Guoqiang Dong

发表

Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies.

Weiqi Wang, Shiping Zhu, Shengzheng Wang, 2013, ACS combinatorial science.

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2015 .

Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective Michael-Michael cascade.

Weiqi Wang, J. Li, Hao Li, 2014, Organic letters.

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes.

Weiqi Wang, Yongqiang Zhang, Shanchao Wu, 2016, Organic & biomolecular chemistry.

Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents.

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, 2010, Journal of medicinal chemistry.

Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, European journal of medicinal chemistry.

Targeting necroptosis in anticancer therapy: mechanisms and modulators

Guoqiang Dong, C. Sheng, Ying Wu, 2020, Acta pharmaceutica Sinica. B.

Design and synthesis of cyclopropylamide analogues of combretastatin-A4 as novel microtubule-stabilizing agents.

Guoqiang Dong, C. Sheng, Tiantian Wang, 2013, Journal of medicinal chemistry.

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.

Shengzheng Wang, Jian Li, Guoqiang Dong, 2015, Journal of medicinal chemistry.

Discovery of Novel PDEδ Degraders for the Treatment of KRAS Mutant Colorectal Cancer.

Guoqiang Dong, C. Sheng, Yu Li, 2020, Journal of medicinal chemistry.

Substrate Modification with Lysine 63-linked Ubiquitin Chains through the UBC13-UEV1A Ubiquitin-conjugating Enzyme*

D. Payan, Guoqiang Dong, Jianing Huang, 2007, Journal of Biological Chemistry.

Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2016, Bioorganic & medicinal chemistry letters.

Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, Bioorganic & medicinal chemistry letters.

Discovery of Novel Tubulin Inhibitors Targeting the Colchicine Binding Site via Virtual Screening, Structural Optimization and Antitumor Evaluation

Hairui Jia, Shengzheng Wang, Guoqiang Dong, 2021, Bioorganic Chemistry.

Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.

Wei Chen, Guoqiang Dong, Zhenyuan Miao, 2015, ACS medicinal chemistry letters.

Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, Acta pharmaceutica Sinica. B.

New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents

Shiping Zhu, Guoqiang Dong, Zhenyuan Miao, 2014 .

Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors

Shengzhang Wang, Wei Guo, Wenfeng Liu, 2011, Archiv der Pharmazie.

Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.

H. Ke, S. Yuan, Hai-bin Luo, 2020, Journal of medicinal chemistry.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, European journal of medicinal chemistry.

Nucleic-Acid-Based Targeted Degradation in Drug Discovery.

Guoqiang Dong, C. Sheng, Wei Wang, 2022, Journal of medicinal chemistry.

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT).

R. Liu, Yu Ding, Shanchao Wu, 2022, Journal of medicinal chemistry.

Identification of pyrazolopyridine derivatives as novel spleen tyrosine kinase inhibitors

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, Archiv der Pharmazie.

From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole–Thiazolidinedione Hybrids as Novel Antifungal Agents

Xiaomeng He, Shengzheng Wang, Yongqiang Zhang, 2014, ChemMedChem.

NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion

Min Huang, Guoqiang Dong, C. Sheng, 2021, Acta pharmaceutica Sinica. B.

Blocking Non-enzymatic Functions by PROTAC-Mediated Targeted Protein Degradation.

Guoqiang Dong, C. Sheng, Shipeng He, 2022, Journal of medicinal chemistry.

Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

Shanchao Wu, Guoqiang Dong, C. Sheng, 2018, ChemMedChem.

Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

Xiaomeng He, Yongqiang Zhang, Shanchao Wu, 2015 .

Discovery of IDO1 and DNA dual targeting antitumor agents.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2017, Organic & biomolecular chemistry.

Total synthesis and structure–activity relationships of caspofungin-like macrocyclic antifungal lipopeptides

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2012 .

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, European journal of medicinal chemistry.

Tackling Fungal Resistance by Biofilm Inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2017, Journal of medicinal chemistry.

Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.

Ying Sun, Shanchao Wu, Guoqiang Dong, 2018, MedChemComm.

