G. Posner

G. Posner, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Treatment with non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 increases responsiveness to 17β-estradiol, dihydrotestosterone or raloxifene in primary human osteoblasts

D. Hendel, G. Posner, D. Somjen, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Systemic treatments with the low‐calcemic 1,25(OH)2D3 analogs JKF or QW increase both the morphological and biochemical responses to estradiol‐17β in rat tibiae

G. Posner, E. Livne, D. Somjen, 2007, Journal of cellular biochemistry.

1α,25-dihydroxyvitamin D3 hybrid analogs with structural changes at both the A-ring and the C,D-ring side-chain

T. Kensler, S. Guggino, G. Posner, 1994 .

A Thiazole Derivative of Artemisinin Moderately Reduces Toxoplasma gondii Cyst Burden in Infected Mice

R. Yolken, G. Posner, V. Carruthers, 2014, The Journal of parasitology.

Asymmetric synthesis of carbon-carbon bonds using sulfinyl cycloalkenones, alkenolides, and pyrones

G. Posner, 1987 .

Asymmetric induction during organometallic conjugate addition to enantiomerically pure 2-(arylsulfinyl)-2-cyclopentenones

L. Frye, G. Posner, M. Hulce, 1982 .

Mutual modulation of femarelle and vitamin D analog activities in human derived female cultured osteoblasts

D. Hendel, G. Posner, D. Somjen, 2014 .

Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts

G. Posner, D. Somjen, J. Vaya, 2011, The Journal of Steroid Biochemistry and Molecular Biology.

Organic reactions at alumina surfaces. Mild and selective opening of arene and related oxides by weak oxygen and nitrogen nucleophiles

D. Z. Rogers, G. Posner, 1977 .

Organic reactions at alumina surfaces. Mild and selective opening of epoxides by alcohols, thiols, benzeneselenol, amines, and acetic acid

D. Z. Rogers, G. Posner, 1977 .

5-Bromo-2-pyrone: An easily prepared ambiphilic diene and a synthetic equivalent of 2-pyrone in mild, thermal, Diels-Alder cycloadditions

G. Posner, K. Afarinkia, 1992 .

Antimalarial Endoperoxides that are Potent and Easily Synthesized

G. Posner, 1997 .

Anticancer effects of the novel 1α, 25‐dihydroxyvitamin D3 hybrid analog QW1624F2‐2 in human neuroblastoma

J. Maris, Asha Guttapalli, C. Reddy, 2006, Journal of cellular biochemistry.

Differential photoprotective effects of 1,25-dihydroxyvitamin D3 and a low calcaemic deltanoid

R. Mason, G. Posner, S. S. Deo, 2012, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH

G. Posner, D. Somjen, A. Kaye, 2013, Journal of Endocrinological Investigation.

A General Method for the Preparation of 9‐, 10‐, and 11‐Membered Unsaturated Macrolides: Synthesis of 8‐Propionyl‐(E)‐5‐Nonenolide

G. Posner, Webb Kevin, E. Asirvatham, 2003 .

Asymmetric Michael additions of ester enolates to enantiomerically pure vinylic sulfoxides: synthesis of 3-substituted glutarate esters in high enantiomeric purity

J. Clardy, G. Posner, T. Hamill, 1986 .

Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines

N. Stern, G. Posner, D. Somjen, 2013, The Journal of Steroid Biochemistry and Molecular Biology.

Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues

S. Ward, P. O’Neill, G. Posner, 2005 .

Generation and reactions of 1-(arylsulfinyl)alkenyllithium reagents. Terminal allenes from 2-alkenyl aryl sulfoxides.

J. Mallamo, G. Posner, P. Tang, 1978 .

New synthetic methodology for ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones: 3-step synthesis of fragrant phoracantholide ☆

G. Posner, J. Maxwell, J. S. Elias, 2000 .

Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

D. Sullivan, G. Posner, A. Tripathi, 2014, Bioorganic & medicinal chemistry letters.

Cyanocuprates convert carboxylic acids directly into ketones.

G. Posner, D. T. Genna, D. Genna, 2011, Organic letters.

Short, simple, stereocontrolled, steroid synthesis: (.+-.)-11-oxoequilenin methyl ether and a new 9,11-seco-13-ethyl steroid

G. Posner, M. Chapdelaine, C. M. Lentz, 1979 .

Organic Reactions at Alumina Surfaces

G. Posner, 1978 .

Methyl and -alkyl ketones from carboxylic acid chlorides and organocopper reagents

G. Posner, C. E. Whitten, 1970 .

Reaction of .alpha.,.alpha.'-dibromo ketones with organocopper reagents. New method for .alpha. alkylation of ketones

G. Posner, J. Sterling, 1973 .

Synthetic Approaches to Vitamin D

G. Posner, H. Dai, 2010 .

Total synthesis of natural estrone and estradiol methyl ethers in extremely high enantiomeric purity via an asymmetric Michael addition to an unsaturated sulfoxide

C. Switzer, G. Posner, 1986 .

Alkylation of enolate ions generated regiospecifically via organocopper reactions. Synthesis of decalin sesquiterpene valerane and of prostaglandin model systems.

