to hyperoxia.

H. Nagase, C. Chae, R. Berg, 2015, The American review of respiratory disease.

Antinociceptive effects of (+)-matrine in mice.

M. Ohsawa, J. Kamei, H. Nagase, 1997, European Journal of Pharmacology.

In silico design of novel probes for the atypical opioid receptor MRGPRX2

Jing Liu, Jian Jin, John D. McCorvy, 2016, Nature chemical biology.

The effects of dopamine D1 and D2 receptor antagonists on the rewarding effects of δ1 and δ2 opioid receptor agonists in mice

T. Mori, M. Misawa, H. Nagase, 1996, Psychopharmacology.

The role of mu- and kappa-opioid receptors in cocaine-induced conditioned place preference.

M. Misawa, Tsutomu Suzuki, H. Nagase, 1992, Japanese journal of pharmacology.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry.

Antinociceptive effect of buprenorphine in mu1-opioid receptor deficient CXBK mice.

M. Tsuda, J. Kamei, H. Nagase, 1997, Life sciences.

Involvement of β-arrestin-2 in modulation of the spinal antinociception induced by μ-opioid receptor agonists in the mouse

N. Dun, M. Ohsawa, M. Narita, 2003, Neuroscience Letters.

Usefulness of Olanzapine as an Adjunct to Opioid Treatment and for the Treatment of Neuropathic Pain

M. Rahmadi, M. Narita, Akira Yamashita, 2012, Anesthesiology.

Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

P. Portoghese, M. Sultana, A. Takemori, 1988, Journal of medicinal chemistry.

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2020, Bioorganic & medicinal chemistry letters.

Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept.

H. Nagase, A. Saitoh, 2018, Handbook of experimental pharmacology.

Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.

H. Nagase, Toshihiro Takahashi, Shigeto Hirayama, 2017, Bioorganic & medicinal chemistry letters.

The application of a specific morphinan template to the synthesis of galanthamine

H. Nagase, Tsuyoshi Saitoh, Noriki Kutsumura, 2017 .

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Synthesis of novel basic skeletons derived from naltrexone.

H. Nagase, H. Fujii, 2011, Topics in current chemistry.

Opioids in preclinical and clinical trials.

H. Nagase, H. Fujii, 2011, Topics in current chemistry.

Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.

N. Yamaotsu, S. Hirono, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Discovery of the First in Class Drug for Intractable Itch, Nalfurafine Hydrochloride

H. Nagase, K. Kawai, K. Kawamura, 2011 .

Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2009, Bioorganic & medicinal chemistry.

Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: mu, kappa, and putative epsilon opioid receptor antagonists.

M. Narita, Tsutomu Suzuki, H. Nagase, 2009, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

S. Hirono, H. Gouda, H. Nagase, 2009, Bioorganic & medicinal chemistry letters.

Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists.

H. Nagase, Y. Imamura, T. Miyamoto, 2008, Bioorganic & medicinal chemistry.

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

M. Narita, Tsutomu Suzuki, H. Nagase, 2008, Bioorganic & medicinal chemistry.

Synthesis of a novel 4,6′-epoxymorphinan derivative and a highly strained novel conjugated ketone

H. Nagase, N. Sato, H. Fujii, 2007 .

The effect of chronic treatment with naltrindole, a selective δ-opioid antagonist, on μ-opioid receptor-mediated antinociception in diabetic mice

M. Misawa, J. Kamei, Tsutomu Suzuki, 2005, Psychopharmacology.

Rational drug design and synthesis of a selective opioid receptor antagonist on the basis of the accessory site concept.

M. Narita, H. Nagase, H. Mizoguchi, 2004, Bioorganic & medicinal chemistry letters.

Solid-phase synthesis of naltrindole derivatives using Fischer indole synthesis based on one-pot release and cyclization methodology.

H. Ohno, Takashi Takahashi, H. Nagase, 2003, Organic letters.

Antitussive effects of naltrindole, a selective δ-opioid receptor antagonist, in mice and rats

M. Misawa, J. Kamei, Tsutomu Suzuki, 1993 .

Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone.

P. Portoghese, M. Sultana, A. Takemori, 1992, Life sciences.

Pentazocine-induced biphasic analgesia in mice.

M. Misawa, M. Narita, H. Nagase, 1991, Life sciences.

Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2022, Bioorganic & Medicinal Chemistry Letters.

Protection of cardiac myocytes via δ1-opioid receptors, protein kinase C, and mitochondrial KATP channels

G. Gross, H. Nagase, B. Liang, 2001 .

Modification of morphine-induced locomotor activity by pertussis toxin: biochemical and behavioral studies in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 1993, Brain Research.

Involvement of dopamine-dependent and -independent mechanisms in the rewarding effects mediated by δ opioid receptor subtypes in mice

H. Ikeda, M. Misawa, Tsutomu Suzuki, 1997, Brain Research.

Morphine-induced place preference in the CXBK mouse: characteristics of μ opioid receptor subtypes

M. Misawa, M. Narita, Tsutomu Suzuki, 1993, Brain Research.

Blockade of morphine reward through the activation of κ-opioid receptors in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 1993, Neuropharmacology.

Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels.

R. Fryer, A. Hsu, G. Gross, 2000, The Journal of pharmacology and experimental therapeutics.

Opioid Kappa Receptor Selective Agonist TRK-820 (Nalfurafine Hydrochloride)

H. Nagase, Shigeto Hirayama, H. Fujii, 2012 .

Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms.

N. Koshikawa, A. Cools, Tsutomu Suzuki, 2004, European journal of pharmacology.

Possible Pharmacotherapy of the Opioid κ Receptor Agonist for Drug Dependence

M. Narita, Tsutomu Suzuki, H. Nagase, 2004 .

Different roles of μ-, δ- and κ-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress

M. Misawa, Tsutomu Suzuki, H. Nagase, 1999 .

Involvement of μ- and δ-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress

M. Misawa, Tsutomu Suzuki, H. Nagase, 1998, Brain Research.

Discriminative stimulus properties of morphine mediated by mu 1-opioid receptors.

T. Mori, M. Misawa, H. Nagase, 1995, European journal of pharmacology.

Discovery of a structurally novel opioid kappa-agonist derived from 4,5-epoxymorphinan.

H. Nagase, K. Kawai, K. Kawamura, 1998, Chemical & pharmaceutical bulletin.

TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.

A. Hsu, G. Gross, H. Nagase, 1998, American journal of physiology. Heart and circulatory physiology.

Different motivational effects induced by the endogenous μ-opioid receptor ligands endomorphin-1 and -2 in the mouse

M. Narita, H. Nagase, H. Mizoguchi, 2001, Neuroscience.

Blockade of δ-Opioid Receptors Prevents Morphine-Induced Place Preference in Mice

M. Misawa, J. Kamei, Tsutomu Suzuki, 1994 .

ZINC-ACETIC ACID PROMOTED REDUCTIVE CARBON-NITROGEN BOND CLEAVAGE REACTION OF α-AMINOKETONES (Dedicated to Professor Victor Snieckus on the occasion of his 77th birthday)

H. Nagase, Kyoko Ishikawa, M. Tomatsu, 2014 .

Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo

Teruhiko Yoshida, H. Sakamoto, H. Katai, 2015, PloS one.

Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.

N. Yamaotsu, S. Hirono, H. Nagase, 2010, Bioorganic & medicinal chemistry.

Decreased opioid-induced antinociception but unaltered G-protein activation in the genetic-diabetic NOD mouse.

M. Ohsawa, J. Kamei, H. Nagase, 2000, European Journal of Pharmacology.

Dependence of delta1-opioid receptor-induced cardioprotection on a tyrosine kinase-dependent but not a Src-dependent pathway.