Emerging New Targets for the Treatment of Resistant Fungal Infections.

Guoqiang Dong, C. Sheng, Na Liu, 2018, Journal of medicinal chemistry.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Xiaomeng He, Shengzheng Wang, Jian Li, 2014, ACS medicinal chemistry letters.

Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents.

Guoqiang Dong, C. Sheng, Dan Liu, 2021, Bioorganic & medicinal chemistry letters.

Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, Journal of medicinal chemistry.

Novel benzothiazole derivatives with a broad antifungal spectrum: design, synthesis and structure–activity relationships

Yongqiang Zhang, Shanchao Wu, Guoqiang Dong, 2013 .

Structure–activity relationships of tetrahydrocarbazole derivatives as antifungal lead compounds

Shiping Zhu, Shengzheng Wang, Yongqiang Zhang, 2013 .

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Three-Dimensional Model of Lanosterol 14 (cid:2) -Demethylase from Cryptococcus neoformans : Active-Site Characterization and Insights into Azole Binding (cid:1) †

Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, 2009 .

Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2017, Bioorganic & medicinal chemistry letters.

The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor.

Shiping Zhu, Xiaonan Zhang, Guoqiang Dong, 2016, Chemical communications.

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)-H activations.

Guoqiang Dong, C. Sheng, Xinglin Yang, 2017, Chemical communications.

Design, synthesis and antifungal activity of carbazole derivatives

Shiping Zhu, Guoqiang Dong, Zhenyuan Miao, 2014 .

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3'-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors.

Shengzheng Wang, Shanchao Wu, Guoqiang Dong, 2016, Organic letters.

Structural simplification: an efficient strategy in lead optimization

Guoqiang Dong, Chunquan Sheng, Shengzheng Wang, 2019, Acta pharmaceutica Sinica. B.

Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans.

Wei Chen, Guoqiang Dong, Zhenyuan Miao, 2014, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers.

Shiping Zhu, J. Li, Hao Li, 2013, Organic letters.

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.

Jian Li, Guoqiang Dong, Zhenyuan Miao, 2017, Journal of medicinal chemistry.

Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors

Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, 2014, International journal of molecular sciences.

Structural Simplification of Natural Products.

Shengzheng Wang, Guoqiang Dong, C. Sheng, 2019, Chemical reviews.

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2014, European journal of medicinal chemistry.

Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2012, Journal of enzyme inhibition and medicinal chemistry.

Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

Haitao Ji, Wei Guo, Guoqiang Dong, 2009, Antimicrobial Agents and Chemotherapy.

Improved Model of Lanosterol 14α‐Demethylase by Ligand‐Supported Homology Modeling: Validation by Virtual Screening and Azole Optimization

Shengzheng Wang, Haitao Ji, Guoqiang Dong, 2010, ChemMedChem.

Novel conformationally restricted triazole derivatives with potent antifungal activity.

Shengzheng Wang, Yongbing Cao, Guoqiang Dong, 2010, European journal of medicinal chemistry.

Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement.

Shengzheng Wang, G. Fan, Guoqiang Dong, 2013, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains.

Shengzheng Wang, G. Jin, Yongqiang Zhang, 2012, European journal of medicinal chemistry.

Discovery of highly potent antifungal triazoles by structure-based lead fusion

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2011 .

The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine.

Haiying He, Yuan-Ying Jiang, Guoqiang Dong, 2015, Chemical communications.

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

Y. Sham, Guoqiang Dong, Zhenyuan Miao, 2014, Oncotarget.

Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy.

Buhong Li, Guoqiang Dong, Zou Tan, 2016, Journal of medicinal chemistry.

Hydrophobic Tagging-Induced Degradation of PDEδ in Colon Cancer Cells.

Y. Li, Guoqiang Dong, C. Sheng, 2022, ACS medicinal chemistry letters.

Strategies for designing proteolysis targeting chimaeras (PROTACs)

Guoqiang Dong, C. Sheng, Shipeng He, 2022, Medicinal research reviews.

Small Molecules Simultaneously Inhibiting p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs): Discovery of Novel Multitargeting Antitumor Agents.

