P. Petersen

发表

3,5-Dioxopyrazolidines, Novel Inhibitors of UDP-N- Acetylenolpyruvylglucosamine Reductase (MurB) with Activity against Gram-Positive Bacteria

R. Chopra, K. Svenson, G. Krishnamurthy, 2006, Antimicrobial Agents and Chemotherapy.

Pulvinones as bacterial cell wall biosynthesis inhibitors.

C. Caufield, Youjun Yang, Guy Singh, 2006, Bioorganic & medicinal chemistry letters.

Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors.

R. Williamson, M. Siegel, G. Carter, 2002, Journal of the American Chemical Society.

Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.

T. Mansour, Guy Singh, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.

A. Agarwal, T. Mansour, Youjun Yang, 2008, Bioorganic & medicinal chemistry.

Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489

T. Mansour, P. Bradford, S. Projan, 2008, Antimicrobial Agents and Chemotherapy.

Effect of Medium Age and Supplementation with the Biocatalytic Oxygen-Reducing Reagent Oxyrase on In Vitro Activities of Tigecycline against Recent Clinical Isolates

P. Bradford, P. Petersen, 2005, Antimicrobial Agents and Chemotherapy.

Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98.

R. Williamson, S. Sakya, E. Graziani, 2002, Journal of the American Chemical Society.

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

Nancy Torres, T. Mansour, E. Graziani, 2003, Bioorganic & medicinal chemistry letters.

Mannopeptimycins, New Cyclic Glycopeptide Antibiotics Produced by Streptomyces hygroscopicus LL-AC98: Antibacterial and Mechanistic Activities

P. Bradford, P. Petersen, E. Lenoy, 2003, Antimicrobial Agents and Chemotherapy.

Novel ether derivatives of mannopeptimycin glycopeptide antibiotic.

Nancy Torres, T. Mansour, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

S. Lang, Nancy Torres, T. Mansour, 2004, Journal of medicinal chemistry.

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.

F. Koehn, G. Carter, P. Petersen, 2004, Bioorganic & medicinal chemistry letters.

Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin α, and Other Antimicrobial Agents against Gram-Positive Clinical Isolates

P. Bradford, P. Petersen, R. Dushin, 2004, Antimicrobial Agents and Chemotherapy.

Comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam

N. Jacobus, P. Petersen, W. Weiss, 1989, Antimicrobial Agents and Chemotherapy.

Identification and Analysis of Bacterial Protein Secretion Inhibitors Utilizing a SecA-LacZ Reporter Fusion System

L. Barbieri, B. Feld, W. Hu, 2000, Antimicrobial Agents and Chemotherapy.

Characterization of expanded-spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease.

I. Fingerman, P. Bradford, P. Petersen, 1999, The Journal of antimicrobial chemotherapy.

Saccharomicins, Novel Heptadecaglycoside Antibiotics Produced by Saccharothrix espanaensis: Antibacterial and Mechanistic Activities

P. Petersen, W. Weiss, M. P. Singh, 2000, Antimicrobial Agents and Chemotherapy.

In Vitro Activity of Tigecycline against Staphylococcus epidermidis Growing in an Adherent-Cell Biofilm Model

P. Bradford, P. Petersen, Pornpen Labthavikul, 2003, Antimicrobial Agents and Chemotherapy.

Uses of Staphylococcus aureus GeneChips in Genotyping and Genetic Composition Analysis

E. Marsilio, F. Tenover, L. Mcdougal, 2004, Journal of Clinical Microbiology.

In vitro activity of tigecycline and occurrence of tetracycline resistance determinants in isolates from patients enrolled in phase 3 clinical trials for community-acquired pneumonia.

P. Bradford, P. Petersen, C. H. Jones, 2008, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

Tigecycline: a case study

S. Projan, E. Loh, P. Petersen, 2007, Expert opinion on drug discovery.

In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections.

P. Bradford, P. Petersen, D. T. Weaver-Sands, 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Tigecycline MIC Testing by Broth Dilution Requires Use of Fresh Medium or Addition of the Biocatalytic Oxygen-Reducing Reagent Oxyrase To Standardize the Test Method

J. O'Connell, P. Bradford, M. Young, 2005, Antimicrobial Agents and Chemotherapy.

Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.

P. Petersen, V. Sandanayaka, Y. Yang, 2001, Bioorganic & medicinal chemistry letters.

Glycothiohexides, novel antibiotics produced by "Sebekia" sp. LL-14E605. I. Taxonomy, fermentation and biological evaluation.

C. Pearce, N. Jacobus, D. Montenegro, 1994, The Journal of antibiotics.

Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.

T. Rush, L. Mosyak, Yuanhong Li, 2004, Bioorganic & medicinal chemistry letters.

Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors.