R. Fryer, A. Hsu, G. Gross, 2001, The Journal of pharmacology and experimental therapeutics.

Differential involvement of μ1-opioid receptors in endomorphin- and β-endorphin-induced G-protein activation in the mouse pons/medulla

M. Narita, H. Nagase, H. Mizoguchi, 2000, Neuroscience.

Differential antinociceptive effects of endomorphin-1 and endomorphin-2 in the mouse.

J. Kampine, M. Ohsawa, M. Narita, 2000, The Journal of pharmacology and experimental therapeutics.

A novel kappa-opioid receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice.

M. Narita, Tsutomu Suzuki, H. Takeda, 2000, Life sciences.

Effects of a highly selective nonpeptide delta opioid receptor agonist, TAN-67, on morphine-induced antinociception in mice.

T. Mori, M. Misawa, H. Nagase, 1995, Life sciences.

Antipruritic activity of the κ-opioid receptor agonist, TRK-820

J. Kamei, H. Nagase, T. Endoh, 2002 .

Antipruritic activity of the kappa-opioid receptor agonist, TRK-820.

J. Kamei, H. Nagase, T. Endoh, 2002, European journal of pharmacology.

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

Hiromasa Funato, Y. Nagumo, Y. Irukayama-Tomobe, 2022, PloS one.

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

K. Vogt, T. Sakurai, M. Yanagisawa, 2017, Proceedings of the National Academy of Sciences.

Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation

A. Murakami, Jun Zhu, Takenori Inomata, 2020, Scientific Reports.

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of 5,6,7-trinor-4,8-inter-m-phenylene-PGI2 derivatives and their inhibitory activities to human platelet aggregation.

H. Nagase, H. Nishiyama, K. Ohno, 1985, Advances in prostaglandin, thromboxane, and leukotriene research.

The role of the mu 2-opioid receptor in the antitussive effect of morphine in mu 1-opioid receptor-deficient CXBK mice.

M. Misawa, J. Kamei, H. Nagase, 1993, European journal of pharmacology.

Blockade of morphine reward through the activation of kappa-opioid receptors in mice.

M. Misawa, M. Narita, H. Nagase, 1993, Neuropharmacology.

Synthesis of (-)-homogalanthamine from naltrexone.

H. Tomoda, H. Nagase, J. Inokoshi, 2011, Journal of Organic Chemistry.

In vivo properties of KNT‐127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice

C. Gaveriaux-Ruff, B. Kieffer, H. Nagase, 2014, British journal of pharmacology.

Relative efficacies of δ-opioid receptor agonists at the cloned human δ-opioid receptor

R. Quock, V. Hruby, R. Knapp, 1997 .

TAN-67, a delta 1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels.

A. Hsu, G. Gross, H. Nagase, 1998, The American journal of physiology.

Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: synthesis of decahydroisoquinoline derivatives and their pharmacologies.

N. Yamaotsu, S. Hirono, H. Nagase, 2012, Chemical & pharmaceutical bulletin.

TRK-820, a selective kappa-opioid agonist, produces potent antinociception in cynomolgus monkeys.

J. Kamei, M. Narita, H. Nagase, 2001, Japanese journal of pharmacology.

Novel δ1-receptor agonist KNT-127 increases the release of dopamine and l-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex

S. Yamamura, M. Okada, H. Nagase, 2012, Neuropharmacology.

The antitussive effects of endomorphin-1 and endomorphin-2 in mice.

J. Kamei, H. Nagase, A. Saitoh, 2003, European Journal of Pharmacology.

Antagonistic effect of buprenorphine on the antitussive effect of morphine is mediated via the activation of mu 1-opioid receptors.

J. Kamei, H. Nagase, A. Saitoh, 1995, Life sciences.

Buprenorphine exerts its antinociceptive activity via mu 1-opioid receptors.

M. Misawa, J. Kamei, H. Nagase, 1995, Life sciences.

Antitussive effect of dihydroetorphine in mice.

M. Misawa, J. Kamei, H. Nagase, 1994, European journal of pharmacology.

Antitussive effect of [Met5]enkephalin-Arg6-Phe7 in mice.

M. Misawa, J. Kamei, H. Nagase, 1994, European journal of pharmacology.

Involvement of δ1-opioid receptor antagonism in the antitussive effect of δ-opioid receptor antagonists

M. Misawa, J. Kamei, Tsutomu Suzuki, 1994 .

Involvement of adenosine A1 receptors in antitussive effect in mice.

M. Misawa, J. Kamei, H. Nagase, 1994, Life sciences.

Involvement of delta 1-opioid receptor antagonism in the antitussive effect of delta-opioid receptor antagonists.

M. Misawa, J. Kamei, H. Nagase, 1994, European journal of pharmacology.

Differential modulation of μ-opioid receptor-mediated antitussive activity by δ-opioid receptor agonists in mice

M. Misawa, J. Kamei, Tsutomu Suzuki, 1993 .

Antitussive effect of β-endorphin is mediated by μ-opioid receptors, but not by κ- or ϵ-opioid receptors

M. Misawa, J. Kamei, H. Nagase, 1993 .

Antitussive effect of beta-endorphin is mediated by mu-opioid receptors, but not by kappa- or epsilon-opioid receptors.

M. Misawa, J. Kamei, H. Nagase, 1993, European Journal of Pharmacology.

Possible involvement of μ 2-mediated mechanisms in μ-mediated antitussive activity in the mouse

M. Misawa, J. Kamei, Tsutomu Suzuki, 1993, Neuroscience Letters.

Possible involvement of mu 2-mediated mechanisms in mu-mediated antitussive activity in the mouse.

M. Misawa, J. Kamei, N. Kawashima, 1993, Neuroscience letters.

Differential modulation of mu-opioid receptor-mediated antitussive activity by delta-opioid receptor agonists in mice.

M. Misawa, J. Kamei, H. Nagase, 1993, European journal of pharmacology.

Antitussive effects of naltrindole, a selective delta-opioid receptor antagonist, in mice and rats.

M. Misawa, J. Kamei, H. Nagase, 1993, European journal of pharmacology.

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

T. Sakurai, M. Yanagisawa, H. Gouda, 2021, European journal of medicinal chemistry.

Involvement of beta-arrestin-2 in modulation of the spinal antinociception induced by mu-opioid receptor agonists in the mouse.

N. Dun, M. Ohsawa, M. Narita, 2003, Neuroscience letters.

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2019, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2019, Bioorganic & medicinal chemistry.

Nonpeptide Orexin-2 Receptor Agonist Attenuates Morphine-induced Sedative Effects in Rats

M. Yanagisawa, Y. Tagaito, H. Nagase, 2018, Anesthesiology.

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels.

R. Fryer, A. Hsu, G. Gross, 1999, Circulation research.

Opioid-Induced Second Window of Cardioprotection

R. Fryer, A. Hsu, G. Gross, 1999 .

Rational Drug Design of δ Opioid Receptor Agonist TAN-67

H. Nagase, H. Fujii, 2006 .

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain.

Y. Nagumo, H. Nagase, A. Saitoh, 2015, Bioorganic & medicinal chemistry.

Pharmacological properties of TRK-820 on cloned μ-, δ- and κ-opioid receptors and nociceptin receptor

H. Nagase, S. Ide, M. Satoh, 1999 .

Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.

P. Portoghese, A. Takemori, H. Nagase, 1991, Journal of medicinal chemistry.

Novel Baeyer–Villiger-type oxidation of 4,5-epoxymorphinan derivatives

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2020 .

Cold-restraint stress-induced ultrasonic vocalization as a novel tool to measure anxiety in mice.

Daisuke Yamada, H. Ichikawa, H. Nagase, 2022, Biological & pharmaceutical bulletin.

Roles of endogenous opioid peptides in modulation of nocifensive response to formalin.

H. Nagase, H. Mizoguchi, L. Tseng, 2002, The Journal of pharmacology and experimental therapeutics.

Algogenic mediator-induced nociceptive response in diabetic mice.

