Shanchao Wu

发表

Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies.

Weiqi Wang, Shiping Zhu, Shengzheng Wang, 2013, ACS combinatorial science.

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2015 .

Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective Michael-Michael cascade.

Weiqi Wang, J. Li, Hao Li, 2014, Organic letters.

Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity.

Yunbo Guo, Shanchao Wu, C. Sheng, 2019, Bioorganic & medicinal chemistry letters.

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes.

Weiqi Wang, Yongqiang Zhang, Shanchao Wu, 2016, Organic & biomolecular chemistry.

Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, Acta pharmaceutica Sinica. B.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, European journal of medicinal chemistry.

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).

R. Liu, Yu Ding, Shanchao Wu, 2022, Journal of medicinal chemistry.

From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole–Thiazolidinedione Hybrids as Novel Antifungal Agents

Xiaomeng He, Shengzheng Wang, Yongqiang Zhang, 2014, ChemMedChem.

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

Shanchao Wu, Guoqiang Dong, C. Sheng, 2018, ChemMedChem.

Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

Xiaomeng He, Yongqiang Zhang, Shanchao Wu, 2015 .

Discovery of IDO1 and DNA dual targeting antitumor agents.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2017, Organic & biomolecular chemistry.

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, European journal of medicinal chemistry.

Tackling Fungal Resistance by Biofilm Inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2017, Journal of medicinal chemistry.

Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.

Ying Sun, Shanchao Wu, Guoqiang Dong, 2018, MedChemComm.

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, Journal of medicinal chemistry.

Novel benzothiazole derivatives with a broad antifungal spectrum: design, synthesis and structure–activity relationships

Yongqiang Zhang, Shanchao Wu, Guoqiang Dong, 2013 .

Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2017, Bioorganic & medicinal chemistry letters.

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3'-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors.

Shengzheng Wang, Shanchao Wu, Guoqiang Dong, 2016, Organic letters.

Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers.

Shiping Zhu, J. Li, Hao Li, 2013, Organic letters.

Iridium-Catalyzed Enantioselective and Diastereoselective Allylation of Dioxindoles: A One-Step Synthesis of 3-Allyl-3-hydroxyoxindoles.

Shanchao Wu, Wanbin Zhang, R. He, 2018, Organic letters.

Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents.

Shanchao Wu, Guoqiang Dong, Zhenyuan Miao, 2018, Journal of medicinal chemistry.

Highly Potent Dual BET/HDAC Inhibitors for the Efficient Treatment of Pancreatic Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, Angewandte Chemie.

Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, ACS medicinal chemistry letters.

Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2022, Bioorganic chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Y. Liu, Shanchao Wu, Guoqiang Dong, 2020, Acta pharmaceutica Sinica. B.

Discovery of novel triple targeting G‑quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine

Shanchao Wu, Guoqiang Dong, C. Sheng, 2022, Chinese Chemical Letters.

A photochemically covalent lock stabilizes aptamer conformation and strengthens its performance for biomedicine

Zilong Zhao, Ting Fu, Shanchao Wu, 2022, Nucleic acids research.

Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices

Keliang Li, Minyong Li, Shanchao Wu, 2023, Chinese Chemical Letters.

Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure-activity relationship.

Y. Li, Yongqiang Zhang, Shanchao Wu, 2016, European journal of medicinal chemistry.

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors.

Shengzheng Wang, Jian Li, Shanchao Wu, 2016, Chemical communications.

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, Bioorganic & medicinal chemistry letters.

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.

Y. Li, Shanchao Wu, Guoqiang Dong, 2018, ACS medicinal chemistry letters.

Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020 .

One-Pot Synthesis of Deuterated Aldehydes from Arylmethyl Halides.

Hai-bin Luo, Xiangmin Li, Shanchao Wu, 2018, Organic letters.

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2018, Acta pharmaceutica Sinica. B.

Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy.

Min Huang, Shanchao Wu, Guoqiang Dong, 2022, Journal of medicinal chemistry.

Discovery of potent natural product higenamine derivatives as novel Anti-Fusobacterium nucleatum agents.

Jie Hong, Qingwei Bu, Shanchao Wu, 2023, Bioorganic chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, ACS medicinal chemistry letters.