Wannian Zhang

发表

Facile construction of structurally diverse thiazolidinedione-derived compounds via divergent stereoselective cascade organocatalysis and their biological exploratory studies.

Weiqi Wang, Shiping Zhu, Shengzheng Wang, 2013, ACS combinatorial science.

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2015 .

Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective Michael-Michael cascade.

Weiqi Wang, J. Li, Hao Li, 2014, Organic letters.

Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes.

Weiqi Wang, Yongqiang Zhang, Shanchao Wu, 2016, Organic & biomolecular chemistry.

Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

Min Zhang, Hui Xu, Youjun Zhou, 2006, Journal of medicinal chemistry.

Selection of evodiamine as a novel topoisomerase I inhibitor by structure-based virtual screening and hit optimization of evodiamine derivatives as antitumor agents.

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, 2010, Journal of medicinal chemistry.

Identification of Y118 amino acid residue in Candida albicans sterol 14alpha-demethylase associated with the enzyme activity and selective antifungal activity of azole analogues.

Cheng He, Yuan-Ying Jiang, Wannian Zhang, 2007, Biological & pharmaceutical bulletin.

Preparation and characterization of wet-milled cyclovirobuxine D nanosuspensions

Qiang Liu, Jianhong Yang, Wannian Zhang, 2020, Journal of Thermal Analysis and Calorimetry.

Design, synthesis and antifungal activity of isosteric analogues of benzoheterocyclic N-myristoyltransferase inhibitors.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, European journal of medicinal chemistry.

Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening.

Juan Wang, Zhenyuan Miao, Wannian Zhang, 2017, European journal of medicinal chemistry.

N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[ d]thiazol-2-yl)cyclopropanecarboxamide (TAK-632) Analogues as Novel Necroptosis Inhibitors by Targeting Receptor-Interacting Protein Kinase 3 (RIPK3): Synthesis, Structure-Activity Relationships, and in Vivo Efficacy.

Xiaofei Chen, Zhenyuan Miao, Wannian Zhang, 2019, Journal of medicinal chemistry.

Small molecule-drug conjugates: A novel strategy for cancer-targeted treatment.

Zhenyuan Miao, Wannian Zhang, Chun-lin Zhuang, 2019, European journal of medicinal chemistry.

In vivo pharmacokinetics and in vitro antifungal activity of iodiconazole, a new triazole, determined by microdialysis sampling.

G. Fan, Hongzhuan Chen, Yongbing Cao, 2013, International journal of antimicrobial agents.

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.

Shengzheng Wang, Jian Li, Guoqiang Dong, 2015, Journal of medicinal chemistry.

Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2021, European journal of medicinal chemistry.

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

Zhiqiang Ma, Zhenyuan Miao, Jianzhong Yao, 2019, Chinese Chemical Letters.

Amino acid derivatives of pyropheophorbide-a ethers as photosensitizer: Synthesis and photodynamic activity

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2016 .

Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.

C. Xing, Wannian Zhang, Lijuan Xu, 2019, Journal of medicinal chemistry.

Chalcone: A Privileged Structure in Medicinal Chemistry.

C. Xing, Zhenyuan Miao, Wannian Zhang, 2017, Chemical reviews.

Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice.

Wannian Zhang, Xueqin Ma, Chunlin Zhuang, 2021, Chemico-biological interactions.

Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2016, Bioorganic & medicinal chemistry letters.

Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.

Shengzheng Wang, Haitao Ji, Yongbing Cao, 2010, Bioorganic & medicinal chemistry letters.

Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury

Wannian Zhang, Lijuan Xu, Zhi-bin Wang, 2021, Chinese Chemical Letters.

A three-dimensional model of lanosterol 14α-demethylase of Candida albicans

Wannian Zhang, Jie Zhu, Youjun Zhou, 1998 .

Design, Synthesis and Biological Activity of (20S,21S)‐7‐Cyclohexyl‐21‐fluorocamptothecin Carbamates as Potential Antitumor Agents

Yuan Wang, Zhenyuan Miao, Jianzhong Yao, 2020, Chemistry & biodiversity.

Synthesis and biological activities of fluorinated 10-hydroxycamptothecin and SN38

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2014 .

Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.

Wei Chen, Guoqiang Dong, Zhenyuan Miao, 2015, ACS medicinal chemistry letters.

New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents

Shiping Zhu, Guoqiang Dong, Zhenyuan Miao, 2014 .

Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors.

