C. Dickey

D. Dickson, C. Eckman, M. Stallings-Mann, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide.

D. Weiner, S. Kudchodkar, K. Ugen, 2001, DNA and cell biology.

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

D. Zheng, S. Stevens, C. Dickey, 2016, The EMBO journal.

Short-term β-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP+PS1 mice

D. Diamond, K. Ugen, G. Arendash, 2003 .

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Cam Patterson, Michael Hutton, Leonard Petrucelli, 2007, The Journal of clinical investigation.

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism*

B. Blagg, M. Cockman, J. Koren, 2012, The Journal of Biological Chemistry.

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

B. Blagg, C. Dickey, Vincent M Crowley, 2014, Human molecular genetics.

Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain

P. Bickford, V. Uversky, S. Stevens, 2022, International journal of molecular sciences.

Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.

J. Gamsby, C. Dickey, April L Darling, 2021, The Journal of clinical investigation.

Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice.

D. Diamond, K. Ugen, G. Arendash, 2003, Behavioral neuroscience.

Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD)

D. Dickson, C. Eckman, M. Delucia, 2006, Neurobiology of Disease.

Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.

J. Lloyd, C. Dickey, Jonathan J. Sabbagh, 2016, Journal of neurotrauma.

Cell-based assays for regulators of tau biology.

U. Jinwal, C. Dickey, 2011, Methods in molecular biology.

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

S. Melquist, D. Neary, B. Boeve, 2006, Nature.

Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone

B. Tait, W. Balch, J. Gestwicki, 2018, bioRxiv.

Identification of dihydropyridines that reduce cellular tau levels.

J. Gestwicki, U. Jinwal, C. Dickey, 2011, Chemical communications.

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

J. Rogers, E. Weeber, J. Brodsky, 2013, Biological Psychiatry.

Natural products as a rich source of tau-targeting drugs for Alzheimer's disease.

B. Zhang, B. Baker, U. Jinwal, 2012, Future medicinal chemistry.

Chaperones in Neurodegeneration

I. Lindberg, F. Chiti, P. McLean, 2015, The Journal of Neuroscience.

Mini-Symposium Chaperones in Neurodegeneration

I. Lindberg, F. Chiti, J. Shorter, 2015 .

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex.

H. Paulson, E. Zuiderweg, J. Gestwicki, 2013, Biochemistry.

Chaperone signalling complexes in Alzheimer's disease

J. Koren, U. Jinwal, C. Dickey, 2008, Journal of cellular and molecular medicine.

ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity

E. Weeber, C. B. Rickman, D. Birch, 2011, The Journal of Neuroscience.

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

H. Fu, Yuhong Du, B. Blagg, 2018, ACS chemical biology.

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.

B. Blagg, A. Muth, C. Dickey, 2016, Journal of medicinal chemistry.

Aging enhances classical activation but mitigates alternative activation in the central nervous system

D. Morgan, M. Gordon, C. Dickey, 2013, Neurobiology of Aging.

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

D. Morgan, M. Gordon, C. Dickey, 2010, Journal of Neuroinflammation.

Exploiting the Diversity of the Heat-Shock Protein Family for Primary and Secondary Tauopathy Therapeutics

J. Koren, J. Abisambra, U. Jinwal, 2011, Current neuropharmacology.

Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases.

J. Koren, J. Abisambra, U. Jinwal, 2010, Molecular and cellular pharmacology.

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

E. Weeber, E. Zuiderweg, J. Gestwicki, 2009, The Journal of Neuroscience.

FKBP51 and FKBP52 in signaling and disease

M. Galigniana, Cheryl L. Storer, T. Rein, 2011, Trends in Endocrinology & Metabolism.

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

J. Abisambra, U. Jinwal, C. Dickey, 2013, Alzheimer's & Dementia.

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics*

E. Weeber, Lisa Y. Lawson, J. Koren, 2011, The Journal of Biological Chemistry.

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

C. Dickey, L. Blair, Sojeong Kim, 2019, International journal of molecular sciences.

Hsp90 activator Aha1 drives production of pathological tau aggregates

B. Blagg, J. Koren, D. Zheng, 2017, Proceedings of the National Academy of Sciences.

Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau Species

Wen-Lang Lin, Guy A. Caldwell, Dennis W. Dickson, 2006, The Journal of Neuroscience.

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

C. Beaudry, D. Stephan, E. Reiman, 2010, BMC Genomics.

Trafficking CD11b-Positive Blood Cells Deliver Therapeutic Genes to the Brain of Amyloid-Depositing Transgenic Mice

K. Szekeres, J. Koren, D. Morgan, 2010, The Journal of Neuroscience.

Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice

J. Loring, D. Morgan, M. Gordon, 2003, The Journal of Neuroscience.

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

J. Hardy, D. Diamond, D. Wilcock, 2000, Nature.

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

J. Hardy, D. Diamond, D. Wilcock, 2000, Nature.

Synthesis, stereochemical analysis, and derivatization of myricanol provide new probes that promote autophagic tau clearance.