G. Posner, D. Brunelle, J. Sterling, 1975, Journal of the American Chemical Society.

New class of mixed cuprate(I) reagents, lithium hetero(alkyl) cuprate(I), which allow selective alkyl group transfer

G. Posner, J. Sterling, C. E. Whitten, 1973 .

Multicomponent one-pot annulations forming 3 to 6 bonds

G. Posner, 1986 .

Organic reactions at alumina surfaces. Displacement reactions effected by alcohols, thiols, and acetic acid on dehydrated alumina.

D. Z. Rogers, G. Posner, C. Kinzig, 1975 .

Stereocontrolled preparation of chiral (E)-1-alkenyl sulfoxides. Efficient reduction of alkenyl sulfoxides to the corresponding alkenyl sulfides

G. Posner, P. Tang, 1978 .

Photochemical deoxygenation of aryl sulfoxides

G. Posner, G. M. Gurria, 1973 .

Alkyl and aryl isothiocyanates as masked primary amines

G. Posner, C. Cho, 1992 .

Diels-Alder cycloadditions using nucleophilic 3-(p-tolylthio)-2-pyrone. Regiocontrolled and stereocontrolled synthesis of unsaturated, bridged, bicyclic lactones

G. Posner, C. M. Kinter, T. Nelson, 1992 .

Three-component, one-flask synthesis of rhodanines (thiazolidinones).

Alexander M. Jacobine, G. Posner, 2011, The Journal of organic chemistry.

A convenient, one-step, high-yield replacement of an anomeric hydroxyl group by a fluorine atom using dast. Preparation of glycosyl fluorides.

G. Posner, S. Haines, 1985 .

Conversion of glycosyl fluorides into C-glycosides using organoaluminum reagents. Stereospecific alkylation at C-6 of a pyranose sugar

G. Posner, S. Haines, 1985 .

A one-flask multicomponent annulation reaction as the key step in a total synthesis of spirobicyclic (±)-β-vetivone

G. Posner, E. M. Shulman-Roskes, 1992 .

Multicomponent One-Pot Annulations Forming Three to Six Bonds

G. Posner, 1987 .

Formation of olefins via pyrolysis of sulfonate esters

E. Corey, G. Posner, John J Nash, 1989 .

Highly stereocontrolled and regiocontrolled syntheses of polyoxygenated [2.2.2]oxabicyclic synthons

G. Posner, M. Siegler, Rachel D. Slack, 2013 .

Diels‐Alder Cycloadditions Using Nucleophilic 3‐(p‐Tolylthio)‐2‐pyrone. Regiocontrolled and Stereocontrolled Synthesis of Unsaturated, Bridged, Bicyclic Lactones.

G. Posner, C. M. Kinter, T. Nelson, 2010 .

An Improved Preparation of 3‐Bromo‐2H‐Pyran‐2‐one: An Ambiphilic Diene for Diels‐Alder Cycloadditions

G. Posner, K. Afarinkia, H. Dai, 2003 .

Recent Advances in Diels—Alder Cycloadditions of 2-Pyrones

G. Posner, B. T. Woodard, 1999 .

Lewis acid-catalyzed, high pressure, stereospecific, regiospecific, Diels-Alder cycloaddition of unsubstituted 2-pyrone: Short synthesis of a racemic A-ring precursor to physiologically active 1-hydroxyvitamin D3 steroids

G. Posner, Y. Ishihara, 1994 .

Mild, asymmetric Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers

G. Posner, J. Carry, Jae Kyoo Lee, 1994 .

1.5 – Alkylations of Nonstabilized Carbanions

G. Posner, J. M. Klunder, 1991 .

Antiproliferative Hybrid Analogs of the Hormone 1alpha,25-Dihydroxyvitamin D(3): Design, Synthesis, and Preliminary Biological Evaluation.

T. Kensler, M. White, G. Posner, 1997, The Journal of organic chemistry.

3-Cuprio-2-pyrone: an extraordinary organocopper reagent

G. Posner, D. G. Wettlaufer, Wayne N. Harrison, 1985 .

.alpha.,.beta.-Ethylenic sulfones from sulfonomethylphosphonate carbanions and aldehydes and ketones

G. Posner, D. Brunelle, 1972 .

Lewis Acid-Promoted, Stereocontrolled, Gram Scale, Diels-Alder Cycloadditions of Electronically Matched 2-Pyrones and Vinyl Ethers: The Critical Importance of Molecular Sieves and the Temperature of Titanium Coordination with the Pyrone.

