Xiaokai Li

发表

Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.

J. Brodsky, J. Gestwicki, Yoshinari Miyata, 2013, ACS chemical neuroscience.

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

R. Andino, J. Frydman, A. Fernández-Sesma, 2015, Cell.

Allosteric Inhibitors of Hsp70: Drugging the Second Chaperone of Tumorigenesis

J. Gestwicki, Xiaokai Li, S. Srinivasan, 2015 .

Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.

E. Zuiderweg, J. Gestwicki, Atta Ahmad, 2013, ACS medicinal chemistry letters.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades

C. Duckett, J. Gestwicki, M. Zhuang, 2017, Molecular Cancer Research.

Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cell Death

C. Duckett, M. Zhuang, I. Maillard, 2017 .

Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy.

G. Carlson, E. Zuiderweg, J. Gestwicki, 2016, Cell chemical biology.

Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).

J. Gestwicki, Xiaokai Li, I. Taylor, 2016, Current topics in medicinal chemistry.

Hsp70-Bag3 interactions regulate cancer-related signaling networks.

Hu Li, J. Gestwicki, S. Takayama, 2014, Cancer research.

Glioma Shapes Blood–Brain Barrier Integrity and Remodels the Tumor Microenvironment: Links with Clinical Features and Prognosis

Xiaokai Li, Chuanrui Xu, Lei Li, 2022, Journal of clinical medicine.

Validation of the Hsp 70-Bag 3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

J. Weissman, B. Hann, P. Walter, 2014 .

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

J. Rogers, E. Weeber, J. Brodsky, 2013, Biological Psychiatry.

LINC00665 regulates hepatocellular carcinoma by modulating mRNA via the m6A enzyme

Xiaokai Li, Xing-hua Du, Ling Gu, 2022, Open life sciences.

Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.

Benjamin C. Tang, J. Gestwicki, S. Hayashi, 2021, Bioorganic & medicinal chemistry letters.

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Catherine A. Collins, T. Komiyama, J. Gestwicki, 2012, Nature chemical biology.

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).

Luke A. Gilbert, J. Weissman, B. Hann, 2018, Journal of medicinal chemistry.

Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer

J. Weissman, B. Hann, P. Walter, 2015, Molecular Cancer Therapeutics.

Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng

Xiaokai Li, Guijiang Sun, Yubo Li, 2021, Biogerontology.

Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells†

G. Colombo, G. Morra, S. Rinaldi, 2020, Chemical science.

Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau

J. Rogers, E. Weeber, J. Brodsky, 2013, Biological Psychiatry.

Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer

J. Weissman, B. Hann, P. Walter, 2015, Molecular Cancer Therapeutics.

Targeting aENaC with an epithelial RNAi trigger delivery platform for the treatment of cystic fibrosis

T. Schluep, P. Kuehl, Xiaokai Li, 2018, Cystic fibrosis.