R. Williamson, M. Siegel, G. Carter, 2002, Journal of the American Chemical Society.

Occurrence of Tetracycline Resistance Genes among Escherichia coli Isolates from the Phase 3 Clinical Trials for Tigecycline

A. Howe, M. Orlowski, P. Bradford, 2007, Antimicrobial Agents and Chemotherapy.

Taxonomy and Biological Activities

G. Carter, P. Petersen, W. Weiss, 2008 .

Biological and mechanistic activities of phenazine antibiotics produced by culture LL-14I352.

P. Petersen, W. Ding, M. P. Singh, 1997, The Journal of antibiotics.

Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.

R. Bonomo, A. Hujer, A. Agarwal, 2004, Journal of medicinal chemistry.

Pyrazolidine-3,5-diones and 5-hydroxy-1H-pyrazol-3(2H)-ones, inhibitors of UDP-N-acetylenolpyruvyl glucosamine reductase.

Youjun Yang, A. Severin, Guy Singh, 2006, Journal of medicinal chemistry.

In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I

N. Jacobus, P. Petersen, W. Weiss, 1991, Antimicrobial Agents and Chemotherapy.

Phenyl thiazolyl urea and carbamate derivatives as new inhibitors of bacterial cell-wall biosynthesis.

T. Mansour, Youjun Yang, Guy Singh, 2004, Bioorganic & medicinal chemistry letters.

Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.

T. Rush, L. Mosyak, S. Haney, 2004, Bioorganic & medicinal chemistry.

Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials.

P. Petersen, C. Ziegler, C B Ziegler, 1990, Journal of medicinal chemistry.

The synthesis and evaluation of 6-alkylidene-2'β-substituted penam sulfones as β-lactamase inhibitors

P. Petersen, J. Buynak, V. Doppalapudi, 1999 .

Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

S. Lang, K. Bush, S. Sakya, 1997 .

Novel imidazole substituted 6-methylidene-penems as broad-spectrum beta-lactamase inhibitors.

A. Agarwal, T. Mansour, J. Ryan, 2004, Bioorganic & medicinal chemistry.

Synthesis and biological activity of derivatives of glycopeptide antibiotics eremomycin and vancomycin nitrosated, acylated or carbamoylated at the N-terminal.

M. Preobrazhenskaya, P. Petersen, R. Testa, 1993, The Journal of antibiotics.

In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9-t-Butylglycylamido Derivative of Minocycline (GAR-936)

N. Jacobus, P. Petersen, W. Weiss, 1999, Antimicrobial Agents and Chemotherapy.

Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus LL-42D005. II. Biological activities.

N. Jacobus, P. Petersen, M. P. Singh, 1994, The Journal of antibiotics.

In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines

N. Jacobus, F. Tally, P. Petersen, 1993, Antimicrobial Agents and Chemotherapy.

In Vitro and In Vivo Activities of Tigecycline (GAR-936), Daptomycin, and Comparative Antimicrobial Agents against Glycopeptide-Intermediate Staphylococcus aureus and Other Resistant Gram-Positive Pathogens

P. Bradford, S. Projan, P. Petersen, 2002, Antimicrobial Agents and Chemotherapy.

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.

A. Agarwal, T. Mansour, J. Knox, 2006, Journal of medicinal chemistry.

In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors

J. O'Connell, T. Mansour, P. Bradford, 2004, Antimicrobial Agents and Chemotherapy.

2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis.

J. Skotnicki, T. Mansour, Youjun Yang, 2003, Bioorganic & medicinal chemistry letters.

Validation and Reproducibility Assessment of Tigecycline MIC Determinations by Etest

Anette Engelhardt, A. Bolmström, P. Bradford, 2007, Journal of Clinical Microbiology.

In Vitro Activities of Aminomethyl-Substituted Analogs of Novel Tetrahydrofuranyl Carbapenems

N. Jacobus, P. Petersen, Yang-i Lin, 1999, Antimicrobial Agents and Chemotherapy.

Synergistic activity of piperacillin: YTR-830H combinations in vitro and in vivo.

N. Jacobus, F. Tally, P. Petersen, 1989, Journal of chemotherapy.

In vitro and in vivo efficacy of YTR-830H and piperacillin combinations versus beta-lactamase-producing bacteria.

P. Petersen, W. Weiss, R. Testa, 1989, Journal of chemotherapy.

Pyrosequencing Using the Single-Nucleotide Polymorphism Protocol for Rapid Determination of TEM- and SHV-Type Extended-Spectrum β-Lactamases in Clinical Isolates and Identification of the Novel β-Lactamase Genes blaSHV-48, blaSHV-105, and blaTEM-155

P. Bradford, P. Petersen, A. Ruzin, 2008, Antimicrobial Agents and Chemotherapy.

A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline

P. Bradford, S. Projan, E. Murphy, 2005, Antimicrobial Agents and Chemotherapy.

Synthesis and Structure—Activity Relationship of Novel Glycylcycline Derivatives Leading to the Discovery of GAR‐936.