J. Gestwicki, L. Wojtas, B. Baker, 2015, ACS chemical biology.

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

E. Mandelkow, H. Urlaub, J. Biernat, 2018, Nature Communications.

Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance

J. Cheng, J. Gestwicki, Jian-ping Guo, 2012, PloS one.

The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling

E. Weeber, D. Zheng, C. Dickey, 2019, eNeuro.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

C. Cotman, H. Paulson, V. Uversky, 2013, The Journal of clinical investigation.

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

E. Mandelkow, R. Boelens, D. Veprintsev, 2014, Cell.

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

J. Gestwicki, J. Koren, Yoshinari Miyata, 2011, Future medicinal chemistry.

Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice

D. Wilcock, D. Morgan, M. Gordon, 2005, BMC Neuroscience.

Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice

J. Guzowski, D. Diamond, D. Morgan, 2003, Journal of neurochemistry.

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.

J. Buchner, D. Rutz, J. Koren, 2018, ACS chemical biology.

Imbalance of Hsp70 family variants fosters tau accumulation

V. Uversky, E. Mandelkow, J. Gestwicki, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Hsc70 Rapidly Engages Tau after Microtubule Destabilization*

J. Gestwicki, S. Borysov, Lisa Y. Lawson, 2010, The Journal of Biological Chemistry.

The emerging role of peptidyl‐prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

C. Dickey, Jonathan J. Sabbagh, L. Blair, 2015, Journal of neurochemistry.

The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed.

J. Koren, C. Dickey, Kellen Voss, 2011, The American journal of pathology.

Bending Tau into Shape: The Emerging Role of Peptidyl-Prolyl Isomerases in Tauopathies

J. Koren, U. Jinwal, C. Dickey, 2011, Molecular Neurobiology.

Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels.

D. Wilcock, K. Ugen, J. Hardy, 2001, DNA and cell biology.

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

E. Mandelkow, H. Urlaub, J. Biernat, 2018, Nature Communications.

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

D. Morgan, M. Gordon, C. Dickey, 2012, Neurodegenerative Diseases.

Chaperoning activity of the cyclophilin family prevents tau aggregation

C. Dickey, S. Hill, L. Blair, 2022, Protein science : a publication of the Protein Society.

Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations

J. Gumbart, C. Dickey, S. Hill, 2019, The Journal of Biological Chemistry.

Ligands for glaucoma-associated myocilin discovered by a generic binding assay.

H. Fu, S. France, Katherine C. Turnage, 2014, ACS chemical biology.

Akt and CHIP coregulate tau degradation through coordinated interactions

L. Petrucelli, J. Cheng, M. Birnbaum, 2008, Proceedings of the National Academy of Sciences.

Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

E. Weeber, D. Morgan, M. Gordon, 2019, Alzheimer's Research & Therapy.

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

C. Dickey, Jonathan J. Sabbagh, M. Selenica, 2015, Acta neuropathologica communications.

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

L. Petrucelli, M. Hutton, C. Eckman, 2006, Molecular Neurodegeneration.

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

C. Passaglia, B. Blagg, J. Koren, 2017, Scientific Reports.

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

J. Rogers, E. Weeber, D. Wilcock, 2010, The Journal of Neuroscience.

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.

L. Petrucelli, S. Kasibhatla, M. Hutton, 2005, Current Alzheimer research.

A Novel Therapeutic Approach to Polyomavirus-Associated Diseases

H. Paulson, I. Benjamin, E. Binder, 2014 .

Current strategies for the treatment of Alzheimer’s disease and other tauopathies

L. Petrucelli, C. Dickey, 2006, Expert opinion on therapeutic targets.

A global view of Hsp90 functions

G. Chiosis, C. Dickey, Jill L. Johnson, 2013, Nature Structural &Molecular Biology.

Brain CHIP: removing the culprits in neurodegenerative disease.

L. Petrucelli, C. Patterson, Dennis Dickson, 2007, Trends in molecular medicine.

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70.

J. Gestwicki, A. Thompson, Yoshinari Miyata, 2012, Chemistry & biology.

The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau.

John Koren, E. Weeber, C. Eckman, 2011, Journal of natural products.

Neuronal Life Span Versus Health Span: Principles of Natural Selection at Work in the Degenerating Brain

J. Koren, C. Dickey, John C. O'Leary, 2011, Journal of Molecular Neuroscience.

HSP induction mediates selective clearance of tau phosphorylated at proline‐directed Ser/Thr sites but not KXGS (MARK) sites

L. Petrucelli, M. Hutton, C. Eckman, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

Jason E Gestwicki, John Koren, Laura J Blair, 2010, Molecular Neurodegeneration.