Shanchao Wu, Guoqiang Dong, Zhenyuan Miao, 2018, Journal of medicinal chemistry.

Highly Potent Dual BET/HDAC Inhibitors for the Efficient Treatment of Pancreatic Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, Angewandte Chemie.

Natural Product Evodiamine with Borate Trigger Unit: Discovery of Potent Antitumor Agents against Colon Cancer.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020, ACS medicinal chemistry letters.

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery.

Yu Ding, Guoqiang Dong, C. Sheng, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Structure-Activity relationships of Evodiamine-Based topoisomerase (Top)/Histone deacetylase (HDAC) dual inhibitors.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2022, Bioorganic chemistry.

Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development

Guoqiang Dong, C. Sheng, 2018 .

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Synthesis and Biological Assays of 9‐(Acylamino)homocamptothecins as DNA Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2013, Chemistry & biodiversity.

Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Synthesis of 9‐(Heteroarylmethylidene)amino Derivatives of Homocamptothecin with Biological Activities

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2011, Chemistry & biodiversity.

Synthesis and Biological Evaluation of 7‐Alkenyl Homocamptothecins as Potent Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2012, Chemistry & biodiversity.

Topoisomerase I‐Mediated Antiproliferative Activity of 10‐Substituted and 12‐Substituted Homocamptothecins

W. Guo, Wenfeng Liu, Yongqiang Zhang, 2011 .

Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.

Shengzheng Wang, Wei Guo, Wenfeng Liu, 2011, European journal of medicinal chemistry.

Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities.

Juan Wang, Wei Guo, Wenfeng Liu, 2010, Bioorganic & medicinal chemistry.

The Poxvirus p28 Virulence Factor Is an E3 Ubiquitin Ligase*

D. Payan, R. Buller, M. Shen, 2004, Journal of Biological Chemistry.

High-throughput screening for inhibitors of the e3 ubiquitin ligase APC.

D. Payan, Guoqiang Dong, Jianing Huang, 2005, Methods in enzymology.

Fluorescent and theranostic probes for imaging nicotinamide phosphoribosyl transferase (NAMPT).

Minyong Li, Guoqiang Dong, C. Sheng, 2022, European journal of medicinal chemistry.

A theranostic probe of indoleamine 2,3-dioxygenase 1 (IDO1) for small molecule cancer immunotherapy.

Yanhui Zhang, Guoqiang Dong, C. Sheng, 2021, European journal of medicinal chemistry.

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Y. Liu, Shanchao Wu, Guoqiang Dong, 2020, Acta pharmaceutica Sinica. B.

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

Wei Chen, Guoqiang Dong, Wannian Zhang, 2017, Journal of medicinal chemistry.

Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, Journal of medicinal chemistry.

Discovery of novel triple targeting G‑quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine

Shanchao Wu, Guoqiang Dong, C. Sheng, 2022, Chinese Chemical Letters.

Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, 2012, Journal of medicinal chemistry.

Discovery of Highly Potent Nicotinamide Phosphoribosyltransferase Degraders for Efficient Treatment of Ovarian Cancer.

Guoqiang Dong, C. Sheng, Shipeng He, 2022, Journal of medicinal chemistry.

Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT.

Min Huang, Guoqiang Dong, C. Sheng, 2022, Journal of medicinal chemistry.

Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices

Keliang Li, Minyong Li, Shanchao Wu, 2023, Chinese Chemical Letters.

Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

Jing Zhang, Guoqiang Dong, C. Sheng, 2021, Acta pharmaceutica Sinica. B.

Targeted delivery of a PROTAC induced PDEδ degrader by a biomimetic drug delivery system for enhanced cytotoxicity against pancreatic cancer cells.

Guoqiang Dong, Shipeng He, Hui Cai, 2022, American journal of cancer research.

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.

Guoqiang Dong, Wei Wang, Wannian Zhang, 2015, Chemical Society reviews.

Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure-activity relationship.

Y. Li, Yongqiang Zhang, Shanchao Wu, 2016, European journal of medicinal chemistry.

Aptamer-PROTAC Conjugates (APCs) for Tumor-specific Targeting in Breast Cancer.

