R. A. Lewthwaite

发表

Fragment based discovery of a novel and selective PI3 kinase inhibitor.

David S. Millan, J. Mathias, A. Phelan, 2011, Bioorganic & medicinal chemistry letters.

The discovery of long acting β2-adrenoreceptor agonists

Alan Daniel Brown, Mark E. Bunnage, M. Bunnage, 2007 .

A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging We gratefully acknowledge financial support from Pfizer Global Research and Development, the University of Ferrara (Italy, Postdoctoral Fellowship to A.M.), the EU (Marie C

S. Ley, R. A. Lewthwaite, F. Rodríguez, 2001, Angewandte Chemie.

PD 165929 — the first high affinity non-peptide neuromedin-B (NMB) receptor selective antagonist

R. Jordan, R. A. Lewthwaite, A. McKnight, 1996 .

Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.

R. A. Lewthwaite, G. Woodruff, A. McKnight, 1996, Journal of medicinal chemistry.

PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.

R. A. Lewthwaite, A. McKnight, D. Horwell, 1998, Bioorganic & medicinal chemistry letters.

A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis.

S. Ley, I. Baxendale, R. A. Lewthwaite, 2005, Organic & biomolecular chemistry.

Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfonamide agonist headgroup.

M. Bunnage, David A. Price, A. Brown, 2010, Journal of medicinal chemistry.

The use of heterocycles for the conformational restriction of biologically active peptoids

J. Rubin, R. A. Lewthwaite, D. Horwell, 1998 .

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor.

S. Ley, M. Baumann, I. Baxendale, 2007, Organic & biomolecular chemistry.

Synthesis and transition temperatures of some novel, chiral nematic, laterally attached, side-chain, siloxane polymers

G. W. Gray, R. A. Lewthwaite, K. Toyne, 1992 .

The effect of a lateral hydroxy substituent on the thermal stability of the chiral smectic C phase

J. Goodby, R. A. Lewthwaite, K. Toyne, 1994 .

Effect of backbone flexibility and the position of the lateral group on the mesophase stability of laterally attached, side-chain polymers

J. Goodby, R. A. Lewthwaite, K. Toyne, 1993 .

Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.

S. McCleary, R. A. Lewthwaite, D. Horwell, 2001, Journal of medicinal chemistry.

The discovery of adamantyl-derived, inhaled, long acting beta(2)-adrenoreceptor agonists.

Mark E Bunnage, M. Bunnage, David A. Price, 2008, Bioorganic & medicinal chemistry letters.

The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD 170292

Jean Martinez, R. A. Lewthwaite, D. Horwell, 2000 .

The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD.

Mark E Bunnage, M. Bunnage, David A. Price, 2007, Bioorganic & medicinal chemistry letters.

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Mark E Bunnage, Samantha J Hughes, Peter G. Dodd, 2011, Journal of medicinal chemistry.

PD 165929 - The First High Affinity Non-Peptide Neuromedin-B (NMB) Receptor Selective Antagonist.

R. Jordan, R. A. Lewthwaite, A. McKnight, 1997 .