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

P. Bickford, V. Uversky, C. Dickey, 2020, International journal of molecular sciences.

FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

C. Dickey, L. Blair, Salma S. Abdelmaboud, 2021, npj Aging and Mechanisms of Disease.

FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model

C. Dickey, L. Blair, Salma S. Abdelmaboud, 2021, NPJ aging and mechanisms of disease.

Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency

E. Binder, T. Klengel, C. Dickey, 2014, PloS one.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Cellular factors modulating the mechanism of tau protein aggregation

C. Dickey, April L Darling, Jonathan J. Sabbagh, 2015, Cellular and Molecular Life Sciences.

Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau

V. Uversky, C. Dickey, April L Darling, 2021, Protein science : a publication of the Protein Society.

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

E. Weeber, Joyce Cheung-Flynn, U. Jinwal, 2011, PloS one.

The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.

J. Koren, C. Dickey, L. Blair, 2013, CNS & neurological disorders drug targets.

FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism

C. Dickey, L. Blair, D. Gulick, 2020, Brain, behavior, & immunity - health.

Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

E. Weeber, D. Morgan, M. Gordon, 2019, Alzheimer's Research & Therapy.

DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

M. Cockman, J. Abisambra, Ying Jin, 2012, Journal of molecular biology.

A b peptide vaccination prevents memory loss in an animal model of Alzheimer ' s disease

D. Diamond, D. Wilcock, C. Hope, 2001 .

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

T. Haystead, J. Gestwicki, D. Zheng, 2016, ACS chemical biology.

Hippocampal Neurogenesis Is Enhanced in Adult Tau Deficient Mice

C. Dickey, Jonathan J. Sabbagh, L. Blair, 2020, Cells.

correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

J. Hardy, D. Diamond, D. Wilcock, 2001, Nature.

Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation.

A. Chinnaiyan, H. Paulson, J. Gestwicki, 2012, ACS chemical biology.

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

J. Gestwicki, S. Borysov, M. Zweckstetter, 2015, Human molecular genetics.

Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.

C. Dickey, Jonathan J. Sabbagh, Sarah N. Fontaine, 2016, Experimental eye research.

Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes

D. Kang, C. Dickey, Tian Liu, 2017, Human molecular genetics.

Potential synergy between tau aggregation inhibitors and tau chaperonemodulators

C. Dickey, L. Blair, Bo Zhang, 2013, Alzheimer's Research & Therapy.

Benzothiazole Substitution Analogs of Rhodacyanine Hsp70 Inhibitors Modulate Tau Accumulation.

C. Dickey, S. Hill, April L Darling, 2023, ACS chemical biology.

Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.

B. Tait, W. Balch, J. Gestwicki, 2020, Cell chemical biology.

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

J. Rogers, E. Weeber, J. Brodsky, 2013, Biological Psychiatry.

Commentary on “Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery.” The last stand: The dichotomy of chaperone function in Alzheimer’s disease

L. Petrucelli, C. Dickey, 2007, Alzheimer's & Dementia.

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.

B. Blagg, C. Dickey, Suman Ghosh, 2017, ACS Chemical Biology.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

C. Cotman, H. Paulson, V. Uversky, 2013, The Journal of clinical investigation.

Targeting the ER-autophagy system in the trabecular meshwork to treat glaucoma.

C. Dickey, Jonathan J. Sabbagh, Sarah N. Fontaine, 2016, Experimental eye research.

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

H. Fu, Yuhong Du, B. Blagg, 2018, ACS chemical biology.

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

B. Blagg, C. Dickey, Vincent M Crowley, 2014, Human molecular genetics.

Aging enhances classical activation but mitigates alternative activation in the central nervous system

D. Morgan, M. Gordon, C. Dickey, 2013, Neurobiology of Aging.

The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.

J. Gestwicki, S. Borysov, M. Zweckstetter, 2015, Human molecular genetics.

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

C. Passaglia, B. Blagg, J. Koren, 2017, Scientific Reports.

Facilitating Akt Clearance via Manipulation of Hsp70 Activity and Levels*

J. Cheng, J. Gestwicki, Jian-ping Guo, 2009, The Journal of Biological Chemistry.

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy

D. Morgan, M. Gordon, C. Dickey, 2015, The Journal of Neuroscience.

Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development.

C. Dickey, Sarah N. Fontaine, Mackenzie D. Martin, 2016, Current topics in medicinal chemistry.

Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis.

R. Kennedy, J. Gestwicki, C. Dickey, 2016, Analytical chemistry.