C. Distelhorst

发表

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.

B. Jha, Yan Xu, D. Lindner, 2016, Cancer research.

Creating a New Cancer Therapeutic Agent by Targeting the Interaction between Bcl-2 and IP3 Receptors.

M. Bootman, C. Distelhorst, 2019, Cold Spring Harbor perspectives in biology.

Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.

C. Distelhorst, 2018, Biochimica et biophysica acta. Molecular cell research.

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.

E. Greenberg, C. Distelhorst, A. Lavik, 2014, Biochimica et biophysica acta.

Apoptosis and autophagy: decoding calcium signals that mediate life or death.

C. Distelhorst, Clark W Distelhorst, M. Harr, 2010, Cold Spring Harbor perspectives in biology.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

M. de Maeyer, L. Missiaen, J. Parys, 2011, Cell Death and Differentiation.

Autosomal Dominant familial erythrocytosis due to autonomous erythropoietin production.

J. Adamson, E. Goldwasser, C. Distelhorst, 1981, Blood.

Autosomal Dominant familial erythrocytosis due to autonomous erythropoietin production

J. Adamson, E. Goldwasser, C. Distelhorst, 1981 .

Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation

F. Zhong, C. Distelhorst, Michael C. Davis, 2006, The Journal of cell biology.

Comparison of the 90-kilodalton heat shock protein interaction with in vitro translated glucocorticoid and estrogen receptors.

M. Parker, C. Distelhorst, K. J. Howard, 1992, Molecular endocrinology.

The Endoplasmic Reticulum Pathway

C. Distelhorst, M. Harr, Michael W. Harr, 2009 .

Involvement of c-Fos in signaling grp78 induction following ER calcium release

Huiling He, C. Distelhorst, K. McColl, 2000, Oncogene.

Basic and Clinical Studies of Glucocorticosteroid Receptors in Lymphoid Malignancies

C. Distelhorst, 1996 .

Maintenance of Calcium Homeostasis in the Endoplasmic Reticulum by Bcl-2

Huiling He, T. McCormick, C. Distelhorst, 1997, The Journal of cell biology.

Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

M. Berridge, J. Parys, F. Zhong, 2014, Proceedings of the National Academy of Sciences.

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction.

J. Parys, H. de Smedt, G. Bultynck, 2011, Blood.

Bcl-2-regulated calcium signals as common mediators of both apoptosis and autophagy.

C. Distelhorst, Sarah J Swerdlow, Sarah J. Swerdlow, 2007, Developmental cell.

Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells.

G. Dubyak, C. Distelhorst, M. Lam, 1993, Molecular endocrinology.

c-Fos Degradation by the Proteasome

Huiling He, C. Distelhorst, J. Grossmann, 1998, The Journal of Biological Chemistry.

Role of Calcium in Glucocorticosteroid-Induced Apoptosis of Thymocytes and Lymphoma Cells: Resurrection of Old Theories by New Findings

G. Dubyak, C. Distelhorst, 1998 .

Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: resurrection of old theories by new findings.

C. Distelhorst, G. Dubyak, 1998, Blood.

Apoptosis induction by the glucocorticoid hormone dexamethasone and the calcium-ATPase inhibitor thapsigargin involves Bc1-2 regulated caspase activation

Huiling He, C. Whitacre, N. Berger, 1998, Molecular and Cellular Endocrinology.

Bcl-2 acts subsequent to and independent of Ca2+ fluxes to inhibit apoptosis in thapsigargin- and glucocorticoid-treated mouse lymphoma cells.

T. McCormick, C. Distelhorst, Thomas S. McCormick, 1996, Cell calcium.

Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis

C. Distelhorst, M. Malone, Z. Wang, 2008, Oncogene.

Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis

C. Distelhorst, Zhengqi Wang, M. Malone, 2006, Oncogene.

A single common electrophoretic abnormality of glucocorticoid receptors in human leukemia cells.

R. Griffith, C. Distelhorst, B. M. Benutto, 1985, Blood.

Metabolic emergencies in clinical oncology.

P. Silverman, C. Distelhorst, Paula Silverman, 1989, Seminars in oncology.

Characterization of glucocorticoid receptors and glucocorticoid receptor mRNA in human leukemia cells: stabilization of the receptor by diisopropylfluorophosphate.

R. Miesfeld, C. Distelhorst, 1987, Blood.

Bcl-2 inhibits hydrogen peroxide-induced ER Ca2+ pool depletion.