K. Taki, J. Kamei, H. Nagase, 1999, European journal of pharmacology.

Selective agonists of the δ-opioid receptor, KNT-127 and SNC80, act differentially on extinction learning of contextual fear memory in mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2019, Neuropharmacology.

Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.

Scott F. Hall, I. Sora, G. Uhl, 2003, Journal of pharmacological sciences.

Loss of μ-opioid receptor-mediated G-protein activation in the pons/medulla of mice lacking the exons 2 and 3 of μ-opioid receptor gene

H. Loh, M. Narita, H. Nagase, 2002, Neuroscience Letters.

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

N. Yamaotsu, S. Hirono, N. Wada, 2014, Bioorganic & Medicinal Chemistry Letters.

The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives.

N. Wada, H. Nagase, Shigeto Hirayama, 2013, Bioorganic & medicinal chemistry letters.

Rearrangement of 4,5α-epoxymorphinan derivatives with carbamoylepoxy rings provide novel oxazatricyclodecane structures

H. Nagase, Shigeto Hirayama, H. Fujii, 2011 .

Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.

M. Narita, Tsutomu Suzuki, H. Nagase, 2008, Bioorganic & medicinal chemistry letters.

Effect of repeated administration of TRK-820, a κ-opioid receptor agonist, on tolerance to its antinociceptive and sedative actions

H. Nagase, T. Endoh, Y. Togashi, 2004, Brain Research.

Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells

H. Okano, Y. Okada, H. Okano, 2012, British Journal of Cancer.

Synthesis of Unnatural Morphinan Compounds to Induce Itch-like Behaviors in Mice: Towards the Development of MRGPRX2 Selective Ligands.

A. Inoue, Y. Nagumo, H. Nagase, 2021, Bioorganic & medicinal chemistry letters.

Effect of naltrindole on the development of physical dependence on morphine in mice: a behavioral and biochemical study.

T. Mori, M. Misawa, Tsutomu Suzuki, 1995, Life sciences.

A delta opioid receptor agonist, KNT-127, in the prelimbic medial prefrontal cortex attenuates glial glutamate transporter blocker-induced anxiety-like behavior in mice.

H. Nagase, A. Saitoh, M. Yamada, 2018, Journal of pharmacological sciences.

The delta opioid receptor agonist KNT-127 in the prelimbic medial prefrontal cortex attenuates veratrine-induced anxiety-like behaviors in mice

H. Nagase, A. Saitoh, M. Yamada, 2018, Behavioural Brain Research.

Modulation of opioidergic system on mecamylamine-precipitated nicotine-withdrawal aversion in rats

M. Narita, Tsutomu Suzuki, H. Nagase, 2000, Psychopharmacology.

Differential properties between TRK-820 and U-50,488H on the discriminative stimulus effects in rats.

M. Narita, Tsutomu Suzuki, H. Nagase, 2004, Life sciences.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Modulation of κ-opioidergic systems on mecamylamine-precipitated nicotine-withdrawal aversion in rats

M. Narita, Tsutomu Suzuki, H. Nagase, 2002, Neuroscience Letters.

The novel kappa-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice.

M. Narita, Tsutomu Suzuki, H. Takeda, 2001, Life sciences.

Synthesis of a stable iminium salt and propellane derivatives.

S. Hirono, H. Nagase, K. Kamiya, 2008, The Journal of organic chemistry.

Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.

D. L. Larson, A. Lipkowski, P. Portoghese, 1988, Journal of medicinal chemistry.

Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.

P. Portoghese, A. Takemori, H. Nagase, 1988, Journal of medicinal chemistry.

Potent antinociceptive effects of TRK-820, a novel κ-opioid receptor agonist

M. Narita, Tsutomu Suzuki, H. Nagase, 1999 .

Different effects of NMDA/group I metabotropic glutamate receptor agents in δ- and μ-opioid receptor agonist-induced supraspinal antinociception

M. Narita, Tsutomu Suzuki, H. Nagase, 2000 .

Inhibitory effects of TRK-820 on systemic skin scratching induced by morphine in rhesus monkeys.

H. Nagase, T. Endoh, Toshiaki Tanaka, 2004, Life sciences.

Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice.

J. Kamei, H. Nagase, 2001, European journal of pharmacology.

Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

H. Nagase, Y. Togashi, K. Nakao, 2003 .

Blockade of mu-opioid receptor-mediated G-protein activation and antinociception by TRK-820 in mice.

M. Narita, Tsutomu Suzuki, H. Nagase, 2003, European journal of pharmacology.

TRK-820 , a Selective-Opioid Agonist , Produces Potent Antinociception in Cynomolgus Monkeys

J. Kamei, M. Narita, Tsutomu Suzuki, 2001 .

ZnCl2-Promoted Intramolecular Hetero-Diels-Alder Reaction of o-Alkynylphenylcarbodiimides for Synthesis of Dihydrodibenzo[b,g][1,8]naphthyridines.

Takao Saito, H. Nagase, Noriki Kutsumura, 2016, Chemical & pharmaceutical bulletin.

Metal-halogen exchange between polybromoanisoles and aliphatic Grignard reagents: a synthesis of cyclopenta[b]benzofurans

H. Nagase, K. Itoh, H. Nishiyama, 1992 .

Structure-antitussive activity relationships of naltrindole derivatives. Identification of novel and potent antitussive agents.

J. Kamei, S. Ueno, H. Nagase, 2008, Journal of medicinal chemistry.

Non-peptidic δ opioid receptor agonists and antagonists (2000 – 2012)

H. Nagase, Toshihiro Takahashi, H. Fujii, 2013, Expert opinion on therapeutic patents.

Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 1992, Brain Research.

Chemistry of opioids

H. Nagase, S. Calderon, 2011 .

An ATP-sensitive potassium channel blocker abolishes the potentiating effect of morphine on the bicuculline-induced convulsion in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 2005, Psychopharmacology.

Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice

M. Misawa, J. Kamei, M. Narita, 1993, Psychopharmacology.

Effects of kappa optolds on the morphine-induced pharmacological actions

M. Misawa, M. Narita, H. Nagase, 1990 .

Involvement of the opioid system in the anxiolytic effect of diazepam in mice.

M. Tsuda, M. Misawa, H. Nagase, 1996, European journal of pharmacology.

Intrathecal morphine-3-glucuronide-induced nociceptive behavior via Delta-2 opioid receptors in the spinal cord

H. Nagase, H. Mizoguchi, S. Sakurada, 2016, Pharmacology Biochemistry and Behavior.

Effects of differential modulation of μ-, δ- and κ-opioid systems on bicuculline-induced convulsions in the mouse

M. Misawa, M. Narita, Tsutomu Suzuki, 2000, Brain Research.

Effects of differential modulation of mu-, delta- and kappa-opioid systems on bicuculline-induced convulsions in the mouse.

M. Misawa, M. Narita, H. Nagase, 2000, Brain research.

APPLICATION OF SO₃H SILICA GEL TO DEPROTECTION OF SILYL ETHERS

H. Nagase, H. Fujii, A. Hamasaki, 2012 .

A mild methylation of alcohols with diazomethane catalyzed by silica gel

H. Nagase, H. Nishiyama, K. Ohno, 1980 .

Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851.

H. Ohno, S. Ueno, H. Nagase, 2008, Bioorganic & Medicinal Chemistry.

Michael Reactions of 4-Acylmethylene-1, 3 (2H, 4H)-isoquinolinediones with Malononitrile

H. Nagase, K. Kawai, Ryoji Yamaguchi, 1985 .

Michael reactions of 3-acylmethyleneoxindoles with active methylene compounds

H. Nagase, K. Kawai, K. Higashiyama, 1985 .

Design and Synthesis of Novel Opioid Ligands and Their Pharmacologies

H. Nagase, H. Fujii, 2012 .

Reaction of Some Amides and Thioamides with Diazomethane Catalyzed by Silica Gel

H. Nagase, H. Nishiyama, Kiyotaka Ohio, 1980 .

Convenient methods for deoxygenation of epoxides to olefins

H. Nagase, Kiyoyuki Yamada, Y. Hirata, 1978 .

A NOVEL ABNORMAL REARRANGEMENT IN THE FISCHER INDOLE SYNTHESIS

H. Nagase, R. Tanimura, H. Fujii, 1997 .

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & Medicinal Chemistry Letters.