P. Fu, Wannian Zhang, Yin Shi, 2022, European journal of medicinal chemistry.

Structure-based bioisosterism design of thio-benzoxazepinones as novel necroptosis inhibitors.

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2021, European journal of medicinal chemistry.

Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy

Congcong Xu, Wannian Zhang, Zhi-bin Wang, 2021, Acta pharmaceutica Sinica. B.

Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors

Shengzhang Wang, Wei Guo, Wenfeng Liu, 2011, Archiv der Pharmazie.

Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors.

Jian Li, Yuan-Ying Jiang, Wannian Zhang, 2018, European journal of medicinal chemistry.

Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells.

Zhenyuan Miao, Wannian Zhang, Hao Ma, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, European journal of medicinal chemistry.

ERK1/2 and Akt pathway activated during (3R, 6R)‐bassiatin(1)‐induced apoptosis in MCF‐7 cells

Weiming Zhu, Caiguo Huang, Hong-Wen Tao, 2012, Cell biology international.

Identification of pyrazolopyridine derivatives as novel spleen tyrosine kinase inhibitors

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, Archiv der Pharmazie.

From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole–Thiazolidinedione Hybrids as Novel Antifungal Agents

Xiaomeng He, Shengzheng Wang, Yongqiang Zhang, 2014, ChemMedChem.

[Recent advances in the study of antifungal lead compounds with new chemical scaffolds].

Wannian Zhang, C. Sheng, Lücheng Shao, 2007, Yao xue xue bao = Acta pharmaceutica Sinica.

In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine.

Zheng Xu, Yuan-Ying Jiang, Wannian Zhang, 2005, Biological & pharmaceutical bulletin.

Discovery of highly potent triazoleantifungal agents with piperidine-oxadiazole side chains

Xiaomeng He, Yongqiang Zhang, Shanchao Wu, 2015 .

Total synthesis and structure–activity relationships of caspofungin-like macrocyclic antifungal lipopeptides

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2012 .

Total synthesis and structure-activity relationships of new echinocandin-like antifungal cyclolipohexapeptides.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2012, European journal of medicinal chemistry.

Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.

Ying Sun, Shanchao Wu, Guoqiang Dong, 2018, MedChemComm.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Xiaomeng He, Shengzheng Wang, Jian Li, 2014, ACS medicinal chemistry letters.

Novel benzothiazole derivatives with a broad antifungal spectrum: design, synthesis and structure–activity relationships

Yongqiang Zhang, Shanchao Wu, Guoqiang Dong, 2013 .

Structure–activity relationships of tetrahydrocarbazole derivatives as antifungal lead compounds

Shiping Zhu, Shengzheng Wang, Yongqiang Zhang, 2013 .

Design, Synthesis, and Antifungal Activity of Novel Conformationally Restricted Triazole Derivatives

Haitao Ji, Zhenyuan Miao, Jianzhong Yao, 2009, Archiv der Pharmazie.

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Three-Dimensional Model of Lanosterol 14 (cid:2) -Demethylase from Cryptococcus neoformans : Active-Site Characterization and Insights into Azole Binding (cid:1) †

Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, 2009 .

Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors.

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2017, Bioorganic & medicinal chemistry letters.

The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor.

Shiping Zhu, Xiaonan Zhang, Guoqiang Dong, 2016, Chemical communications.

[Recent advances in the study of new antifungal lead compounds].

Shengzheng Wang, Wannian Zhang, C. Sheng, 2010, Yao xue xue bao = Acta pharmaceutica Sinica.

An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2010 .

New homocamptothecins: synthesis, antitumor activity, and molecular modeling.

M. Zhang, Haitao Ji, Zhenyuan Miao, 2008, Bioorganic & medicinal chemistry.

Trifluoromethyl-promoted homocamptothecins: synthesis and biological activity.

Wei Guo, Wenfeng Liu, Zhenyuan Miao, 2010, European journal of medicinal chemistry.

Design, synthesis and antifungal activity of carbazole derivatives

Shiping Zhu, Guoqiang Dong, Zhenyuan Miao, 2014 .

Discovery of highly potent novel antifungal azoles by structure-based rational design.

Haitao Ji, Yongbing Cao, Zhenyuan Miao, 2009, Bioorganic & medicinal chemistry letters.

Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi.

Min Zhang, Youjun Zhou, Jiaguo Lü, 2003, Journal of medicinal chemistry.

Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping.

Shengzheng Wang, Yongbing Cao, Zhenyuan Miao, 2011, European journal of medicinal chemistry.

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3'-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors.