G. Posner, Y. Ishihara, F. Eydoux, 1996, The Journal of organic chemistry.

Regiospecifically oxygen-18 labeled 1,2,4-trioxane: a simple chemical model system to probe the mechanism(s) for the antimalarial activity of artemisinin (qinghaosu).

Chang Ho Oh, G. Posner, Gary H. Posner, 1992 .

Tandem michael-michael-ring closure (mimirc) reactions: One-pot steroid total synthesis-(±)-9,11-dehydroestrones

J. Mallamo, G. Posner, Alison Y. Black, 1981 .

Nitroolefins in one-flask, tandem. A+B+C coupling reactions producing heterocycles

G. Posner, R. Crouch, 1990 .

A directing effect of neighboring aromatic groups on the regiochemistry of formation and stereochemistry of alkylation and bromination of ketone lithium enolates. Evidence for lithium-arene coordination and dramatic effect of copper(I) in controlling stereochemistry and limiting polyalkylation

G. Posner, C. M. Lentz, 1979 .

An Introduction to Synthesis Using Organocopper Reagents

G. Posner, 1980 .

Organic reactions at alumina surfaces. chemospecific oxidation of β-hydroxy sulfides and selenides into the corresponding β-keto sulfides and selenides using chloral on activated alumina.

G. Posner, M. Chapdelaine, 1977 .

Organic reactions at alumina surfaces. V. Highly selective alcohol and diol oxidation reactions on alumina

G. Posner, R. Perfetti, Alphonse W. Runquist, 1976 .

Organic reactions at alumina surfaces II. 2-propanol on dehydrated alumina as a reagent for selective reduction of aldehydes

G. Posner, A. Runquist, 1975 .

16 – ALUMINA AND ALUMINA-SUPPORTED REAGENTS

G. Posner, 1987 .

Carbon-carbon bond formation by selective coupling of n-alkylcopper reagents with organic halides

E. Corey, G. Posner, 1968 .

Cyclopentanone ring expansion leading to functionalized delta-lactams: short synthesis of simple sedum alkaloids.

G. Posner, W. Maio, Sandra Sinishtaj, 2007, Organic letters.

Phenoxide-directed ortho lithiation

G. Posner, K. Canella, 1985 .

Titanium-promoted stereoselective synthesis of hydroindolones from p-quinamines by domino conjugate additions.

G. Posner, M. C. Carreño, M. Ribagorda, 2002, Angewandte Chemie.

Asymmetric synthesis using enantiomerically pure 2-(p-anisylsulfinyl)-2-cycloalkenones

L. Frye, G. Posner, M. Hulce, 1984 .

New stereospecific synthesis of trisubstituted olefins. Stereospecific synthesis of farnesol

E. Corey, J. Katzenellenbogen, G. Posner, 1967 .

A new approach to the bicyclo[3.2.1]octane ring system: Intramolecular michael and aldol reactions of 3-(5-oxohexyl)-2-cyclopentenones

A. Alexakis, G. Posner, M. Chapdelaine, 1978 .

Asymmetric induction during organometallic conjugate addition to enantiomerically pure 2-(arylsulfinyl)-2-cyclopentenones

L. Frye, G. Posner, M. Hulce, 1982 .

High asymmetric induction during organometallic .beta.-addition to .alpha.,.beta.-ethylenic sulfoxides. Synthesis of optically active .beta.-alkylcarboxylic acids, .beta.-substituted cyclopentanones, and steroidal 11-oxoequilenin methyl ether

K. Miura, J. Mallamo, G. Posner, 1981 .

Asymmetric synthesis using organometallic reagents and optically pure vinylic sulfoxides

K. Miura, G. Posner, M. Hulce, 1981 .

A study of cross coupling reactions between halides and anionic manganese, iron, and cobalt alkyls

E. Corey, G. Posner, 1970 .

One-flask, consecutive [3,3]- and [2,3]-sigmatropic rearrangements for conversions of propargylic alcohols into 2-carbon-extended 4-oxo-2-alkenoate esters. Use of a new 1-chloro-1-ethoxy-2-sulfinylethylene

G. Posner, J. Carry, Neil Johnson, 1991 .

Regiocontrolled and Stereocontrolled Diels-Alder Cycloadditions of 2-Pyrones and Unactivated, Unbranched 1-Alkenes

G. Posner, R. Hutchings, B. T. Woodard, 1997 .

Synthesis and antimalarial activity of heteroatom-containing bicyclic endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1997 .

Enantiocontrolled synthesis of (S)-3-substituted cycloalkanones from (s)-2-(p-tolylsulfinyl)-2-cycloalkenones and diorganomagnesium reagents.