T. McCormick, C. Distelhorst, M. Lam, 1996, Oncogene.

Role of nicotinamide adenine dinucleotide and adenosine triphosphate in glucocorticoid-induced cytotoxicity in susceptible lymphoid cells.

N. Berger, C. Distelhorst, S. J. Berger, 1987, The Journal of clinical investigation.

Bcl-2 on the Endoplasmic Reticulum Regulates Bax Activity by Binding to BH3-only Proteins*

C. Distelhorst, Zhengqi Wang, M. Thomenius, 2003, The Journal of Biological Chemistry.

Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor fragments in the cytosol of human leukemia cells

C. Distelhorst, K. Janiga, S. Strandjord, 1987 .

Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor fragments in the cytosol of human leukemia cells.

C. Distelhorst, K. Janiga, S. Strandjord, 1987, Blood.

Regulation of Bcl-xl Channel Activity by Calcium*

G. Núñez, C. Distelhorst, J. Ma, 1998, The Journal of Biological Chemistry.

Gene expression analysis of glucocorticoid-induced apoptosis by a gene microarray technique

Huiling He, C. Distelhorst, M. Malone, 2001, Nature Genetics.

Evidence from pulse-chase labeling studies that the antiglucocorticoid hormone RU486 stabilizes the nonactivated form of the glucocorticoid receptor in mouse lymphoma cells.

C. Distelhorst, K. J. Howard, 1990, Journal of steroid biochemistry.

Immunochemical comparison of mutant glucocorticoid receptors and wild type receptor fragments produced by neutrophil elastase and chymotrypsin.

C. Distelhorst, E. Rehmus, K. Janiga, 1987, Journal of steroid biochemistry.

Glucocorticoids downregulate Fyn and inhibit IP3-mediated calcium signaling to promote autophagy in T lymphocytes

F. Zhong, C. Distelhorst, M. Harr, 2010, Autophagy.

Glucocorticoid-mediated Inhibition of Lck Modulates the Pattern of T Cell Receptor-induced Calcium Signals by Down-regulating Inositol 1,4,5-Trisphosphate Receptors

M. Bootman, H. Roderick, C. Distelhorst, 2009, The Journal of Biological Chemistry.

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content.

M. Bootman, R. Wojcikiewicz, H. Roderick, 2008, Cell calcium.

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate

M. Berridge, M. Bootman, H. Roderick, 2004, The Journal of cell biology.

Centrifugal elutriation of human lymphoid cells: synchronization and separation of aneuploid cells into diploid and tetraploid populations.

C. Distelhorst, B. M. Benutto, R. Bergamini, 1983, Cellular immunology.

Glucocorticosteroids induce DNA fragmentation in human lymphoid leukemia cells.

C. Distelhorst, 1988, Blood.

Effect of the 90 kDa heat shock protein, HSP90, on glucocorticoid receptor binding to DNA-cellulose.

C. Distelhorst, K. J. Howard, 1988, Biochemical and biophysical research communications.

Glucocorticoid-induced apoptosis.

C. Distelhorst, 1997, Advances in pharmacology.

Preferential synthesis of the 78-Kd glucose-regulated protein in glucocorticoid-treated S49 mouse lymphoma cells.

L. Vimmerstedt, J. Hensold, C. Distelhorst, 1992, Blood.

Steroid Hormones and Hormone Receptors in Neoplastic Diseases

C. Distelhorst, 1991 .

Effect of cell cycle position on dexamethasone binding by mouse and human lymphoid cell lines: correlation between an increase in dexamethasone binding during S phase and dexamethasone sensitivity.

C. Distelhorst, B. M. Benutto, R. Bergamini, 1984, Blood.

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis.

C. Distelhorst, Y. Rong, 2008, Annual review of physiology.

Bcl-2 and calcium: controversy beneath the surface

G. Shore, C. Distelhorst, Gordon C Shore, 2004, Oncogene.

Microarray Analysis Uncovers the Induction of the Proapoptotic BH3-only Protein Bim in Multiple Models of Glucocorticoid-induced Apoptosis*

Huiling He, C. Distelhorst, Zhengqi Wang, 2003, Journal of Biological Chemistry.

