D. Ferraris

发表

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.

M. Botta, M. Mori, M. Rizzi, 2014, Bioorganic & medicinal chemistry letters.

Crystal Structure of Mycobacterium tuberculosis Zinc-dependent Metalloprotease-1 (Zmp1), a Metalloprotease Involved in Pathogenicity*

M. Coletta, S. Marini, M. Rizzi, 2011, The Journal of Biological Chemistry.

The Synthesis of Kynurenic Acid in Mammals: An Updated Kynurenine Aminotransferase Structural KATalogue

R. Miggiano, F. Rossi, M. Rizzi, 2019, Front. Mol. Biosci..

Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

T. Blundell, V. Mizrahi, J. Pató, 2019, European journal of medicinal chemistry.

Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH.

T. Blundell, V. Mizrahi, J. Pató, 2019 .

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

M. Rizzi, D. Ferraris, P. Kharkar, 2018, Bioorganic & medicinal chemistry letters.

Crystal structure of trans-3-Hydroxy-L-proline dehydratase in complex with substrate - closed conformation

R. Miggiano, M. Rizzi, Seiya Watanabe, 2019 .

Absolute structure and structure-function relationships of 4R,2′R and 4S,2′S Pidotimod®

R. Miggiano, M. Rizzi, M. Milanesio, 2017 .

Curcumin-based-fluorescent probes targeting ALDH1A3 as a promising tool for glioblastoma precision surgery and early diagnosis

E. Aronica, A. Minassi, M. Rizzi, 2021, Communications Biology.

The integration of AlphaFold-predicted and crystal structures of human trans-3-hydroxy-l-proline dehydratase reveals a regulatory catalytic mechanism

R. Miggiano, M. Rizzi, D. Ferraris, 2022, Computational and structural biotechnology journal.

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety

P. Circosta, B. Rolando, S. Al-Karadaghi, 2022, Journal of medicinal chemistry.

Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment

R. Miggiano, M. Rizzi, D. Ferraris, 2020, Pathogens.

Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents.

A. Joachimiak, L. Hedstrom, V. Mizrahi, 2018, Journal of medicinal chemistry.

Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer.

R. Miggiano, M. Rizzi, S. Garavaglia, 2020, Biochemical Society transactions.

A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro

E. Aronica, C. La Motta, M. Mori, 2021, Cancers.

Imidazo[1,2-a]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells.

C. La Motta, I. Nakano, M. Mori, 2020, Journal of medicinal chemistry.

Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets

R. Miggiano, F. Rossi, M. Rizzi, 2018, Pathogens.

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells

Mike Heilemann, M. Heilemann, H. Niemann, 2013, BMC biophysics.

1 1 STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASE MET IN COMPLEX WITH THE LISTERIA MONOCYTOGENES INVASION PROTEIN INLB

E. Gherardi, P. Butler, D. Heinz, 2009 .

Structure of the Human Receptor Tyrosine Kinase Met in Complex with the Listeria Invasion Protein InlB

E. Gherardi, P. Butler, D. Heinz, 2007, Cell.

Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.

G. Perugino, R. Miggiano, F. Rossi, 2018, Biochemical and biophysical research communications.

Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-a]pyridines against the 1A Family.

C. La Motta, M. Rizzi, Luca Quattrini, 2020, ACS medicinal chemistry letters.

Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis

R. Miggiano, M. Rizzi, A. Massarotti, 2017, Scientific Reports.

Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity

M. Rizzi, L. Chaloin, A. Wilk, 2020, Scientific Reports.

Design, synthesis, SAR and biological investigation of 3-(carboxymethyl)rhodanine and aminothiazole inhibitors of Mycobacterium tuberculosis Zmp1.

M. Botta, M. Mori, M. Rizzi, 2018, Bioorganic & medicinal chemistry letters.

Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis

R. Miggiano, M. Rizzi, A. Massarotti, 2017, Scientific Reports.

Engineering, Characterization, and Biological Evaluation of an Antibody Targeting the HGF Receptor

P. Comoglio, R. Miggiano, A. Bertolotto, 2021, Frontiers in Immunology.

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

M. Coletta, S. Marini, Simone Brogi, 2018, ChemMedChem.

Zinc‐Dependent Metalloprotease‐1 (Zmp1)

M. Rizzi, D. Ferraris, 2013 .

Functional characterization of the Mycobacterium tuberculosis zinc metallopeptidase Zmp1 and identification of potential substrates

M. Coletta, Magda Gioia, S. Marini, 2012, Biological chemistry.

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

E. Gherardi, D. Heinz, H. Niemann, 2010, Journal of molecular biology.

Structure of Thermococcus litoralis Δ1-pyrroline-2-carboxylate reductase in complex with NADH and L-proline.

R. Miggiano, M. Rizzi, D. Ferraris, 2020, Acta crystallographica. Section D, Structural biology.

Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor

R. Miggiano, M. Rizzi, D. Boschi, 2023, FEBS Letters.

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

M. Coletta, S. Marini, Simone Brogi, 2018, ChemMedChem.

Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

E. Gherardi, D. Heinz, H. Niemann, 2010, Journal of molecular biology.

Structure of Thermococcus litoralis trans-3-hydroxy-l-proline dehydratase in the free and substrate-complexed form.

R. Miggiano, M. Rizzi, Seiya Watanabe, 2019, Biochemical and biophysical research communications.

Crystal structure of the Mycobacterium tuberculosis phosphate binding protein PstS3

Mahavir Singh, M. Rizzi, D. Ferraris, 2014, Proteins.

Synthesis and StructureeActivity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

T. Blundell, V. Mizrahi, J. Pató, 2022 .

Hit discovery of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase, GuaB2, inhibitors.

M. Rizzi, D. Ferraris, P. Kharkar, 2018, Bioorganic & medicinal chemistry letters.

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.

Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in situ

M. Heilemann, D. Ferraris, Roberto Covino, 2024, bioRxiv.