G. Posner, M. Hulce, 1984 .

Organocopper chemistry. Reaction of α,β-ethylenic sulfones with lithium dialkylcuprates

G. Posner, D. Brunelle, 1973 .

Alkylation of enolate ions generated regiospecifically via organocopper conjugate addition reactions. Synthesis of decalin sesquiterpene valerane and of a prostaglandin model system

G. Posner, D. Brunelle, J. Sterling, 1974 .

BF3.OEt2 promotes fast, mild, clean and regioselective dehydration of tertiary alcohols

G. Posner, C. Oh, J. Carry, 1991 .

An efficient synthesis of bridged-bicyclic peroxides structurally related to antimalarial yingzhaosu A based on radical co-oxygenation of thiols and monoterpenes

G. Posner, L. Konstantinovski, A. Szpilman, 2002 .

Organic reactions at alumina surfaces. 6. Isopropyl alcohol and diisopropylcarbinol on dehydrated alumina as reagents for very selective carbonyl reductions

G. Posner, M. Chapdelaine, A. Runquist, 1977 .

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

C. Cho, P. Talalay, G. Posner, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Organic reactions at alumina surfaces. An extremely simple, convenient and selective method for acetylating primary alcohols in the presence of secondary alcohols.

M. Oda, G. Posner, 1981 .

Antimalarially potent, easily prepared, fluorinated endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1996 .

Mechanism-based design of simple, symmetrical, easily prepared, potent antimalarial endoperoxides

J. Cumming, T. Shapiro, G. Posner, 1996 .

An efficient method for dibromomethylenation and isopropylidenation of ketones (). Synthesis of a selinadiene sesquiterpene.

G. Posner, G. Loomis, H. S. Sawaya, 1975 .

One-flask, regiospecific conversions of allylic alcohols into 2-carbon-extended, conjugated dienoate esters. Use of a new sulfinyl orthoester

G. Posner, C. M. Kinter, J. Carry, 1991 .

Asymmetric total synthesis of an A-ring precursor to hormonally active 1.alpha.,25-dihydroxyvitamin D3

G. Posner, C. M. Kinter, 1990 .

Organocopper chemistry. reaction of benzal and other benzylic chlorides with lithium dimethylcopper

G. Posner, D. Brunelle, 1972 .

A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides.

T. Shapiro, G. Posner, A. Szpilman, 2003, Journal of medicinal chemistry.

Alumina-promoted Opening of Medium Ring Epoxides: cis-Cyclooctene Oxide - trans-2-Acetoxycyclooctanol

G. Posner, M. Hulce, R. K. Rose, 1981 .

Direct conversion of pyranose anomeric OH→F→R in the artemisinin family of antimalarial trioxanes

S. Woo, G. Posner, P. Ploypradith, 1998 .

Reductive Elimination of Bromine from 1,2-Dibromoalkanes Using Organometallic Reagents

G. Posner, J. Ting, 1973 .

Anticancer activity of artemisinin-derived trioxanes

G. Posner, A. Mercer, J. D'Angelo, 2006 .

Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

B. Foster, T. Shapiro, A. Mcriner, 2004, Journal of medicinal chemistry.

A mechanistic study of organocopper substitution reactions with some ethylenic p-toluenesulfonate esters

G. Posner, J. Ting, 1974 .

Direct and Convenient Preparation of Lithium Phenylthio(alkyl)cuprate Reagents

G. Posner, D. Brunelle, L. Sinoway, 1974 .

Enantiocontrolled Synthesis of (R)-3-Substituted Cyclohexanones Using (S)-2-(p-Tolylsulfinyl)-2-cyclohexenone and Various Organometallic Reagents in 2,5-Dimethyltetrahydrofuran

L. Frye, G. Posner, 1984 .

Molecular sieves promote stereocontrolled αα-disaccharide formation via direct dimerization of free sugars

G. Posner, D. Bull, 1996 .

Scope of [1+2+3] annulations using aminonitriles as Michael donors

G. Posner, M. Nierlich, M. Lance, 1993 .

Diels–Alder cycloadditions using alkenyl sulphoxides

G. Posner, Wayne N. Harrison, 1985 .

Highly stereocontrolled synthesis of some trioxygenated cyclohexenes: an asymmetric total synthesis of (-)-methyl triacetyl-4-epishikimate

G. Posner, D. G. Wettlaufer, 1986 .

Organic reactions at alumina surfaces. Mild and selective opening of arene and related oxides by weak oxygen and nitrogen nucleophiles

D. Z. Rogers, G. Posner, 1977 .

Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.

J. Cumming, G. Posner, P. Ploypradith, 1997, Advances in pharmacology.

Unexpected steric effects of remote alkyl groups on the rate of conjugate additions to alkyl α/β-ethylenic sulfones, sulfoxides, and esters

G. Posner, A. Usera, 2007 .

Direct conversion of cinnamate esters into β,β-disubstituted ketones mediated by cyano-magnesio cuprates

G. Posner, D. T. Genna, 2016 .

Organocopper chemistry. Halo-, cyano-, and carbonyl-substituted ketones from the corresponding acyl chlorides and organocopper reagents

G. Posner, C. E. Whitten, Paul E. Mcfarland, 1972 .

Sequential Michael-Michael-aldol additions for easy, one-pot, 2 + 2 + 2 construction of polyfunctionalized cyclohexanols.

