D. Schrier

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Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.

R. D. Dyer, A. Sercel, K. Chan, 1999, Journal of medicinal chemistry.

Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-tert-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series1

R. D. Dyer, A. Sercel, R. Gilbertsen, 1999 .

The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis. A biochemical evaluation.

S. Phan, D. Schrier, B. Mcgarry, 1983, The American review of respiratory disease.

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991, Journal of medicinal chemistry.

Oral treatment with PD-0200347, an α2δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis

J. Martel-Pelletier, J. Pelletier, C. Flory, 2004, Arthritis Research & Therapy.

Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.

J. Pelletier, J. Martel-Pelletier, C. Flory, 2005, Arthritis and rheumatism.

PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.

J. Martel-Pelletier, J. Pelletier, C. Flory, 2006, Annals of the rheumatic diseases.

PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect

J. Pelletier, J. Martel-Pelletier, J. Pelletier, 2005 .

Anti-inflammatory properties of the protein kinase C inhibitor, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride (GF109203X) in the PMA-mouse ear edema model

D. Schrier, P. Jacobson, A. Metz, 2005, Agents and Actions.

Streptococcal cysteine protease augments lung injury induced by products of group A streptococci

J. Musser, V. Kapur, P. Ward, 1996, Infection and immunity.

Expression of lung vascular and airway ICAM-1 after exposure to bacterial lipopolysaccharide.

P. Ward, B. Beck-Schimmer, C. Flory, 1997, American journal of respiratory cell and molecular biology.

Inhibition of vascular permeability changes in rats by captopril.

D. Schrier, J. Fantone, B. Weingarten, 1982, The Journal of clinical investigation.

Anti-inflammatory properties of Gö 6850: a selective inhibitor of protein kinase C.

C. Schächtele, D. Schrier, P. Jacobson, 1995, The Journal of pharmacology and experimental therapeutics.

The role of strain variation in murine bleomycin-induced pulmonary fibrosis.

S. Phan, R. Kunkel, D. Schrier, 2015, The American review of respiratory disease.

1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.

R. D. Dyer, D. Boschelli, R. Dyer, 1993, Journal of medicinal chemistry.

Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.

R. D. Dyer, R. Gilbertsen, R. Dyer, 1998, The Journal of pharmacology and experimental therapeutics.

Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2.

D. Schrier, P. Jacobson, 1993, Journal of immunology.

Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-gamma, and monocyte chemoattractant protein-1.

P. Ward, J. Warren, C. Flory, 1998, Journal of immunology.

Monocyte Chemoattractant Protein-1 , and γ Requirements for IL-4 , IL-10 , IFN-Streptococcal Cell Wall-Induced Arthritis :

Conroy, P. Ward, J. Warren, 1998 .

The effects of the phospholipase A2 inhibitor, manoalide, on cartilage degradation, stromelysin expression, and synovial fluid cell count induced by intraarticular injection of human recombinant interleukin-1 alpha in the rabbit.

C. Flory, D. Schrier, P. Jacobson, 1996, Arthritis and rheumatism.

A comparative study of pulmonary fibrosis induced by bleomycin and an O2 metabolite producing enzyme system.

P. Ward, S. Phan, K. Johnson, 1983, Chest.

Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats.

D. Schrier, C. Schaefer, P. Juneau, 1999, International journal of immunopharmacology.

The pharmacologic effects of 5-[3,5-bis(1,1-dimethylethyl)-4- hydroxyphenyl]-1,3,4-thiadiazole-2(3H)-thione, choline salt (CI-986), a novel inhibitor of arachidonic acid metabolism in models of inflammation, analgesia and gastric irritation.

M. D. Mullican, R. Dyer, D. T. Connor, 1994, Prostaglandins.

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994, Journal of medicinal chemistry.

PD-0200347, AN α 2 δ LIGAND OF VOLTAGE-DEPENDENT CALCIUM CHANNEL, INHIBITS IN VIVO THE ACTIVATION OF THE ERK1/2 PATHWAY IN OSTEOARTHRITIC CHONDROCYTES: A PKC α -DEPENDENT EFFECT

J. Pelletier, J. Martel-Pelletier, C. Flory, 2005 .

In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes.

J. Pelletier, J. Martel-Pelletier, J. Fernandes, 2003, Arthritis and rheumatism.

Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamide-sensitive T cells.

S. Phan, D. Schrier, 1984, The American journal of pathology.

Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.

R. D. Dyer, M. D. Mullican, M. Wilson, 1993, Journal of medicinal chemistry.

Streptococcal cell wall-induced arthritis. Requirements for neutrophils, P-selectin, intercellular adhesion molecule-1, and macrophage-inflammatory protein-2.

P. Ward, J. Dykens, C. Flory, 1997, Journal of immunology.

The role of neutrophils in type II collagen-induced arthritis in rats.

R. Gilbertsen, D. Schrier, J. Fantone, 1984, The American journal of pathology.

Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.

R. Dyer, D. T. Connor, P. Unangst, 1992, Journal of medicinal chemistry.

Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.

R. D. Dyer, R. Dyer, D. T. Connor, 1992, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 5-((3,5-Bis(1,1-dimethylethyl)- 4-hydroxyphenyl)methylene)oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994 .

Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors

R. D. Dyer, R. Sorenson, R. Dyer, 1993 .

Styrylpyrazoles, Styrylisoxazoles, and Styrylisothiazoles. Novel 5‐ Lipoxygenase and Cyclooxygenase Inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991 .

BCG-induced macrophage suppression in mice: suppression of specific and nonspecific antibody-medicated and cellular immunologic responses.

D. Schrier, V. Moore, E. Allen, 1980, Cellular immunology.

Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion.

J. Wallace, D. Schrier, A. Metz, 1995, Gastroenterology.

Hyperimmune human ABO blood-typing sera: reactivity with murine laminin and cytotoxicity for metastatic murine tumour cells.

J. Varani, D. Schrier, J. McCoy, 1983, Journal of cell science.

Nuclease-resistant ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint.

T. Jarvis, L. Beigelman, C. Flory, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.

S. Barrett, D. T. Dudley, H. Tecle, 2007, Arthritis and rheumatism.

Ribozymes as Tools for Therapeutic Target Validation in Arthritis

T. Jarvis, C. Flory, D. Schrier, 2000, The Journal of Immunology.

Validation in Arthritis Ribozymes as Tools for Therapeutic Target

T. Jarvis, C. Flory, D. Schrier, 2000 .

The effects of adenosine agonists on human neutrophil function.

D. Schrier, K. Imre, 1986, Journal of immunology.

3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.

D. Boschelli, D. T. Connor, D. Schrier, 1994, Journal of medicinal chemistry.

Inhibition of adhesion molecule expression by N-alkylthiopyridine-benzo[b]thiophene-2-carboxamides.

D. Boschelli, D. T. Connor, D. Schrier, 1996, Bioorganic & medicinal chemistry.

Role of angiotensin-converting enzyme in Bacille Calmette-Guérin-induced granulomatous inflammation. Increased angiotensin-converting enzyme levels in lung lavage and suppression of inflammation with captopril.

A. Katzenstein, D. Schrier, V. Moore, 1982, The Journal of clinical investigation.

Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis.

R. E. Guzman, R. Guzman, S. Calcaterra, 2003, Osteoarthritis and cartilage.

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

A. Wagers, T. Schulz, Y. Tseng, 2010, Proceedings of the National Academy of Sciences.

Cellular sensitivity to collagen in bleomycin-treated rats.

P. Ward, S. Phan, D. Schrier, 1982, Journal of immunology.

Effects of antiarthritic compounds on type II collagen-induced arthritis in rats.

R. Gilbertsen, D. Schrier, A. Probert, 1984, Archives internationales de pharmacodynamie et de therapie.

The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats.

R. Gilbertsen, D. Schrier, C. Wright, 1990, Journal of immunology.

Genetic basis of BCG-induced suppression of delayed hypersensitivity

D. Schrier, V. Moore, E. Allen, 1981, Nature.

R. D. Dyer, A. Sercel, K. Chan, 1999, Journal of medicinal chemistry.

Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor

R. Gilbertsen, M. Bennett, D. Schrier, 1987, Agents and Actions.

Inhibition of E-Selectin-, ICAM-1, and VCAM-1-Mediated Cell Adhesion by Benzo(b)thiophene-, Benzofuran-, Indole-, and Naphthalene-2- carboxamides: Identification of PD 144795 as an Antiinflammatory Agent.

D. Boschelli, R. Sorenson, D. T. Connor, 1996 .

Emerging Therapeutic Advances for the Development of Second Generation Matrix Metalloproteinase Inhibitors

A. D. White, D. Schrier, T. Bocan, 1997, Current Pharmaceutical Design.

BCG-induced granulomatous pulmonary inflammation and splenomegaly in mice: A T-cell-dependent response

D. Schrier, V. Moore, E. Allen, 1981 .

BCG-induced chronic pulmonary inflammation and splenomegaly in mice: suppression of PHA-induced proliferation, delayed hypersensitivity to sheep erythrocytes, and chronic pulmonary inflammation by soluble factors from adherent spleen cells.

D. Schrier, V. Moore, E. Allen, 1981, Cellular immunology.

Strain variation in BCG-induced chronic pulmonary inflammation in mice: control by a cyclophosphamide-sensitive thymus-derived suppressor cell.

D. Schrier, G. Pedersen, V. Moore, 1981, Journal of immunology.

Genetic control of BCG-induced granulomatous inflammation in mice.

D. Schrier, V. Moore, J. Sternick, 1983, Experimental lung research.

Effects of antiarthritic compounds on sheep erythrocyte-induced delayed-type hypersensitivity.

D. Schrier, 1985, Journal of immunopharmacology.

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

R. D. Dyer, R. Dyer, D. Flynn, 1990, Journal of medicinal chemistry.

The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function

D. Schrier, C. Wright, M. Lesch, 1991, Agents and Actions.

Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls

C. Flory, D. Schrier, R. Schimmer, 1998, Journal of leukocyte biology.

The topical anti‐inflammatory effects of a topical preparation of meclofenamic acid on carrageenan‐induced footpad swelling in mice

R. Gilbertsen, D. Schrier, M. I. Gluckman, 1987, The Journal of pharmacy and pharmacology.