Convenient synthesis of oxazolidinones by the use of halomethyloxirane, primary amine, and carbonate salt.

S. Hirono, Yoko Sato, H. Nagase, 2005, The Journal of organic chemistry.

Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives

N. Shimada, H. Nagase, T. Nagamitsu, 2017 .

Application of SO3H Silica Gel to Deprotection of Silyl Ethers.

H. Nagase, H. Fujii, A. Hamasaki, 2013 .

Antitrichomonal activity of δ opioid receptor antagonists, 7-benzylidenenaltrexone derivatives.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2017, Bioorganic & medicinal chemistry.

A highly selective δ1-opioid receptor antagonist : 7-benzylidenenaltrexone

P. Portoghese, M. Sultana, A. Takemori, 1992 .

Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.

P. Portoghese, A. Takemori, H. Nagase, 1991, Journal of medicinal chemistry.

The facility of formation of a .DELTA.6 bond in dihydromorphinone and related opiates

P. Portoghese, H. Nagase, Akira Abe, 1989 .

The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival.

H. Nagase, M. Okamoto, T. Oka, 1992, Transplantation.

Synthesis of heterocyclic compounds with adamantane-like cage structures consisting of phosphorus, sulfur, and carbon

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2017 .

Stereocontrolled total synthesis (-)-picrotoxinin and (+)-coriamyrtin via a common isotwistane intermediate

K. Wakamatsu, Masaaki Suzuki, H. Niwa, 1984 .

Novel rearrangement reaction of a 6,14-endoethanomorphinan derivative to a benzomorphan derivative

H. Nagase, N. Sato, H. Fujii, 2009 .

Asymmetric induction in cyclohexadienones carrying α-d-glucopyranosyl moiety

Y. Einaga, Kensuke Nakamura, H. Nagase, 2016 .

Hydrogenolysis of the cyclopropyl group into an isopropyl group in the presence of a platinum catalyst and hydrobromic acid

H. Nagase, H. Fujii, T. Nemoto, 2009 .

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.

Investigation of Beckett-Casy model 3: synthesis of novel naltrexone derivatives with contracted and expanded D-rings and their pharmacology.

S. Hirono, H. Gouda, H. Nagase, 2010, Bioorganic & medicinal chemistry letters.

Oxidative Cleavage of the Acyl‐Carbon Bond in Phenylacetone with Electrogenerated Superoxide Anions

Y. Einaga, H. Nagase, Tsuyoshi Saitoh, 2018, ChemElectroChem.

The role of spinal delta1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice.

J. Kamei, H. Nagase, H. Hitosugi, 1997, European journal of pharmacology.

Antagonism of the morphine-induced Straub tail reaction by κ-opioid receptor activation in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 2005, Psychopharmacology.

Effects of diabetes on the morphine-induced Straub tail reaction in mice

M. Misawa, M. Ohsawa, J. Kamei, 1994, Neuroscience Letters.

Role of cholecystokinin in the reduction of endomorphin-2-induced antinociception in diabetic mice.

J. Kamei, H. Nagase, K. Zushida, 2001, European journal of pharmacology.

Effects of kappa-agonist on the antinociception and locomotor enhancing action induced by morphine in mice.

M. Misawa, M. Narita, Tsutomu Suzuki, 1993, Japanese journal of pharmacology.

Attenuation of the discriminative stimulus properties of cocaine by delta-opioid receptor antagonists.

T. Mori, M. Misawa, H. Nagase, 1994, European Journal of Pharmacology.

The role of δ-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences

M. Misawa, H. Nagase, Tomohisa Mori, 1994 .

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.

H. Nagase, Shigeto Hirayama, H. Fujii, 2012, Bioorganic & medicinal chemistry letters.

Effects of a newly synthesized κ-opioid receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats

M. Narita, Tsutomu Suzuki, H. Nagase, 2002, Psychopharmacology.

kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice.

M. Ohsawa, J. Kamei, H. Nagase, 1999, Planta medica.

Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice.

M. Ohsawa, J. Kamei, H. Nagase, 1999, European journal of pharmacology.

Identification of the G‐protein‐coupled ORL1 receptor in the mouse spinal cord by [35S]‐GTPγS binding and immunohistochemistry

N. Dun, M. Narita, H. Nagase, 1999, British journal of pharmacology.

Differential antinociception induced by spinally administered endomorphin-1 and endomorphin-2 in the mouse.

J. Kampine, M. Ohsawa, M. Narita, 2001, The Journal of pharmacology and experimental therapeutics.

Differential mechanisms mediating descending pain controls for antinociception induced by supraspinally administered endomorphin-1 and endomorphin-2 in the mouse.

M. Ohsawa, M. Narita, H. Nagase, 2000, The Journal of pharmacology and experimental therapeutics.

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

The antinociceptive effects of endomorphin-1 and endomorphin-2 in diabetic mice.

M. Ohsawa, J. Kamei, H. Nagase, 2000, European journal of pharmacology.

Suppression of Acute Herpetic Pain-Related Responses by the κ-Opioid Receptor Agonist (-)-17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-3-trans-3-(3-furyl) Acrylamido] Morphinan Hydrochloride (TRK-820) in Mice

Hiroshi Nagase, Hiroshi Nojima, Ichiro Takasaki, 2004, Journal of Pharmacology and Experimental Therapeutics.

Suppression of Acute Herpetic Pain-Related Responses by the (cid:1) -Opioid Receptor Agonist ( (cid:1) )-17-Cyclopropylmethyl-3,14 (cid:2) -dihydroxy-4,5 (cid:3) -epoxy-6 (cid:2) -[ N -methyl-3- tran s-3-(3-furyl) Acrylamido] Morphinan Hydrochloride (TRK-820) in Mice

I. Takasaki, H. Nojima, H. Nagase, 2004 .

Use of antisense oligodeoxynucleotide to δ-opioid receptor mRNA in the study of turnover of δ-opioid receptors in the spinal cord of the mouse

M. Narita, H. Nagase, H. Mizoguchi, 1997, Psychopharmacology.

Characterization of the antinociceptive effects of TRK-820 in the rat.

J. Kamei, M. Narita, H. Nagase, 2000, European journal of pharmacology.

Differential effects of μ-, δ- and κ-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats

M. Misawa, Tsutomu Suzuki, H. Nagase, 1997 .

Blockade of the morphine-induced increase in turnover of dopamine on the mesolimbic dopaminergic system by kappa-opioid receptor activation in mice.

M. Misawa, M. Narita, H. Nagase, 1993, Life sciences.

Effects of nor-binaltorphimine on the development of analgesic tolerance to and physical dependence on morphine.

M. Misawa, M. Narita, H. Nagase, 1992, European journal of pharmacology.

A highly selective delta 1-opioid receptor antagonist: 7-benzylidenenaltrexone.

P. Portoghese, M. Sultana, A. Takemori, 1992, European journal of pharmacology.

Pertussis toxin abolishes mu- and delta-opioid agonist-induced place preference.

M. Misawa, M. Narita, H. Nagase, 1991, European journal of pharmacology.

Differential mediation of cold water swim stress-induced antinociception by delta-opioid receptor subtypes in diabetic mice.

M. Misawa, J. Kamei, H. Nagase, 1994, Life sciences.

Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord.