P. Petersen, P. Sum, 1999 .

"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides.

P. Petersen, R. Testa, B. Buckwalter, 1994, Journal of medicinal chemistry.

Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936.

P. Petersen, P E Sum, P Petersen, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and antibacterial activity of 9-substituted minocycline derivatives.

P. Petersen, R. Testa, P. Sum, 2006, Bioorganic & medicinal chemistry letters.

In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis.

P. Bradford, P. Petersen, P. Labthavikul, 2006, The Journal of antimicrobial chemotherapy.

Susceptibility of enterococci, methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae to the glycylcyclines.

N. Jacobus, P. Petersen, W. Weiss, 1995, The Journal of antimicrobial chemotherapy.

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for diabetic foot infections.

P. Petersen, A. Ruzin, M. Tuckman, 2010, Diagnostic microbiology and infectious disease.

Tigecycline: First class glycylcycline: a new choice for empiric therapy

P. Petersen, C. Jones, 2006 .

Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics.

Nancy Torres, T. Mansour, P. Petersen, 2003, Bioorganic & medicinal chemistry letters.

Resistance development profiling of piperacillin in combination with the novel {beta}-lactamase inhibitor BLI-489.

P. Petersen, A. Ruzin, C. Jones, 2010, The Journal of antimicrobial chemotherapy.

Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection

P. Bradford, P. Petersen, A. Venkatesan, 2009, Antimicrobial Agents and Chemotherapy.

Anthranilate 4H-oxazol-5-ones: novel small molecule antibacterial acyl carrier protein synthase (AcpS) inhibitors.

D. Joseph-McCarthy, C. Fritz, I. McFadyen, 2004, Bioorganic & medicinal chemistry letters.

Naphthyl Tetronic Acids as Multi‐Target Inhibitors of Bacterial Peptidoglycan Biosynthesis

C. Caufield, R. Chopra, K. Svenson, 2007, ChemMedChem.

InVitro andInVivoActivities ofLJC10,627, a New Carbapenem withStability toDehydropeptidase I

P. J. Petersen, N. V. Jacobus, W. J. Weiss, 1991 .

Novel alpha-pyrones produced by a marine Pseudomonas sp. F92S91: taxonomy and biological activities.

G. Carter, P. Petersen, W. Weiss, 2003, The Journal of antibiotics.

Mechanistic studies and biological activity of bioxalomycin alpha 2, a novel antibiotic produced by Streptomyces viridodiastaticus subsp. "litoralis" LL-31F508

N. Jacobus, P. Petersen, M. P. Singh, 1994, Antimicrobial Agents and Chemotherapy.

Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.

S. Projan, P. Petersen, M. Tuckman, 2000, Microbial drug resistance.

In vitro activity of tigecycline against patient isolates collected during phase 3 clinical trials for hospital acquired pneumonia

P. Petersen, M. Tuckman, C. Jones, 2010, Infectious disease reports.

In Vivo Activities of Peptidic Prodrugs of Novel Aminomethyl Tetrahydrofuranyl-1β-Methylcarbapenems

N. Jacobus, P. Petersen, Yang-i Lin, 1999, Antimicrobial Agents and Chemotherapy.

Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.

Dominick Quagliato, Diane Joseph-McCarthy, Elena Severina, 2005, Journal of medicinal chemistry.

Therapeutic Efficacy of GAR-936, a Novel Glycylcycline, in a Rat Model of Experimental Endocarditis

P. Petersen, W. Weiss, Timothy M. Murphy, 2000, Antimicrobial Agents and Chemotherapy.

6-(1-Hydroxyalkyl))penam sulfone derivatives as inhibitors of class A and class C beta-lactamases II.

P. Petersen, G. Francisco, E. Lenoy, 1999, Bioorganic & medicinal chemistry letters.

6-(1-Hydroxyalkyl)penam Sulfone Derivatives as Inhibitors of Class A and Class C β-Lactamases. Part 2.

Youjun Yang, P. Petersen, Yang-i Lin, 1999 .

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

S. Lang, K. Bush, S. Sakya, 1997 .

Mono and bis double ester prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

S. Lang, K. Bush, S. Sakya, 1997 .

In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth.

P. Bradford, P. Petersen, C. Jones, 2007, Diagnostic microbiology and infectious disease.

Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.

J. Alvarez, T. Rush, L. Mosyak, 2003, Organic & biomolecular chemistry.

A novel antibiotic bone assay by liquid chromatography/tandem mass spectrometry for quantitation of tigecycline in rat bone.

E. Fluhler, P. Petersen, A. Ji, 2007, Journal of pharmaceutical and biomedical analysis.

Resistance development profiling of piperacillin in combination with the novel {beta}-lactamase inhibitor BLI-489.

P. Petersen, A. Ruzin, C. H. Jones, 2010, The Journal of antimicrobial chemotherapy.