Shengzheng Wang, Shanchao Wu, Guoqiang Dong, 2016, Organic letters.

Scaffold hopping of sampangine: discovery of potent antifungal lead compound against Aspergillus fumigatus and Cryptococcus neoformans.

Wei Chen, Guoqiang Dong, Zhenyuan Miao, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacological Evaluation of Novel Homocamptothecin-Dihydropyridine Derivative Conjugates as Potent Topoisomerase I Inhibitors

W. Guo, Wenfeng Liu, Zhenyuan Miao, 2011 .

Asymmetric synthesis of chiral dihydrothiopyrans via an organocatalytic enantioselective formal thio [3 + 3] cycloaddition reaction with binucleophilic bisketone thioethers.

Shiping Zhu, J. Li, Hao Li, 2013, Organic letters.

Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.

Jian Li, Guoqiang Dong, Zhenyuan Miao, 2017, Journal of medicinal chemistry.

Strategies in the discovery of novel antifungal scaffolds.

Wannian Zhang, C. Sheng, Na Liu, 2016, Future medicinal chemistry.

Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51).

Yuan-Ying Jiang, Wannian Zhang, Qingyan Sun, 2007, European journal of medicinal chemistry.

Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors

Guoqiang Dong, Zhenyuan Miao, Jianzhong Yao, 2014, International journal of molecular sciences.

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains.

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2014, European journal of medicinal chemistry.

Synthesis of novel benzoxanthone analogues as non-Camptothecin topoisomerase I inhibitors

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2012, Journal of enzyme inhibition and medicinal chemistry.

Three-Dimensional Model of Lanosterol 14α-Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

Haitao Ji, Wei Guo, Guoqiang Dong, 2009, Antimicrobial Agents and Chemotherapy.

Asymmetric Synthesis, Antifungal Activity and Molecular Modeling of Iodiconazole Isomers

Shengzheng Wang, Yongqiang Zhang, Zhenyuan Miao, 2013 .

Improved Model of Lanosterol 14α‐Demethylase by Ligand‐Supported Homology Modeling: Validation by Virtual Screening and Azole Optimization

Shengzheng Wang, Haitao Ji, Guoqiang Dong, 2010, ChemMedChem.

Chapter 1 – Topoisomerase I Inhibitors Derived from Natural Products: Structure–Activity Relationships and Antitumor Potency

Zhenyuan Miao, Wannian Zhang, C. Sheng, 2016 .

New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors.

Zhenyuan Miao, Wannian Zhang, C. Sheng, 2011, Current medicinal chemistry.

Novel conformationally restricted triazole derivatives with potent antifungal activity.

Shengzheng Wang, Yongbing Cao, Guoqiang Dong, 2010, European journal of medicinal chemistry.

An liquid chromatography-tandem mass spectrometry assay for determination of trace amount of new antifungal drug iodiconazole in human plasma.

Wannian Zhang, C. Sheng, Shouhong Gao, 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement.

Shengzheng Wang, G. Fan, Guoqiang Dong, 2013, European journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains.

Shengzheng Wang, G. Jin, Yongqiang Zhang, 2012, European journal of medicinal chemistry.

An ultra-fast LC method for the determination of iodiconazole in microdialysis samples and its application in the calibration of laboratory-made linear probes.

G. Fan, Z. Hong, Yutian Wu, 2010, Journal of pharmaceutical and biomedical analysis.

Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I.

Wei Guo, Wenfeng Liu, Zhenyuan Miao, 2010, European journal of medicinal chemistry.

New triazole derivatives containing substituted 1,2,3-triazole side chains: Design, synthesis and antifungal activity

Wannian Zhang, C. Sheng, Na Liu, 2017 .

Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update

Wannian Zhang, Chunquan Sheng, Wannian Zhang, 2013, Medicinal research reviews.

Discovery of highly potent antifungal triazoles by structure-based lead fusion

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2011 .

Homology Modeling of Lanosterol 14α-Demethylase of Candida albicans and Aspergillus fumigatus and Insights into the Enzyme-Substrate Interactions

Haitao Ji, Yunlong Song, Jianzhong Yao, 2004, Journal of biomolecular structure & dynamics.

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism.

Shengzheng Wang, Yongbing Cao, Zhenyuan Miao, 2011, European journal of medicinal chemistry.

Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents.

Yuan-Ying Jiang, Wannian Zhang, Qingyan Sun, 2007, European journal of medicinal chemistry.

The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine.

Haiying He, Yuan-Ying Jiang, Guoqiang Dong, 2015, Chemical communications.