G. Posner, S. Lu, E. Asirvatham, 1986, Journal of the American Chemical Society.

Sequential Michael-Michael-Michael-ring closure reactions for high-yield, one-pot, 4-component coupling

G. Posner, E. Asirvatham, 1986 .

Sequential Michael-Michael-Ring Closure reactions for 3-different-component, one-pot, 2+2+2 construction of acylcyclohexenes and an acylcyclohexanol

G. Posner, E. Asirvatham, Shuang Lu, 1986 .

Complete Asymmetric Induction in Synthesis of Enantiomerically Pure Steroid Intermediates of Natural Configuration

J. Clardy, J. Mallamo, G. Posner, 1981 .

Selective formation of carbon-carbon bonds between unlike groups using organocopper reagents

E. Corey, G. Posner, 1967 .

Reaction of .alpha.,.beta.-ethylenic sulfur compounds with organocopper reagents

G. Posner, D. Brunelle, 1973 .

Secondary and Tertiary Alkyl Ketones from Carboxylic Acid Chlorides and Lithium Phenylthio(Alkyl)Cuprate Reagents: tert‐Butyl Phenyl Ketone

G. Posner, C. E. Whitten, 2003 .

A mechanistic and synthetic study of organocopper substitution reactions with some homoallylic and cyclopropylcarbinyl substrates : Application to isoprenoid synthesis

G. Posner, C. M. Lentz, J. Ting, 1976 .

Asymmetric synthesis using enantiomerically pure 2-(p-anisylsulfinyl)-2-cycloalkenones

L. Frye, G. Posner, M. Hulce, 1984 .

Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones.

G. Posner, M. Siegler, D. T. Genna, 2011, The Journal of organic chemistry.

A NEW DIRECT METHOD FOR SELECTIVE DEMETHYLATION OF N(+)‐METHYL QUATERNARY AMMONIUM IODIDES

G. Posner, J. Ting, 1975 .

Dechloroethylation of Chloroethyl Ethers and Amines Using n-Butyllithium

G. Posner, J. Ting, 1975 .

Chemiluminescence mechanism and quantum yield of synthetic vinylpyrene analogues of benzo[a]pyrene-7,8-dihydrobiol

H. Seliger, K. Miura, G. Posner, 1986 .

Chemiluminescence Mechanism and Quantum Yield of Synthetic Vinylpyrene Analogues of Benzo[a]pyrene‐7,8‐dihydrodiol.

H. Seliger, K. Miura, G. Posner, 1986 .

Organic reactions at alumina surfaces. A mechanistic and synthetic study of sulfonate ester elimination reactions effected by chromatographic alumina

G. Posner, K. Babiak, G. M. Gurria, 1977 .

Evidence for Fe(IV):O in the Molecular Mechanism of Action of the Trioxane Antimalarial Artemisinin

Poonsakdi Ploypradith, Chang Ho Oh, J. Cumming, 1995 .

Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation

G. Posner, R. Arav-Boger, R. He, 2015, Antimicrobial Agents and Chemotherapy.

In Vitro Inhibition of Toxoplasma gondii by Four New Derivatives of Artemisinin

R. Yolken, G. Posner, L. Jones-Brando, 2006, Antimicrobial Agents and Chemotherapy.

Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds.

T. Shapiro, G. Posner, I. Paik, 2002, International journal for parasitology.

Artemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs

Jun O. Liu, C. Civin, M. Rudek, 2016, Oncotarget.

Antimalarial chemotherapy: orally curative artemisinin-derived trioxane dimer esters.

D. Sullivan, G. Posner, A. Tripathi, 2015, Bioorganic & medicinal chemistry letters.

Artemisinin-Derived Dimers Have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers

C. Chiou, G. Posner, Jianyong Liu, 2010, PloS one.

Olefin oxidative cleavage and dioxetane formation using triethylsilyl hydrotrioxide: Applications to preparation of potent antimalarial 1,2,4-trioxanes

G. Posner, C. Oh, W. K. Milhous, 1991 .

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.

Dominic P. Williams, B. K. Park, James Chadwick, 2004, Journal of medicinal chemistry.

Inhibition of P-glycoprotein by two artemisinin derivatives

T. Efferth, G. Posner, G. Fricker, 2012, Natural Products and Bioprospecting.

EVIDENCE FOR THE IMPORTANCE OF HIGH-VALENT FE=O AND OF A DIKETONE IN THE MOLECULAR MECHANISM OF ACTION OF ANTIMALARIAL TRIOXANE ANALOGS OF ARTEMISININ

J. Cumming, T. Shapiro, G. Posner, 1996 .

Artemisinin-Derived Dimer Diphenyl Phosphate Is an Irreversible Inhibitor of Human Cytomegalovirus Replication

Kyoungsook Park, B. Mott, G. Posner, 2012, Antimicrobial Agents and Chemotherapy.