J. Kamei, M. Narita, H. Nagase, 1997, The Journal of pharmacology and experimental therapeutics.

The efficacy of δ-opioid receptor-selective drugs

R. Quock, V. Hruby, H. Yamamura, 1998 .

Involvement of δ1 and δ2 Opioid Receptor Subtypes in the Development of Physical Dependence on Morphine in Mice

M. Misawa, Tsutomu Suzuki, H. Nagase, 1997, Pharmacology Biochemistry and Behavior.

Streptozotocin-induced diabetes selectively enhances antinociception mediated by δ1-but not δ2-opioid receptors

M. Misawa, J. Kamei, H. Nagase, 1994 .

Antitussive effects of μ- and κ-agonists in diabetic rats

M. Misawa, J. Kamei, Tsutomu Suzuki, 1993, Neuroscience Letters.

Antisense oligodeoxynucleotide to a δ-opioid receptor blocks the antinociception induced by cold water swimming

M. Narita, H. Nagase, H. Mizoguchi, 1995, Regulatory Peptides.

The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine.

T. Mori, M. Misawa, H. Nagase, 1997, European journal of pharmacology.

Chicken egg white cystatin. Molecular cloning, nucleotide sequence, and tissue distribution.

H. Nagase, Y. Sakaguchi, R. Colella, 1989, The Journal of biological chemistry.

Synthetic studies on spirovetivanes. I. Spirocondensation of a 4-(3′-formylpropyl)-3-cyclohexenone and stereospecific total synthesis of d1-β-vetivone.

Y. Hayakawa, H. Nagase, Kiyoyuki Yamada, 1973 .

Syntheses of Potential Metabolites of a Potent κ-Opioid Receptor Agonist, TRK-820

Kentaro Yoshizawa, H. Nagase, K. Kawamura, 2004 .

Opioid δ₁ receptor antagonist 7-benzylidenenaltrexone as an effective resistance reverser for chloroquine-resistant Plasmodium chabaudi.

Seiki Kobayashi, T. Takeuchi, H. Nagase, 2011, Bioorganic & medicinal chemistry letters.

Protection of tertiary hydroxyl groups as methylthiomethyl ethers

H. Nagase, Kiyoyuki Yamada, Y. Hirata, 1976 .

Involvement of Spinal Protein Kinase Cγ in the Attenuation of Opioid μ-Receptor-Mediated G-Protein Activation after Chronic Intrathecal Administration of [d-Ala2,N-MePhe4,Gly-Ol5]Enkephalin

M. Narita, Tsutomu Suzuki, H. Nagase, 2001, The Journal of Neuroscience.

Enhanced μ-Opioid Responses in the Spinal Cord of Mice Lacking Protein Kinase Cγ Isoform*

N. Dun, S. Imai, Tsutomu Suzuki, 2001, The Journal of Biological Chemistry.

Preparative resolution of 2-methyl-4-hexynic acid for the synthesis of optically active m-phenylene PGI2 derivatives and determination of their absolute configuration

Y. Kitano, H. Nagase, H. Nishiyama, 2000 .

Catalytic Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4,5-Epoxy Bridge Affords a More Selective Ligand for κ Opioid Receptor than the Representative κ Antagonist nor-BNI

H. Nagase, H. Mochizuki, H. Fujii, 2007 .

Immunosuppression by delta opioid receptor antagonist.

H. Nagase, K. Akioka, M. Okamoto, 1993, Transplantation proceedings.

Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats

H. Nagase, A. Saitoh, M. Yamada, 2018, Psychopharmacology.

Effect of diabetes on the antinociceptive effect of β-endorphin

M. Misawa, J. Kamei, N. Kawashima, 1993, Brain Research.

Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.

H. Nagase, Satomi Imaide, Mayumi Nakajima, 2010, Bioorganic & medicinal chemistry letters.

Antinociceptive and antitussive effects of morphine in the DA-bg/bg (beige) rat.

J. Kamei, H. Nagase, A. Saitoh, 1996, European journal of pharmacology.

Evidence for differential modulation of μ-opioid receptor-mediated antinociceptive and antitussive activities by spleen-derived factor(s) from diabetic mice

M. Misawa, J. Kamei, H. Nagase, 1994, Neuropharmacology.

Delta Opioid Receptor Agonists Ameliorate Colonic Inflammation by Modulating Immune Responses

C. Nishiyama, H. Nagase, Kazuki Nagata, 2021, Frontiers in Immunology.

Agonist-specific down-regulation of the human δ-opioid receptor

V. Hruby, E. Navratilova, K. Rice, 2003 .

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Reiko Kobayakawa, Xiaowei Zhan, T. Sakurai, 2018, Nature Communications.

Blockade of delta-opioid receptors prevents morphine-induced place preference in mice.

M. Misawa, J. Kamei, H. Nagase, 1994, Japanese journal of pharmacology.

Total Synthesis of Optically Active m‐Phenylene PGl2 Derivative: Beraprost.

H. Nagase, H. Nishiyama, H. Wakita, 2000 .

Total Synthesis of Optically Active m-Phenylene PGl2 Derivative: Beraprost

H. Nagase, H. Nishiyama, H. Wakita, 2000 .

Generalization of NMDA-receptor antagonists to the discriminative stimulus effects of kappa-opioid receptor agonists U-50,488H, but not TRK-820 in rats.

M. Narita, Tsutomu Suzuki, H. Nagase, 2006, Journal of pharmacological sciences.

Roles of 5-HT3 and opioid receptors in the ethanol-induced place preference in rats exposed to conditioned fear stress.

M. Misawa, H. Nagase, T. Suzuki, 1999, Life sciences.

NOR-BINALTORPHIMINE (NOR-BNI) : POTENT AND SELECTIVE KAPPAOPIOID RECEPTOR ANTAGONIST WITH LONG-LASTING ACTIVITY IN VIVO

H. Nagase, T. Endoh, H. Matsuura, 1991 .

Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.

J. Kamei, H. Nagase, A. Saitoh, 2004, Journal of pharmacological sciences.

Effects of a μ-opioid receptor agonist on G-protein activation in streptozotocin-induced diabetic mice

M. Ohsawa, J. Kamei, M. Narita, 2000 .

Supraspinal δ1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice

J. Kamei, M. Narita, H. Nagase, 1997 .

Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes.

M. Misawa, M. Ohsawa, J. Kamei, 1995, The Journal of pharmacology and experimental therapeutics.

Antinociceptive effects of the selective non-peptidic δ-opioid receptor agonist TAN-67 in diabetic mice

M. Misawa, M. Ohsawa, J. Kamei, 1995 .

Effects of diabetes on the antinociceptive effect of (+/-)pentazocine in mice.

M. Misawa, J. Kamei, H. Nagase, 1994, Research communications in chemical pathology and pharmacology.

Streptozotocin-induced diabetes selectively reduces antinociception mediated by μ 1-opioid receptors, but not that mediated by μ 2-opioid receptors

M. Misawa, J. Kamei, H. Nagase, 1994, Neuroscience Letters.

DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127

H. Nagase, A. Saitoh, M. Yamada, 2014, Neuropharmacology.

Antagonistic property of buprenorphine for putative ϵ-opioid receptor-mediated G-protein activation by β-endorphin in pons/medulla of the μ-opioid receptor knockout mouse

I. Sora, G. Uhl, M. Narita, 2002, Neuroscience.

Modification of morphine-induced place preference by diabetes.

M. Ohsawa, J. Kamei, H. Nagase, 1997, European journal of pharmacology.

Buprenorphine Blocks ϵ- and μ-Opioid Receptor-Mediated Antinociception in the Mouse

H. Nagase, H. Mizoguchi, L. Tseng, 2003, Journal of Pharmacology and Experimental Therapeutics.

Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels.

G. Gross, H. Nagase, B. Liang, 2001, American journal of physiology. Heart and circulatory physiology.

Design and synthesis of novel δ opioid receptor agonists with an azatricyclodecane skeleton for improving blood-brain barrier penetration.

T. Kanda, H. Nagase, Toshihiro Takahashi, 2017, Bioorganic & medicinal chemistry letters.

Rewarding effects of ethanol combined with low doses of morphine through dopamine D1 receptors.