Apoptosis--the Calcium Connection

N. Demaurex, C. Distelhorst, Nicolas Demaurex, 2003, Science.

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2

K. Mikoshiba, L. Missiaen, J. Parys, 2013, Cell Death and Disease.

Live Free or Die: An Immature T Cell Decision Encoded in Distinct Bcl-2 Sensitive and Insensitive Ca2+ Signals

C. Distelhorst, Michael C. Davis, 2006, Cell cycle.

An Immature T cell Decision Encoded in Distinct Bcl-2 Sensitive and Insensitive Ca 2+ Signals

C. Distelhorst, Michael C. Davis, 2006 .

Unreliability of the Cytochromec-Enhanced Green Fluorescent Fusion Protein as a Marker of Cytochrome c Release in Cells That Overexpress Bcl-2*

C. Distelhorst, K. Heiskanen, M. Unkila, 2001, The Journal of Biological Chemistry.

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

G. Dubyak, G. Núñez, R. Miesfeld, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mapping the HSP90 binding region of the glucocorticoid receptor.

K. Yamamoto, C. Distelhorst, K. J. Howard, 1990, The Journal of biological chemistry.

Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance

C. Distelhorst, Michael J Thomenius, Clark W Distelhorst, 2003, Journal of Cell Science.

Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes*

S. Matsuyama, C. Distelhorst, T. Finkel, 2011, The Journal of Biological Chemistry.

fragments in the cytosol of human leukemia cells Neutrophil elastase produces 52-kD and 30-kD glucocorticoid receptor

C. Distelhorst, K. Janiga, E. Campbell, 2011 .

Characterization of glucocorticoid receptors in S49 mouse lymphoma cells by affinity labeling with [3H]dexamethasone 21-mesylate.

L. Kullman, J. Wasson, C. Distelhorst, 1987, Journal of steroid biochemistry.

Lyn Facilitates Glioblastoma Cell Survival under Conditions of Nutrient Deprivation by Promoting Autophagy

Amy S. Nowacki, Niladri Kar, Ping Huang, 2013, PloS one.

Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosis.

C. Distelhorst, J. Molitoris, K. McColl, 2011, Molecular endocrinology.

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.

Xiang Li, M. Bootman, H. Roderick, 2008, Molecular cell.

Recent insights into the mechanism of glucocorticosteroid-induced apoptosis

C. Distelhorst, 2002, Cell Death and Differentiation.

Expression of a defective mouse mammary tumor virus envelope glycoprotein precursor which binds stably to GRP78 within the lumen of the endoplasmic reticulum is associated with decreased glucocorticoid-induced apoptosis in mouse lymphoma cells

M. Stallcup, C. Distelhorst, M. Lam, 1997, Cell Death and Differentiation.

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.

M. Bootman, C. Distelhorst, 2011, Cell calcium.

Transient Expression of Wild-type or Mitochondrially Targeted Bcl-2 Induces Apoptosis, whereas Transient Expression of Endoplasmic Reticulum-targeted Bcl-2 Is Protective against Bax-induced Cell Death*

C. Distelhorst, M. Unkila, Edmunds Z. Reineks, 2001, The Journal of Biological Chemistry.

Selective regulation of IP3 receptors by the BH4 domain of Bcl-2 versus Bcl-Xl

L. Missiaen, J. Parys, E. Decrock, 2020 .

Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.

V. Yee, C. Distelhorst, P. Barr, 2009, Biochimica et biophysica acta.

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect.

M. Bootman, H. Roderick, C. Distelhorst, 2008, Cell calcium.

Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

Anu Gupta, C. Distelhorst, M. Lam, 2008, Autophagy.

Acidosis blocks CCAAT/enhancer-binding protein homologous protein (CHOP)- and c-Jun-mediated induction of p53-upregulated mediator of apoptosis (PUMA) during amino acid starvation.

C. Distelhorst, K. McColl, Christopher B. Ryder, 2013, Biochemical and biophysical research communications.

Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia

F. Zhong, C. Distelhorst, P. Caimi, 2010, Cell Death and Differentiation.

Hormone Effects on Tumors

N. Berger, R. Keri, N. Sharifi, 2020 .

Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment

A. Sattar, A. Almasan, B. Hill, 2014, Journal of leukemia.

Effect of mitogen concentration on glucocorticoid suppression of normal and cystic fibrosis lymphocyte activation.