Apc(MIN) modulation of vitamin D secosteroid growth control.

F. Campbell, Haibo Xu, G. Posner, 2010, Carcinogenesis.

ORGANIC REACTIONS AT ALUMINA SURFACES. MILD, SELECTIVE, AND HIGH-YIELD OXIDATION OF CYCLOBUTANOL TO CYCLOBUTANONE

G. Posner, M. Chapdelaine, 1977 .

Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate.

G. Posner, W. Maio, Alvin S. Kalinda, 2008, Bioorganic & medicinal chemistry.

ASYMMETRIC SYNTHESES OF ENANTIOMERIC 3-P-FLUOROPHENYL 1,2,4-TRIOXANE ANALOGUES OF THE ANTIMALARIAL ARTEMISININ

P. O’Neill, G. Posner, C. Oh, 1999 .

2-Fluoroalkyl A-Ring Analogues of 1,25-Dihydroxyvitamin D3. Stereocontrolled Total Synthesis via Intramolecular and Intermolecular Diels-Alder Cycloadditions. Preliminary Biological Testing.

R. Horst, G. Posner, N. Tsugawa, 1995 .

8 – Addition of Organometallic Reagents to Chiral Vinylic Sulfoxides

G. Posner, 1983 .

Antimalarial artemisinin analogs. Synthesis via chemoselective CC bond formation and preliminary biological evaluation

T. Shapiro, G. Posner, P. Ploypradith, 1999 .

In Vitro Combination of Anti-Cytomegalovirus Compounds Acting through Different Targets: Role of the Slope Parameter and Insights into Mechanisms of Action

G. Posner, R. Arav-Boger, R. Venkatadri, 2013, Antimicrobial Agents and Chemotherapy.

New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones

G. Posner, M. Hatcher, Kristina Borstnik, 2003 .

Antitumor Effects of Two Less-Calcemic Vitamin D Analogs (Paricalcitol and QW-1624F2-2) in Squamous Cell Carcinoma Cells

B. Foster, D. Trump, Candace S. Johnson, 2007, Oncology.

Diels-Alder cycloadditions using nucleophilic 2-pyridones. Regiocontrolled and stereocontrolled synthesis of unsaturated, bridged, bicyclic lactams

G. Posner, V. Vinader, K. Afarinkia, 1992 .

AN IMPROVED PREPARATION OF 3-BROMO-2(H)-PYRAN-2-ONE : AN AMBIPHILIC DIENE FOR DIELS-ALDER CYCLOADDITIONS : (2H-PYRAN-2-ONE, 3-BROMO-)

G. Posner, K. Afarinkia, H. Dai, 1996 .

Highly regiocontrolled and stereocontrolled syntheses of polysubstituted aminocyclohexanes: mild inverse-electron-demand Diels–Alder cycloadditions of electrophilic 2-pyridones

G. Posner, M. Siegler, Ryan C. Conyers, 2016 .

Diels‐Alder Cycloadditions Using Nucleophilic 2‐Pyridones. Regiocontrolled and Stereocontrolled Synthesis of Unsaturated, Bridged, Bicyclic Lactams.

G. Posner, V. Vinader, K. Afarinkia, 1992 .

1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2

D. Dean, V. Sylvia, Z. Schwartz, 1999, Steroids.

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

A. Bodley, J. Cumming, T. Shapiro, 1995, Journal of medicinal chemistry.

An extremely efficient method for one-pot, three-component, 2+2+2 construction of functionalized cyclohexenes

G. Posner, S. Lu, 1985 .

Highly stereocontrolled synthesis of some polyfunctionalized cyclohexenes. A short formal total synthesis of (±)-chorismic acid

G. Posner, C. M. Kinter, A. Haces, 1987 .

A new synthetic approach to pseudoguaianes.

A. Alexakis, G. Posner, M. Chapdelaine, 1978 .

Binaphthol-titanium-promoted, highly enantiocontrolled, Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: Streamlined asymmetric synthesis of an A-ring precursor to physiologically active 1α-hydroxyvitamin D3 steroids

G. Posner, F. Eydoux, Jae Kyoo Lee, 1994 .

An organometallic route to (±)-3-p-toluenesulfinyl-2-pyrone

G. Posner, Wayne N. Harrison, 1985 .

Ground state oxygen in synthesis of cyclic peroxides. Part 1: Benzo fused ketals

T. Shapiro, Junwon Kim, G. Posner, 2006 .

A surprising effect of 3-aryl groups on the regiochemistry of formation of cyclopentanone lithium enolates. Evidence for lithium-arene π-coordination

G. Posner, C. M. Lentz, 1977 .

Chemiluminescent probes for singlet oxygen in biological reactions.