Tsutomu Suzuki, H. Nagase, Tomohisa Mori, 2013, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

Synthesis of Novel Triplets with a 1,3,5‐Trioxazatriquinane Skeleton and Their Pharmacologies for Opioid Receptors

H. Nagase, Noriki Kutsumura, 2015, Archiv der Pharmazie.

Involvement of mu- and delta-opioid receptors in the ethanol-associated place preference in rats exposed to foot shock stress.

M. Misawa, H. Nagase, T. Suzuki, 1998, Brain research.

Implications of protein kinase C in the nucleus accumbens in the development of sensitization to methamphetamine in rats

T. Kita, Y. Nagumo, M. Narita, 2004, Neuroscience.

Research and development of κ opioid receptor agonists and δ opioid receptor agonists.

H. Nagase, A. Saitoh, 2019, Pharmacology & therapeutics.

Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for σ receptors

K. Sonehara, H. Nagase, S. Takahashi, 1999, Psychopharmacology.

The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines

H. Nagase, M. Inagaki, A. Saitoh, 2013, Neuropharmacology.

Structural Confirmation of 15-Norlubiminol and 15-Norepilubiminol, Isolated from Solanum aethiopicum, by Chemical Conversion from Lubimin and Epilubimin, and their Antifungal Activity

T. Nagaoka, H. Nagase, T. Yoshihara, 2001, Bioscience, biotechnology, and biochemistry.

Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors.

K. Vogt, M. Yanagisawa, Takehiro Miyazaki, 2021, Cell reports.

Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans on streptozotocin-induced diabetic mice.

G. Soma, M. Misawa, J. Kamei, 1994, European Journal of Pharmacology.

STUDIES ON FUNGICIDES PART 24, REACTION OF 5-METHOXYCARBONYLMETHYLIDENE-2-THIOXO(OR -OXO)-4-THIAZOLIDONES WITH O-AMINOBENZENETHIOL AND OTHER THIOLS

H. Nagase, 1974 .

Studies on fungicides. XXV. Addition reaction of dithiocarbamates to fumaronitrile, bis(alkylthio)maleonitrile, 2,3-dicyano-5,6-dihydro-1,4-dithiin and 4,5-dicyano-2-oxo-1,4-dithiole.

H. Nagase, 1974, Chemical & pharmaceutical bulletin.

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

M. Yanagisawa, H. Gouda, H. Nagase, 2015, Journal of medicinal chemistry.

Involvement of dopamine D1 and D2 receptors in the ethanol-associated place preference in rats exposed to conditioned fear stress

M. Misawa, Tsutomu Suzuki, H. Nagase, 1999, Brain Research.

"Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists.

M. Misawa, H. Nagase, Y. Fukagawa, 1990, Life sciences.

The modulatory effect of (+)-TAN-67 on the antinociceptive effects of the nociceptin/orphanin FQ in mice.

M. Ohsawa, J. Kamei, M. Narita, 1999, European journal of pharmacology.

Effects of a mu-opioid receptor agonist on G-protein activation in streptozotocin-induced diabetic mice.

M. Ohsawa, J. Kamei, M. Narita, 2000, European journal of pharmacology.

Role of intracellular calcium in modification of mu and delta opioid receptor-mediated antinociception by diabetes in mice.

M. Ohsawa, J. Kamei, H. Nagase, 1998, The Journal of pharmacology and experimental therapeutics.

Different roles of mu-, delta- and kappa-opioid receptors in ethanol-associated place preference in rats exposed to conditioned fear stress.

M. Misawa, H. Nagase, S. Matsuzawa, 1999, European journal of pharmacology.

Antagonistic property of buprenorphine for putative epsilon-opioid receptor-mediated G-protein activation by beta-endorphin in pons/medulla of the mu-opioid receptor knockout mouse.

I. Sora, G. Uhl, M. Narita, 2002, Neuroscience.

Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform.

N. Dun, M. Narita, S. Imai, 2001, The Journal of biological chemistry.

Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.

M. Misawa, H. Nagase, Y. Kishimoto, 1998, Life sciences.

Lack of the involvement of μ1-opioid receptor subtype on motivational effects induced by the endogenous μ-opioid receptor ligands endomorphin-1 and -2 in the mouse

M. Narita, Tsutomu Suzuki, H. Nagase, 2001, Neuroscience Letters.

The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals

H. Ikeda, N. Koshikawa, A. Cools, 2005, Neuroscience.

Role of μ- and δ-opioid receptors in the nucleus accumbens in turning behaviour of rats

H. Ikeda, G. Akiyama, N. Koshikawa, 2004, Neuropharmacology.

Effect of the highly selective and nonpeptide delta opioid receptor agonist TAN-67 on the morphine-induced place preference in mice.

T. Mori, M. Misawa, H. Nagase, 1996, The Journal of pharmacology and experimental therapeutics.

к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling

Akira Yamashita, N. Kuzumaki, H. Nagase, 2013, Scientific Reports.

The pharmacological profile of δ opioid receptor ligands, (+) and (−) TAN-67 on pain modulation

J. Kamei, M. Narita, Tsutomu Suzuki, 2001 .

Rational Drug Design and Synthesis of a Highly Selective Nonpeptide δ‐Opioid Agonist, (4aS*,12aR*)‐4a‐ (3‐Hydroxyphenyl)‐2‐methyl‐1,2,3,4,4a,5,12,12a‐octahydropyrido [3,4‐b]acridine (TAN‐67).

H. Nagase, T. Endoh, K. Kawai, 1999 .

Rational drug design and synthesis of a highly selective nonpeptide delta-opioid agonist, (4aS*,12aR*)-4a-(3-hydroxyphenyl)-2-methyl- 1,2,3,4,4a,5,12,12a-octahydropyrido[3,4-b]acridine (TAN-67).

H. Nagase, T. Endoh, K. Kawai, 1998, Chemical & pharmaceutical bulletin.

Agonist and antagonist properties of dihydroetorphine for μ-opioid receptors in mice

J. Kamei, Tsutomu Suzuki, H. Nagase, 1996, Neuroscience Letters.

ATTENUATION OF THE MORPHINE-INDUCED REWARDING EFFECT UNDER CHRONIC INFLAMMATORY PAIN-LIKE STATE IN RATS : IMPLICATION OF THE ACTIVATION OF ENDOGENOUS ic-OPIOID SYSTEM

M. Narita, H. Nagase, Y. Yajima, 2009 .

Role of Intracellular Calcium in Modification of Opioid Receptor-Mediated Antinociception by Micel Mu and Delta Diabetes in

M. Ohsawa, H. Nagase, J. Kamel, 2002 .

Effects of diabetes on spontaneous locomotor activity in mice

Hiroshi Nagase, Miwa Misawa, M. Misawa, 1994, Neuroscience Letters.

The κ opioid system regulates endothelial cell differentiation and pathfinding in vascular development.

S. Imai, N. Kuzumaki, Tsutomu Suzuki, 2011, Blood.

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

M. Yanagisawa, H. Nagase, A. Saitoh, 2018, Pharmacological reports : PR.

Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors.

S. Hirono, H. Gouda, H. Nagase, 2015, Bioorganic & medicinal chemistry.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.

S. Hirono, H. Gouda, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

H. Nagase, H. Mochizuki, H. Fujii, 2011, Bioorganic & medicinal chemistry letters.

Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2009, Bioorganic & medicinal chemistry letters.

Rational Drug Design of δ Opioid Receptor Agonist TAN-67 from δ Opioid Receptor Antagonist NTI

H. Nagase, H. Fujii, 2007 .

Drug design and synthesis of epsilon opioid receptor agonist: 17-(cyclopropylmethyl)-4,5alpha-epoxy-3,6beta-dihydroxy-6,14-endoethenomorphinan-7alpha-(N-methyl-N-phenethyl)carboxamide (TAN-821) inducing antinociception mediated by putative epsilon opioid receptor.