C. Distelhorst, B. M. Benutto, J. Corry, 1983, Cellular immunology.

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

M. Bootman, H. Roderick, J. Parys, 2009, Proceedings of the National Academy of Sciences.

A Novel Peptide that Disrupts the Lck-IP3R Protein-Protein Interaction Induces Widespread Cell Death in Leukemia and Lymphoma

V. Yee, C. Distelhorst, A. Lavik, 2023, Research square.

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263

G. Wildey, A. Dowlati, E. Greenberg, 2015, Cell Death and Disease.

Mouse Lymphoma Cells Destined to Undergo Apoptosis in Response to Thapsigargin Treatment Fail to Generate a Calcium-mediated grp78/grp94 Stress Response*

T. McCormick, C. Distelhorst, K. McColl, 1997, The Journal of Biological Chemistry.

Chemotherapy-induced emergencies.

C. Distelhorst, S. Schneider, 1989, Seminars in oncology.

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

J. Pink, S. Matsuyama, E. Greenberg, 2015, Oncotarget.

The Glucocorticoid-induced Gene tdag8 Encodes a Pro-apoptotic G Protein-coupled Receptor Whose Activation Promotes Glucocorticoid-induced Apoptosis*

C. Distelhorst, Zhengqi Wang, M. Malone, 2004, Journal of Biological Chemistry.

Dexamethasone-induced Inositol 1,4,5-Trisphosphate Receptor Elevation in Murine Lymphoma Cells Is Not Required for Dexamethasone-mediated Calcium Elevation and Apoptosis*

F. Zhong, C. Distelhorst, Zhengqi Wang, 2008, Journal of Biological Chemistry.

Dexamethasone-induced Gene 2 (dig2) Is a Novel Pro-survival Stress Gene Induced Rapidly by Diverse Apoptotic Signals*

F. Zhong, C. Distelhorst, Zhengqi Wang, 2003, Journal of Biological Chemistry.

A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors.

K. Mikoshiba, M. Bootman, F. Crea, 2022, Biochimica et biophysica acta. Molecular cell research.

Glucocorticoids inhibit trypsin-induced DNA release from phytohemagglutinin-stimulated blood lymphocytes.

J. Rogers, C. Distelhorst, 1979, Journal of Immunology.

Selective release of excreted DNA sequences from phytohemagglutinin-stimulated human peripheral blood lymphocytes. Effects of trypsin and divalent cations.

J. Rogers, C. Distelhorst, K. Cramer, 1978, The Journal of clinical investigation.

Bcl-2 interacts with inositol 1, 4, 5-trisphosphate receptors and inhibits inositol 1, 4, 5-trisphosphate mediated calcium release from the endoplasmic reticulum

M. Berridge, M. Bootman, H. Roderick, 2004 .

Steroid Hormones and Hormone Receptors

T. McCormick, C. Distelhorst, 2002 .

Kinetic pulse-chase labeling study of the glucocorticoid receptor in mouse lymphoma cells. Effect of glucocorticoid and antiglucocorticoid hormones on intracellular receptor half-life.

C. Distelhorst, K. J. Howard, 1989, The Journal of biological chemistry.

Glucocorticoid receptor content of T lymphocytes: evidence for heterogeneity.

C. Distelhorst, B. M. Benutto, 1981, Journal of immunology.

Relationship between defective mouse mammary tumor virus envelope glycoprotein synthesis and GRP78 synthesis in glucocorticoid-treated mouse lymphoma cells. Evidence for translational control of GRP78 synthesis.

M. Stallcup, C. Distelhorst, M. Lam, 1993, The Journal of biological chemistry.

Bcl-2 inhibits c-fos induction by calcium

M. Simonson, C. Distelhorst, Xiaoping Qi, 1997, Oncogene.

Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis

F. Zhong, C. Distelhorst, K. McColl, 2012, The Journal of Biological Chemistry.

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1.

D. Templeton, L. Parrott, J. Cross, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Glucocorticoid-induced DNA fragmentation in acute lymphoblastic leukemia cells.

N. Berger, C. Distelhorst, 1988, Transactions of the Association of American Physicians.

Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells

Huiling He, C. Distelhorst, Xiaoping Qi, 1997, Oncogene.

Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.

C. Distelhorst, K. J. Howard, 1988, The Journal of biological chemistry.

Recent insight into the structure and function of the glucocorticoid receptor.

C. Distelhorst, 1989, Journal of Laboratory and Clinical Medicine.

Evidence thatBCL-2represses apoptosis byregulating endoplasmic reticulum-associated

C. Distelhorst, 1994 .

Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2?

H. Roderick, C. Distelhorst, 2003, Biochemical Society transactions.