H. Seliger, G. Posner, A. Thompson, 1986, Methods in enzymology.

A short, asymmetric synthesis of natural (-)-methyl jasmonate

G. Posner, E. Asirvatham, 1985 .

Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition

G. Posner, R. Arav-Boger, F. Zhu, 2020, The Journal of Biological Chemistry.

Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.

C. Civin, B. Mott, G. Posner, 2013, Bioorganic & medicinal chemistry.

A covalent fluorescence probe based on excited-state proton transfer.

L. Brand, W. Laws, G. Posner, 1979, Archives of biochemistry and biophysics.

Quantitation of isothiocyanates by cyclocondensation with 1,2-benzenedithiol

K. Waldron, I. Johnson, P. Talalay, 1993 .

S)-(+)-2-(p-tolylsulfinyl)-2-buten-4-olide: an enantiomerically pure Michael acceptor for asymmetric synthesis of 3-substituted 4-butanolides. (—)-podorhizon.

L. Frye, G. Posner, S. Haines, 1984 .

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.

G. Posner, R. Cooper, C. L. Hartwig, 2009, Biochemical pharmacology.

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

D. Sullivan, T. Shapiro, B. Mott, 2012, Journal of medicinal chemistry.

(S)‐( + )‐2‐(p‐Toluenesulfinyl)‐2‐Cyclopentenone: Precursor for Enantioselective Synthesis of 3‐Substituted Cyclopentanones

L. Frye, G. Posner, M. Hulce, 2003 .

Enantiocontrolled synthesis of quaternary carbon centers. 3,3-disubstituted cyclopentanones. (+)-α-cuparenone

G. Posner, M. Hulce, P. KoganTimothy, 1984 .

Modulation of response to estrogens in cultured human female bone cells by a non-calcemic Vitamin D analog: changes in nuclear and membranal binding

G. Posner, F. Kohen, D. Somjen, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

A non-calcemic analog of 1α,25 dihydroxy vitamin D3 (JKF) upregulates the induction of creatine kinase B by 17β estradiol in osteoblast-like ROS 17/2.8 cells and in rat diaphysis

G. Posner, D. Somjen, A. Kaye, 2001, The Journal of Steroid Biochemistry and Molecular Biology.

Modulation of the response to estradiol-17β of rat vascular tissues by a non calcemic vitamin D analog

N. Stern, G. Posner, D. Somjen, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Physiological Importance of the 1,25(OH)2D3 Membrane Receptor and Evidence for a Membrane Receptor Specific for 24,25(OH)2D3

D. Dean, V. Sylvia, Z. Schwartz, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

QW-1624F2-2, a synthetic analogue of 1,25-dihydroxyvitamin D3, enhances the response to other deltanoids and suppresses the invasiveness of human metastatic breast tumor cells

Kathleen M. Smith, D. Gewirtz, S. Sundaram, 2006, Molecular Cancer Therapeutics.

Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose–response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry

I. Kapetanovic, T. Kensler, Amy A Sarjeant, 2004, Steroids.

2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology.

T. Kensler, S. Peleg, G. Posner, 2002, Bioorganic & medicinal chemistry.

A 24-Phenylsulfone Analog of Vitamin D Inhibits 1α,25-Dihydroxyvitamin D3 Degradation in Vitamin D Metabolism-Competent Cells

E. Bajna, H. Cross, T. Manhardt, 2007, Journal of Pharmacology and Experimental Therapeutics.

One-pot, four-different-component annulations: flexible and efficient conversion of n-sized cycloalkenones into n+4 alkenolides

G. Posner, S. Jew, Webb Kevin, 1987 .

New chemical and biological aspects of artemisinin-derived trioxane dimers.

T. Shapiro, T. Kensler, G. Posner, 2002, Bioorganic & medicinal chemistry.

Antimalarial sulfide, sulfone, and sulfonamide trioxanes.

T. Shapiro, G. Posner, M. Krasavin, 2000, Bioorganic & medicinal chemistry.

Antimalarial sulfone trioxanes

J. Cumming, T. Shapiro, G. Posner, 1998 .

Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis.

S. Gange, T. Kensler, G. Posner, 2000, Carcinogenesis.

Mild, fast, and stereoselective epoxide opening by ketone enolate anions. Application to synthesis of the norlignan curculigine.

M. Kahraman, G. Posner, J. Maxwell, 2003, The Journal of organic chemistry.

A new oxidizing reagent: triethylsilyl hydrotrioxide

H. Seliger, G. Posner, W. M. Nelson, 1989 .

Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.

S. Meshnick, G. Posner, D. McGarvey, 1995, Journal of medicinal chemistry.

Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes.

L. Gerena, G. Posner, C. Oh, 1992, Journal of medicinal chemistry.

Antimalarial cyclic peroxy ketals.