β‐Alanine‐DBU: A Highly Efficient Catalytic System for Knoevenagel‐Doebner Reaction under Mild Conditions

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2012 .

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

Y. Sham, Guoqiang Dong, Zhenyuan Miao, 2014, Oncotarget.

Chemical Composition and Antidiabetic Activity of Opuntia Milpa Alta Extracts

C. Zheng, Zhenyuan Miao, Jianzhong Yao, 2010, Chemistry & biodiversity.

Chlorin p6-Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy.

Buhong Li, Guoqiang Dong, Zou Tan, 2016, Journal of medicinal chemistry.

Drug repurposing of anti-infective clinical drugs: Discovery of two potential anti-cytokine storm agents

Wannian Zhang, Zhi-bin Wang, Chen-xi Zhang, 2020, Biomedicine & Pharmacotherapy.

Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2021, European journal of medicinal chemistry.

Peramivir, an Anti-Influenza Virus Drug, Exhibits Potential Anti-Cytokine Storm Effects

Xiao-chen Sun, Wannian Zhang, Zhi-bin Wang, 2020, bioRxiv.

Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2014, Journal of medicinal chemistry.

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease.

Wannian Zhang, Hao Shang, Ling He, 2020, Bioorganic chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Synthesis and Biological Assays of 9‐(Acylamino)homocamptothecins as DNA Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2013, Chemistry & biodiversity.

Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Synthesis of 9‐(Heteroarylmethylidene)amino Derivatives of Homocamptothecin with Biological Activities

Wei Guo, Wenfeng Liu, Yongqiang Zhang, 2011, Chemistry & biodiversity.

Synthesis and Biological Evaluation of 7‐Alkenyl Homocamptothecins as Potent Topoisomerase I Inhibitors

Wei Guo, Wenfeng Liu, Guoqiang Dong, 2012, Chemistry & biodiversity.

Topoisomerase I‐Mediated Antiproliferative Activity of 10‐Substituted and 12‐Substituted Homocamptothecins

W. Guo, Wenfeng Liu, Yongqiang Zhang, 2011 .

Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors.

Shengzheng Wang, Wei Guo, Wenfeng Liu, 2011, European journal of medicinal chemistry.

Phosphate ester derivatives of homocamptothecin: synthesis, solution stabilities and antitumor activities.

Juan Wang, Wei Guo, Wenfeng Liu, 2010, Bioorganic & medicinal chemistry.

Transcription Factor NRF2 as a Promising Therapeutic Target for Alzheimer's Disease.

Jiachen Sun, Wannian Zhang, Jianqiang Yu, 2020, Free radical biology & medicine.

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

Wei Chen, Guoqiang Dong, Wannian Zhang, 2017, Journal of medicinal chemistry.

Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, Journal of medicinal chemistry.

Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, 2012, Journal of medicinal chemistry.

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.

Guoqiang Dong, Wei Wang, Wannian Zhang, 2015, Chemical Society reviews.

Novel spiropyrazolone antitumor scaffold with potent activity: Design, synthesis and structure-activity relationship.

Y. Li, Yongqiang Zhang, Shanchao Wu, 2016, European journal of medicinal chemistry.

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Nan Li, Xuetao Cao, J. Hou, 2022, Hepatology.

Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors.

Shengzheng Wang, Jian Li, Shanchao Wu, 2016, Chemical communications.

Discovery of 7‐Methyl‐10‐Hydroxyhomocamptothecins with 1,2,3‐Triazole Moiety as Potent Topoisomerase I Inhibitors

Wenfeng Liu, Guoqiang Dong, Zhenyuan Miao, 2016, Chemical biology & drug design.

Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.

Shiping Zhu, Shengzheng Wang, Shanchao Wu, 2014, Bioorganic & medicinal chemistry letters.

3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors.

M. Zhang, Yunlong Song, Zhenyuan Miao, 2007, European journal of medicinal chemistry.

Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes.

Jianqiang Yu, Wannian Zhang, Jianhong Yang, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Synthesis and biological evaluation of thio-benzodiazepines as novel small molecule inhibitors of the p53-MDM2 protein-protein interaction.

Guoqiang Dong, Shengzheng Wang, Yang Liu, 2011, European journal of medicinal chemistry.

Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design

Wei Guo, Wenya Wang, Guoqiang Dong, 2009, J. Comput. Aided Mol. Des..

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.

Y. Sham, D. Odde, John K. Lee, 2018, Molecular pharmaceutics.

Targeting Receptor-Interacting Protein Kinase 1 by Novel Benzothiazole Derivatives: Treatment of Acute Lung Injury through the Necroptosis Pathway.