M. Narita, H. Nagase, H. Mizoguchi, 2004, Bioorganic & medicinal chemistry.

Zonisamide enhances delta receptor-associated neurotransmitter release in striato-pallidal pathway

S. Yamamura, M. Okada, H. Nagase, 2009, Neuropharmacology.

Modulation of glutamatergic synaptic transmission and neuronal excitability in the prelimbic medial prefrontal cortex via delta-opioid receptors in mice.

Daisuke Yamada, H. Nagase, A. Saitoh, 2021, Biochemical and biophysical research communications.

G Protein Activation by Endomorphins in the Mouse Periaqueductal Gray Matter

N. Dun, M. Narita, Tsutomu Suzuki, 2000, Journal of Biomedical Science.

G protein activation by endomorphins in the mouse periaqueductal gray matter.

N. Dun, M. Narita, H. Nagase, 2000, Journal of biomedical science.

Antinociceptive effect of dihydroetorphine in diabetic mice.

M. Misawa, J. Kamei, H. Nagase, 1995, European journal of pharmacology.

Acute antinociceptive tolerance and partial cross-tolerance to endomorphin-1 and endomorphin-2 given intrathecally in the mouse

H. Nagase, L. Tseng, M. Darpolor, 2003, Neuroscience Letters.

The role of delta-opioid receptor subtypes in cocaine- and methamphetamine-induced place preferences.

T. Mori, M. Misawa, H. Nagase, 1994, Life sciences.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).

N. Wada, H. Nagase, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).

N. Wada, H. Nagase, Mayumi Nakajima, 2011, Bioorganic & medicinal chemistry letters.

Rational Drug Design of Selective ℇ Opioid Receptor Agonist TAN-821 and Antagonist TAN-1014

H. Nagase, H. Fujii, 2006 .

The novel kappa-opioid receptor agonist TRK-820 has no affect on the development of antinociceptive tolerance to morphine in mice.

M. Narita, H. Takeda, T. Matsumiya, 2000, European journal of pharmacology.

Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors.

H. Gouda, H. Nagase, Shigeto Hirayama, 2021, Bioorganic & medicinal chemistry.

Synthesis of optically active TAN-67, a highly selective delta opioid receptor agonist, and investigation of its pharmacological properties.

H. Nagase, T. Endoh, H. Fujii, 2001, Drug design and discovery.

Selective δ-Opioid Receptor Agonist, KNT-127, Facilitates Contextual Fear Extinction via Infralimbic Cortex and Amygdala in Mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2022, Frontiers in Behavioral Neuroscience.

A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice

Daisuke Yamada, H. Nagase, A. Saitoh, 2021, Brain Research.

Release of [Met5]enkephalin from the spinal cord by intraventricularly administered endomorphin-2, but not endomorphin-1 in the anesthetized rat

M. Ohsawa, M. Narita, H. Nagase, 2001, Neuroscience Letters.

Up-regulation of spinal μ-opioid receptor function to activate G-protein by chronic naloxone treatment

M. Narita, Tsutomu Suzuki, H. Nagase, 2001, Brain Research.

Characterization of endomorphin-1 and -2 on [35S]GTPgammaS binding in the mouse spinal cord.

M. Narita, H. Nagase, H. Mizoguchi, 1998, European journal of pharmacology.

Discovery of Orexin 2 Receptor Selective and Dual Orexin Receptor Agonists based on the Tetralin Structure: Switching of Receptor Selectivity by Chirality on the Tetralin Ring.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & Medicinal Chemistry Letters.

Allosteric modulation of adenosine A 2A receptors in mice induces slow-wave sleep without cardiovascular effects

F. Sugiyama, Y. Chérasse, H. Nagase, 2017 .

Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats.

T. Mori, M. Misawa, H. Nagase, 1997, European journal of pharmacology.

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities

S. Ōmura, Y. Nagumo, H. Nagase, 2020, Molecules.

Involvement of δ-opioid receptors in the effects of morphine on locomotor activity and the mesolimbic dopaminergic system in mice

M. Misawa, M. Narita, Tsutomu Suzuki, 2005, Psychopharmacology.

Antagonism of the morphine-induced Straub tail reaction by kappa-opioid receptor activation in mice.

M. Misawa, M. Narita, H. Nagase, 1993, Psychopharmacology.

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

N. Wada, H. Nagase, Shigeto Hirayama, 2014, ACS medicinal chemistry letters.

Synthesis of Novel Triplet Drugs with 1,3,5-Trioxazatriquinane Skeletons and Their Pharmacologies. Part 1. Synthesis of Triplet Drugs with Morphinan Skeletons.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2011 .

Novel synthesis of a 1,3,5-trioxazatriquinane skeleton using a nitrogen clamp.

H. Nagase, K. Yoza, Mayumi Nakajima, 2009, Organic letters.

Use of antisense oligodeoxynucleotide to determine delta-opioid receptor involvement in [D-Ala2]deltorphin II-induced locomotor hyperactivity.

R. Quock, M. Narita, H. Nagase, 1996, Life sciences.

Involvement of delta 1 and delta 2 opioid receptor subtypes in the development of physical dependence on morphine in mice.

T. Mori, M. Misawa, H. Nagase, 1997, Pharmacology, biochemistry, and behavior.

Supraspinal delta 1-opioid receptor-mediated antinociceptive properties of (-)-TAN-67 in diabetic mice.

J. Kamei, M. Narita, H. Nagase, 1997, European journal of pharmacology.

Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors.

V. Hruby, R. Knapp, H. Yamamura, 1995, European journal of pharmacology.

Streptozotocin-induced diabetes selectively enhances antinociception mediated by delta 1- but not delta 2-opioid receptors.

M. Misawa, J. Kamei, H. Nagase, 1994, Life sciences.

Design and synthesis of novel orexin 2 receptor agonists with a 1,3,5-trioxazatriquinane skeleton.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2023, Bioorganic & medicinal chemistry letters.

Design and Synthesis of Orexin 1 Receptor-Selective Agonists.

A. Inoue, K. Takeuchi, Y. Nagumo, 2023, Journal of medicinal chemistry.

Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence.

M. Narita, Tsutomu Suzuki, H. Nagase, 2004, Annals of the New York Academy of Sciences.

Syntheses of 10-Oxo, 10α-Hydroxy, and 10β-Hydroxy Derivatives of a Potent κ-Opioid Receptor Agonist, TRK-820

H. Nagase, K. Kawamura, H. Hatakeyama, 2004 .

Synthesis of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 and Beraprost

H. Nagase, H. Nishiyama, H. Wakita, 1999 .

Activation of G-proteins in the mouse pons/medulla by β-endorphin is mediated by the stimulation of μ- and putative ε-receptors

M. Narita, H. Nagase, H. Mizoguchi, 2000 .

Synthesis of opioid ligands having oxabicyclo[2.2.2]octane and oxabicyclo[2.2.1]heptane skeletons

H. Nagase, K. Yoza, N. Sato, 2007 .

Novel synthesis of the ortho ester derivative of 4,5-epoxymorphinan.

H. Nagase, T. Kai, A. Watanabe, 2006, Organic letters.

Synthesis of a Novel Universal Opioid Receptor Agonist with the 1,3,5‐Trioxazatriquinane Skeleton and Its Pharmacologies.

N. Yamaotsu, S. Hirono, N. Wada, 2015 .

Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.

Y. Nagumo, H. Nagase, Tsuyoshi Saitoh, 2023, Organic letters.

Region-dependent G-protein activation by μ-, δ1- and δ2-opioid receptor agonists in the brain: Comparison between the midbrain and forebrain

M. Ohsawa, J. Kamei, H. Takeda, 1999 .

Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor.

R. Quock, V. Hruby, R. Knapp, 1997, European journal of pharmacology.

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2019, Bioorganic & medicinal chemistry letters.