J. Cumming, T. Shapiro, G. Posner, 1998, Journal of Medicinal Chemistry.

Malaria-infected mice are cured by a single dose of novel artemisinin derivatives.

T. Shapiro, G. Posner, Wonsuk Chang, 2007, Journal of medicinal chemistry.

ASYMMETRIC SYNTHESIS USING ENANTIOMERICALLY PURE SULFOXIDES

K. Miura, J. Mallamo, G. Posner, 1983 .

New silicon-mediated, sequential ring expansions of n-sized 2-cycloalkenones into hydroxyolefinic n + m + p medium-sized lactones: short synthesis of (-)-phoracantholide-J.

G. Posner, M. Hatcher, W. Maio, 2005, Organic letters.

Unique and Highly Selective Anticytomegalovirus Activities of Artemisinin-Derived Dimer Diphenyl Phosphate Stem from Combination of Dimer Unit and a Diphenyl Phosphate Moiety

B. Mott, G. Posner, R. Arav-Boger, 2013, Antimicrobial Agents and Chemotherapy.

A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.

D. Sullivan, S. Parkin, G. Posner, 2011, Bioorganic & medicinal chemistry letters.

Antimalarial preclinical drug development: a single oral dose of a 5‐carbon‐linked trioxane dimer plus mefloquine cures malaria‐infected mice

T. Shapiro, Nirbhay Kumar, G. Posner, 2010, Drug development research.

Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

Jun O. Liu, T. Shapiro, G. Posner, 2009, Journal of medicinal chemistry.

The Unique and Highly-Selective Anti-Cytomegalovirus Activities of Artemisinin-Derived

B. Mott, G. Posner, R. Venkatadri, 2013 .

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

T. Shapiro, T. Kensler, S. Woo, 1999, Journal of medicinal chemistry.

Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.

T. Shapiro, G. Posner, Amy A. Narducci Sarjeant, 2006, Journal of medicinal chemistry.

A non-calcemic Vitamin D analog modulates both nuclear and putative membranal estrogen receptors in cultured human vascular smooth muscle cells

N. Stern, G. Posner, F. Kohen, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Vitamin D analogs as anti-carcinogenic agents.

T. Kensler, G. Posner, M. Hatcher, 2006, Anti-cancer agents in medicinal chemistry.

Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs

R. Mason, M. Slater, A. Norman, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).

T. Kensler, U. Saha, S. S. Chuang, 2004, Journal of medicinal chemistry.

Organic Reactions at Alumina Surfaces: An Extremely Simple, Mild and Convenient Method for Acetylating Primary Alcohols

K. Miura, G. Posner, S. Okada, 1981 .

Reaction of lithium dialkylcuprates with β-alkoxy and β-alkylthio αβ-unsaturated carbonyl compounds

G. Posner, D. Brunelle, 1973 .

Vitamin D analogs as modulators of vitamin D receptor action.

S. Peleg, G. Posner, 2003, Current topics in medicinal chemistry.

Stereocontrolled Total Synthesis of Calcitriol Derivatives: 1,25- Dihydroxy-2-(4′-hydroxybutyl)vitamin D3 Analogues of an Osteoporosis Drug.

G. Posner, N. Johnson, 1995 .

Asymmetric total synthesis, x-ray crystallography, and preliminary biological evaluation of 1-(1'-hydroxyethyl)-25-hydroxyvitamin D3 analogs of natural calcitriol

K. Guyton, T. Kensler, G. Posner, 1993 .

Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

T. Kensler, S. Peleg, B. Suh, 2006, Journal of medicinal chemistry.

Low-calcemic vitamin D analogs (deltanoids) for human cancer prevention.

G. Posner, 2002, The Journal of nutrition.

One-pot, three-component, sequential Michael-Michael-ring-closure reactions. Annulation of meta-dicarboxylated aromatic rings. Total synthesis of juncunol

G. Posner, K. Canella, E. Silversmith, 1988, Proceedings / Indian Academy of Sciences.

Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.

T. Shapiro, G. Posner, P. Ploypradith, 1999, Journal of medicinal chemistry.

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

T. Kensler, C. Cho, P. Talalay, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

D. Sullivan, T. Shapiro, B. Mott, 2012, Journal of medicinal chemistry.

Iron(II)-induced degradation of antimalarial beta-sulfonyl endoperoxides: evidence for the generation of potentially cytotoxic carbocations.

G. Posner, A. Szpilman, E. Korshin, 2001, The Journal of organic chemistry.

'Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities'.

T. Kensler, G. Posner, A. Usera, 2009, Bioorganic & Medicinal Chemistry.

A non-calcemic analog of 1 alpha,25 dihydroxy vitamin D(3) (JKF) upregulates the induction of creatine kinase B by 17 beta estradiol in osteoblast-like ROS 17/2.8 cells and in rat diaphysis.

G. Posner, D. Somjen, A. Kaye, 2001, The Journal of steroid biochemistry and molecular biology.