Wannian Zhang, Lijuan Xu, L. Xue, 2023, Journal of medicinal chemistry.

Radiosensitization of human pancreatic cancer by piperlongumine analogues

Zhenyuan Miao, Wannian Zhang, Huojun Zhang, 2020 .

Isoliquiritigenin Nanosuspension Enhances Cytostatic Effects in A549 Lung Cancer Cells

Jianhong Yang, Wannian Zhang, Luning Dong, 2020, Planta Medica.

Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery.

Guoqiang Dong, Wannian Zhang, C. Sheng, 2018, ACS medicinal chemistry letters.

Receptor-interacting protein kinase 1 (RIPK1) inhibitor: a review of the patent literature (2018-present)

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2023, Expert opinion on therapeutic patents.

Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.

Wannian Zhang, Zhi-bin Wang, Hao Ma, 2020, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel 31-hexyloxy chlorin e6-based 152- or 131-amino acid derivatives as potent photosensitizers for photodynamic therapy.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2020, European journal of medicinal chemistry.

Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

Weihong Zhou, Guoqiang Dong, Zhenyuan Miao, 2017 .

Optical evodiamine derivatives: Asymmetric synthesis and antitumor activity

Shengzheng Wang, Guoqiang Dong, Zhenyuan Miao, 2015 .

Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Shanchao Wu, Guoqiang Dong, Wannian Zhang, 2018, Acta pharmaceutica Sinica. B.

Fragment‐growing guided design of Keap1‐Nrf2 protein‐protein interaction inhibitors for targeting myocarditis

H. Zhang, N. Meng, Hua Tang, 2018, Free radical biology & medicine.

New lead structures in antifungal drug discovery.

Wannian Zhang, C. Sheng, W. Zhang, 2011, Current medicinal chemistry.

Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design

Shuanghong Chen, Haitao Ji, Wei Guo, 2010, Journal of molecular modeling.

Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review.

Zhenyuan Miao, Wannian Zhang, C. Sheng, 2014, Current medicinal chemistry.

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.

Y. Sham, Wannian Zhang, Chunlin Zhuang, 2014, Journal of medicinal chemistry.

A new strategy to improve the metabolic stability of lactone: discovery of (20S,21S)-21-fluorocamptothecins as novel, hydrolytically stable topoisomerase I inhibitors.

Shiping Zhu, Shengzheng Wang, Jian Li, 2013, Journal of medicinal chemistry.

Enantiomeric profiling of a chiral benzothiazole necroptosis inhibitor.

Wannian Zhang, Lijuan Xu, Hao Zhang, 2021, Bioorganic & Medicinal Chemistry Letters.

New azoles with potent antifungal activity: design, synthesis and molecular docking.

Haitao Ji, Yongbing Cao, Guoqiang Dong, 2009, European journal of medicinal chemistry.

Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors.

Shengzheng Wang, Yongqiang Zhang, Guoqiang Dong, 2012, European journal of medicinal chemistry.

Novel carboline derivatives as potent antifungal lead compounds: design, synthesis, and biological evaluation.

Shengzheng Wang, Jian Li, Yongqiang Zhang, 2014, ACS Medicinal Chemistry Letters.

A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals.

Wannian Zhang, Y. Zhou, Jie Zhu, 2000, Journal of medicinal chemistry.

Discovery of new Syk inhibitors through structure-based virtual screening.

Jian Li, Bo-hua Li, Guoqiang Dong, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and antitumor activity of novel 10-amino acids ester homocamptothecin analogues

W. Guo, Zhenyuan Miao, Wannian Zhang, 2008 .

Antitumor Activities and Structure–Activity Relationship of Phosphotriester Derivatives of Homocamptothecin Based on a Semisynthetic Route

Juan Wang, Shengzheng Wang, Yongqiang Zhang, 2011 .

Synthesis and evaluation of 9-benzylideneamino derivatives of homocamptothecin as potent inhibitors of DNA topoisomerase I.

Wei Guo, Wenfeng Liu, Zhenyuan Miao, 2010, European journal of medicinal chemistry.

Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione

Zhenyuan Miao, Wannian Zhang, Fangfang Lu, 2024, Molecules.

The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor.

Shiping Zhu, Xiaonan Zhang, Guoqiang Dong, 2016, Chemical communications.

A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

Y. Sham, Guoqiang Dong, Zhenyuan Miao, 2014, Oncotarget.