Effects of mirtazapine on sleep disturbance under neuropathic pain‐like state

E. Inada, M. Narita, Akira Yamashita, 2012, Synapse.

Agonist-specific down-regulation of the human delta-opioid receptor.

V. Hruby, E. Navratilova, H. Yamamura, 2003, European journal of pharmacology.

Immunosuppressive effect of δ-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction

H. Nagase, M. Okamoto, T. Oka, 1992 .

Immunosuppressive effect of delta-opioid receptor antagonist on xenogeneic mixed lymphocyte reaction.

H. Nagase, M. Okamoto, T. Oka, 1992, Transplantation proceedings.

Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2021, Bioorganic & medicinal chemistry letters.

Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system.

H. Nagase, Y. Togashi, K. Nakao, 2003, European journal of pharmacology.

Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & medicinal chemistry letters.

Essential structure of the κ opioid receptor agonist nalfurafine for binding to the κ receptor.

H. Nagase, H. Fujii, 2014, Current pharmaceutical design.

Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.

H. Nagase, Satomi Imaide, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry letters.

Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats

Y. Nagumo, M. Narita, H. Nagase, 2005, Neuroscience.

Synthetic Study of a New Class of Stable PGI2 Analogue, m-Phenylene PGI2

H. Nagase, H. Nishiyama, Kazuhisa Matsumoto, 1996 .

Antinociceptive effect of L-arginine in diabetic mice.

M. Misawa, J. Kamei, H. Nagase, 1994, European journal of pharmacology.

Modulation of NMDA- and (+)TAN-67-induced nociception by GABA(B) receptors in the mouse spinal cord.

M. Tsuda, J. Kamei, M. Narita, 2000, Life Science.

δ-opioid receptor antagonists exhibit properties of partial δ-receptor agonists in isolated perfused heart

H. Nagase, L. Maslov, Z. Bespalova, 2004 .

Systemic administration of a delta opioid receptor agonist, KNT-127, facilitates extinction learning of fear memory in rats.

Leo Gotoh, H. Nagase, A. Saitoh, 2019, Journal of pharmacological sciences.

δ-Opiod receptor-mediated forced swimming stress-induced antinociception in the formalin test

M. Misawa, J. Kamei, H. Nagase, 2005, Psychopharmacology.

Drug Design and Synthesis of a Novel ϰ Opioid Receptor Agonist with an Oxabicyclo[2.2.2]octane Skeleton and Its Pharmacology.

H. Nagase, 2010 .

Species specificity of pharmacological characteristics of CCK-B receptors

M. Arisawa, H. Nagase, M. Takamiya, 1993, Neuroscience Letters.

Remedy for itch

J. Kamei, H. Nagase, T. Endoh, 1997 .

Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats

Leo Gotoh, H. Nagase, A. Saitoh, 2017, Behavioural Brain Research.

Novel cleavage reaction of the C16–N17 bond in naltrexone derivatives

H. Nagase, Satomi Imaide, H. Fujii, 2008 .

Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist.

M. Narita, H. Nagase, A. Saitoh, 1999, Life sciences.

Possible involvement of mu 2-opioid receptor-mediated mechanisms in morphine-induced enhancement of the pentobarbital-induced loss of the righting reflex in the mouse.

M. Ohsawa, J. Kamei, H. Nagase, 1996, Life sciences.

Preparative resolution of a key intermediate for the synthesis of optically active m-phenylene PGI2 derivatives

Y. Kitano, H. Nagase, H. Wakita, 1999 .

[Research and development of beraprost sodium, a new stable PGI2 analogue].

H. Nagase, S. Nishio, Y. Kanbayashi, 1997, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Studies on Fungicides. XXI. Reaction of Dimethyl Acetylenedicarboxylate with Thioureas

H. Nagase, 1973 .

Discovery of a Structurally Novel Opioid ϰ-Agonist Derived from 4,5-Epoxymorphinan.

H. Nagase, K. Kawai, K. Kawamura, 1998 .

Suppression of acute herpetic pain-related responses by the kappa-opioid receptor agonist (-)-17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-beta-[n-methyl-3-trans-3-(3-furyl) acrylamido] morphinan hydrochloride (TRK-820) in mice.

Hiroshi Nagase, Hiroshi Nojima, Ichiro Takasaki, 2004, The Journal of pharmacology and experimental therapeutics.

Pharmacological properties of TRK-820 on cloned mu-, delta- and kappa-opioid receptors and nociceptin receptor.

H. Nagase, S. Ide, M. Satoh, 1999, European journal of pharmacology.

Studies on fungicides. XXVI. Addition of 2,3-dimethylbutadiene to 5-methoxycarbonylmethylidene-2-thioxo-4-thiazolidones and 5-aroylmethylidene-2-thioxo-4-thiazolidones.

H. Nagase, 1974, Chemical & pharmaceutical bulletin.

Stereochemistry of intermediates in the syntheses of alkaloids

Masaaki Suzuki, Y. Hayakawa, H. Nagase, 1973 .

The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists.

V. Hruby, R. Knapp, H. Yamamura, 1996, Molecular pharmacology.

Investigation of 7-benzylidenenaltrexone derivatives as resistance reverser for chloroquine-resistant Plasmodium chabaudi.

Seiki Kobayashi, T. Takeuchi, H. Nagase, 2012, Bioorganic & medicinal chemistry letters.

Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation.

V. Hruby, R. Knapp, H. Yamamura, 2001, Life sciences.

Region-dependent G-protein activation by κ-opioid receptor agonists in the mouse brain

M. Narita, Tsutomu Suzuki, H. Nagase, 2004, Neuroscience Letters.

The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

K. Wada, H. Nagase, A. Saitoh, 2011, Behavioural Brain Research.

Design and synthesis of quinolinopropellane derivatives with selective δ opioid receptor agonism.

S. Hirono, H. Gouda, H. Nagase, 2014, Bioorganic & medicinal chemistry letters.

Design and Synthesis of a Metabolically Stable and Potent Antitussive Agent, a Novel δ Opioid Receptor Antagonist, TRK‐851.

H. Nagase, 2009 .

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Y. Uezono, M. Yamada, H. Nagase, 2014, ACS medicinal chemistry letters.

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2013, Bioorganic & medicinal chemistry.

Zinc‐Acetic Acid Promoted Reductive Carbon‐Nitrogen Bond Cleavage Reaction of α‐Aminoketones.

H. Nagase, H. Fujii, Kyoko Ishikawa, 2014 .

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists.

H. Nagase, Shigeto Hirayama, H. Fujii, 2015, Bioorganic & medicinal chemistry letters.

Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists.

H. Nagase, T. Kanemasa, Shigeto Hirayama, 2012, Bioorganic & medicinal chemistry.

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

H. Nagase, Mayumi Nakajima, H. Mochizuki, 2008, Bioorganic & medicinal chemistry letters.

A new useful conversion method of naltrexone to 14-deoxynaltrexone

H. Nagase, K. Furuhata, Yoshihiro Ida, 2006 .

Novel δ1-receptor agonist KNT-127 increases the release of dopamine and l-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex

M. Okada, H. Nagase, Y. Ueda, 2012, Neuropharmacology.

KNT-127, a selective delta opioid receptor agonist, shows beneficial effects in the hippocampal dentate gyrus of a chronic vicarious social defeat stress mouse model

Daisuke Yamada, H. Nagase, A. Saitoh, 2023, Neuropharmacology.

Prolongation of heart xenograft survival in the NK-deficient rat.

H. Nagase, K. Akioka, M. Okamoto, 1994, Transplantation proceedings.

Moyens de traitement et de prevention contre la miction frequente et l'incontinence d'urine

H. Nagase, M. Fujimura, Kuniaki Kawamura, 2000 .

Effects of mirtazapine on sleep disturbance under neuropathic pain‐like state

E. Inada, M. Narita, Akira Yamashita, 2012, Synapse.