Guoqiang Dong, C. Sheng, Shipeng He, 2021, Angewandte Chemie.

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections.

Guoqiang Dong, C. Sheng, Na Liu, 2018, Chemical communications.

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors.

Shengzheng Wang, Jian Li, Shanchao Wu, 2016, Chemical communications.

Discovery of 7‐Methyl‐10‐Hydroxyhomocamptothecins with 1,2,3‐Triazole Moiety as Potent Topoisomerase I Inhibitors

Wenfeng Liu, Guoqiang Dong, Zhenyuan Miao, 2016, Chemical biology & drug design.

Computational Fragment-Based Drug Design

Chen Wang, Guoqiang Dong, Chunquan Sheng, 2015 .

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Yang Liu, 2011, European journal of medicinal chemistry.

Enhanced remanence and (BH)max of BaFe12O19/CoFe2O4 composite ceramics prepared by the microwave sintering method

Haibo Yang, Guoqiang Dong, Ying Zhang, 2015 .

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design

Wei Guo, Wenya Wang, Guoqiang Dong, 2009, J. Comput. Aided Mol. Des..

A homogeneous FRET assay system for multiubiquitin chain assembly and disassembly.

D. Payan, Guoqiang Dong, T. Pray, 2005, Methods in enzymology.

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors.

Y. Li, Shanchao Wu, Guoqiang Dong, 2018, ACS medicinal chemistry letters.

Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, ACS medicinal chemistry letters.

Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

Shanchao Wu, Guoqiang Dong, C. Sheng, 2020 .

First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase†

Chu‐Young Kim, Guoqiang Dong, C. Sheng, 2020, Chemical science.

Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

Weihong Zhou, Guoqiang Dong, Zhenyuan Miao, 2017 .

Optical evodiamine derivatives: Asymmetric synthesis and antitumor activity

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2015 .

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2018, Acta pharmaceutica Sinica. B.

Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy.

Min Huang, Shanchao Wu, Guoqiang Dong, 2022, Journal of medicinal chemistry.

Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors.

Guoqiang Dong, C. Sheng, Youjun Zhou, 2014, Bioorganic & medicinal chemistry letters.

Discovery of novel human acrosin inhibitors by virtual screening

Jue Zhang, Xuefei Liu, Guoqiang Dong, 2011, J. Comput. Aided Mol. Des..

Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design

Shuanghong Chen, Haitao Ji, Wei Guo, 2010, Journal of molecular modeling.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2014, ACS Medicinal Chemistry Letters.

Discovery of Potent NAMPT-Targeting PROTACs Using FK866 as the Warhead.

Guoqiang Dong, C. Sheng, Defeng Xu, 2023, Bioorganic & medicinal chemistry letters.

Nicotinamide Phosphoribosyltransferase (NAMPT) Is a New Target of Antitumor Agent Chidamide.

Shanchao Wu, Guoqiang Dong, C. Sheng, 2019, ACS medicinal chemistry letters.

Discovery of new Syk inhibitors through structure-based virtual screening.

Jian Li, Bo-hua Li, Guoqiang Dong, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Benzylidene Derivatives as Potent Syk Inhibitors: Synthesis, SAR Analysis, and Biological Evaluation

Hualiang Jiang, Jian Li, L. Miao, 2015, Archiv der Pharmazie.

Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion.

Guoqiang Dong, C. Sheng, Yahui Huang, 2023, Journal of medicinal chemistry.

Antitumor Activities and Structure–Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route

Juan Wang, Shengzheng Wang, Yongqiang Zhang, 2011 .

Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities.

Guoqiang Dong, Xiaoyu Zhang, Wei Wang, 2024, Bioorganic & medicinal chemistry letters.

Dual-Programmable Semiconducting Polymer NanoPROTACs for Deep-Tissue Sonodynamic-Ferroptosis Activatable Immunotherapy.

Guoqiang Dong, C. Sheng, Ningyue Yu, 2023, Small.

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)-H activations.

Guoqiang Dong, C. Sheng, Xinglin Yang, 2017, Chemical communications.